Published in Cell Death Differ on October 12, 2012
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev (2013) 2.31
Hypoxia-regulated target genes implicated in tumor metastasis. J Biomed Sci (2012) 1.23
MicroRNAs as Haematopoiesis Regulators. Adv Hematol (2013) 1.03
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. Proc Natl Acad Sci U S A (2014) 0.93
HypoxamiRs and cancer: from biology to targeted therapy. Antioxid Redox Signal (2013) 0.92
The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression. Oncotarget (2014) 0.84
Targeted Disruption of miR-17-92 Impairs Mouse Spermatogenesis by Activating mTOR Signaling Pathway. Medicine (Baltimore) (2016) 0.83
MiR-17 partly promotes hematopoietic cell expansion through augmenting HIF-1α in osteoblasts. PLoS One (2013) 0.83
Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis. J Funct Foods (2015) 0.81
miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo. Oncotarget (2015) 0.80
MicroRNA-130a expression is decreased in Xinjiang Uygur patients with type 2 diabetes mellitus. Am J Transl Res (2015) 0.80
The Silencing Effect of microRNA miR-17 on p21 Maintains the Neural Progenitor Pool in the Developing Cerebral Cortex. Front Neurol (2014) 0.79
The potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer. Int J Clin Exp Pathol (2015) 0.79
RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. Stem Cells Transl Med (2014) 0.76
The progress of angiogenic factors in the development of leukemias. Intractable Rare Dis Res (2016) 0.76
Hypoxia and Hypoxia-Inducible Factors in Leukemias. Front Oncol (2016) 0.76
Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang. Cancer Biol Med (2016) 0.76
MiR-17-5p promotes cancer cell proliferation and tumorigenesis in nasopharyngeal carcinoma by targeting p21. Cancer Med (2016) 0.75
EMMPRIN Down-regulating miR-106a/b Modifies Breast Cancer Stem-like Cell Properties via Interaction with Fibroblasts Through STAT3 and HIF-1α. Sci Rep (2016) 0.75
Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6. Kidney Int (2016) 0.75
STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget (2017) 0.75
Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells. Toxicol Appl Pharmacol (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09
c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81
Targeting HIF-1 for cancer therapy. Nat Rev Cancer (2003) 28.01
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res (2005) 10.46
p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer (2009) 9.21
Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer (2010) 7.39
A microRNA signature of hypoxia. Mol Cell Biol (2006) 7.24
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature (2011) 6.39
Oxygen sensing, homeostasis, and disease. N Engl J Med (2011) 5.03
The JAK-STAT signaling pathway: input and output integration. J Immunol (2007) 4.92
Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem (2006) 4.57
MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol (2007) 4.02
Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev (1996) 3.49
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02
Small RNA-mediated regulation of iPS cell generation. EMBO J (2011) 2.95
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis. J Clin Invest (2010) 2.32
Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J (2009) 2.21
Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res (2008) 2.08
The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res (2010) 1.88
miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells. J Cell Physiol (2010) 1.74
Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice. J Exp Med (1993) 1.67
miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation. Dev Biol (2008) 1.43
Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene (2007) 1.22
Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. J Exp Med (2010) 1.15
Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression. J Immunol (2011) 1.15
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood (2005) 1.07
The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response. Cell Res (2009) 1.04
The JAK-STAT pathway: signal transduction involved in proliferation, differentiation and transformation. Leuk Lymphoma (1998) 0.99
Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha. Leukemia (2003) 0.97
CCAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction. Carcinogenesis (2007) 0.97
Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. Blood (2002) 0.90
Reprogramming cell fate to pluripotency: the decision-making signalling pathways. Int J Dev Biol (2010) 0.88
Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells. J Biol Chem (2011) 0.87
Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death. Toxicology (2006) 0.85
Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation. Oncogene (2006) 0.83
Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. Exp Hematol (2005) 0.81
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
Comparative genomics of the eukaryotes. Science (2000) 26.62
Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01
Construction of a colicin E1-R factor composite plasmid in vitro: means for amplification of deoxyribonucleic acid. J Bacteriol (1975) 13.95
Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science (1998) 13.64
Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J Virol (1999) 9.11
RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell (1999) 8.55
Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage (2004) 8.50
The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J (2001) 7.97
Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat Med (2000) 7.48
Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1. DNA Res (1999) 7.39
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08
The nucleotide sequence of pUB110: some salient features in relation to replication and its regulation. Plasmid (1986) 7.07
Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell (1999) 6.83
Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3. DNA Res (1998) 6.79
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature (2000) 6.70
Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet (1999) 6.18
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity (1994) 6.18
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science (1999) 6.04
Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N Engl J Med (1996) 6.01
Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol (1992) 5.93
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts. Nat Med (1998) 5.54
Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell (2000) 5.49
The 5'-terminal sequence of the hepatitis C virus genome. Jpn J Exp Med (1990) 5.46
Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol (1993) 5.41
Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int (1995) 5.22
Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa. Mol Microbiol (1996) 5.20
Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology (1992) 5.16
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci U S A (2001) 5.05
Syringe method for stepwise chemical synthesis of oligonucleotides. Nucleic Acids Res (1982) 4.70
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45
Norwalk virus infection of volunteers: new insights based on improved assays. J Infect Dis (1994) 4.37
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science (1997) 4.19
Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome. Nat Genet (1997) 4.15
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell (2001) 3.97
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell (2000) 3.95
Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid. Neuropharmacology (2006) 3.93
Integrating primary medical care with addiction treatment: a randomized controlled trial. JAMA (2001) 3.91
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
A neomycin resistance gene cassette selectable in a single copy state in the Bacillus subtilis chromosome. Nucleic Acids Res (1989) 3.87
Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression. Antimicrob Agents Chemother (1996) 3.86
Real-time detection system for quantification of hepatitis C virus genome. Gastroenterology (1999) 3.83
Transcriptional sequencing: A method for DNA sequencing using RNA polymerase. Proc Natl Acad Sci U S A (1998) 3.78
High guanine plus cytosine content in the third letter of codons of an extreme thermophile. DNA sequence of the isopropylmalate dehydrogenase of Thermus thermophilus. J Biol Chem (1984) 3.76
An endothelial receptor for oxidized low-density lipoprotein. Nature (1997) 3.76
Calcium-induced conformational transition revealed by the solution structure of apo calmodulin. Nat Struct Biol (1995) 3.75
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J Biol Chem (1986) 3.64
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A (2000) 3.61
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56
Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science (1996) 3.54
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Latent and active p53 are identical in conformation. Nat Struct Biol (2001) 3.47
Molecular mechanics of calcium-myristoyl switches. Nature (1997) 3.36
Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient. J Med Virol (2001) 3.29
Structure of Rhodopseudomonas sphaeroides R-26 reaction center. FEBS Lett (1986) 3.28
Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product. Genes Dev (1992) 3.26
Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology (1992) 3.22
Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron (2001) 3.20
A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18
Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release (2009) 3.08
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature (1997) 3.07
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc Natl Acad Sci U S A (1981) 3.04
Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7. DNA Res (2001) 2.99
A stoichiometric complex of neurexins and dystroglycan in brain. J Cell Biol (2001) 2.98
Hypocholesterolemia is associated with immune dysfunction in early human immunodeficiency virus-1 infection. Am J Med (1993) 2.96
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A (2000) 2.96
Cloning of the genes for penicillinase, penP and penI, of Bacillus licheniformis in some vector plasmids and their expression in Escherichia coli, Bacillus subtilis, and Bacillus licheniformis. J Bacteriol (1981) 2.93
Assessment of rheumatoid arthritis using a modified scoring method on digitized and original radiographs. Arthritis Rheum (1998) 2.91
Single-molecule analysis of chemotactic signaling in Dictyostelium cells. Science (2001) 2.89
RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response. Genes Immun (2002) 2.88
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature (1998) 2.88
The evolution of cell adhesion. J Cell Biol (2000) 2.84
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet (1998) 2.80
Nature of phosphorus limitation in the ultraoligotrophic eastern Mediterranean. Science (2005) 2.79
Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proc Natl Acad Sci U S A (2000) 2.75
Finer features for functional microdevices. Nature (2001) 2.73
Sextant localization of prostate cancer: comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology. J Urol (2000) 2.73
Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ. Nat Struct Biol (1999) 2.72
Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region. Jpn J Exp Med (1990) 2.72
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A (1996) 2.70
Contrast extravasation on CT predicts mortality in primary intracerebral hemorrhage. AJNR Am J Neuroradiol (2007) 2.69
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet (1995) 2.65
Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphite triester approach. Nucleic Acids Res (1986) 2.64
Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res (1998) 2.63
Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant (2007) 2.61
Isolation and characterization of four plasmids from Bacillus subtilis. J Bacteriol (1977) 2.59
Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239. J Virol (1997) 2.59
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature (1996) 2.57
Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus. J Ethnopharmacol (1996) 2.57
A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. RNA (1998) 2.55
The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res (2003) 2.48