Published in Adv Virol on August 08, 2012
Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol (2013) 1.75
The fundamental role of endothelial cells in hantavirus pathogenesis. Front Microbiol (2014) 0.87
Hantavirus GnT elements mediate TRAF3 binding and inhibit RIG-I/TBK1-directed beta interferon transcription by blocking IRF3 phosphorylation. J Virol (2014) 0.87
Hantavirus interferon regulation and virulence determinants. Virus Res (2014) 0.81
Effects of Different Doses of Nucleocapsid Protein from Hantaan Virus A9 Strain on Regulation of Interferon Signaling. Viral Immunol (2015) 0.75
What Do We Know about How Hantaviruses Interact with Their Different Hosts? Viruses (2016) 0.75
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (1994) 26.02
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature (2008) 10.73
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature (2009) 9.74
Hantaviruses: a global disease problem. Emerg Infect Dis (1997) 9.67
Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science (1993) 9.11
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem (1995) 8.52
Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The Hantavirus Study Group. N Engl J Med (1994) 7.61
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature (2005) 5.72
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature (2005) 5.56
Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol (1995) 5.30
A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev (2010) 4.64
DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 3.88
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J (1999) 3.78
Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs. J Virol (2001) 3.65
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal (2012) 3.59
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription. J Virol (2004) 3.52
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell (2006) 3.23
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J (2006) 3.13
Antiviral innate immunity pathways. Cell Res (2006) 2.80
Function of RIG-I-like receptors in antiviral innate immunity. J Biol Chem (2007) 2.74
Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology (1998) 2.71
Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production. J Gen Virol (1979) 2.69
beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci U S A (1998) 2.54
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon. J Virol (2002) 2.50
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity (2012) 2.47
Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol (2011) 2.19
Virus evolution and genetic diversity of hantaviruses and their rodent hosts. Curr Top Microbiol Immunol (2001) 2.16
Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order. Virology (1987) 2.10
Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? Trends Biochem Sci (2008) 2.08
Isolation of the causative agent of hantavirus pulmonary syndrome. Am J Trop Med Hyg (1994) 2.07
Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol (1999) 2.03
Hantavirus pulmonary syndrome in the United States: a pathological description of a disease caused by a new agent. Hum Pathol (1995) 2.00
RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity. Cytokine Growth Factor Rev (2007) 1.94
Person-to-person transmission of Andes virus. Emerg Infect Dis (2005) 1.94
La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J Virol (2007) 1.90
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat Struct Mol Biol (2012) 1.82
Tula virus: a newly detected hantavirus carried by European common voles. J Virol (1994) 1.81
Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. J Virol (1996) 1.76
Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway. J Biol Chem (2006) 1.75
Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses. Proc Natl Acad Sci U S A (2002) 1.74
The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responses. J Virol (2006) 1.66
Hantaan virus infection of human endothelial cells. J Virol (1992) 1.65
Genetic characterization and phylogeny of Andes virus and variants from Argentina and Chile. Virus Res (1997) 1.61
Isolation and initial characterization of a newfound hantavirus from California. Virology (1995) 1.59
Hantavirus pulmonary syndrome in Argentina. Possibility of person to person transmission. Medicina (B Aires) (1996) 1.56
Isolation and characterization of Tula virus, a distinct serotype in the genus Hantavirus, family Bunyaviridae. J Gen Virol (1996) 1.52
Regulation of gene expression by cytokines and virus in human cells lacking the type-I interferon locus. Eur J Biochem (1992) 1.51
Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus. J Virol (1995) 1.50
Experimental infection of human vascular endothelial cells by pathogenic and nonpathogenic hantaviruses. Arch Virol (1990) 1.49
Isolation of pathogenic hantavirus from white-footed mouse (Peromyscus leucopus) Lancet (1994) 1.43
The STING pathway and regulation of innate immune signaling in response to DNA pathogens. Cell Mol Life Sci (2010) 1.38
Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter. J Med Virol (2007) 1.32
Andes and Prospect Hill hantaviruses differ in early induction of interferon although both can downregulate interferon signaling. J Virol (2007) 1.32
Expression of the Hantaan virus M genome segment by using a vaccinia virus recombinant. J Virol (1988) 1.32
TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. J Biol Chem (2010) 1.29
The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation. J Virol (2008) 1.24
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation. J Biol Chem (2004) 1.24
The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA. Virology (2001) 1.23
First human isolate of Hantavirus (Andes virus) in the Americas. Emerg Infect Dis (2002) 1.21
Treatment of hantavirus pulmonary syndrome. Antiviral Res (2007) 1.21
Induction of innate immune response genes by Sin Nombre hantavirus does not require viral replication. J Virol (2005) 1.20
Pathogenesis of puumala and other hantavirus infections. Rev Med Virol (1998) 1.20
Hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B. J Virol (2008) 1.20
Hantavirus. Antiviral Res (2003) 1.19
Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties. Arch Virol (2005) 1.19
Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements. J Virol (2003) 1.17
Pathogenic hantaviruses selectively inhibit beta3 integrin directed endothelial cell migration. Arch Virol (2002) 1.17
Sin Nombre virus glycoprotein trafficking. Virology (2003) 1.17
Differential antiviral response of endothelial cells after infection with pathogenic and nonpathogenic hantaviruses. J Virol (2004) 1.16
Alternative and accessory pathways in the regulation of IFN-beta-mediated gene expression. J Interferon Cytokine Res (2005) 1.11
Downstream regulator TANK binds to the CD40 recognition site on TRAF3. Structure (2002) 1.11
Pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. J Virol (2010) 1.08
Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J Gen Virol (2010) 1.08
Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. J Virol (2010) 1.06
Hemorrhagic fever with renal syndrome in Korea. Rev Infect Dis (1989) 1.05
Serological survey of Prospect Hill virus infection in indigenous wild rodents in the USA. Trans R Soc Trop Med Hyg (1987) 1.05
Hantavirus Gc glycoprotein: evidence for a class II fusion protein. J Gen Virol (2005) 1.04
Circulating immune complexes, immunoconglutinins, and rheumatoid factors in nephropathia epidemica. J Infect Dis (1981) 1.04
Hemorrhagic fever virus-induced changes in hemostasis and vascular biology. Blood Coagul Fibrinolysis (2000) 1.03
Tyrosine residues direct the ubiquitination and degradation of the NY-1 hantavirus G1 cytoplasmic tail. J Virol (2003) 1.02
Antagonism of type I interferon responses by new world hantaviruses. J Virol (2010) 1.00
Andes virus stimulates interferon-inducible MxA protein expression in endothelial cells. J Med Virol (2005) 1.00
Clinical features of HFRS in Scandinavia as compared with East Asia. Scand J Infect Dis Suppl (1982) 0.99
Effects of human and murine interferons against hemorrhagic fever with renal syndrome (HFRS) virus (Hantaan virus). Antiviral Res (1987) 0.97
Degrons at the C terminus of the pathogenic but not the nonpathogenic hantavirus G1 tail direct proteasomal degradation. J Virol (2007) 0.95
Inhibition of TNF-alpha-induced activation of NF-kappaB by hantavirus nucleocapsid proteins. Ann N Y Acad Sci (2009) 0.93
Pleural fluid characteristics in hantavirus pulmonary syndrome. Chest (1997) 0.93
New York 1 and Sin Nombre viruses are serotypically distinct viruses associated with hantavirus pulmonary syndrome. J Clin Microbiol (1999) 0.93
TRAF3: a new component of the TLR-signaling apparatus. Trends Mol Med (2006) 0.93
TRAF3: a new regulator of type I interferons. Cell Cycle (2006) 0.92
Expression strategy of the M genome segment of Hantaan virus. Virus Res (1994) 0.92
Comparison of innate immune responses to pathogenic and putative non-pathogenic hantaviruses in vitro. Virus Res (2011) 0.90
The C-terminal 42 residues of the Tula virus Gn protein regulate interferon induction. J Virol (2011) 0.90
The Hantaan virus M-segment glycoproteins G1 and G2 can be expressed independently. J Virol (1992) 0.89
Hantaviruses: history and overview. Curr Top Microbiol Immunol (2001) 0.88
Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses. Proc Natl Acad Sci U S A (2002) 1.74
The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responses. J Virol (2006) 1.66
Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry. J Virol (2003) 1.56
Pathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent alphavbeta3 integrin conformers. Proc Natl Acad Sci U S A (2005) 1.29
The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation. J Virol (2008) 1.24
Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements. J Virol (2003) 1.17
Productive dengue virus infection of human endothelial cells is directed by heparan sulfate-containing proteoglycan receptors. J Virol (2011) 1.15
Pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. J Virol (2010) 1.08
Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. J Virol (2010) 1.06
VEGFR2 and Src kinase inhibitors suppress Andes virus-induced endothelial cell permeability. J Virol (2010) 1.02
Tyrosine residues direct the ubiquitination and degradation of the NY-1 hantavirus G1 cytoplasmic tail. J Virol (2003) 1.02
Endothelial cells elicit immune-enhancing responses to dengue virus infection. J Virol (2012) 1.00
The cytokine osteopontin modulates the severity of rotavirus diarrhea. J Virol (2005) 0.99
Andes virus regulation of cellular microRNAs contributes to hantavirus-induced endothelial cell permeability. J Virol (2010) 0.98
The formation of viroplasm-like structures by the rotavirus NSP5 protein is calcium regulated and directed by a C-terminal helical domain. J Virol (2007) 0.97
Roles for endothelial cells in dengue virus infection. Adv Virol (2012) 0.95
Degrons at the C terminus of the pathogenic but not the nonpathogenic hantavirus G1 tail direct proteasomal degradation. J Virol (2007) 0.95
Andes virus recognition of human and Syrian hamster beta3 integrins is determined by an L33P substitution in the PSI domain. J Virol (2010) 0.92
The C-terminal 42 residues of the Tula virus Gn protein regulate interferon induction. J Virol (2011) 0.90
Discrete domains within the rotavirus VP5* direct peripheral membrane association and membrane permeability. J Virol (2004) 0.89
Hantavirus GnT elements mediate TRAF3 binding and inhibit RIG-I/TBK1-directed beta interferon transcription by blocking IRF3 phosphorylation. J Virol (2014) 0.87
Andes virus infection of lymphatic endothelial cells causes giant cell and enhanced permeability responses that are rapamycin and vascular endothelial growth factor C sensitive. J Virol (2012) 0.82
An innate immunity-regulating virulence determinant is uniquely encoded by the Andes virus nucleocapsid protein. MBio (2014) 0.81
Slit2-Robo4 receptor responses inhibit ANDV directed permeability of human lung microvascular endothelial cells. Antiviral Res (2013) 0.81
Hypoxia induces permeability and giant cell responses of Andes virus-infected pulmonary endothelial cells by activating the mTOR-S6K signaling pathway. J Virol (2013) 0.79