Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability.

PubWeight™: 0.90‹?›

🔗 View Article (PMC 3527188)

Published in Vasc Cell on August 28, 2012

Authors

Vincent J D Krouwer1, Liesbeth H P Hekking, Miriam Langelaar-Makkinje, Elsa Regan-Klapisz, Jan Andries Post

Author Affiliations

1: Department of Biomolecular Imaging, Faculty of Science, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. j.a.post@uu.nl.

Articles citing this

Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med (2015) 1.82

Cellular and molecular biology of aging endothelial cells. J Mol Cell Cardiol (2015) 1.07

Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity. J Gerontol A Biol Sci Med Sci (2013) 0.89

Resistin increases monolayer permeability of human coronary artery endothelial cells. PLoS One (2013) 0.87

Vascular hyperpermeability and aging. Aging Dis (2014) 0.87

Modeling the Role of the Glymphatic Pathway and Cerebral Blood Vessel Properties in Alzheimer's Disease Pathogenesis. PLoS One (2015) 0.85

Oxidative stress impact on barrier function of porcine angular aqueous plexus cell monolayers. Invest Ophthalmol Vis Sci (2013) 0.82

Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance. Aging Cell (2015) 0.81

Senescence affects endothelial cells susceptibility to dengue virus infection. Int J Med Sci (2014) 0.79

Circulating Plasma Extracellular Microvesicle MicroRNA Cargo and Endothelial Dysfunction in Children with Obstructive Sleep Apnea. Am J Respir Crit Care Med (2016) 0.78

KNDC1 knockdown protects human umbilical vein endothelial cells from senescence. Mol Med Rep (2014) 0.77

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2017) 0.75

Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells. PLoS One (2015) 0.75

Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21. Int J Biol Sci (2017) 0.75

Articles cited by this

Inflammation in atherosclerosis. Nature (2002) 28.92

Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55

Atherosclerosis. Nature (2000) 15.95

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73

Cellular senescence in cancer and aging. Cell (2007) 9.04

The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58

Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation (2002) 4.12

Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev (2004) 4.12

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol (2008) 3.15

Senescence stimulates U937-endothelial cell interactions. Exp Cell Res (1993) 2.15

Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985) (2008) 1.87

Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A (2010) 1.68

Telomere shortening in human coronary artery diseases. Arterioscler Thromb Vasc Biol (2004) 1.57

Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J (2001) 1.49

Vascular endothelial responses to altered shear stress: pathologic implications for atherosclerosis. Ann Med (2009) 1.26

A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination. J Biol Chem (2002) 1.23

Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening. Am J Physiol Heart Circ Physiol (2004) 1.12

Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol (2001) 1.10

Increased expression of extracellular proteins as a hallmark of human endothelial cell in vitro senescence. Exp Gerontol (2006) 1.08

The role of apoptosis in LDL transport through cultured endothelial cell monolayers. Atherosclerosis (2009) 1.03

Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab (2009) 0.99

Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells. Am J Physiol Heart Circ Physiol (2010) 0.97

RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction. Arterioscler Thromb Vasc Biol (2011) 0.97

Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins. Mol Biol Cell (2009) 0.95

Hemodynamic forces in endothelial dysfunction and vascular aging. Exp Gerontol (2010) 0.91

Identification of CD44 as a senescence-induced cell adhesion gene responsible for the enhanced monocyte recruitment to senescent endothelial cells. Am J Physiol Heart Circ Physiol (2010) 0.90

Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkB. J Vasc Res (2009) 0.87

Tannic acid-mediated osmium impregnation after freeze-substitution: a strategy to enhance membrane contrast for electron tomography. J Struct Biol (2008) 0.86

Identification of cultivation-independent markers of human endothelial cell senescence in vitro. Biogerontology (2007) 0.86

Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system. Exp Gerontol (2008) 0.85

Protein expression dynamics during replicative senescence of endothelial cells studied by 2-D difference in-gel electrophoresis. Electrophoresis (2006) 0.84

Evaluation of endothelial cell culture as a model system of vascular ageing. Exp Gerontol (2010) 0.83

A novel approach for intracellular 3D immuno-labeling for electron tomography. Traffic (2012) 0.82

Endothelial hyperpermeability in vascular leakage. Vascul Pharmacol (2002) 0.79

Articles by these authors

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat Cell Biol (2006) 4.05

Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene (2004) 2.50

Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase. Hypertension (2005) 1.29

Cellular solid-state nuclear magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (2012) 1.25

Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening. Am J Physiol Heart Circ Physiol (2004) 1.12

Better preservation of the peritoneum in rats exposed to amino acid-based peritoneal dialysis fluid. Perit Dial Int (2005) 1.12

Gold nanocrystal labeling allows low-density lipoprotein imaging from the subcellular to macroscopic level. ACS Nano (2013) 1.07

Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation. Part Fibre Toxicol (2010) 1.03

Oxidation of ER resident proteins upon oxidative stress: effects of altering cellular redox/antioxidant status and implications for protein maturation. Antioxid Redox Signal (2003) 1.03

The influence of reactive oxygen species on cell cycle progression in mammalian cells. Gene (2012) 1.00

Quantum dot and Cy5.5 labeled nanoparticles to investigate lipoprotein biointeractions via Förster resonance energy transfer. Nano Lett (2010) 0.98

Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins. Mol Biol Cell (2009) 0.95

Contribution of lactate buffer, glucose and glucose degradation products to peritoneal injury in vivo. Nephrol Dial Transplant (2003) 0.91

Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. Biochem J (2002) 0.89

Novel role of cPLA(2)alpha in membrane and actin dynamics. Cell Mol Life Sci (2010) 0.87

Nitric oxide donor induces temporal and dose-dependent reduction of gene expression in human endothelial cells. Am J Physiol Heart Circ Physiol (2004) 0.87

Novel role for mast cells in omental tissue remodeling and cell recruitment in experimental peritoneal dialysis. J Am Soc Nephrol (2006) 0.85

Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion. Cardiovasc Res (2008) 0.85

Protein expression dynamics during replicative senescence of endothelial cells studied by 2-D difference in-gel electrophoresis. Electrophoresis (2006) 0.84

Induced membrane domains as visualized by electron tomography and template matching. J Struct Biol (2009) 0.83

A novel approach for intracellular 3D immuno-labeling for electron tomography. Traffic (2012) 0.82

Alpha-2-macroglobulin and albumin are useful serum proteins to detect subclinical peritonitis in the rat. Perit Dial Int (2006) 0.82

Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis. J Cell Mol Med (2009) 0.82

Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD. Nephrol Dial Transplant (2005) 0.81

P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma. Acta Neuropathol (2014) 0.80

Anti-oxidant sensitivity of donor age-related gene expression in cultured fibroblasts. Eur J Pharmacol (2006) 0.80

Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites. Arch Toxicol (2014) 0.78

Immunopathological changes in a uraemic rat model for peritoneal dialysis. Nephrol Dial Transplant (2005) 0.78

In vitro and in vivo models for peritonitis demonstrate unchanged neutrophil migration after exposure to dialysis fluids. Nephrol Dial Transplant (2004) 0.78

Cobblestone HUVECs: a human model system for studying primary ciliogenesis. J Struct Biol (2011) 0.77

Visualizing tubular lipid peroxidation in intact renal tissue in hypertensive rats. J Am Soc Nephrol (2002) 0.76

Defect engineering in sedimentary colloidal photonic crystals. Langmuir (2013) 0.75

Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo. Toxicol In Vitro (2015) 0.75