Published in Int J Cancer on October 11, 2012
The pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noise. PLoS Comput Biol (2014) 1.42
p53 Family and Cellular Stress Responses in Cancer. Front Oncol (2014) 1.33
Targeting p53-MDM2-MDMX loop for cancer therapy. Subcell Biochem (2014) 0.85
The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer. Oncotarget (2015) 0.85
Therapeutic inhibition of the MDM2-p53 interaction prevents recurrence of adenoid cystic carcinomas. Clin Cancer Res (2016) 0.80
Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer. Oncotarget (2016) 0.79
MiR-218 inhibits HMGB1-mediated autophagy in endometrial carcinoma cells during chemotherapy. Int J Clin Exp Pathol (2015) 0.78
Enrichment Analysis Identifies Functional MicroRNA-Disease Associations in Humans. PLoS One (2015) 0.78
Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. Oncol Rep (2015) 0.77
Lidocaine sensitizes the cytotoxicity of cisplatin in breast cancer cells via up-regulation of RARβ2 and RASSF1A demethylation. Int J Mol Sci (2014) 0.77
Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways. Drug Des Devel Ther (2016) 0.76
Chemoresistance and targeted therapies in ovarian and endometrial cancers. Oncotarget (2017) 0.75
Exosomes as mediators of platinum resistance in ovarian cancer. Oncotarget (2017) 0.75
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell (2007) 3.27
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A (2011) 2.21
Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. J Am Soc Nephrol (2006) 1.79
p63 and TTF-1 immunostaining. A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of lung. Am J Clin Pathol (2003) 1.79
Ki-67 proliferative index predicts clinical outcome in patients with atypical or anaplastic meningioma. Neuropathology (2007) 1.76
MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. Blood (2006) 1.71
Gibberellins repress photomorphogenesis in darkness. Plant Physiol (2004) 1.70
Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. Clin Cancer Res (2005) 1.53
Idiopathic pleuroparenchymal fibroelastosis: an unrecognized or misdiagnosed entity? Mod Pathol (2008) 1.50
Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva. Eur J Cancer (2013) 1.42
Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells. J Neurosci Res (2003) 1.41
Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Exp Hematol (2006) 1.39
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. Blood (2002) 1.30
Case report: Lung disease in World Trade Center responders exposed to dust and smoke: carbon nanotubes found in the lungs of World Trade Center patients and dust samples. Environ Health Perspect (2010) 1.27
Overcoming drug resistance by enhancing apoptosis of tumor cells. Curr Cancer Drug Targets (2009) 1.26
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood (2003) 1.21
CD10 expression in epithelial tissues and tumors of the gynecologic tract: a useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol (2003) 1.20
Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer Res (2009) 1.19
Potassium channels: new targets in cancer therapy. Cancer Detect Prev (2006) 1.18
P63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors. Hum Pathol (2002) 1.16
Epigenetic disruption of cadherin-11 in human cancer metastasis. J Pathol (2012) 1.14
5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved. Biochem J (2003) 1.12
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. Blood (2010) 1.12
Light Regulation of Gibberellin Biosynthesis and Mode of Action. J Plant Growth Regul (2001) 1.11
Identification of somatic and germline mitochondrial DNA sequence variants in prostate cancer patients. Mutat Res (2006) 1.10
Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme. PLoS One (2011) 1.10
Transcriptional and translational control of Mcl-1 during apoptosis. Arch Biochem Biophys (2003) 1.07
Vulvar angiomyxoma, aggressive angiomyxoma, and angiomyofibroblastoma: an immunohistochemical and ultrastructural study. Ultrastruct Pathol (2006) 1.05
Clinicopathological and molecular characterization of colorectal micropapillary carcinoma. Mod Pathol (2011) 1.05
BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer. Epigenetics (2012) 1.05
Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer. Clin Cancer Res (2012) 1.04
Idiopathic organizing pneumonia: a relapsing disease. 19 years of experience in a hospital setting. Respiration (2007) 1.04
P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells. Prostate (2004) 1.02
Placental transmogrification of the lung presenting as emphysema and a lung mass. Ann Thorac Surg (2009) 1.02
Do alloreactivity and prolonged cold ischemia cause different elementary lesions in chronic allograft nephropathy? Am J Pathol (2003) 1.02
Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C{beta}. J Leukoc Biol (2006) 1.01
Leptomeningeal carcinomatosis: prognostic implications of clinical and cerebrospinal fluid features. Cancer (2009) 1.01
The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer. Front Physiol (2013) 1.00
The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer. EMBO Mol Med (2012) 1.00
In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts. Clin Cancer Res (2010) 1.00
TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells. Radiother Oncol (2011) 0.98
Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. Cancer Lett (2011) 0.98
Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility. BMC Genomics (2008) 0.97
Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage? Nephrol Dial Transplant (2009) 0.97
KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies. J Cell Physiol (2005) 0.96
Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors. Clin Cancer Res (2009) 0.96
Pigmented paget disease of the breast nipple with underlying infiltrating carcinoma: a case report and review of the literature. Am J Dermatopathol (2011) 0.96
Potassium channels are a new target field in anticancer drug design. Recent Pat Anticancer Drug Discov (2007) 0.96
Multiplex ligation-dependent probe amplification for detection of genomic alterations in chronic lymphocytic leukaemia. Br J Haematol (2008) 0.95
Prostatic sarcoma after conservative treatment with brachytherapy for low-risk prostate cancer. Acta Oncol (2012) 0.95
Activated ERBB2/HER2 licenses sensitivity to apoptosis upon endoplasmic reticulum stress through a PERK-dependent pathway. Cancer Res (2014) 0.94
Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. Blood (2002) 0.94
Regression of advanced diabetic nephropathy by hepatocyte growth factor gene therapy in rats. Diabetes (2004) 0.94
p53 and p21 Expression levels predict organ preservation and survival in invasive bladder carcinoma treated with a combined-modality approach. Cancer (2004) 0.94
Decomposing cross-country differences in levels of obesity and overweight: does the social environment matter? Soc Sci Med (2010) 0.92
Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts. J Biol Chem (2002) 0.91
Intergenerational and socioeconomic gradients of child obesity. Soc Sci Med (2013) 0.91
Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin. J Biol Chem (2012) 0.90
Different renal toxicity profiles in the association of cyclosporine and tacrolimus with sirolimus in rats. Nephrol Dial Transplant (2008) 0.90
Human papillomavirus-related cervical lesions in adolescents: a histologic and morphometric study. Gynecol Oncol (2003) 0.89
Effects of dopamine on LC3-II activation as a marker of autophagy in a neuroblastoma cell model. Neurotoxicology (2009) 0.88
The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells. Haematologica (2007) 0.88
Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype. Mol Carcinog (2011) 0.88
Obesity and the incidence of chronic diseases in Spain: a seemingly unrelated probit approach. Econ Hum Biol (2005) 0.88
Protein kinases in the regulation of apoptosis in B-cell chronic lymphocytic leukemia. Leuk Lymphoma (2003) 0.87
Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis (2010) 0.87
AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. Apoptosis (2013) 0.86
Genetic and immunophenotype analyses of TP53 in bladder cancer: TP53 alterations are associated with tumor progression. Diagn Mol Pathol (2004) 0.86
Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study. Transpl Int (2012) 0.86
Extranodal follicular dendritic cell tumor of the tonsil: report of a diagnostic pitfall and literature review. Arch Otolaryngol Head Neck Surg (2004) 0.86
Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy. J Leukoc Biol (2013) 0.85
The influence of obesity and overweight on medical costs: a panel data perspective. Eur J Health Econ (2014) 0.85
Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas. Cancer Invest (2012) 0.84
Aneuploidy of chromosome Y in prostate tumors and seminal vesicles: a possible sign of aging rather than an indicator of carcinogenesis? Mol Carcinog (2007) 0.84
Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells. Epigenetics (2011) 0.84
Identification of prefoldin amplification (1q23.3-q24.1) in bladder cancer using comparative genomic hybridization (CGH) arrays of urinary DNA. J Transl Med (2013) 0.83
YM155 sensitizes ovarian cancer cells to cisplatin inducing apoptosis and tumor regression. Gynecol Oncol (2013) 0.83
The combination of sirolimus and rosiglitazone produces a renoprotective effect on diabetic kidney disease in rats. Life Sci (2010) 0.83
Fructose 1,6-bisphosphate reduced TNF-alpha-induced apoptosis in galactosamine sensitized rat hepatocytes through activation of nitric oxide and cGMP production. Eur J Pharmacol (2009) 0.83
A novel logistic model based on clinicopathological features predicts microsatellite instability in colorectal carcinomas. Diagn Mol Pathol (2005) 0.82
Isoform-selective phosphoinositide 3-kinase inhibitors induce apoptosis in chronic lymphocytic leukaemia cells. Br J Haematol (2010) 0.82
Reduction of postischemic immune inflammatory response: an effective strategy for attenuating chronic allograft nephropathy. Transplantation (2005) 0.82
Altered expression of 12S/MT-RNR1, MT-CO2/COX2, and MT-ATP6 mitochondrial genes in prostate cancer. Prostate (2008) 0.82
Generational effects and gender height dimorphism in contemporary Spain. Econ Hum Biol (2007) 0.82
Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium. Purinergic Signal (2012) 0.81
Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human fetus. Cell Physiol Biochem (2010) 0.81
Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Haematologica (2009) 0.81