PubRank

Aris N Economides

Author PubWeight™ 57.38‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 2003 7.47
2 Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 2003 3.85
3 Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature 2002 3.67
4 Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell 2011 3.12
5 Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy. Mol Cell Biol 2004 2.58
6 Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2. J Immunol 2009 2.44
7 Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev 2010 2.28
8 The BMP antagonist noggin regulates cranial suture fusion. Nature 2003 2.09
9 Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism. J Bone Miner Res 2011 1.89
10 Targeted deletion of Sost distal enhancer increases bone formation and bone mass. Proc Natl Acad Sci U S A 2012 1.78
11 In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification. J Bone Joint Surg Am 2003 1.59
12 Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology 2004 1.58
13 Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients. J Biol Chem 2001 1.43
14 Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. J Biol Chem 2010 1.38
15 Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone. J Neurosci 2004 1.30
16 Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A 2011 1.26
17 Podocyte-derived BMP7 is critical for nephron development. J Am Soc Nephrol 2008 1.19
18 Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J Biol Chem 2007 1.12
19 Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome. J Clin Invest 2010 1.09
20 Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Proc Natl Acad Sci U S A 2011 1.06
21 Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development 2011 1.03
22 Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Endocrinology 2010 1.02
23 A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest 2014 0.98
24 Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis. Endocrinology 2009 0.97
25 Generation and functional characterization of mice with a conditional BMP7 allele. Int J Dev Biol 2009 0.97
26 Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Am J Physiol Endocrinol Metab 2012 0.93
27 The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development 2008 0.92
28 Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease. Cell Stem Cell 2013 0.91
29 Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. J Bone Joint Surg Am 2003 0.90
30 Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function. Bone 2006 0.90
31 Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc Natl Acad Sci U S A 2010 0.89
32 Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. Dev Biol 2013 0.89
33 Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proc Natl Acad Sci U S A 2005 0.85
34 Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth. PLoS One 2013 0.85
35 Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2. PLoS One 2012 0.82
36 Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice. Biol Reprod 2011 0.81