PubRank

Masoud Vedadi

Author PubWeight™ 80.47‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat Protoc 2007 9.92
2 In situ proteolysis for protein crystallization and structure determination. Nat Methods 2007 3.05
3 Structural biology of human H3K9 methyltransferases. PLoS One 2010 2.45
4 An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell 2011 2.35
5 Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J Biol Chem 2008 2.12
6 L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol 2007 2.12
7 Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO J 2006 2.08
8 Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem 2009 1.92
9 Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat Struct Mol Biol 2010 1.91
10 Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol 2007 1.90
11 An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol 2013 1.89
12 Recognition and specificity determinants of the human cbx chromodomains. J Biol Chem 2010 1.76
13 Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem 2010 1.73
14 Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun 2012 1.67
15 The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa. J Biol Chem 2004 1.58
16 Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens. Proteins 2003 1.58
17 Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. Structure 2007 1.53
18 Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem 2011 1.46
19 Small-molecule ligands of methyl-lysine binding proteins. J Med Chem 2011 1.45
20 A strategy for modulation of enzymes in the ubiquitin system. Science 2013 1.43
21 Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. Nucleic Acids Res 2009 1.32
22 Screening for ligands using a generic and high-throughput light-scattering-based assay. J Biomol Screen 2006 1.31
23 Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins. J Biomol Screen 2009 1.27
24 Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem 2013 1.23
25 Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator. J Biol Chem 2007 1.22
26 A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. Biochem J 2009 1.19
27 Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. J Am Chem Soc 2012 1.17
28 Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J Biol Chem 2007 1.12
29 Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J 2013 1.12
30 A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors. Mol Biosyst 2010 1.12
31 Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell 2013 1.11
32 An allosteric inhibitor of protein arginine methyltransferase 3. Structure 2012 1.11
33 Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem 2014 1.05
34 Structural insights into the inhibited states of the Mer receptor tyrosine kinase. J Struct Biol 2008 1.04
35 Structural studies of a four-MBT repeat protein MBTD1. PLoS One 2009 1.03
36 Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family. Bioinformatics 2007 1.03
37 Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands. J Biomol Screen 2008 1.00
38 Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J Med Chem 2013 1.00
39 Thermal denaturation assays in chemical biology. Assay Drug Dev Technol 2011 0.97
40 Structural basis of allele variation of human thiopurine-S-methyltransferase. Proteins 2007 0.97
41 Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Org Lett 2012 0.97
42 Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. PLoS One 2010 0.94
43 Specificity of Campylobacter jejuni adhesin PEB3 for phosphates and structural differences among its ligand complexes. Biochemistry 2009 0.92
44 Fluorescence-based methods for screening writers and readers of histone methyl marks. J Biomol Screen 2011 0.89
45 Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein. J Biol Chem 2014 0.89
46 Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering. J Biomol Screen 2010 0.87
47 The Cryptosporidium parvum kinome. BMC Genomics 2011 0.86
48 A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a. ChemMedChem 2014 0.86
49 A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl 2015 0.85
50 Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. J Biol Chem 2010 0.84
51 Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Sci Signal 2012 0.83
52 Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. FEBS Lett 2013 0.83
53 Strategy to target the substrate binding site of SET domain protein methyltransferases. J Chem Inf Model 2013 0.81
54 Characterization of 14-3-3 proteins from Cryptosporidium parvum. PLoS One 2011 0.79
55 Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol 2015 0.78
56 Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. ACS Infect Dis 2016 0.75
57 Correction to Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem 2016 0.75
58 Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol 2017 0.75