Embalmed and fresh frozen human bones in orthopedic cadaveric studies: which bone is authentic and feasible?

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 3488184)

Published in Acta Orthop on September 14, 2012

Authors

Tobias Topp1, Thorben Müller, Sebastian Huss, Peter Herbert Kann, Eberhard Weihe, Steffen Ruchholtz, Ralph Peter Zettl

Author Affiliations

1: Departments of Trauma, Hand and Reconstructive Surgery, University Hospital Giessen and Marburg, Marburg, Germany. tobiastopp@gmail.com

Articles cited by this

Mechanical validation of whole bone composite femur models. J Biomech (1996) 2.66

Biomechanical time-tolerance of fresh cadaveric human spine specimens. J Orthop Res (1985) 1.38

The effect of different storage methods on the mechanical properties of trabecular bone. J Biomech (1993) 1.34

Effect of formaldehyde fixation on some mechanical properties of bovine bone. Biomaterials (1995) 1.16

The benefit of wire cerclage stabilisation of the medial hinge in intramedullary nailing for the treatment of subtrochanteric femoral fractures: a biomechanical study. Int Orthop (2011) 1.14

Biomechanical properties of bone allografts. Clin Orthop Relat Res (1983) 1.12

Effect of long-term preservation on the mechanical properties of cortical bone in goats. Acta Orthop (2008) 1.04

Cancellous bone screw purchase: a comparison of synthetic femurs, human femurs, and finite element analysis. Proc Inst Mech Eng H (2008) 1.04

Influence of formalin fixation on the biomechanical properties of human diaphyseal bone. Biomed Tech (Berl) (2010) 0.98

Comparison of mechanical rigidity between plate augmentation leaving the nail in situ and interlocking nail using cadaveric fracture model of the femur. Int Orthop (2010) 0.98

The effects of embalming using a 4% formalin solution on the compressive mechanical properties of human cortical bone. Clin Biomech (Bristol, Avon) (2008) 0.97

Effect of preservation medium on the mechanical properties of cat bones. Acta Orthop Scand (1989) 0.95

Differences in the mechanical properties of calcaneal artificial specimens, fresh frozen specimens, and embalmed specimens in experimental testing. Foot Ankle Int (2006) 0.91

Transmission of Mycobacterium tuberculosis from a cadaver to an embalmer. N Engl J Med (2000) 0.90

Biomechanical examinations of cancellous bone concerning the influence of duration and temperature of cryopreservation. J Biomed Mater Res (2001) 0.87

Mechanical strength repercussions of various fixative storage methods on bone. Biomed Sci Instrum (2006) 0.85

Pullout strength and load to failure properties of self-tapping cortical screws in synthetic and cadaveric environments representative of healthy and osteoporotic bone. J Trauma (2008) 0.84

The effect of pilot hole size on the insertion torque and pullout strength of self-tapping cortical bone screws in osteoporotic bone. J Trauma (2008) 0.84

EFFECT OF EMBALMING ON THE MECHANICAL PROPERTIES OF BEEF BONE. J Appl Physiol (1964) 0.81

Biomechanical properties of canine cortical bone allografts: effects of preparation and storage. Am J Vet Res (1988) 0.79

Articles by these authors

Identification of the differentiation-associated Na+/PI transporter as a novel vesicular glutamate transporter expressed in a distinct set of glutamatergic synapses. J Neurosci (2002) 2.50

Management of pulmonary cement embolism after percutaneous vertebroplasty and kyphoplasty: a systematic review of the literature. Eur Spine J (2009) 2.44

Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma (2006) 2.15

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut (2011) 2.06

CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron (2005) 1.94

Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons. J Biol Chem (2002) 1.89

Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome. Am J Surg Pathol (2006) 1.71

Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc Natl Acad Sci U S A (2001) 1.63

Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits. J Neurosci (2005) 1.58

Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas. J Clin Endocrinol Metab (2006) 1.55

Immunostimulatory CpG-DNA activates murine microglia. J Immunol (2002) 1.52

Treatment with ozone/oxygen-pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas. Int J Cancer (2008) 1.51

Expression of the two isoforms of the vesicular monoamine transporter (VMAT1 and VMAT2) in the endocrine pancreas and pancreatic endocrine tumors. J Histochem Cytochem (2003) 1.50

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer. Mod Pathol (2012) 1.50

A single amino acid change in rabies virus glycoprotein increases virus spread and enhances virus pathogenicity. J Virol (2005) 1.47

Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U S A (2011) 1.44

Early or delayed stabilization in severely injured patients with spinal fractures? Current surgical objectivity according to the Trauma Registry of DGU: treatment of spine injuries in polytrauma patients. J Trauma Acute Care Surg (2014) 1.44

A comparison of the treatment of severe injuries between the former East and West German States. Dtsch Arztebl Int (2013) 1.41

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation. Virchows Arch (2005) 1.40

The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine. Pflugers Arch (2003) 1.31

Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. Gastroenterology (2005) 1.28

Plasma chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumors. Clin Gastroenterol Hepatol (2008) 1.27

Reduction in mortality of severely injured patients in Germany. Dtsch Arztebl Int (2008) 1.25

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology (2012) 1.25

Damage control orthopedics in patients with multiple injuries is effective, time saving, and safe. J Trauma (2005) 1.23

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer. Gut (2012) 1.22

Intraspinal migration of a Kirschner wire 3 months after clavicular fracture fixation. Neurosurg Rev (2002) 1.19

Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons. J Biol Chem (2003) 1.17

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology (2013) 1.15

The benefit of wire cerclage stabilisation of the medial hinge in intramedullary nailing for the treatment of subtrochanteric femoral fractures: a biomechanical study. Int Orthop (2011) 1.14

Chemical coding of the human gastrointestinal nervous system: cholinergic, VIPergic, and catecholaminergic phenotypes. J Comp Neurol (2003) 1.12

VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse. Ann N Y Acad Sci (2011) 1.12

Mortality in severely injured elderly trauma patients--when does age become a risk factor? World J Surg (2005) 1.11

C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation. J Neurosci Res (2009) 1.10

Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFalpha) and TNF receptors in rat dorsal root ganglion. J Neurosci (2004) 1.10

Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biochem Biophys Res Commun (2006) 1.09

Microglial activation and increased synthesis of complement component C1q precedes blood-brain barrier dysfunction in rats. Mol Immunol (2004) 1.08

Early orthogeriatric treatment of trauma in the elderly: a systematic review and metaanalysis. Dtsch Arztebl Int (2013) 1.07

Activity-dependent regulation of vesicular glutamate and GABA transporters: a means to scale quantal size. Neurochem Int (2006) 1.05

SRC signaling is crucial in the growth of synovial sarcoma cells. Cancer Res (2013) 1.03

Knee function and prevalence of osteoarthritis after isolated anterior cruciate ligament reconstruction using bone-patellar tendon-bone graft: long-term follow-up. Int Orthop (2011) 1.03

Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats. Lab Invest (2012) 0.99

A challenging case of rapid progressive Kaposi sarcoma after renal transplantation: diagnostics by FDG PET/CT. Medicine (Baltimore) (2014) 0.99

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects. J Hepatol (2012) 0.98

Does increased prehospital replacement volume lead to a poor clinical course and an increased mortality? A matched-pair analysis of 1896 patients of the Trauma Registry of the German Society for Trauma Surgery who were managed by an emergency doctor at the accident site. Injury (2012) 0.98

Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts. Liver Int (2011) 0.98

Vesicular monoamine transporter 2 (VMAT2) expression in hematopoietic cells and in patients with systemic mastocytosis. J Histochem Cytochem (2005) 0.97

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology (2014) 0.96

Constitutive expression of p55TNFR mRNA and mitogen-specific up-regulation of TNF alpha and p75TNFR mRNA in mouse brain. J Comp Neurol (2003) 0.96

Standardized outcome evaluation after blunt multiple injuries by scoring systems: a clinical follow-up investigation 2 years after injury. J Trauma (2002) 0.96

Re-admission to Level 2 unit after hip-fracture surgery - Risk factors, reasons and outcome. Injury (2013) 0.96

Do concomitant fractures with hip fractures influence complication rate and functional outcome? Clin Orthop Relat Res (2012) 0.95

Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1. Neurochem Int (2006) 0.94

Kyphoplasty for the treatment of incomplete osteoporotic burst fractures. Eur Spine J (2010) 0.93

Deltoid-split or deltopectoral approaches for the treatment of displaced proximal humeral fractures? Clin Orthop Relat Res (2013) 0.93

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice. Hepatology (2012) 0.93

Overexpression of tumor necrosis factor alpha by a recombinant rabies virus attenuates replication in neurons and prevents lethal infection in mice. J Virol (2005) 0.92

The temperature-sensitive ion channel TRPV2 is endogenously expressed and functional in the primary sensory cell line F-11. Cell Physiol Biochem (2005) 0.92

Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor. FEBS Lett (2006) 0.92

Early clinical outcome and complications related to balloon kyphoplasty. Orthop Rev (Pavia) (2012) 0.91

Induced hypothermia does not impair coagulation system in a swine multiple trauma model. J Trauma Acute Care Surg (2013) 0.90

Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease. J Neuroimmunol (2011) 0.89

Possible involvement of complement factor C1q in the clearance of extracellular neuromelanin from the substantia nigra in Parkinson disease. J Neuropathol Exp Neurol (2011) 0.89

Effect of Preexisting Cognitive Impairment on In-Patient Treatment and Discharge Management among Elderly Patients with Hip Fractures. Dement Geriatr Cogn Disord (2015) 0.88

The vesicular monoamine transporter 2 (VMAT2) is expressed by normal and tumor cutaneous mast cells and Langerhans cells of the skin but is absent from Langerhans cell histiocytosis. J Histochem Cytochem (2004) 0.88

Use of the Gamma3™ nail in a teaching hospital for trochanteric fractures: mechanical complications, functional outcomes, and quality of life. BMC Res Notes (2012) 0.87

Downregulation of the potassium chloride cotransporter KCC2 in vulnerable motoneurons in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol (2010) 0.87

Brain virus burden and indoleamine-2,3-dioxygenase expression during lentiviral infection of rhesus monkey are concomitantly lowered by 6-chloro-2',3'-dideoxyguanosine. Eur J Neurosci (2004) 0.86

Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration. Glia (2002) 0.86

Intravenous inoculation of a bat-associated rabies virus causes lethal encephalopathy in mice through invasion of the brain via neurosecretory hypothalamic fibers. PLoS Pathog (2009) 0.85

The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes. Am J Physiol Gastrointest Liver Physiol (2012) 0.85

Height restoration and maintenance after treating unstable osteoporotic vertebral compression fractures by cement augmentation is dependent on the cement volume used. Clin Biomech (Bristol, Avon) (2013) 0.84

Monoaxial versus polyaxial locking systems: a biomechanical analysis of different locking systems for the fixation of proximal humeral fractures. Int Orthop (2011) 0.84

Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice. Hepatology (2012) 0.84

Influence of prehospital volume replacement on outcome in polytraumatized children. Crit Care (2012) 0.84

Morphine and endomorphin-1 differently influence pronociceptin/orphanin FQ system in neuropathic rats. Pharmacol Biochem Behav (2004) 0.84

Gastrointestinal stromal tumors with KIT exon 9 mutations: Update on genotype-phenotype correlation and validation of a high-resolution melting assay for mutational testing. Am J Surg Pathol (2013) 0.84

Fibroblast growth factor receptor-1 as a potential therapeutic target in sinonasal cancer. Head Neck (2014) 0.83

Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice. Biochim Biophys Acta (2011) 0.83

STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons. J Mol Neurosci (2012) 0.83

Prognostic factors of liver injury in polytraumatic patients. Results from 895 severe abdominal trauma cases. J Gastrointestin Liver Dis (2009) 0.83

Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2',3'-dideoxyguanosine. Neurobiol Dis (2005) 0.83

Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis. Liver Int (2012) 0.83

Numbers of Severely Injured Patients in Germany. Dtsch Arztebl Int (2015) 0.82

Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer. PLoS One (2013) 0.82

Increased APOBEC3G expression is associated with extensive G-to-A hypermutation in viral DNA in rhesus macaque brain during lentiviral infection. J Neuropathol Exp Neurol (2007) 0.82

Influence of GH substitution therapy in deficient adults on the recurrence rate of hormonally inactive pituitary adenomas: a case control study. Eur J Endocrinol (2007) 0.82

Identification of a region from the human cholinergic gene locus that targets expression of the vesicular acetylcholine transporter to a subset of neurons in the medial habenular nucleus in transgenic mice. J Neurochem (2003) 0.82

Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of duodenal origin. Gastroenterology (2002) 0.82

Localization and expression of VMAT2 aross mammalian species: a translational guide for its visualization and targeting in health and disease. Adv Pharmacol (2013) 0.82

Analysis of the dorsal spinal cord synaptic architecture by combined proteome analysis and in situ hybridization. J Proteome Res (2005) 0.82

Prevalence and influence of tibial tunnel widening after isolated anterior cruciate ligament reconstruction using patella-bone-tendon-bone-graft: long-term follow-up. Orthop Rev (Pavia) (2012) 0.82

Bone morphogenetic protein-7 enhances bone-tendon integration in a murine in vitro co-culture model. Int Orthop (2015) 0.82

Long-term follow-up after severe suicide attempt by multiple blunt trauma. Eur Psychiatry (2005) 0.81

Early magnetic resonance imaging in spinal cord injury without radiological abnormality in adults: a retrospective study. J Trauma Acute Care Surg (2013) 0.81

Musculoskeletal injuries in auto racing: a retrospective study of 137 drivers. Phys Sportsmed (2014) 0.81

The influence of hip rotation on femoral offset in plain radiographs. Acta Orthop (2014) 0.81