PubRank

Istvan Toth

Author PubWeight™ 102.76‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nat Nanotechnol 2010 2.00
2 A new principle for tight junction modulation based on occludin peptides. Mol Pharmacol 2003 1.88
3 Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorg Med Chem 2006 1.23
4 Modern subunit vaccines: development, components, and research opportunities. ChemMedChem 2013 1.22
5 Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection. Atherosclerosis 2007 1.16
6 Self-adjuvanting lipopeptide vaccines. Curr Med Chem 2008 1.10
7 Recent progress in adjuvant discovery for peptide-based subunit vaccines. Hum Vaccin Immunother 2013 1.10
8 Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. Am J Physiol Heart Circ Physiol 2003 1.06
9 Particulate systems as adjuvants and carriers for peptide and protein antigens. Curr Drug Deliv 2006 1.01
10 Cellular uptake of densely packed polymer coatings on gold nanoparticles. ACS Nano 2010 0.98
11 Molecular interaction of poly(acrylic acid) gold nanoparticles with human fibrinogen. ACS Nano 2012 0.97
12 Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses. Nanotoxicology 2012 0.94
13 Polyacrylate dendrimer nanoparticles: a self-adjuvanting vaccine delivery system. Angew Chem Int Ed Engl 2010 0.94
14 Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group a streptococcal vaccine candidates. J Med Chem 2007 0.94
15 Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates. Bioorg Med Chem 2008 0.92
16 Strategies for intranasal delivery of vaccines. Drug Deliv Transl Res 2012 0.92
17 Gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers. Curr Drug Deliv 2005 0.91
18 Cellular uptake of self-assembled cationic peptide-DNA complexes: multifunctional role of the enhancer chloroquine. J Control Release 2009 0.90
19 Immunization with a tetraepitopic lipid core peptide vaccine construct induces broadly protective immune responses against group A streptococcus. J Infect Dis 2006 0.89
20 Specific modulation of airway epithelial tight junctions by apical application of an occludin peptide. Mol Pharmacol 2005 0.89
21 Immunological evaluation of lipopeptide group A streptococcus (GAS) vaccine: structure-activity relationship. PLoS One 2012 0.87
22 A lipid core peptide construct containing a conserved region determinant of the group A streptococcal M protein elicits heterologous opsonic antibodies. Infect Immun 2002 0.87
23 Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. Exp Eye Res 2004 0.87
24 Chemical methods for peptide and protein production. Molecules 2013 0.87
25 Immunostimulation by synthetic lipopeptide-based vaccine candidates: structure-activity relationships. Front Immunol 2013 0.86
26 Micellar aggregation and membrane partitioning of bile salts, fatty acids, sodium dodecyl sulfate, and sugar-conjugated fatty acids: correlation with hemolytic potency and implications for drug delivery. Mol Pharm 2005 0.86
27 Potential of lipid core peptide technology as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens. Infect Immun 2003 0.85
28 Synthesis and biological evaluation of an orally active glycosylated endomorphin-1. J Med Chem 2012 0.85
29 In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin. Bioorg Med Chem 2008 0.85
30 Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers. Biomacromolecules 2011 0.84
31 Toll-like receptor agonists: a patent review (2011 - 2013). Expert Opin Ther Pat 2014 0.84
32 Encapsulation of lipopeptides within liposomes: effect of number of lipid chains, chain length and method of liposome preparation. Int J Pharm 2005 0.84
33 Peptide-based subunit nanovaccines. Curr Drug Deliv 2011 0.84
34 Design of fully synthetic, self-adjuvanting vaccine incorporating the tumor-associated carbohydrate Tn antigen and lipoamino acid-based Toll-like receptor 2 ligand. J Med Chem 2012 0.83
35 Lipid-core-peptide system for self-adjuvanting synthetic vaccine delivery. Methods Mol Biol 2011 0.83
36 Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides. Bioorg Med Chem 2008 0.83
37 Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide. Bioorg Med Chem Lett 2007 0.83
38 Design of three-component vaccines against group A streptococcal infections: importance of spatial arrangement of vaccine components. J Med Chem 2010 0.83
39 Enhanced transdermal peptide delivery and stability by lipid conjugation: epidermal permeation, stereoselectivity and mechanistic insights. Pharm Res 2014 0.83
40 Simple synthetic toll-like receptor 2 ligands. Bioorg Med Chem Lett 2011 0.82
41 Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin. Bioorg Med Chem 2005 0.82
42 Peptide-based subunit vaccine against hookworm infection. PLoS One 2012 0.82
43 Oral vaccine delivery--new strategies and technologies. Curr Drug Deliv 2009 0.82
44 Lipophilic derivatives of leu-enkephalinamide: in vitro permeability, stability and in vivo nasal delivery. Bioorg Med Chem 2010 0.82
45 Peptide conjugation via CuAAC 'click' chemistry. Molecules 2013 0.82
46 Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules 2013 0.82
47 Design, synthesis, and evaluation of a liposaccharide drug delivery agent: application to the gastrointestinal absorption of gentamicin. J Med Chem 2004 0.82
48 Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. J Med Chem 2003 0.81
49 Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. Bioorg Med Chem 2007 0.81
50 Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology. Immunol Cell Biol 2002 0.81
51 Expression of maturation markers on murine dendritic cells in response to group A streptococcal lipopeptide vaccines. Vaccine 2009 0.81
52 Structure-activity relationship of lipopeptide Group A streptococcus (GAS) vaccine candidates on toll-like receptor 2. Vaccine 2009 0.81
53 Advances in peptide-based human papillomavirus therapeutic vaccines. Curr Top Med Chem 2012 0.81
54 Biological properties and therapeutic potential of bilirubin. Mini Rev Med Chem 2003 0.81
55 Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues. Eur J Pharm Sci 2002 0.80
56 Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A streptococcal vaccine, and subsequent immunological evaluation. J Med Chem 2006 0.80
57 Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One 2012 0.80
58 Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids II. Experimental and computational evidence using biomembrane models. Int J Pharm 2006 0.80
59 Modern lipid-, carbohydrate-, and peptide-based delivery systems for peptide, vaccine, and gene products. Med Res Rev 2009 0.80
60 Polymer-peptide hybrids as a highly immunogenic single-dose nanovaccine. Nanomedicine (Lond) 2013 0.80
61 Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue. Biochem Biophys Res Commun 2007 0.80
62 Liposome-based delivery system for vaccine candidates: constructing an effective formulation. Nanomedicine (Lond) 2012 0.80
63 Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hydrophobic peptide dramatically enhances in vitro and in vivo function. Biochim Biophys Acta 2006 0.80
64 Synthetic polyacrylate polymers as particulate intranasal vaccine delivery systems for the induction of mucosal immune response. Curr Drug Deliv 2010 0.79
65 Immunogenicity of liposomes containing lipid core peptides and the adjuvant Quil A. Pharm Res 2006 0.79
66 Toward the development of a synthetic group a streptococcal vaccine of high purity and broad protective coverage. J Med Chem 2004 0.79
67 Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines. J Med Chem 2008 0.79
68 Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines. J Med Chem 2007 0.79
69 Lipoamino acid-based adjuvant carrier system: enhanced immunogenicity of group a streptococcal peptide epitopes. J Med Chem 2002 0.79
70 Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis. Bioorg Med Chem 2010 0.79
71 Endomorphin derivatives with improved pharmacological properties. Curr Med Chem 2013 0.78
72 Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives. Bioorg Med Chem 2012 0.78
73 Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides. Immunol Cell Biol 2004 0.78
74 Effect of polymer grafting density on silica nanoparticle toxicity. Bioorg Med Chem 2012 0.78
75 Nanovaccines and their mode of action. Methods 2013 0.78
76 A novel synthetic adjuvant enhances dendritic cell function. Immunology 2008 0.78
77 Enhancement of oral drug absorption-effect of lipid conjugation on the enzymatic stability and intestinal permeability of l-Glu-l-Trp-NH(2). Bioorg Med Chem 2007 0.78
78 Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein. J Infect Dis 2006 0.78
79 M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus. Curr Drug Deliv 2013 0.78
80 Versatile peptide dendrimers for nucleic acid delivery. J Pharm Sci 2005 0.78
81 Method for the synthesis of multi-epitopic Streptococcus pyogenes lipopeptide vaccines using native chemical ligation. J Org Chem 2006 0.78
82 Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. Bioorg Med Chem 2013 0.78
83 Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides. Bioorg Med Chem Lett 2002 0.78
84 Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method. Org Biomol Chem 2013 0.78
85 Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine. Nanomedicine 2010 0.78
86 The characterization of a novel dendritic system for gene delivery by isothermal titration calorimetry. Biopolymers 2008 0.77
87 Cellular transport pathways of polymer coated gold nanoparticles. Nanomedicine 2011 0.77
88 Recent advances in peptide-based subunit nanovaccines. Nanomedicine (Lond) 2014 0.77
89 Lipid core peptide technology and group A streptococcal vaccine delivery. Expert Rev Vaccines 2004 0.77
90 Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem 2008 0.77
91 Synthesis and in vivo studies of carbohydrate-based vaccines against group A streptococcus. Biopolymers 2008 0.77
92 Oral absorption enhancement of dipeptide L-Glu-L-Trp-OH by lipid and glycosyl conjugation. Biopolymers 2008 0.77
93 In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs. J Pharm Sci 2010 0.77
94 Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model. PLoS One 2012 0.77
95 Group A streptococcal vaccine delivery by immunization with a self-adjuvanting M protein-based lipid core peptide construct. Indian J Med Res 2004 0.77
96 The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide. Bioorg Med Chem Lett 2005 0.77
97 Stability, permeability and growth-inhibitory properties of gonadotropin-releasing hormone liposaccharides. Pharm Res 2014 0.77
98 Anti-proliferative effects of novel glyco-lipid-arsenicals (III) on MCF-7 human breast cancer cells. Med Chem 2006 0.77
99 Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes. J Med Chem 2012 0.77
100 Development of conformational mimetics of conserved Streptococcus pyogenes minimal epitope as vaccine candidates. Curr Drug Deliv 2009 0.77
101 Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope. Bioorg Med Chem Lett 2008 0.77
102 A novel method for preparing immune stimulating complexes (ISCOMs) by hydration of freeze-dried lipid matrix. Eur J Pharm Biopharm 2007 0.77
103 In vitro stability and permeability studies of liposomal delivery systems for a novel lipophilic endomorphin 1 analogue. Int J Pharm 2008 0.77
104 Synthesis and in vitro evaluation of glycosyl derivatives of luteinizing hormone-releasing hormone (LHRH). Bioorg Med Chem 2013 0.77
105 Synthesis and characterisation of self-assembled and self-adjuvanting asymmetric multi-epitope lipopeptides of ovalbumin. Chemistry 2014 0.76
106 Urotensin-II-converting enzyme activity of furin and trypsin in human cells in vitro. J Pharmacol Exp Ther 2004 0.76
107 An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system. Nanomedicine 2013 0.76
108 Cytotoxicity and vitreous stability of chemically modified connexin43 mimetic peptides for the treatment of optic neuropathy. J Pharm Sci 2013 0.76
109 Site-specific incorporation of three toll-like receptor 2 targeting adjuvants into semisynthetic, molecularly defined nanoparticles: application to group a streptococcal vaccines. Bioconjug Chem 2014 0.76
110 Oral delivery of nanoparticle-based vaccines. Expert Rev Vaccines 2014 0.76
111 Group A Streptococcal vaccine candidate: contribution of epitope to size, antigen presenting cell interaction and immunogenicity. Nanomedicine (Lond) 2014 0.76
112 Protein transduction by lipidic peptide dendrimers. J Pharm Sci 2006 0.76
113 Investigation toward multi-epitope vaccine candidates using native chemical ligation. Biopolymers 2008 0.76
114 The transport and efflux of glycosylated luteinising hormone-releasing hormone analogues in caco-2 cell model: contributions of glucose transporters and efflux systems. J Pharm Sci 2014 0.76
115 Modification of peptides and other drugs using lipoamino acids and sugars. Methods Mol Biol 2005 0.76
116 Caco-2 cell permeability and stability of two d-glucopyranuronamide conjugates of thyrotropin-releasing hormone. Bioorg Med Chem 2007 0.76
117 Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine. J Med Chem 2014 0.76
118 Design, synthesis and biological evaluation of novel lipoamino acid-based glycolipids for oral drug delivery. Bioorg Med Chem 2007 0.76
119 Chemo-enzymatic synthesis of a trisaccharide-linked peptide aimed at improved drug-delivery. Curr Drug Deliv 2005 0.76
120 Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia. Drug Deliv Transl Res 2015 0.75
121 Investigation of the route of absorption of lipid and sugar modified leu-enkephalin analogues and their enzymatic stability using the caco-2 cell monolayer system. Med Chem 2006 0.75
122 Evaluation of the Biological Properties and the Enzymatic Stability of Glycosylated Luteinizing Hormone-Releasing Hormone Analogs. AAPS J 2015 0.75
123 Functional implications of modifying RyR-activating peptides for membrane permeability. Br J Pharmacol 2005 0.75
124 The Fourth International Peptide Symposium: discovery to drugs: the peptide pipeline. Biopolymers 2008 0.75
125 Thymine, adenine and lipoamino acid based gene delivery systems. Chem Commun (Camb) 2010 0.75
126 Corrigendum: An Overview of Structural Features of Antibacterial Glycoconjugate Vaccines That Influence Their Immunogenicity. Chemistry 2017 0.75
127 Development and characterization of anionic liposaccharides for enhanced oral drug delivery. Int J Pharm 2012 0.75
128 Nucleophilic substitution reactions of pyranose polytosylates. J Org Chem 2004 0.75
129 Optimized LC-MS/MS quantification method for the detection of piperacillin and application to the development of charged liposaccharides as oral penetration enhancers. Int J Pharm 2007 0.75
130 A tribute to a living legend. Med Chem 2012 0.75
131 Increasing entrapment of peptides within poly(alkyl cyanoacrylate) nanoparticles prepared from water-in-oil microemulsions by copolymerization. Int J Pharm 2008 0.75
132 The Eighth Australian Peptide Conference: peptides--tools, targets and therapeutics. Biopolymers 2011 0.75
133 Lipidated analogues of luteinizing hormone-releasing hormone (LHRH) reduce serum levels of follicle-stimulating hormone (FSH) after oral administration. Int J Pharm 2012 0.75
134 Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine (Lond) 2015 0.75
135 Biophysical characterization of lectin-glycan interactions for therapeutics, vaccines and targeted drug-delivery. Future Med Chem 2014 0.75
136 Vaccine delivery utilizing liposaccharides. Adv Exp Med Biol 2009 0.75
137 Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. Bioorg Med Chem 2006 0.75
138 The influence of incorporating lipids or liposaccharides on the particle size of peptide therapeutics. Biopolymers 2011 0.75
139 Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery. Carbohydr Res 2011 0.75
140 Formulation, characterization and permeability study of nano particles of lipo-endomorphin-1 for oral delivery. J Liposome Res 2013 0.75
141 Lipid and carbohydrate based adjuvant/carriers in immunology. J Pept Sci 2003 0.75
142 Editorial: Drug Delivery Australia. Curr Drug Deliv 2015 0.75
143 Dendritic peptide-based carriers for gene delivery. Curr Drug Deliv 2009 0.75
144 Investigation of structure-activity relationships of synthetic anti-gonadotropin releasing hormone vaccine candidates. ChemMedChem 2015 0.75
145 Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system. Drug Deliv Transl Res 2014 0.75
146 Lipoamino acids as major components of absorption promoters in drug delivery. Curr Top Med Chem 2012 0.75
147 Self-adjuvanting therapeutic peptide-based vaccine induce CD8+ cytotoxic T lymphocyte responses in a murine human papillomavirus tumor model. Curr Drug Deliv 2015 0.75
148 Use of mixed micelles for presentation of building blocks in a new combinatorial discovery methodology: proof-of-concept studies. Molecules 2013 0.75
149 Method for the synthesis of highly pure vaccines using the lipid core peptide system. J Pept Sci 2006 0.75
150 Preface. Curr Drug Deliv 2016 0.75