Invariant NKT cells as novel targets for immunotherapy in solid tumors.

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Published in Clin Dev Immunol on October 17, 2012

Authors

Karsten A Pilones1, Joseph Aryankalayil, Sandra Demaria

Author Affiliations

1: Department of Pathology, NYU School of Medicine, 550 First Avenue, MSB-521, New York, NY 10016, USA.

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CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science (1997) 13.67

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Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (2005) 7.72

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med (1994) 7.35

Lysosomal glycosphingolipid recognition by NKT cells. Science (2004) 7.31

Recognition of bacterial glycosphingolipids by natural killer T cells. Nature (2005) 6.38

Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest (2007) 6.31

A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature (2001) 5.08

The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu Rev Immunol (2001) 4.91

Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain. J Exp Med (1993) 4.80

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Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med (2000) 4.45

Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med (2003) 4.44

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The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med (1999) 3.72

Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med (2002) 3.70

Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nat Immunol (2002) 3.61

The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med (2004) 3.59

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J Exp Med (1995) 3.58

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol (2011) 3.48

Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science (1995) 3.37

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells. Proc Natl Acad Sci U S A (1998) 2.96

Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J Exp Med (2004) 2.94

A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors. Clin Cancer Res (2002) 2.86

Harnessing invariant NKT cells in vaccination strategies. Nat Rev Immunol (2009) 2.79

Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science (1998) 2.76

A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J Exp Med (2002) 2.73

Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. Blood (2002) 2.72

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice. J Exp Med (1995) 2.70

Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J Exp Med (2001) 2.67

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol (2011) 2.66

Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide. J Exp Med (2003) 2.64

Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer (2007) 2.62

Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur J Immunol (2005) 2.54

Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol (2003) 2.48

Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J Exp Med (2002) 2.38

A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance. J Exp Med (2005) 2.32

Cross-presentation of disialoganglioside GD3 to natural killer T cells. J Exp Med (2003) 2.30

CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells. J Immunol (1998) 2.25

Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biol (2009) 2.24

Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci U S A (2007) 2.24

Loss of IFN-gamma production by invariant NK T cells in advanced cancer. J Immunol (2001) 2.20

Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proc Natl Acad Sci U S A (2005) 2.13

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The role of NKT cells in tumor immunity. Adv Cancer Res (2008) 2.05

NKT cells are phenotypically and functionally diverse. Eur J Immunol (1999) 1.97

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NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge. J Immunol (2005) 1.89

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NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis. J Immunol (2008) 1.46

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NKT cells direct monocytes into a DC differentiation pathway. J Leukoc Biol (2007) 1.11

Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells. Int Immunol (2000) 1.10

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Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells. J Immunol (2007) 1.05

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Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice. J Autoimmun (2004) 1.02

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