Published in J Virol on September 12, 2012
A test for Creutzfeldt-Jakob disease using nasal brushings. N Engl J Med (2014) 3.58
Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility. PLoS Pathog (2016) 1.38
Aerosol transmission of chronic wasting disease in white-tailed deer. J Virol (2012) 1.26
In vitro detection of prionemia in TSE-infected cervids and hamsters. PLoS One (2013) 1.17
The immunobiology of prion diseases. Nat Rev Immunol (2013) 1.13
Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay. PLoS One (2013) 0.91
Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations. J Virol (2015) 0.87
Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol (2012) 0.82
Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie. BMC Genomics (2014) 0.79
Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice. J Virol (2016) 0.76
Nasal associated lymphoid tissue of the Syrian golden hamster expresses high levels of PrPC. PLoS One (2015) 0.76
Intra-host mathematical model of chronic wasting disease dynamics in deer (Odocoileus). Prion (2016) 0.75
Clay Components in Soil Dictate Environmental Stability and Bioavailability of Cervid Prions in Mice. Front Microbiol (2016) 0.75
Pathways of Prion Spread during Early Chronic Wasting Disease in Deer. J Virol (2017) 0.75
PrPSc formation and clearance as determinants of prion tropism. PLoS Pathog (2017) 0.75
Identification of a protein that purifies with the scrapie prion. Science (1982) 7.00
In vitro generation of infectious scrapie prions. Cell (2005) 6.86
Unconventional viruses and the origin and disappearance of kuru. Science (1977) 6.38
Generating a prion with bacterially expressed recombinant prion protein. Science (2010) 6.26
Formation of native prions from minimal components in vitro. Proc Natl Acad Sci U S A (2007) 5.94
Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res (2000) 3.84
Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol (2004) 3.75
Infectious prions in the saliva and blood of deer with chronic wasting disease. Science (2006) 3.63
Chronic wasting disease of captive mule deer: a spongiform encephalopathy. J Wildl Dis (1980) 3.53
Environmental sources of prion transmission in mule deer. Emerg Infect Dis (2004) 3.44
Recombinant prion protein induces a new transmissible prion disease in wild-type animals. Acta Neuropathol (2010) 3.19
The physiology of the lymphatic system. Adv Drug Deliv Rev (2001) 2.72
Detection of prions in blood. Nat Med (2005) 2.66
Prions and their partners in crime. Nature (2006) 2.55
Epizootiology of chronic wasting disease in free-ranging cervids in Colorado and Wyoming. J Wildl Dis (2000) 2.53
Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus). J Gen Virol (1999) 2.48
Transmission of prion diseases by blood transfusion. J Gen Virol (2002) 2.42
Epithelial M cells: differentiation and function. Annu Rev Cell Dev Biol (2000) 2.36
Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay. PLoS One (2009) 2.34
Prions adhere to soil minerals and remain infectious. PLoS Pathog (2006) 2.32
Transmission and detection of prions in feces. J Infect Dis (2008) 2.20
Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep. J Pathol (2006) 2.10
Asymptomatic deer excrete infectious prions in faeces. Nature (2009) 2.10
De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A (2008) 2.10
Survival of scrapie virus after 3 years' interment. Lancet (1991) 1.99
Prions are secreted into the oral cavity in sheep with preclinical scrapie. J Infect Dis (2010) 1.96
Coincident scrapie infection and nephritis lead to urinary prion excretion. Science (2005) 1.94
Scrapie infectivity and proteinase K-resistant prion protein in sheep placenta, brain, spleen, and lymph node: implications for transmission and antemortem diagnosis. J Infect Dis (1998) 1.86
Purification and properties of the cellular prion protein from Syrian hamster brain. Protein Sci (1992) 1.85
Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake. Clin Exp Immunol (1989) 1.79
Chronic wasting disease prions in elk antler velvet. Emerg Infect Dis (2009) 1.77
Infectious agent of sheep scrapie may persist in the environment for at least 16 years. J Gen Virol (2006) 1.77
Scrapie Agent (Strain 263K) can transmit disease via the oral route after persistence in soil over years. PLoS One (2007) 1.72
Aerosols transmit prions to immunocompetent and immunodeficient mice. PLoS Pathog (2011) 1.71
Evidence of scrapie transmission via milk. BMC Vet Res (2008) 1.68
Urinary excretion and blood level of prions in scrapie-infected hamsters. J Gen Virol (2007) 1.66
The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium. Toxicol Pathol (2006) 1.66
Molecular characteristics of the major scrapie prion protein. Biochemistry (1984) 1.64
Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory. Am J Physiol (1996) 1.63
Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology (2007) 1.61
Migrating intestinal dendritic cells transport PrP(Sc) from the gut. J Gen Virol (2002) 1.58
PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission. J Gen Virol (2002) 1.58
Epidemiology of chronic wasting disease in free-ranging mule deer: spatial, temporal, and demographic influences on observed prevalence patterns. J Wildl Dis (2005) 1.55
Three markers of adult non-myelin-forming Schwann cells, 217c(Ran-1), A5E3 and GFAP: development and regulation by neuron-Schwann cell interactions. Development (1990) 1.47
A prion disease of cervids: chronic wasting disease. Vet Res (2008) 1.46
The nasal cavity is a route for prion infection in hamsters. J Virol (2007) 1.46
Characterization of epithelial cell shedding from human small intestine. Lab Invest (2006) 1.45
Prions in milk from ewes incubating natural scrapie. PLoS Pathog (2008) 1.43
Transepithelial prion transport by M cells. Nat Med (2001) 1.35
Biology and pathology of nonmyelinating Schwann cells. Glia (2008) 1.33
Prion uptake in the gut: identification of the first uptake and replication sites. PLoS Pathog (2011) 1.21
Morphology of the nasal fossae and associated structures of the hamster (Mesocricetus auratus). J Morphol (1972) 1.20
Aerosol and nasal transmission of chronic wasting disease in cervidized mice. J Gen Virol (2010) 1.20
THE LYMPHATIC PATHWAY FROM THE NOSE AND PHARYNX : THE ABSORPTION OF DYES. J Exp Med (1938) 1.18
Protease-resistant human prion protein and ferritin are cotransported across Caco-2 epithelial cells: implications for species barrier in prion uptake from the intestine. J Neurosci (2004) 1.17
Environmental sources of scrapie prions. J Virol (2010) 1.16
Prion shedding from olfactory neurons into nasal secretions. PLoS Pathog (2010) 1.15
A protease-resistant prion protein isoform is present in urine of animals and humans affected with prion diseases. J Biol Chem (2001) 1.13
Demonstration of M cells in the specialized follicle-associated epithelium overlying isolated lymphoid follicles in the gut. J Leukoc Biol (1984) 1.12
Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches--a personal and historical perspective. Semin Immunol (1999) 1.10
Prions are secreted in milk from clinically normal scrapie-exposed sheep. J Virol (2009) 1.09
Prions in the environment: occurrence, fate and mitigation. Prion (2008) 1.07
BSE: a decade on--Part I. Lancet (1997) 1.07
Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor. Am J Pathol (2005) 1.07
Mechanisms of epithelial cell shedding in the Mammalian intestine and maintenance of barrier function. Ann N Y Acad Sci (2009) 1.06
Role of the lymphoreticular system in prion neuroinvasion from the oral and nasal mucosa. J Virol (2009) 1.06
Faecal shedding, alimentary clearance and intestinal spread of prions in hamsters fed with scrapie. Vet Res (2008) 1.05
Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching. Am J Physiol (1996) 1.04
M cell-depletion blocks oral prion disease pathogenesis. Mucosal Immunol (2012) 1.03
Targeted delivery of antigen to hamster nasal lymphoid tissue with M-cell-directed lectins. Infect Immun (1997) 1.02
Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep. Vet Pathol (2008) 1.00
Flow velocity of single lymphatic capillaries in human skin. Am J Physiol (1996) 0.97
Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways. Acta Neuropathol (2008) 0.97
Epidemiology of chronic wasting disease in captive white-tailed and mule deer. J Wildl Dis (2004) 0.97
Mucociliary transport determined by in vivo microdialysis in the airways of normal and CF mice. Am J Physiol Lung Cell Mol Physiol (2003) 0.95
Orally administered prion protein is incorporated by m cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice. Am J Pathol (2011) 0.90
Transmissible mink encephalopathy. Rev Sci Tech (1992) 0.88
Murine cecal patch M cells transport infectious prions in vivo. J Infect Dis (2010) 0.87
The nasal mucociliary apparatus. Correlation of structure and function in the rat. Am Rev Respir Dis (1984) 0.87
Microparticle targeting to M cells. Adv Drug Deliv Rev (1998) 0.86
Transcytosis of murine-adapted bovine spongiform encephalopathy agents in an in vitro bovine M cell model. J Virol (2010) 0.85
PrP(Sc) detection and infectivity in semen from scrapie-infected sheep. J Gen Virol (2012) 0.85
Experimental transmission of abnormal prion protein (PrPsc) in the small intestinal epithelial cells of neonatal mice. Vet Pathol (2003) 0.84
Iron content of ferritin modulates its uptake by intestinal epithelium: implications for co-transport of prions. Mol Brain (2010) 0.81
Mechanisms of prion protein aggregation. Protein Pept Lett (2009) 0.76
Exosome-producing follicle associated epithelium is not involved in uptake of PrPd from the gut of sheep (Ovis aries): an ultrastructural study. PLoS One (2011) 0.76
The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease. PLoS Pathog (2011) 1.49
The nasal cavity is a route for prion infection in hamsters. J Virol (2007) 1.46
Occurrence, transmission, and zoonotic potential of chronic wasting disease. Emerg Infect Dis (2012) 1.34
Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus). J Virol (2005) 1.33
Coinfecting prion strains compete for a limiting cellular resource. J Virol (2010) 1.32
Prion infection of skeletal muscle cells and papillae in the tongue. J Virol (2004) 1.29
In vitro detection of prionemia in TSE-infected cervids and hamsters. PLoS One (2013) 1.17
Replication efficiency of soil-bound prions varies with soil type. J Virol (2011) 1.11
Environmentally-relevant forms of the prion protein. Environ Sci Technol (2008) 1.08
Prions in the environment: occurrence, fate and mitigation. Prion (2008) 1.07
Influence of prion strain on prion protein adsorption to soil in a competitive matrix. Environ Sci Technol (2009) 1.05
Prion protein adsorption to soil in a competitive matrix is slow and reduced. Environ Sci Technol (2009) 1.02
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci (2013) 1.01
Prion interference with multiple prion isolates. Prion (2008) 0.98
Enzymatic digestion of chronic wasting disease prions bound to soil. Environ Sci Technol (2010) 0.98
Prion strain targeting independent of strain-specific neuronal tropism. J Virol (2008) 0.97
In vitro generation of high-titer prions. J Virol (2011) 0.97
In vitro amplification of misfolded prion protein using lysate of cultured cells. PLoS One (2011) 0.91
Rapid, high-throughput detection of PrPSc by 96-well immunoassay. Prion (2009) 0.89
Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations. J Virol (2015) 0.87
Transmission of transmissible mink encephalopathy to raccoons (Procyon lotor) by intracerebral inoculation. J Vet Diagn Invest (2004) 0.85
Soil-mediated prion transmission: is local soil-type a key determinant of prion disease incidence? Chemosphere (2012) 0.85
An enzymatic treatment of soil-bound prions effectively inhibits replication. Appl Environ Microbiol (2011) 0.84
Behavior of prions in the environment: implications for prion biology. PLoS Pathog (2013) 0.82
Selection and characterization of DNA aptamers against PrP(Sc). Exp Biol Med (Maywood) (2011) 0.81
Effects of solution chemistry and aging time on prion protein adsorption and replication of soil-bound prions. PLoS One (2011) 0.81
Resistance of soil-bound prions to rumen digestion. PLoS One (2012) 0.80
Protein misfolding cyclic amplification of prions. J Vis Exp (2012) 0.78
Prion formation, but not clearance, is supported by protein misfolding cyclic amplification. Prion (2014) 0.78
Tracking protein aggregate interactions. Prion (2011) 0.76