Published in Tissue Antigens on December 01, 2012
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A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertension. J Biol Chem (2013) 0.83
Immune-mediated vascular injury and dysfunction in transplant arteriosclerosis. Front Immunol (2015) 0.82
Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. PLoS One (2016) 0.81
Real-time detection of CTL function reveals distinct patterns of caspase activation mediated by Fas versus granzyme B. J Immunol (2014) 0.79
The effector T cell response to influenza infection. Curr Top Microbiol Immunol (2015) 0.79
Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing. Cell Death Dis (2014) 0.79
Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection. Infect Immun (2014) 0.77
A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl. J Vis Exp (2014) 0.75
Conservation of the extended substrate specificity profiles among homologous granzymes across species. Mol Cell Proteomics (2013) 0.75
Concerning immune synapses: a spatiotemporal timeline. F1000Res (2016) 0.75
Mineralocorticoid effects in the late gestation ovine fetal lung. Physiol Rep (2014) 0.75
Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients. Front Immunol (2017) 0.75
Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization. Cell Death Differ (2017) 0.75
Oncolytic measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells. Oncoimmunology (2016) 0.75
Decreased expression of perforin in CD8(+) T lymphocytes in patients with Mycobacterium tuberculosis infection and its potential value as a marker for efficacy of treatment. J Thorac Dis (2017) 0.75
CD64: An Attractive Immunotherapeutic Target for M1-type Macrophage Mediated Chronic Inflammatory Diseases. Biomedicines (2017) 0.75
Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med (2000) 4.45
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci U S A (1996) 3.53
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A fresh look at tumor immunosurveillance and immunotherapy. Nat Immunol (2001) 2.87
Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. Oncogene (1997) 2.35
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A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J Biol Chem (1996) 1.75
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Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway. Mol Cell Biol (1998) 1.59
Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization. J Exp Med (1997) 1.54
A new quantitative assay for cytochrome c release in apoptotic cells. Cell Death Differ (2003) 1.44
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol (1999) 1.39
Unlocking the secrets of cytotoxic granule proteins. J Leukoc Biol (2001) 1.25
Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J Immunol (1997) 1.25
A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). J Biol Chem (1997) 1.23
Processing of the Nedd2 precursor by ICE-like proteases and granzyme B. Genes Cells (1996) 1.23
Transcription and growth regulatory functions of the HIN-200 family of proteins. Mol Cell Biol (1999) 1.20
The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. J Biol Chem (1999) 1.18
Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin. Gastroenterology (1985) 1.18
Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro. J Biol Chem (1996) 1.16
The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology. J Virol (1998) 1.13
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. Oncogene (2000) 1.12
The human interferon-inducible protein, IFI 16, is a repressor of transcription. J Biol Chem (1998) 1.10
Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway. J Immunol (2000) 1.10
Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma. J Immunol (2001) 1.07
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The role of perforin and granzymes in diabetes. Cell Death Differ (2009) 1.04
Perforin deficiency and susceptibility to cancer. Cell Death Differ (2010) 1.02
Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen. Gene Ther (2010) 1.00
The structure and function of mammalian membrane-attack complex/perforin-like proteins. Tissue Antigens (2010) 0.98
The interferon-inducible autoantigen, IFI 16: localization to the nucleolus and identification of a DNA-binding domain. Biochem Biophys Res Commun (1995) 0.98
Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis. Cell Death Differ (2006) 0.97
Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction. Mol Hum Reprod (2001) 0.97
Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. Biochemistry (1998) 0.96
Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL. J Immunol (2000) 0.94
Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity. Cell Death Differ (2008) 0.93
Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16. Biochem J (2001) 0.93
Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis. J Biol Chem (2000) 0.92
Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing. Cell Death Differ (2009) 0.92
Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia (2010) 0.90
Isolation and expression of a cDNA clone encoding HLA-Cw6: unique characteristics of HLA-C encoded gene products. Immunogenetics (1989) 0.90
Production of anti-breast cancer monoclonal antibodies using a glutathione-S-transferase-MUC1 bacterial fusion protein. Br J Cancer (1993) 0.90
Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1. Cell Death Differ (2000) 0.90
Mechanisms of interferon mediated anti-viral resistance. Curr Drug Targets Immune Endocr Metabol Disord (2001) 0.90
Nuclear targeting of the serine protease granzyme A (fragmentin-1). J Cell Sci (1998) 0.89
Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis. Cell Death Differ (2013) 0.89
Activation of cytotoxic cells in hyperplastic lymph nodes from HIV-infected patients. AIDS (1991) 0.89
Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype. Gene Ther (2010) 0.89
IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. J Cell Biochem (1995) 0.88
Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma. Eur J Immunol (1998) 0.88
HIN-200: a novel family of IFN-inducible nuclear proteins expressed in leukocytes. J Leukoc Biol (1996) 0.88
Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity. Eur J Immunol (2001) 0.88
CTL: Caspases Terminate Life, but that's not the whole story. Tissue Antigens (2002) 0.87
Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth. Oncol Res (1998) 0.87
Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction. Immunol Cell Biol (1999) 0.87
The structure of the mouse lymphocyte pore-forming protein perforin. Biochem Biophys Res Commun (1989) 0.86
Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes. Genomics (1989) 0.86
Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene. J Immunol (1988) 0.86
Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing. J Exp Med (1996) 0.86
Adoptive transfer: the role of perforin in mouse cytotoxic T lymphocyte rejection of human tumor xenografts in vivo. Xenotransplantation (1998) 0.85
Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. J Immunol (1993) 0.85
Monoclonal antibodies detecting discrete epitopes of human perforin. Tissue Antigens (1990) 0.84
Two-dimensional gel analysis demonstrates no structural alteration of HLA-B27 polypeptides between patients with ankylosing spondylitis and healthy individuals. Ann Rheum Dis (1984) 0.84
BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis. J Biol Chem (1999) 0.83
The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations. J Leukoc Biol (1998) 0.83
Isolation and characterization of cDNA clones for mouse Ly-9. J Immunol (1992) 0.83
Lymphocyte-mediated immunosurveillance of epithelial cancers? Trends Immunol (2001) 0.83
Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30. J Immunol (1989) 0.83
Expression of human perforin in a mouse cytotoxic T lymphocyte cell line: evidence for perturbation of granule-mediated cytotoxicity. J Leukoc Biol (1993) 0.82
Xenospecific cytotoxic T lymphocytes use perforin- and Fas-mediated lytic pathways. Transplantation (1996) 0.82
Lack of apoptosis of Sézary cells in the circulation following oral bexarotene therapy. Br J Dermatol (2005) 0.81
A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1. J Immunol (1996) 0.81
The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. Immunogenetics (1995) 0.81
Molecular cloning and partial nucleotide sequence of a 3.5 kb HLA-B27-associated fragment of genomic DNA. Immunogenetics (1985) 0.81
Cytotoxic lymphocytes: redirecting the cell-mediated immune response for the therapy of cancer. Ther Immunol (1995) 0.80
Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice. Gene Ther (2008) 0.80
Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5'-flanking sequences. Immunogenetics (1995) 0.80
Hypothesis: cytotoxic lymphocyte granule serine proteases activate target cell endonucleases to trigger apoptosis. Clin Exp Pharmacol Physiol (1994) 0.79
Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737. Cell Death Dis (2012) 0.79
Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes. Cancer Immunol Immunother (1999) 0.79
The use of chimeric human Fc(epsilon) receptor I to redirect cytotoxic T lymphocytes to tumors. J Leukoc Biol (1996) 0.78
Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. J Biol Chem (1992) 0.78
Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis? Immunol Cell Biol (1999) 0.78
Expression of recombinant human Met-ase-1: a NK cell-specific granzyme. Biochem Biophys Res Commun (1995) 0.77
Xenospecific cytotoxic T lymphocytes: potent lysis in vitro and in vivo. Transplantation (1997) 0.77
Distinct granzyme expression in human CD3- CD56+ large granular- and CD3- CD56+ small high density-lymphocytes displaying non-MHC-restricted cytolytic activity. J Leukoc Biol (1995) 0.76
Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16. J Cell Biochem (2003) 0.76
Chimeric (mouse/human) anti-colon cancer antibody c30.6 inhibits the growth of human colorectal cancer xenografts in scid/scid mice. Cancer Res (1994) 0.76
In vitro and in vivo antitumor activity of a chimeric anti-CD19 antibody. Cancer Immunol Immunother (1995) 0.76
Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C). Tissue Antigens (1990) 0.76
Klebsiella 'modifying factor': binding studies with HLA-B27+ and B27- lymphocytes. Ann Rheum Dis (1985) 0.75
Use of the 5'-flanking region of the mouse perforin gene to express human Fc gamma receptor I in cytotoxic T lymphocytes. J Leukoc Biol (1994) 0.75
Familial haemophagocytic lymphohistiocytosis: Australian experience and perspectives. Intern Med J (2014) 0.75
A direct comparison of cytolytic T-lymphocyte responses to Melan-A peptides in vitro: differential immunogenicity of Melan-A27-35 and Melan-A26-35. Melanoma Res (2000) 0.75
The peptide loop consisting of amino acids 139-157 of human granzyme B (fragmentin 2) contains an immunodominant epitope recognized by the mouse. Mol Immunol (1995) 0.75