Hip ontogenesis: how evolution, genes, and load history shape hip morphotype and cartilotype.

PubWeight™: 0.93‹?›

🔗 View Article (PMC 3492609)

Published in Clin Orthop Relat Res on December 01, 2012

Authors

Tom Hogervorst1, Wouter Eilander, Joost T Fikkers, Ingrid Meulenbelt

Author Affiliations

1: Orthopaedic Surgeon, Haga Hospital, The Hague, The Netherlands. thogervorst@gmail.com

Articles cited by this

(truncated to the top 100)

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

The contour of the femoral head-neck junction as a predictor for the risk of anterior impingement. J Bone Joint Surg Br (2002) 7.38

Congenital Deformities of Mechanical Origin: (Section for the Study of Disease in Children). Proc R Soc Med (1936) 5.71

The etiology of osteoarthritis of the hip: an integrated mechanical concept. Clin Orthop Relat Res (2008) 4.63

Femoroacetabular impingement and the cam-effect. A MRI-based quantitative anatomical study of the femoral head-neck offset. J Bone Joint Surg Br (2001) 4.46

The control of chondrogenesis. J Cell Biochem (2006) 4.36

A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet (2007) 4.31

Etiology of osteoarthritis of the hip. Clin Orthop Relat Res (1986) 4.15

Exome sequencing: the sweet spot before whole genomes. Hum Mol Genet (2010) 3.50

The aetiology of primary osteoarthritis of the hip. Br J Radiol (1965) 3.24

Slipped capital femoral epiphysis: early mechanical damage to the acetabular cartilage by a prominent femoral metaphysis. Acta Orthop Scand (2000) 3.20

Subclinical slipped capital femoral epiphysis. Relationship to osteoarthrosis of the hip. J Bone Joint Surg Am (1997) 2.97

Athletic activity in adolescence as an etiological factor in degenerative hip disease. J Bone Joint Surg Br (1971) 2.89

Multiple congenital dislocations associated with characteristic facial abnormality. J Pediatr (1950) 2.84

Three-dimensional computed tomography of the hip in the assessment of femoroacetabular impingement. J Orthop Res (2005) 2.62

Hip joint loading during walking and running, measured in two patients. J Biomech (1993) 2.49

Natural history of congenital hip dislocation (CDH) and hip dysplasia. Clin Orthop Relat Res (1987) 2.48

Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum (2007) 2.45

Prevalence of cam-type femoroacetabular impingement morphology in asymptomatic volunteers. J Bone Joint Surg Am (2010) 2.32

Acetabular dysplasia and hip osteoarthritis in Britain and Japan. Br J Rheumatol (1998) 2.22

Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum (2005) 2.19

Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell (2009) 2.09

Prevalence of malformations of the hip joint and their relationship to sex, groin pain, and risk of osteoarthritis: a population-based survey. J Bone Joint Surg Am (2010) 2.08

Hip damage occurs at the zone of femoroacetabular impingement. Clin Orthop Relat Res (2008) 2.06

The cam-type deformity of the proximal femur arises in childhood in response to vigorous sporting activity. Clin Orthop Relat Res (2011) 1.94

Predictors of progression of osteoarthritis in femoroacetabular impingement: a radiological study with a minimum of ten years follow-up. J Bone Joint Surg Br (2009) 1.87

Effects of biomechanical stress on bones in animals. Bone (2002) 1.82

Diseases of the hip. A comparative study of Japanese Oriental and American white patients. J Bone Joint Surg Am (1985) 1.72

The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. Ann Rheum Dis (2010) 1.70

The demographics of slipped capital femoral epiphysis. An international multicenter study. Clin Orthop Relat Res (1996) 1.61

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet (2008) 1.60

Normal hip and knee active range of motion: the relationship to age. Phys Ther (1991) 1.58

Early identification of radiographic osteoarthritis of the hip using an active shape model to quantify changes in bone morphometric features: can hip shape tell us anything about the progression of osteoarthritis? Arthritis Rheum (2007) 1.57

The association between hip morphology parameters and nineteen-year risk of end-stage osteoarthritis of the hip: a nested case-control study. Arthritis Rheum (2011) 1.56

Nonspherical femoral head shape (pistol grip deformity), neck shaft angle, and risk of hip osteoarthritis: a case-control study. Arthritis Rheum (2008) 1.55

A new radiological index for assessing asphericity of the femoral head in cam impingement. J Bone Joint Surg Br (2007) 1.54

Do normal radiographs exclude asphericity of the femoral head-neck junction? Clin Orthop Relat Res (2008) 1.54

Prevalence of cam-type deformity on hip magnetic resonance imaging in young males: a cross-sectional study. Arthritis Care Res (Hoboken) (2010) 1.53

The effects of contact pressure elevations and aseptic necrosis on the long-term outcome of congenital hip dislocation. J Orthop Res (1990) 1.45

An examination of the association between different morphotypes of femoroacetabular impingement in asymptomatic subjects and the development of osteoarthritis of the hip. J Bone Joint Surg Br (2011) 1.44

The association of proximal femoral shape and incident radiographic hip OA in elderly women. Osteoarthritis Cartilage (2009) 1.41

Proximal femoral anatomy in the normal human population. Clin Orthop Relat Res (2008) 1.39

Femoroacetabular impingement and classification of the cam deformity: the reference interval in normal hips. Acta Orthop (2010) 1.38

Association of mild acetabular dysplasia with an increased risk of incident hip osteoarthritis in elderly white women: the study of osteoporotic fractures. Arthritis Rheum (2000) 1.36

Influences of mechanical stress on prenatal and postnatal skeletal development. Clin Orthop Relat Res (1987) 1.29

Prevalence of radiographic findings thought to be associated with femoroacetabular impingement in a population-based cohort of 2081 healthy young adults. Radiology (2011) 1.29

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum (2010) 1.29

Vertebral shape: automatic measurement with active shape models. Radiology (1999) 1.27

The development of Cam-type deformity in adolescent and young male soccer players. Am J Sports Med (2012) 1.23

Femoral anteversion in the rabbit. J Bone Joint Surg Br (1962) 1.21

Advances in magnetic resonance imaging of articular cartilage. J Am Acad Orthop Surg (2011) 1.18

Changing incidence of slipped capital femoral epiphysis: a relationship with obesity? J Bone Joint Surg Br (2008) 1.16

Mechanobiology of embryonic skeletal development: Insights from animal models. Birth Defects Res C Embryo Today (2010) 1.16

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation. Hum Mol Genet (2011) 1.15

Ontogeny of locomotion in mountain gorillas and chimpanzees. J Hum Evol (1997) 1.14

The VCL hypothesis revisited: patterns of femoral morphology among quadrupedal and saltatorial prosimian primates. Am J Phys Anthropol (1990) 1.13

Prevalence of femoroacetabular impingement in Asian patients with osteoarthritis of the hip. Int Orthop (2009) 1.13

Gender differences in 3D morphology and bony impingement of human hips. J Orthop Res (2010) 1.11

New insights into osteoarthritis: early developmental features of an ageing-related disease. Curr Opin Rheumatol (2008) 1.10

Genetics of osteoarthritis. Curr Opin Rheumatol (2011) 1.09

Normal range of motion of the hip, knee and ankle joints in male subjects, 30-40 years of age. Acta Orthop Scand (1982) 1.09

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes. Ann Rheum Dis (2010) 1.07

Morphologic differences between the hips of Chinese women and white women: could they account for the ethnic difference in the prevalence of hip osteoarthritis? Arthritis Rheum (2011) 1.06

Genetic influences in the aetiology of femoroacetabular impingement: a sibling study. J Bone Joint Surg Br (2010) 1.06

Changes in shape of the human hip joint during its development and their relation to its stability. J Bone Joint Surg Br (1973) 1.06

Mechanical influences on morphogenesis of the knee joint revealed through morphological, molecular and computational analysis of immobilised embryos. PLoS One (2011) 1.05

Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. Arthritis Rheum (2012) 1.05

Hip joint forces in sheep. J Biomech (1999) 1.04

Prevalence of hip osteoarthritis and acetabular dysplasia in french and japanese adults. Rheumatology (Oxford) (2000) 1.04

Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis. Arthritis Rheum (2011) 1.02

Osteoarthritis of the hip in a gorilla; report of a third case. Clin Orthop (1958) 1.02

The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol (2010) 1.00

Allometry and heterochrony in the African apes. Am J Phys Anthropol (1983) 0.99

Identification of mechanosensitive genes during embryonic bone formation. PLoS Comput Biol (2008) 0.99

Mechanically modulated cartilage growth may regulate joint surface morphogenesis. J Orthop Res (1999) 0.98

Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese. Arthritis Res Ther (2011) 0.98

Familial predisposition to developmental dysplasia of the hip. J Pediatr Orthop (2009) 0.96

Differential regulation of GDF-5 and FGF-2/4 by immobilisation in ovo exposes distinct roles in joint formation. Dev Dyn (2006) 0.95

Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation. J Biol Chem (2005) 0.94

Developmental dysplasia of the hip in South Australia in 1991: prevalence and risk factors. J Paediatr Child Health (1997) 0.93

Epidemiology and demographics of slipped capital femoral epiphysis in Korea: a multicenter study by the Korean Pediatric Orthopedic Society. J Pediatr Orthop (2010) 0.92

Mechanobiological predictions of growth front morphology in developmental hip dysplasia. J Orthop Res (2004) 0.92

Asporin and transforming growth factor-beta gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis. J Orthop Sci (2009) 0.90

Anatomical study of the proximal femur in the fetus. J Pediatr Orthop B (2005) 0.89

Idiopathic slipped capital femoral epiphysis in Amish children. J Bone Joint Surg Am (2005) 0.89

Short adolescence in early hominids: infantile and adolescent growth of the human femur. Am J Phys Anthropol (1998) 0.86

Validation of statistical shape model based reconstruction of the proximal femur--A morphology study. Med Eng Phys (2010) 0.86

Occlusal asymmetries in children with congenital hip dislocation. Eur J Orthod (2011) 0.86

Slipped capital femoral epiphysis: rising rates with obesity and aboriginality in South Australia. J Bone Joint Surg Br (2011) 0.85

The effectiveness of a programme for neonatal hip screening over a period of 40 years: a follow-up of the New Plymouth experience. J Bone Joint Surg Br (2009) 0.84

Walking, running, and sprinting: a three-dimensional analysis of kinematics and kinetics. Instr Course Lect (1995) 0.83

How the horse moves: 2. Significance of graphical representations of equine hind limb kinematics. Equine Vet J (1995) 0.83

Femoral anteversion: a necessary angle or an evolutionary vestige? J Bone Joint Surg Br (2007) 0.83

Morphometric study of the fetal development of the human hip joint: significance for congenital hip disease. Yale J Biol Med (1982) 0.82

Long bone development in extrinsic fetal akinesia: an experimental study in rat fetuses subjected to oligohydramnios. Teratology (1992) 0.80

Screening for developmental dysplasia of the hip in Hong Kong. J Orthop Surg (Hong Kong) (2011) 0.79

Study of femoral torsion during prenatal growth: interpretations associated with the effects of intrauterine pressure. Am J Phys Anthropol (2011) 0.79

An examination chair to measure internal rotation of the hip in routine settings: a validation study. Osteoarthritis Cartilage (2009) 0.78

Relationship between the sphericity of femoral head-acetabulum and the low incidence of primary osteoarthritis of the hip joint in Koreans. Yonsei Med J (1989) 0.77

Histological study of the fetal development of the human acetabulum and labrum: significance in congenital hip disease. Yale J Biol Med (1982) 0.77

Articles by these authors

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47

A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum (2010) 2.02

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet (2008) 1.91

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis (2012) 1.66

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Epigenetics Chromatin (2013) 1.62

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. Ann Rheum Dis (2012) 1.13

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet (2013) 1.12

New insights into osteoarthritis: early developmental features of an ageing-related disease. Curr Opin Rheumatol (2008) 1.10

Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues. Ann Rheum Dis (2012) 1.04

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis Rheumatol (2014) 1.00

High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes. Twin Res Hum Genet (2006) 0.99

Thumb base involvement in symptomatic hand osteoarthritis is associated with more pain and functional disability. Ann Rheum Dis (2010) 0.98

The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males. Ann Rheum Dis (2013) 0.92

Genetics of osteoarthritis: early developmental clues to an old disease. Nat Clin Pract Rheumatol (2008) 0.90

Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis. Menopause (2013) 0.88

Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation. Arthritis Rheum (2005) 0.87

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors. Arthritis Res Ther (2013) 0.87

Eating disorders: from twin studies to candidate genes and beyond. Twin Res Hum Genet (2005) 0.87

Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis. Eur J Hum Genet (2007) 0.87

A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels. Eur J Hum Genet (2010) 0.85

Genetic association analysis of RHOB and TXNDC3 in osteoarthritis. Am J Hum Genet (2007) 0.84

The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth. J Clin Endocrinol Metab (2007) 0.84

Abdominal fat accumulation in adults born preterm exposed antenatally to maternal glucocorticoid treatment is dependent on glucocorticoid receptor gene variation. J Clin Endocrinol Metab (2011) 0.83

Amino acid profiling in urine by capillary zone electrophoresis - mass spectrometry. J Chromatogr A (2007) 0.83

Are baseline high molecular weight adiponectin levels associated with radiographic progression in rheumatoid arthritis and osteoarthritis? J Rheumatol (2014) 0.80

IGF1 promoter polymorphism and cranial growth in individuals born very preterm. Horm Res Paediatr (2011) 0.79

Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles. Ann Rheum Dis (2012) 0.79

Implementation of Functional Genomics for Bench-to-Bedside Transition in Osteoarthritis. Curr Rheumatol Rep (2015) 0.79

Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis. BMC Med Genet (2010) 0.79

Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders. Behav Genet (2012) 0.77

Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors. Twin Res Hum Genet (2005) 0.77

Molecular epidemiology, candidate genes versus genome-wide scans. Genes Nutr (2007) 0.76

Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: a prospective longitudinal cohort study. Arthritis Rheum (2007) 0.76

Association study of the estrogen receptor I gene (ESR1) in anorexia nervosa and eating disorders: no replication found. Int J Eat Disord (2013) 0.76

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data. Psychiatr Genet (2012) 0.76

Replication in genetic association studies: Comment on the editorial by Spector et al. Arthritis Rheum (2006) 0.75

Reliability of cluster results for different types of time adjustments in complex disease research. Conf Proc IEEE Eng Med Biol Soc (2008) 0.75

A common mineralocorticoid receptor polymorphism (I180V) interacts with life events in relation to perfectionism in eating disorders: a pilot study. Eur Eat Disord Rev (2014) 0.75

Clustering of hand osteoarthritis progression and its relationship to progression of osteoarthritis at the knee. Ann Rheum Dis (2013) 0.75

Familial influence on tibiofemoral alignment. Ann Rheum Dis (2009) 0.75

The role of epigenetics in osteoarthritis: current perspective. Curr Opin Rheumatol (2017) 0.75