Published in PLoS One on September 25, 2012
Role of Corticotropin-releasing Factor in Gastrointestinal Permeability. J Neurogastroenterol Motil (2015) 0.87
Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease. PLoS One (2013) 0.80
Gliadin peptides as triggers of the proliferative and stress/innate immune response of the celiac small intestinal mucosa. Int J Mol Sci (2014) 0.80
Latest in vitro and in vivo models of celiac disease. Expert Opin Drug Discov (2013) 0.79
Gene Expression Profiling of Gliadin Effects on Intestinal Epithelial Cells Suggests Novel Non-Enzymatic Functions of Pepsin and Trypsin. PLoS One (2013) 0.78
Non-celiac gluten sensitivity: Time for sifting the grain. World J Gastroenterol (2015) 0.77
Celiac anti-type 2 transglutaminase antibodies induce phosphoproteome modification in intestinal epithelial Caco-2 cells. PLoS One (2013) 0.76
Calcium glycerophosphate preserves transepithelial integrity in the Caco-2 model of intestinal transport. World J Gastroenterol (2015) 0.75
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86
Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol (2003) 9.07
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol (2003) 6.05
The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci (2001) 5.18
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol (1996) 5.01
ER chaperones in mammalian development and human diseases. FEBS Lett (2007) 4.40
Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology (1998) 3.82
Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet (2003) 3.78
Transglutaminases: nature's biological glues. Biochem J (2002) 3.42
Molecular basis of celiac disease. Annu Rev Immunol (2000) 3.09
Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders. Physiol Rev (2009) 2.17
Mitochondria and Ca(2+)in cell physiology and pathophysiology. Cell Calcium (2001) 1.95
Tissue-mediated control of immunopathology in coeliac disease. Nat Rev Immunol (2009) 1.91
Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology (2009) 1.89
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS One (2008) 1.67
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J Clin Invest (2006) 1.66
Autoantibodies in coeliac disease: tissue transglutaminase--guilt by association? Gut (1997) 1.60
Modulation of the in situ activity of tissue transglutaminase by calcium and GTP. J Biol Chem (1998) 1.45
Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis. Gut (2005) 1.43
Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci U S A (2003) 1.40
Endocytotic segregation of gliadin peptide 31-49 in enterocytes. Gut (2009) 1.34
Distinct nuclear localization and activity of tissue transglutaminase. J Biol Chem (1998) 1.33
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO Mol Med (2010) 1.27
ER stress and the unfolded protein response in intestinal inflammation. Am J Physiol Gastrointest Liver Physiol (2010) 1.26
Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes. PLoS One (2011) 1.22
Cell type-specific activation of intracellular transglutaminase 2 by oxidative stress or ultraviolet irradiation: implications of transglutaminase 2 in age-related cataractogenesis. J Biol Chem (2004) 1.16
Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders. Curr Opin Immunol (2011) 1.13
Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease. Am J Gastroenterol (2003) 1.13
Tissue transglutaminase promotes or suppresses tumors depending on cell context. Anticancer Res (2009) 1.04
Nuclear factor kappa B is activated in small intestinal mucosa of celiac patients. J Mol Med (Berl) (2003) 1.03
BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential. Cell Calcium (2007) 1.02
Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. J Biol Chem (2010) 1.01
Transglutaminase II: a new class of GTP-binding protein with new biological functions. Cell Signal (1997) 1.00
Tissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanisms. J Neurochem (2005) 0.98
Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2. EMBO J (2001) 0.97
Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation. PLoS One (2010) 0.96
Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA. Cell Mol Life Sci (2009) 0.95
Altered colonic glycoprotein expression in unaffected monozygotic twins of inflammatory bowel disease patients. Gut (2006) 0.94
Proteomics identification of acyl-acceptor and acyl-donor substrates for transglutaminase in a human intestinal epithelial cell line. Implications for celiac disease. J Biol Chem (2003) 0.94
PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage. Mol Med (2010) 0.94
New insights into the functions and localization of nuclear transglutaminase 2. FEBS J (2011) 0.92
Transglutaminase-mediated activation of nuclear transcription factor-kappaB in cancer cells: a new therapeutic opportunity. Curr Cancer Drug Targets (2007) 0.92
Cross-linking of cellular proteins by tissue transglutaminase during necrotic cell death: a mechanism for maintaining tissue integrity. Biochem J (2003) 0.90
Celiac anti-tissue transglutaminase antibodies interfere with the uptake of alpha gliadin peptide 31-43 but not of peptide 57-68 by epithelial cells. Biochim Biophys Acta (2010) 0.85
Exposing gliadin as a tasty food for lymphocytes. Nat Med (1998) 0.83
A decapeptide from durum wheat prevents celiac peripheral blood lymphocytes from activation by gliadin peptides. Pediatr Res (2007) 0.80
Anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase by modulating cytosolic Ca2+ homeostasis. Amino Acids (2011) 0.78
Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet (2003) 3.78
Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging? Neurobiol Aging (2002) 2.23
Clinical, HLA, and small bowel immunohistochemical features of children with positive serum antiendomysium antibodies and architecturally normal small intestinal mucosa. Am J Gastroenterol (2005) 1.80
Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans. Am J Hum Genet (2007) 1.51
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J (2010) 1.49
Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation. Am J Physiol Gastrointest Liver Physiol (2008) 1.25
Sourdough bread made from wheat and nontoxic flours and started with selected lactobacilli is tolerated in celiac sprue patients. Appl Environ Microbiol (2004) 1.17
The pharmacological chaperone N-butyldeoxynojirimycin enhances enzyme replacement therapy in Pompe disease fibroblasts. Mol Ther (2009) 1.17
Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis. Gastroenterology (2008) 1.15
Intestinal T cell responses to gluten peptides are largely heterogeneous: implications for a peptide-based therapy in celiac disease. J Immunol (2009) 1.14
Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy. J Pediatr Gastroenterol Nutr (2008) 1.13
Filamin A is mutated in X-linked chronic idiopathic intestinal pseudo-obstruction with central nervous system involvement. Am J Hum Genet (2007) 1.13
Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease. Am J Gastroenterol (2003) 1.13
Growth factor-like activity of gliadin, an alimentary protein: implications for coeliac disease. Gut (2006) 1.12
A novel peroxisome proliferator-activated receptor gamma isoform with dominant negative activity generated by alternative splicing. J Biol Chem (2005) 1.12
Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease. Gastroenterology (2007) 1.08
Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. Toxicol Lett (2003) 1.08
Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca(2+) homeostasis. Cancer Res (2011) 1.08
Androgen-induced cell migration: role of androgen receptor/filamin A association. PLoS One (2011) 1.06
Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells. J Cell Biol (2008) 1.05
IL-15 interferes with suppressive activity of intestinal regulatory T cells expanded in Celiac disease. Am J Gastroenterol (2011) 1.04
Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory. J Neurosci (2011) 1.03
Safety for patients with celiac disease of baked goods made of wheat flour hydrolyzed during food processing. Clin Gastroenterol Hepatol (2010) 1.02
Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. Mol Cell Biol (2004) 1.02
Androgen-stimulated DNA synthesis and cytoskeletal changes in fibroblasts by a nontranscriptional receptor action. J Cell Biol (2003) 1.02
Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilization. J Immunol (2007) 1.02
Adaptive and innate immune responses in celiac disease. Immunol Lett (2005) 1.01
Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells. J Immunol (2006) 1.00
Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. J Neurosci (2008) 0.99
Potential celiac patients: a model of celiac disease pathogenesis. PLoS One (2011) 0.99
Celiac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope. J Immunol (2003) 0.98
NCX1 expression and functional activity increase in microglia invading the infarct core. Stroke (2009) 0.98
Gliadin-mediated proliferation and innate immune activation in celiac disease are due to alterations in vesicular trafficking. PLoS One (2011) 0.96
Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation. PLoS One (2010) 0.96
Proteomics identification of acyl-acceptor and acyl-donor substrates for transglutaminase in a human intestinal epithelial cell line. Implications for celiac disease. J Biol Chem (2003) 0.94
Anoxia-induced NF-kappaB-dependent upregulation of NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons. Stroke (2009) 0.94
Immunogenicity of monococcum wheat in celiac patients. Am J Clin Nutr (2012) 0.93
NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death. J Cell Sci (2013) 0.93
Rotavirus and celiac disease: clues to the pathogenesis and perspectives on prevention. J Pediatr Gastroenterol Nutr (2007) 0.93
Effects of HIV-1 Tat protein on ion secretion and on cell proliferation in human intestinal epithelial cells. Gastroenterology (2003) 0.92
The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway. Mol Pharmacol (2007) 0.91
A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death. J Neurosci (2012) 0.90
Immunogenicity of two oat varieties, in relation to their safety for celiac patients. Scand J Gastroenterol (2011) 0.90
Activation of pre-synaptic M-type K+ channels inhibits [3H]D-aspartate release by reducing Ca2+ entry through P/Q-type voltage-gated Ca2+ channels. J Neurochem (2009) 0.89
Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats. Neuropharmacology (2004) 0.89
An undigested gliadin peptide activates innate immunity and proliferative signaling in enterocytes: the role in celiac disease. Am J Clin Nutr (2013) 0.88
Rapid signalling pathway activation by androgens in epithelial and stromal cells. Steroids (2004) 0.87
Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions. Am J Pathol (2003) 0.87
Expression and function of Na+/Ca2+ exchangers 1 and 3 in human macrophages and monocytes. Eur J Immunol (2009) 0.87
ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na+ /Ca2+ exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells. J Neurochem (2012) 0.86
Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptor. J Allergy Clin Immunol (2006) 0.86
Identification of tissue transglutaminase-reactive lysine residues in glyceraldehyde-3-phosphate dehydrogenase. Protein Sci (2002) 0.86
A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage. J Neurosci (2008) 0.85
NCX1 is a new rest target gene: role in cerebral ischemia. Neurobiol Dis (2012) 0.85
Celiac anti-tissue transglutaminase antibodies interfere with the uptake of alpha gliadin peptide 31-43 but not of peptide 57-68 by epithelial cells. Biochim Biophys Acta (2010) 0.85
A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABAB2 receptor. J Mol Recognit (2013) 0.85
Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis. J Cell Sci (2011) 0.84
Intranasal administration of a recombinant alpha-gliadin down-regulates the immune response to wheat gliadin in DQ8 transgenic mice. Immunol Lett (2003) 0.84
Gliadin increases iNOS gene expression in interferon-gamma-stimulated RAW 264.7 cells through a mechanism involving NF-kappa B. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.83
Evidence of calcium- and SNARE-dependent release of CuZn superoxide dismutase from rat pituitary GH3 cells and synaptosomes in response to depolarization. J Neurochem (2007) 0.83
Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells. Am J Physiol Endocrinol Metab (2012) 0.83
Specific DNA binding and regulation of its own expression by the AidB protein in Escherichia coli. J Bacteriol (2010) 0.83
Impact of age at administration, lysosomal storage, and transgene regulatory elements on AAV2/8-mediated rat liver transduction. PLoS One (2012) 0.83
Tissue transglutaminase in celiac disease: role of autoantibodies. Amino Acids (2008) 0.83
Analysis of transglutaminase protein substrates by functional proteomics. Protein Sci (2003) 0.83
Correction of gliadin transport within enterocytes through celiac disease serum. Pediatr Res (2011) 0.83
Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity. Immunol Lett (2008) 0.83
New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes. Adv Exp Med Biol (2013) 0.82
Cu,Zn superoxide dismutase increases intracellular calcium levels via a phospholipase C-protein kinase C pathway in SK-N-BE neuroblastoma cells. Biochem Biophys Res Commun (2004) 0.82
Identification of immunodominant epitopes of alpha-gliadin in HLA-DQ8 transgenic mice following oral immunization. J Immunol (2005) 0.82
Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease. Pediatr Res (2003) 0.82
Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits. Adv Exp Med Biol (2013) 0.81
Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium. Thyroid (2002) 0.81
The antiepileptic drug levetiracetam decreases the inositol 1,4,5-trisphosphate-dependent [Ca2+]I increase induced by ATP and bradykinin in PC12 cells. J Pharmacol Exp Ther (2005) 0.81
Coeliac disease and extraintestinal autoimmunity. J Pediatr Gastroenterol Nutr (2004) 0.81
Human macrophages and monocytes express functional Na(+)/Ca (2+) exchangers 1 and 3. Adv Exp Med Biol (2013) 0.81
Characterization of the anti-tissue transglutaminase antibody response in nonobese diabetic mice. J Immunol (2005) 0.80
Enterocyte proliferation and signaling are constitutively altered in celiac disease. PLoS One (2013) 0.80
Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells. J Neurosci Res (2006) 0.80
Extracellular signal-related kinase 2/specificity protein 1/specificity protein 3/repressor element-1 silencing transcription factor pathway is involved in Aroclor 1254-induced toxicity in SH-SY5Y neuronal cells. J Neurosci Res (2014) 0.79
Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage. Mol Pharmacol (2012) 0.79
Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization. Biomed Res Int (2013) 0.79
TSH/cAMP up-regulate sarco/endoplasmic reticulum Ca2+-ATPases expression and activity in PC Cl3 thyroid cells. Eur J Endocrinol (2004) 0.79
The gut as site of production of autoimmune antibodies. J Pediatr Gastroenterol Nutr (2004) 0.79
RhoB is associated with the anti-angiogenic effects of celiac patient transglutaminase 2-targeted autoantibodies. J Mol Med (Berl) (2012) 0.78
Anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase by modulating cytosolic Ca2+ homeostasis. Amino Acids (2011) 0.78
Lactobacillus paracasei CBA L74 interferes with gliadin peptides entrance in Caco-2 cells. Int J Food Sci Nutr (2014) 0.78