Alpha-toxin promotes Staphylococcus aureus mucosal biofilm formation.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 3417397)

Published in Front Cell Infect Microbiol on May 09, 2012

Authors

Michele J Anderson1, Ying-Chi Lin, Aaron N Gillman, Patrick J Parks, Patrick M Schlievert, Marnie L Peterson

Author Affiliations

1: Department of Experimental and Clinical Pharmacology, University of Minnesota Minneapolis, MN, USA.

Articles citing this

Detection of Alpha-Toxin and Other Virulence Factors in Biofilms of Staphylococcus aureus on Polystyrene and a Human Epidermal Model. PLoS One (2016) 1.45

Novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms. MBio (2013) 1.08

The Acinetobacter baumannii Two-Component System AdeRS Regulates Genes Required for Multidrug Efflux, Biofilm Formation, and Virulence in a Strain-Specific Manner. MBio (2016) 0.91

Intra- and inter-species interactions within biofilms of important foodborne bacterial pathogens. Front Microbiol (2015) 0.86

Unraveling microbial biofilms of importance for food microbiology. Microb Ecol (2013) 0.85

Impact of the functional status of saeRS on in vivo phenotypes of Staphylococcus aureus sarA mutants. Mol Microbiol (2014) 0.83

The staphylococci and staphylococcal pathogenesis. Front Cell Infect Microbiol (2012) 0.82

Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia. J Leukoc Biol (2015) 0.81

A mucosal model to study microbial biofilm development and anti-biofilm therapeutics. J Microbiol Methods (2012) 0.80

Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model. BMC Microbiol (2015) 0.78

Genotypic and phenotypic analysis of clinical isolates of Staphylococcus aureus revealed production patterns and hemolytic potentials unlinked to gene profiles and source. BMC Microbiol (2016) 0.77

The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms. Infect Immun (2015) 0.77

Methamphetamine Alters the Antimicrobial Efficacy of Phagocytic Cells during Methicillin-Resistant Staphylococcus aureus Skin Infection. MBio (2015) 0.76

Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression. Front Microbiol (2016) 0.75

Diversity of Virulence Factors Associated with West Australian Methicillin-Sensitive Staphylococcus aureus Isolates of Human Origin. Biomed Res Int (2016) 0.75

Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome. PLoS One (2016) 0.75

Articles cited by this

Staphylococcus aureus infections. N Engl J Med (1998) 36.39

Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol (2004) 18.85

Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science (1996) 16.69

Antibiotic resistance of bacteria in biofilms. Lancet (2001) 12.62

Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol (2001) 11.67

Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol (1985) 10.22

The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis (2005) 9.80

Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis (2005) 6.85

Prevalence of Staphylococcus aureus nasal colonization in the United States, 2001-2002. J Infect Dis (2005) 6.78

Staphylococcus and biofilms. Mol Microbiol (2002) 6.39

Alpha-toxin of Staphylococcus aureus. Microbiol Rev (1991) 6.14

Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004. J Infect Dis (2008) 5.41

Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus. Infect Immun (2002) 4.62

Staphylococcal biofilms. Curr Top Microbiol Immunol (2008) 4.26

Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis (2010) 4.19

Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med (2008) 4.01

Biofilms and device-associated infections. Emerg Infect Dis (2001) 3.81

Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureus. J Infect Dis (2006) 3.74

Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement. Infect Immun (1987) 3.45

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med (2011) 3.17

Methicillin-resistant-Staphylococcus aureus hospitalizations, United States. Emerg Infect Dis (2005) 3.09

Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. Nature (2010) 2.85

Presence of icaA and icaD genes and slime production in a collection of staphylococcal strains from catheter-associated infections. J Clin Microbiol (2001) 2.63

A scanning and transmission electron microscopic study of an infected endocardial pacemaker lead. Circulation (1982) 2.43

Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland. Infect Immun (1989) 2.23

Soft-tissue filler complications: the important role of biofilms. Plast Reconstr Surg (2010) 2.18

Characterization of Staphylococcus aureus isolates from nasal cultures collected from individuals in the United States in 2001 to 2004. J Clin Microbiol (2008) 2.16

Prosthetic joint infections: bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis (2003) 2.05

Characterization of a rabbit model of staphylococcal osteomyelitis. J Orthop Res (1997) 1.86

Alpha-toxin is required for biofilm formation by Staphylococcus aureus. J Bacteriol (2003) 1.73

Toxin and enzyme characterization of Staphylococcus aureus isolates from patients with and without toxic shock syndrome. Ann Intern Med (1982) 1.73

Toxic shock syndrome. A newly recognized complication of influenza and influenzalike illness. JAMA (1987) 1.69

The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1. Infect Immun (2005) 1.62

Bacterial biofilms in otitis media: evidence and relevance. Pediatr Infect Dis J (2007) 1.60

Cytolysins augment superantigen penetration of stratified mucosa. J Immunol (2009) 1.27

Biofilms and chronic wound inflammation. J Wound Care (2008) 1.25

Biofilms in vitro and in vivo: do singular mechanisms imply cross-resistance? J Appl Microbiol (2002) 1.19

Adhesion mechanisms of staphylococci. Adv Exp Med Biol (2011) 1.18

Emergence of USA300 MRSA in a tertiary medical centre: implications for epidemiological studies. J Hosp Infect (2008) 1.15

Biofilm-associated proteins. C R Biol (2006) 1.10

Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus. Biochemistry (2011) 1.10

Porcine vagina ex vivo as a model for studying permeability and pathogenesis in mucosa. J Pharm Sci (2008) 1.06

In situ replacement of arterial prosthesis infected by bacterial biofilms: long-term follow-up. J Vasc Surg (1994) 0.85

Channel-forming abilities of spontaneously occurring alpha-toxin fragments from Staphylococcus aureus. J Membr Biol (2010) 0.79

Biological relevance of natural alpha-toxin fragments from Staphylococcus aureus. J Membr Biol (2010) 0.77

Articles by these authors

Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence. Proc Natl Acad Sci U S A (2002) 5.07

Glycerol monolaurate prevents mucosal SIV transmission. Nature (2009) 5.02

Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women. Clin Infect Dis (2003) 2.90

Purpura fulminans due to Staphylococcus aureus. Clin Infect Dis (2005) 2.27

Characterization of virulence factor regulation by SrrAB, a two-component system in Staphylococcus aureus. J Bacteriol (2004) 1.91

Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3. Implications for the evolution of staphylococcal pathogenicity islands. J Biol Chem (2002) 1.88

Quorum sensing in Staphylococcus infections. J Clin Invest (2003) 1.79

Repression of the Staphylococcus aureus accessory gene regulator in serum and in vivo. J Bacteriol (2002) 1.73

The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1. Infect Immun (2005) 1.62

Extreme pyrexia and rapid death due to Staphylococcus aureus infection: analysis of 2 cases. Clin Infect Dis (2009) 1.55

Temperature regulates bacterial protein production: possible role in rosacea. J Am Acad Dermatol (2004) 1.55

Genome diversification in Staphylococcus aureus: Molecular evolution of a highly variable chromosomal region encoding the Staphylococcal exotoxin-like family of proteins. Infect Immun (2003) 1.53

Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. Nat Med (2007) 1.52

Staphylococcal and streptococcal superantigen exotoxins. Clin Microbiol Rev (2013) 1.48

Reduction in Staphylococcus aureus growth and exotoxin production and in vaginal interleukin 8 levels due to glycerol monolaurate in tampons. Clin Infect Dis (2009) 1.48

Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity. Clin Infect Dis (2009) 1.47

Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms. Proc Natl Acad Sci U S A (2010) 1.44

Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. PLoS One (2011) 1.43

Structure and biological activities of beta toxin from Staphylococcus aureus. J Bacteriol (2007) 1.43

Glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginal lactobacilli and is safe for chronic use. Antimicrob Agents Chemother (2008) 1.43

Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis. J Allergy Clin Immunol (2010) 1.42

A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia. PLoS Pathog (2011) 1.37

Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance period. J Clin Microbiol (2004) 1.37

In vivo induction of virulence and antibiotic resistance transfer in Enterococcus faecalis mediated by the sex pheromone-sensing system of pCF10. Infect Immun (2002) 1.35

Glycerol monolaurate inhibits the effects of Gram-positive select agents on eukaryotic cells. Biochemistry (2006) 1.33

Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes. Structure (2002) 1.31

Gram-positive bacterial superantigen outside-in signaling causes toxic shock syndrome. FEBS J (2011) 1.29

Virulence regulation in Staphylococcus aureus: the need for in vivo analysis of virulence factor regulation. FEMS Immunol Med Microbiol (2004) 1.28

Cytolysins augment superantigen penetration of stratified mucosa. J Immunol (2009) 1.27

Characterization of a novel staphylococcal enterotoxin-like superantigen, a member of the group V subfamily of pyrogenic toxins. Biochemistry (2002) 1.23

Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio (2013) 1.19

Alpha and beta chains of hemoglobin inhibit production of Staphylococcus aureus exotoxins. Biochemistry (2007) 1.19

Staphylococcal superantigens cause lethal pulmonary disease in rabbits. J Infect Dis (2010) 1.18

An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid. Mol Microbiol (2004) 1.14

Characterization of Staphylococcus aureus enterotoxin L. Infect Immun (2003) 1.13

Multiple functional domains of Enterococcus faecalis aggregation substance Asc10 contribute to endocarditis virulence. Infect Immun (2008) 1.12

The staphylococcal respiratory response regulator SrrAB induces ica gene transcription and polysaccharide intercellular adhesin expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditions. Mol Microbiol (2007) 1.10

Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus. Biochemistry (2011) 1.10

Glycerol monolaurate inhibits Candida and Gardnerella vaginalis in vitro and in vivo but not Lactobacillus. Antimicrob Agents Chemother (2009) 1.09

ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand. J Immunol Methods (2008) 1.09

Glycerol monolaurate inhibits virulence factor production in Bacillus anthracis. Antimicrob Agents Chemother (2005) 1.09

Prevalence of superantigen-secreting bacteria in patients with Kawasaki disease. J Pediatr (2002) 1.09

Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. J Allergy Clin Immunol (2011) 1.08

Cytolysins, superantigens, and pneumonia due to community-associated methicillin-resistant Staphylococcus aureus. J Infect Dis (2009) 1.08

Glycerol monolaurate antibacterial activity in broth and biofilm cultures. PLoS One (2012) 1.07

Porcine vagina ex vivo as a model for studying permeability and pathogenesis in mucosa. J Pharm Sci (2008) 1.06

Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses. Vaccine (2012) 1.04

Use of recombinase-based in vivo expression technology to characterize Enterococcus faecalis gene expression during infection identifies in vivo-expressed antisense RNAs and implicates the protease Eep in pathogenesis. Infect Immun (2011) 1.03

Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens. J Mol Biol (2007) 1.01

Comparison of Staphylococcus aureus strains for ability to cause infective endocarditis and lethal sepsis in rabbits. Front Cell Infect Microbiol (2012) 1.01

Glycerol monolaurate and dodecylglycerol effects on Staphylococcus aureus and toxic shock syndrome toxin-1 in vitro and in vivo. PLoS One (2009) 1.00

Penetration of toxic shock syndrome toxin-1 across porcine vaginal mucosa ex vivo: permeability characteristics, toxin distribution, and tissue damage. Am J Obstet Gynecol (2003) 0.99

In vivo assessment of human vaginal oxygen and carbon dioxide levels during and post menses. J Appl Physiol (1985) (2005) 0.99

Functional analysis of the TCR binding domain of toxic shock syndrome toxin-1 predicts further diversity in MHC class II/superantigen/TCR ternary complexes. J Immunol (2003) 0.98

Assembly of large, high G+C bacterial DNA fragments in yeast. ACS Synth Biol (2012) 0.98

Enterococcus faecalis endocarditis severity in rabbits is reduced by IgG Fabs interfering with aggregation substance. PLoS One (2010) 0.98

Staphylococcal superantigens interact with multiple host receptors to cause serious diseases. Immunol Res (2014) 0.95

Molecular analysis of staphylococcal superantigens. Methods Mol Biol (2014) 0.94

The two-component system Bacillus respiratory response A and B (BrrA-BrrB) is a virulence factor regulator in Bacillus anthracis. Biochemistry (2007) 0.94

Resistance of antimicrobial skin preparations to saline rinse using a seeded bacteria model. Am J Infect Control (2007) 0.94

Repression of Staphylococcus aureus SrrAB using inducible antisense srrA alters growth and virulence factor transcript levels. Biochemistry (2007) 0.94

Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks. Infect Immun (2002) 0.94

Staphylococcus aureus exotoxins are present in vivo in tampons. Clin Vaccine Immunol (2010) 0.91

A superantigen hypothesis for the pathogenesis of chronic hyperplastic sinusitis with massive nasal polyposis. Am J Rhinol (2004) 0.91

Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity maturation. Structure (2003) 0.91

Vaginal Staphylococcus aureus superantigen profile shift from 1980 and 1981 to 2003, 2004, and 2005. J Clin Microbiol (2007) 0.90

Characterization of a Staphylococcus aureus surface virulence factor that promotes resistance to oxidative killing and infectious endocarditis. Infect Immun (2010) 0.90

A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes. Clin Vaccine Immunol (2010) 0.90

Ecto-5'-nucleotidase: a candidate virulence factor in Streptococcus sanguinis experimental endocarditis. PLoS One (2012) 0.90

Novel toxic shock syndrome toxin-1 amino acids required for biological activity. Biochemistry (2008) 0.89

A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem (2012) 0.89

Efficacy of concurrent application of chlorhexidine gluconate and povidone iodine against six nosocomial pathogens. Am J Infect Control (2010) 0.89

Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophrenia. Psychopharmacol Bull (2007) 0.89

Role of topoisomerase mutations and efflux in fluoroquinolone resistance of Bacteroides fragilis clinical isolates and laboratory mutants. Antimicrob Agents Chemother (2004) 0.89

Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats. J Infect Dis (2008) 0.87

Staphylococcus aureus α-toxin modulates skin host response to viral infection. J Allergy Clin Immunol (2012) 0.87

Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression. J Bacteriol (2007) 0.86

Formation of vegetations during infective endocarditis excludes binding of bacterial-specific host antibodies to Enterococcus faecalis. J Infect Dis (2002) 0.86

Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality. PLoS One (2012) 0.85