Spontaneous latency in a rabbit model of pulmonary tuberculosis.

The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells. Nat Rev Microbiol (2014) 1.46

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses. Immunol Rev (2015) 1.45

A medicinal chemists' guide to the unique difficulties of lead optimization for tuberculosis. Bioorg Med Chem Lett (2013) 1.25

Macrophages in tuberculosis: friend or foe. Semin Immunopathol (2013) 1.04

Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits. Cell Commun Signal (2013) 0.90

Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool. Immunol Rev (2015) 0.86

Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model. EBioMedicine (2016) 0.85

Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis. Cell Commun Signal (2013) 0.85

Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog (2014) 0.83

Detection of Mycobacterium tuberculosis in latently infected lungs by immunohistochemistry and confocal microscopy. J Med Microbiol (2014) 0.80

Rabbit Models for Studying Human Infectious Diseases. Comp Med (2015) 0.78

IL12B expression is sustained by a heterogenous population of myeloid lineages during tuberculosis. Tuberculosis (Edinb) (2013) 0.77

Immunometabolism in Tuberculosis. Front Immunol (2016) 0.75

Animal Models for Tuberculosis in Translational and Precision Medicine. Front Microbiol (2017) 0.75

Alternative activation of macrophages: mechanism and functions. Immunity (2010) 12.43

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat Rev Microbiol (2009) 8.13

A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature (2004) 6.29

Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N Engl J Med (1998) 6.14

Drivers of tuberculosis epidemics: the role of risk factors and social determinants. Soc Sci Med (2009) 5.93

Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection. Infect Immun (2003) 4.16

Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates. J Immunol (1999) 4.15

Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. J Immunol (1999) 3.96

Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J Exp Med (2007) 3.67

Mechanisms of latency in Mycobacterium tuberculosis. Trends Microbiol (1998) 3.62

Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infect Immun (2009) 3.31

Understanding the generation and function of memory T cell subsets. Curr Opin Immunol (2005) 3.22

LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. Eur Respir J (2009) 3.16

Understanding latent tuberculosis: a moving target. J Immunol (2010) 2.95

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns. Am J Respir Crit Care Med (2010) 2.64

Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells. Eur J Immunol (2000) 2.61

Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli. J Infect Dis (2005) 2.50

Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis. Infect Immun (2004) 2.47

Life and death in the granuloma: immunopathology of tuberculosis. Immunol Cell Biol (2007) 2.46

Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection. Am J Pathol (2004) 2.27

Reactivation of latent tuberculosis: variations on the Cornell murine model. Infect Immun (1999) 2.26

Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load. J Immunol (2011) 2.07

Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival. PLoS Pathog (2010) 2.06

Macrophages and control of granulomatous inflammation in tuberculosis. Mucosal Immunol (2011) 1.98

Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent. Infect Immun (2000) 1.91

Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A (2010) 1.85

Initiation and regulation of T-cell responses in tuberculosis. Mucosal Immunol (2011) 1.77

Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors. Cell Microbiol (2007) 1.77

Incipient and subclinical tuberculosis: defining early disease states in the context of host immune response. J Infect Dis (2011) 1.66

Letting sleeping dos lie: does dormancy play a role in tuberculosis? Annu Rev Microbiol (2010) 1.66

Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis. Infect Immun (2003) 1.63

Common variants at 11p13 are associated with susceptibility to tuberculosis. Nat Genet (2012) 1.52

The immunological aspects of latency in tuberculosis. Clin Immunol (2004) 1.48

Penitentiary or penthouse condo: the tuberculous granuloma from the microbe's point of view. Cell Microbiol (2009) 1.47

Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method. Infect Immun (1999) 1.46

Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs. Tuberculosis (Edinb) (2009) 1.45

Differential organization of the local immune response in patients with active cavitary tuberculosis or with nonprogressive tuberculoma. J Infect Dis (2005) 1.40

In vivo phenotypic dominance in mouse mixed infections with Mycobacterium tuberculosis clinical isolates. J Infect Dis (2005) 1.36

Latent tuberculosis: what the host "sees"? Immunol Res (2011) 1.35

Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog (2011) 1.29

Matrix metalloproteinases in tuberculosis. Eur Respir J (2011) 1.28

Local immune responses in human tuberculosis: learning from the site of infection. J Infect Dis (2012) 1.27

Discriminating between latent and active tuberculosis with multiple biomarker responses. Tuberculosis (Edinb) (2011) 1.22

Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles. PLoS One (2011) 1.22

Tuberculosis immunopathology: the neglected role of extracellular matrix destruction. Sci Transl Med (2011) 1.19

Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology. Am J Pathol (2011) 1.19

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response. Open Biol (2011) 1.14

Animal models of tuberculosis. Tuberculosis (Edinb) (2005) 1.13

Lazy, dynamic or minimally recrudescent? On the elusive nature and location of the mycobacterium responsible for latent tuberculosis. Infection (2009) 1.12

Messenger RNA expression of IL-8, FOXP3, and IL-12beta differentiates latent tuberculosis infection from disease. J Immunol (2007) 1.07

Multinucleate giant cells release functionally unopposed matrix metalloproteinase-9 in vitro and in vivo. J Infect Dis (2007) 1.04

Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages. Cell Commun Signal (2012) 1.02

CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques. AIDS Res Hum Retroviruses (2012) 1.02

Differential expression of PE and PE_PGRS genes in Mycobacterium tuberculosis strains. Gene (2003) 1.00

Virulence, immunopathology and transmissibility of selected strains of Mycobacterium tuberculosis in a murine model. Immunology (2008) 0.98

TNF in host resistance to tuberculosis infection. Curr Dir Autoimmun (2010) 0.95

Tuberculosis genes expressed during persistence and reactivation in the resistant rabbit model. Tuberculosis (Edinb) (2008) 0.95

Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism. Infect Immun (2005) 0.91

Association of IFNGR2 gene polymorphisms with pulmonary tuberculosis among the Vietnamese. Hum Genet (2011) 0.91

Determinant role for Toll-like receptor signalling in acute mycobacterial infection in the respiratory tract. Microbes Infect (2006) 0.89

The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species. BMC Microbiol (2007) 0.89

Experimental tuberculosis in the Wistar rat: a model for protective immunity and control of infection. PLoS One (2011) 0.86

The role of toll-like receptor 2 in survival strategies of Mycobacterium tuberculosis in macrophage phagosomes. Anticancer Res (2009) 0.86

Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge. Tuberculosis (Edinb) (2011) 0.86

Variation of the expression of Mycobacterium tuberculosis ppe44 gene among clinical isolates. FEMS Immunol Med Microbiol (2007) 0.84

Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study. Hum Immunol (2011) 0.83

Elevated levels of circulating adhesion molecules in patients with active pulmonary tuberculosis. Respirology (2003) 0.82

A review of murine models of latent tuberculosis infection. Scand J Infect Dis (2011) 0.81

The occurrence of virulent tubercle bacilli in presumably non-tuberculous lung tissue. Am J Pathol (1939) 0.80

Immunological protection against tuberculosis. S Afr Med J (2007) 0.79

Latent tuberculosis: models, mechanisms, and novel prospects for eradication. Semin Pediatr Infect Dis (2002) 0.79

Pattern of matrix metalloproteinases-9, P53 and BCL-2 proteins in Egyptian patients with pulmonary Mycobacterium tuberculosis. Acta Microbiol Immunol Hung (2010) 0.77

A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature (2004) 6.29

Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control. Am J Respir Crit Care Med (2006) 5.73

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31

Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients. Proc Natl Acad Sci U S A (2003) 3.14

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns. Am J Respir Crit Care Med (2010) 2.64

The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice. Proc Natl Acad Sci U S A (2003) 2.60

Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies. J Immunol Methods (2004) 2.50

Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res (2005) 2.50

Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli. J Infect Dis (2005) 2.50

Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis. Infect Immun (2004) 2.47

The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro. Mol Microbiol (2008) 2.44

Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. J Immunol (2008) 2.27

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism. EMBO Mol Med (2010) 2.26

Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load. J Immunol (2011) 2.07

Randomized trial of the effect of tailored versus standard use of the combined oral contraceptive pill on continuation rates at 1 year. Contraception (2013) 2.03

The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis. J Biol Chem (2004) 1.99

Laparoscopic adjustable gastric banding in the treatment of obesity: a systematic literature review. Surgery (2004) 1.94

Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy. Infect Immun (2002) 1.85

In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses. Antimicrob Agents Chemother (2003) 1.83

Genetic polymorphism in Mycobacterium tuberculosis isolates from patients with chronic multidrug-resistant tuberculosis. J Infect Dis (2004) 1.75

In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Antimicrob Agents Chemother (2005) 1.72

FFPRHC Guidance (January 2004). The copper intrauterine device as long-term contraception. J Fam Plann Reprod Health Care (2004) 1.68

Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal (2010) 1.66

The effect of bacille Calmette-Guérin vaccine strain and route of administration on induced immune responses in vaccinated infants. J Infect Dis (2006) 1.64

Effective treatment of erythema nodosum leprosum with thalidomide is associated with immune stimulation. J Infect Dis (2005) 1.64

Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro. Antimicrob Agents Chemother (2005) 1.60

Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence. J Infect Dis (2009) 1.59

Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis (2008) 1.56

The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence. Infect Immun (2008) 1.55

Antibody profiles characteristic of Mycobacterium tuberculosis infection state. Infect Immun (2005) 1.49

Real-time clinical application of quality-of-life assessment in advanced lung cancer. Clin Lung Cancer (2002) 1.47

Induction of ER stress in macrophages of tuberculosis granulomas. PLoS One (2010) 1.45

Antiretroviral program associated with reduction in untreated prevalent tuberculosis in a South African township. Am J Respir Crit Care Med (2010) 1.42

Bacillus Calmette Guerin vaccination of human newborns induces a specific, functional CD8+ T cell response. J Immunol (2006) 1.40

A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis (2008) 1.39

In vivo phenotypic dominance in mouse mixed infections with Mycobacterium tuberculosis clinical isolates. J Infect Dis (2005) 1.36

Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro. J Infect Dis (2003) 1.35

Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J Infect Dis (2008) 1.34

Inhibition of herpesvirus replication by a series of 4-oxo-dihydroquinolines with viral polymerase activity. Antiviral Res (2005) 1.31

Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog (2011) 1.29

Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice. Infect Immun (2002) 1.29

The evolution of Helicobacter pylori antibiotics resistance over 10 years in Beijing, China. Helicobacter (2010) 1.26

Interventions for pain with intrauterine device insertion. Cochrane Database Syst Rev (2009) 1.24

Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitis. Infect Immun (2006) 1.23

Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases. Infect Immun (2003) 1.23

catena-Poly[dieth-yl(2-hydroxy-ethyl)-ammonium [[tetra-μ-acetato-κO:O'-dicuprate(II)(Cu-Cu)]-μ-acetato-κO:O'] dichloro-methane solvate]. Acta Crystallogr Sect E Struct Rep Online (2009) 1.23

Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice. PLoS One (2011) 1.20

Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology. Am J Pathol (2011) 1.19

Longitudinal changes in CD4(+) T-cell memory responses induced by BCG vaccination of newborns. J Infect Dis (2013) 1.17

Mycobacterium tuberculosis H37Ra and H37Rv differential growth and cytokine/chemokine induction in murine macrophages in vitro. J Interferon Cytokine Res (2006) 1.14

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response. Open Biol (2011) 1.14

Advances in immunotherapy for tuberculosis treatment. Clin Chest Med (2009) 1.13

Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants. PLoS Pathog (2011) 1.13

Thalidomide and a thalidomide analogue drug costimulate virus-specific CD8+ T cells in vitro. J Infect Dis (2003) 1.13

HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Guérin vaccine. J Infect Dis (2009) 1.12

Mycobacterium leprae inhibits dendritic cell activation and maturation. J Immunol (2007) 1.12

BCG vaccination confers poor protection against M. tuberculosis HN878-induced central nervous system disease. Vaccine (2006) 1.12

Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis. PLoS One (2012) 1.11

Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. Hum Immunol (2010) 1.09

Innate immune response to Mycobacterium tuberculosis Beijing and other genotypes. PLoS One (2010) 1.07

Macrophages in tuberculosis: friend or foe. Semin Immunopathol (2013) 1.04

Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection. PLoS Pathog (2013) 1.04

Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers. J Immunol (2006) 1.03

Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages. Cell Commun Signal (2012) 1.02

Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. J Infect Dis (2010) 1.02

HIV-M. leprae interaction: can HAART modify the course of leprosy? Public Health Rep (2008) 1.01

Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease. BMC Infect Dis (2013) 1.01

Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2013) 1.00