P Fumoleau

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer. J Clin Oncol 1998 2.52
2 Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer. Eur J Cancer 2002 2.34
3 Multicenter, randomized comparative study of two doses of paclitaxel in patients with metastatic breast cancer. J Clin Oncol 1996 2.17
4 Docetaxel is a major cytotoxic drug for the treatment of advanced breast cancer: a phase II trial of the Clinical Screening Cooperative Group of the European Organization for Research and Treatment of Cancer. J Clin Oncol 1995 1.49
5 Pre-operative systemic (neo-adjuvant) therapy with trastuzumab and docetaxel for HER2-overexpressing stage II or III breast cancer: results of a multicenter phase II trial. Ann Oncol 2005 1.33
6 Immunoscintigraphy of colon carcinoma. J Nucl Med 1984 1.31
7 EORTC Early Clinical Studies Group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer. Br J Cancer 2003 1.25
8 Intraperitoneal recombinant interferon gamma in ovarian cancer patients with residual disease at second-look laparotomy. J Clin Oncol 1996 1.25
9 Phase II trial with S-1 in chemotherapy-naïve patients with gastric cancer. A trial performed by the EORTC Early Clinical Studies Group (ECSG). Eur J Cancer 2003 1.24
10 Final report of the French multicenter phase II study of the nitrosourea fotemustine in 153 evaluable patients with disseminated malignant melanoma including patients with cerebral metastases. Cancer 1990 1.15
11 T-bet expression in intratumoral lymphoid structures after neoadjuvant trastuzumab plus docetaxel for HER2-overexpressing breast carcinoma predicts survival. Br J Cancer 2011 1.14
12 Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumours. Ann Oncol 2003 1.10
13 Oral vinorelbine pharmacokinetics and absolute bioavailability study in patients with solid tumors. Ann Oncol 2001 1.08
14 Population pharmacokinetics of the novel anticancer agent E7070 during four phase I studies: model building and validation. J Clin Oncol 2002 1.07
15 Single-agent gemcitabine is active in previously treated metastatic breast cancer. Oncology 2001 1.07
16 Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy. Ann Oncol 2011 1.03
17 Phase I trial of intravenous aviscumine (rViscumin) in patients with solid tumors: a study of the European Organization for Research and Treatment of Cancer New Drug Development Group. Ann Oncol 2004 1.01
18 Immunoscintigraphy of recurrences of gynecologic carcinomas. J Nucl Med 1987 1.01
19 [Bevacizumab/irinotecan. An active treatment for recurrent high grade gliomas: preliminary results of an ANOCEF Multicenter Study]. Rev Neurol (Paris) 2008 1.01
20 Changes in 18F-FDG tumor metabolism after a first course of neoadjuvant chemotherapy in breast cancer: influence of tumor subtypes. Ann Oncol 2012 0.99
21 Complete hormonal blockade versus epirubicin-based chemotherapy in premenopausal, one to three node-positive, and hormone-receptor positive, early breast cancer patients: 7-year follow-up results of French Adjuvant Study Group 06 randomised trial. Ann Oncol 2006 0.98
22 G388R mutation of the FGFR4 gene is not relevant to breast cancer prognosis. Br J Cancer 2004 0.96
23 Lenograstim prevents morbidity from intensive induction chemotherapy in the treatment of inflammatory breast cancer. J Clin Oncol 1995 0.95
24 Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur J Cancer 2002 0.95
25 Efficacy and safety of docetaxel (Taxotere) in heavily pretreated advanced breast cancer patients: the French compassionate use programme experience. Eur J Cancer 1999 0.95
26 Phase I and pharmacokinetic study of E7070, a novel sulfonamide, given at a daily times five schedule in patients with solid tumors. A study by the EORTC-early clinical studies group (ECSG). Ann Oncol 2001 0.95
27 Gene expression profile and response to trastuzumab-docetaxel-based treatment in breast carcinoma. Br J Cancer 2009 0.94
28 Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report. Eur J Cancer 2001 0.92
29 Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors. Cancer Chemother Pharmacol 2003 0.92
30 Phase I and pharmacokinetic study of the multitargeted antifolate pemetrexed in combination with oxaliplatin in patients with advanced solid tumors. Ann Oncol 2004 0.92
31 Evaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours. Eur J Cancer 2009 0.91
32 Leptomeningeal infiltration in esthesioneuroblastoma: report of two cases with poor prognosis. Eur Neurol 1994 0.91
33 Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell-cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer. J Clin Oncol 2002 0.91
34 Secondary leukemia after epirubicin-based adjuvant chemotherapy in operable breast cancer patients: 16 years experience of the French Adjuvant Study Group. Ann Oncol 2005 0.90
35 FOXP3 expression in cancer cells and anthracyclines efficacy in patients with primary breast cancer treated with adjuvant chemotherapy in the phase III UNICANCER-PACS 01 trial. Ann Oncol 2012 0.90
36 Multicentre EORTC study 16997: feasibility and phase II trial of farnesyl transferase inhibitor & gemcitabine combination in salvage treatment of advanced urothelial tract cancers. Eur J Cancer 2005 0.90
37 Phase II study of E7070 in patients with metastatic melanoma. Ann Oncol 2005 0.90
38 Biodistribution of indium-111-labeled OC 125 monoclonal antibody intraperitoneally injected into patients operated on for ovarian carcinomas. Cancer Res 1989 0.89
39 European Organization for Research and Treatment of Cancer (EORTC) open label phase II study on glufosfamide administered as a 60-minute infusion every 3 weeks in recurrent glioblastoma multiforme. Ann Oncol 2003 0.89
40 Phase II trial combining docetaxel and doxorubicin as neoadjuvant chemotherapy in patients with operable breast cancer. Ann Oncol 2003 0.89
41 Pathological complete response and survival according to the level of HER-2 amplification after trastuzumab-based neoadjuvant therapy for breast cancer. Br J Cancer 2010 0.88
42 Chemotherapy by fotemustine in cerebral metastases of disseminated malignant melanoma. Cancer Chemother Pharmacol 1990 0.87
43 Glufosfamide administered using a 1-hour infusion given as first-line treatment for advanced pancreatic cancer. A phase II trial of the EORTC-new drug development group. Eur J Cancer 2003 0.87
44 A multicentre phase II study of docetaxel 75 mg m-2 as first-line chemotherapy for patients with advanced breast cancer: report of the Clinical Screening Group of the EORTC. European Organization for Research and Treatment of Cancer. Br J Cancer 1996 0.87
45 Results of a European Organization for Research and Treatment of Cancer/Early Clinical Studies Group phase II trial of first-line irinotecan in patients with advanced or recurrent squamous cell carcinoma of the cervix. J Clin Oncol 1999 0.86
46 Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiforme. Eur J Cancer 2002 0.85
47 Phase II study of LU 103793 (dolastatin analogue) in patients with metastatic breast cancer. Eur J Cancer 2003 0.85
48 Vinflunine: a new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy. Br J Cancer 2006 0.84
49 Phase I dose-escalation study of aflibercept in combination with docetaxel and cisplatin in patients with advanced solid tumours. Br J Cancer 2012 0.84
50 Adjuvant treatment of node-positive breast cancer with cyclophosphamide, doxorubicin, fluorouracil, and vincristine versus cyclophosphamide, methotrexate, and fluorouracil: final report after a 16-year median follow-up duration. J Clin Oncol 1996 0.84
51 Phase I study of lapatinib plus vinorelbine in patients with locally advanced or metastatic breast cancer overexpressing HER2. Br J Cancer 2012 0.84
52 Phase II study of XR5000 (DACA) administered as a 120-h infusion in patients with recurrent glioblastoma multiforme. Ann Oncol 2002 0.83
53 Epirubicin-vinorelbine vs FEC100 for node-positive, early breast cancer: French Adjuvant Study Group 09 trial. Br J Cancer 2007 0.82
54 Evaluation of oral versus intravenous dose of vinorelbine to achieve equivalent blood exposures in patients with solid tumours. Cancer Chemother Pharmacol 2007 0.82
55 Epirubicin--docetaxel combination in first-line chemotherapy for patients with metastatic breast cancer: final results of a dose-finding and efficacy study. Am J Clin Oncol 2001 0.82
56 Phase II study of XR 5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with non-small cell lung cancer. Eur J Cancer 2003 0.82
57 Use of serial carcinoembryonic antigen assays in detecting relapses in breast cancer involving high risk of metastasis. Eur J Cancer 1981 0.82
58 Glufosfamide administered by 1-hour infusion as a second-line treatment for advanced non-small cell lung cancer; a phase II trial of the EORTC-New Drug Development Group. Eur J Cancer 2004 0.82
59 Efficacy and safety of single agent capecitabine in pretreated metastatic breast cancer patients from the French compassionate use program. Breast Cancer Res Treat 2004 0.81
60 Phase II study of vinorelbine in patients with androgen-independent prostate cancer. Ann Oncol 2001 0.81
61 Phase II study of OSI-211 (liposomal lurtotecan) in patients with metastatic or loco-regional recurrent squamous cell carcinoma of the head and neck. An EORTC New Drug Development Group study. Eur J Cancer 2004 0.80
62 UFT and leucovorin in first-line chemotherapy for patients with metastatic gastric cancer. An Early Clinical Studies Group (ECSG)/European Organization for Research Treatment of Cancer (EORTC) phase II trial. Eur J Cancer 2001 0.80
63 Carboplatin plus paclitaxel in the first-line treatment of advanced ovarian cancer: preliminary results of a phase I study. Semin Oncol 1996 0.80
64 Phase I and pharmacological study of the oral farnesyltransferase inhibitor SCH 66336 given once daily to patients with advanced solid tumours. Eur J Cancer 2002 0.80
65 Docetaxel in combination with doxorubicin or vinorelbine. Eur J Cancer 1997 0.80
66 An EORTC-ECSG phase II study of vinorelbine in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. Ann Oncol 1998 0.79
67 Association of bolus tetrahydropyranyl adriamycin and 120 hours continuous 5-fluorouracil infusion in patients with metastatic breast cancer. Am J Clin Oncol 1990 0.79
68 A phase II study of intraperitoneal radioimmunotherapy with iodine-131-labeled monoclonal antibody OC-125 in patients with residual ovarian carcinoma. Clin Cancer Res 1999 0.79
69 Phase I dose-escalation study of a novel antitumor agent, SR271425, administered intravenously in split doses (d1-d2-d3) in patients with refractory solid tumors. Cancer Chemother Pharmacol 2006 0.79
70 Gemcitabine plus docetaxel: a new treatment option for anthracycline pretreated metastatic breast cancer patients? Cancer Treat Rev 2005 0.79
71 [Management of metastatic HER2-positive breast cancer: present and future]. Bull Cancer 2010 0.78
72 Gene amplifications detected by fluorescence in situ hybridization in pure intraductal breast carcinomas: relation to morphology, cell proliferation and expression of breast cancer-related genes. Int J Cancer 2000 0.78
73 Phase II study of XR 5000, an inhibitor of topoisomerases I and II, in advanced colorectal cancer. Eur J Cancer 2002 0.78
74 Taxol (paclitaxel) safety in patients with platinum pretreated ovarian carcinoma: an interim analysis of a phase II multicenter study. Ann Oncol 1994 0.78
75 Taxoids in combination chemotherapy for metastatic breast cancer. Anticancer Drugs 1996 0.78
76 Usefulness of imaging ovarian cancer recurrence with In-111-labeled monoclonal antibody (OC 125) specific for CA 125 antigen. The INSERM Research Network (Nantes, Rennes, Reims, Vuillejuif, Saclay. Ann Oncol 1993 0.77
77 Phase II study of pirarubicin (THP) in patients with cervical, endometrial and ovarian cancer: study of the Clinical Screening Group of the European Organization for Research and Treatment of Cancer (EORTC). Eur J Cancer 1993 0.77
78 Modelling of ftorafur and 5-fluorouracil pharmacokinetics following oral UFT administration. A population study in 30 patients with advanced breast cancer. Cancer Chemother Pharmacol 2003 0.77
79 Phase II clinical evaluation of doxifluridine. Cancer Treat Rep 1986 0.77
80 Phase I dose-finding and pharmacokinetic study of docetaxel and vinorelbine as first-line chemotherapy for metastatic breast cancer. Ann Oncol 2001 0.77
81 Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a study of the EORTC early clinical studies group (ECSG). Cancer Chemother Pharmacol 2000 0.77
82 Cost-effectiveness of adjuvant docetaxel for node-positive breast cancer patients: results of the PACS 01 economic study. Ann Oncol 2009 0.76
83 Population pharmacokinetics of short intravenous vinorelbine infusions in patients with metastatic breast cancer. Cancer Chemother Pharmacol 2003 0.76
84 High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer. Br J Cancer 2011 0.76
85 Phase II trial of cystemustine, a new nitrosourea, as treatment of high-grade brain tumors in adults. J Neurooncol 2000 0.76
86 Results of a phase II trial with second-line cystemustine at 60 mg/m2 in advanced soft tissue sarcoma: a trial of the EORTC Early Clinical Studies Group. Eur J Cancer 1998 0.75
87 Docetaxel and cisplatin in head and neck cancer. Ann Oncol 2000 0.75
88 [Use of radio-labelled monoclonal antibodies for the scintigraphic detection of human colorectal cancers]. Bull Cancer 1983 0.75
89 Development and validation of limited sampling strategies for prediction of the systemic exposure to the novel anticancer agent E7070 (N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide). Br J Clin Pharmacol 2002 0.75
90 [2d and 3d line hormonal therapy in postmenopausal metastatic breast tumor. Comparison of medroxyprogesterone acetate and aminoglutethimide in tamoxifen-resistant patients]. Clin Ter 1994 0.75
91 [Bone metastasis revealing a hepatoma. 13 cases]. Rev Rhum Mal Osteoartic 1981 0.75
92 RFS2000 (9-nitrocamptothecin) in advanced small cell lung cancer, a phase II study of the EORTC New Drug Development Group. Eur J Cancer 2004 0.75
93 Radioimmunoassay of the CA 12 5 antigen in ovarian carcinomas: advantages compared with CA 19-9 and CEA. Tumour Biol 1984 0.75
94 [Bone tumors. Case 5: osteoblastoma]. Ann Radiol (Paris) 1984 0.75
95 The EORTC and drug development. European Organisation for Research and Treatment of Cancer. Eur J Cancer 2002 0.75
96 [Endomyocardial biopsy as a method of surveilling adriamycin cardiac toxicity. 28 biopsies in 26 patients]. Arch Mal Coeur Vaiss 1983 0.75
97 [Phase II trial of pepleomycin in metastatic cancer of the prostate]. Bull Cancer 1986 0.75
98 [Phase II trial with cystemustine (60 mg/m2) in advanced or metastatic pretreated lung carcinoma]. Rev Pneumol Clin 2000 0.75
99 Phase I study of MEN-10755, a new anthracycline in patients with solid tumours: a report from the European Organization for Research and Treatment of Cancer, Early Clinical Studies Group. Ann Oncol 2002 0.75
100 [Comparison of the cardiotoxicity of adriamycin and aclacinomycin A in the rat. Optical and electron microscopic study]. Arch Mal Coeur Vaiss 1983 0.75
101 Genetic alterations in early-onset invasive breast carcinomas: correlation of c-erbB-2 amplification detected by fluorescence in situ hybridization with p53 accumulation and tumor phenotype. Int J Cancer 1999 0.75
102 Reproducibility of image interpretation in immunoscintigraphy performed with indium-111- and iodine-131-labeled OC125 F(ab')2 antibody injected into the same patients. J Nucl Med 1991 0.75
103 Complementary roles of immunoscintigraphy and ultrasonography. Eur J Nucl Med 1985 0.75
104 Results of a phase II trial with cystemustine in advanced malignant melanoma. A trial of the EORTC Clinical Screening Group. Eur J Cancer 1996 0.75
105 Results of a phase II trial with cystemustine at 90 mg/m(2) as a first- or second-line treatment in advanced malignant melanoma: a trial of the EORTC Clinical Studies Group. Melanoma Res 1999 0.75
106 A phase I study of vinflunine in combination with capecitabine in patients with metastatic breast cancer previously treated with anthracyclines and taxanes. Cancer Chemother Pharmacol 2011 0.75
107 Phase II study of cystemustine in metastatic colorectal carcinoma. A trial of the EORTC Clinical Screening Group. Eur J Cancer 1993 0.75
108 EORTC/GTO adjuvant chemotherapy program for primary Ewing's sarcoma: results at 5 years. Recent Results Cancer Res 1978 0.75
109 [Intraperitoneal administration of interferon gamma. An efficient adjuvant to the chemotherapy of ovarian cancers. Apropos of an European study of 108 patients]. Bull Cancer 1993 0.75
110 Phase II study of a new vinca alkaloid derivative, S12363, in advanced breast cancer. Cancer Chemother Pharmacol 1995 0.75
111 Phase II study on 9-nitrocamptothecin (RFS 2000) in patients with advanced or metastatic urothelial tract tumors. Invest New Drugs 2004 0.75
112 Adriamycin, vincristine, cyclophosphamide and 5-fluorouracil (AVCF) compared with cyclophosphamide, methotrexate and 5-fluorouracil (CMF) in premenopausal breast carcinoma. Personal results. Drugs Exp Clin Res 1986 0.75
113 Phase II trial of pirarubicin in epidermoid carcinoma of the head and neck. Eur J Cancer 1992 0.75
114 [Non-invasive methods in the monitoring of patients treated with adriamycin]. Arch Mal Coeur Vaiss 1981 0.75
115 Impact of neoadjuvant chemotherapy on survival in breast cancer patients in daily practice: a population-based study. Eur J Cancer Care (Engl) 2013 0.75
116 Cancer drug development in Europe: a selection of new agents under development at the European Drug Development Network. Cancer Invest 2003 0.75
117 [Intraperitoneal recombinant gamma interferon (RU 42369) efficacy in ovarian carcinomas. European BRM Study Group]. Pathol Biol (Paris) 1992 0.75
118 Pirarubicin in advanced breast cancer: a French cooperative phase II study. Eur J Cancer 1990 0.75
119 Fotemustine plus dacarbazine for malignant melanoma. Eur J Cancer 1992 0.75
120 [Intestinal endosalpingiosis. Apropos of 2 cases]. Ann Chir 1995 0.75
121 Neoadjuvant therapy for breast cancer has no benefits on overall survival or on the mastectomy rate in routine clinical practice. A population-based study with a median follow-up of 11 years using propensity score matching. Eur J Cancer 2012 0.75
122 Anti-beta HCG abdominopelvic immunoscintigraphy in patients with resistant gestational trophoblastic disease. Nucl Med Commun 1992 0.75
123 Phase I and pharmacokinetic study of IV vinflunine in cancer patients with liver dysfunction. Invest New Drugs 2012 0.75
124 [Primary heteroplastic dysgerminomas and dysembryomas of the mediastinum. Proposals on management]. Ann Chir 1986 0.75
125 [Report on pure non-seminomatous germinal tumors of the mediastinum]. Ann Chir 1986 0.75
126 [Adjuvant treatment of osteosarcomas. Experience of the Group for the Study of Bone Tumors]. Rev Chir Orthop Reparatrice Appar Mot 1987 0.75
127 Second and third line hormonotherapy in advanced post-menopausal breast cancer: a multicenter randomized trial comparing medroxyprogesterone acetate with aminoglutethimide in patients who have become resistant to tamoxifen. Breast Cancer Res Treat 1992 0.75