Published in Curr Opin Struct Biol on November 08, 2012
Expanded microbial genome coverage and improved protein family annotation in the COG database. Nucleic Acids Res (2014) 2.37
SPASM and twitch domains in S-adenosylmethionine (SAM) radical enzymes. J Biol Chem (2014) 1.01
Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nat Chem Biol (2013) 0.95
Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD. J Biol Chem (2016) 0.89
Glycyl radical activating enzymes: structure, mechanism, and substrate interactions. Arch Biochem Biophys (2014) 0.88
Reactivity landscape of pyruvate under simulated hydrothermal vent conditions. Proc Natl Acad Sci U S A (2013) 0.87
The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites. J Biol Chem (2013) 0.82
Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase. Nat Commun (2015) 0.80
Dark-operative protochlorophyllide oxidoreductase generates substrate radicals by an iron-sulphur cluster in bacteriochlorophyll biosynthesis. Sci Rep (2014) 0.78
Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides. Beilstein J Org Chem (2016) 0.77
At the confluence of ribosomally synthesized peptide modification and radical S-adenosylmethionine (SAM) enzymology. J Biol Chem (2017) 0.76
C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis. J Am Chem Soc (2015) 0.75
Density functional theory calculations on the active site of biotin synthase: mechanism of S transfer from the Fe2S2 cluster and the role of 1st and 2nd sphere residues. J Biol Inorg Chem (2015) 0.75
A tale of two reductases: extending the bacteriochlorophyll biosynthetic pathway in E. coli. PLoS One (2014) 0.75
Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition. Proc Natl Acad Sci U S A (2017) 0.75
Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods. Nucleic Acids Res (2001) 6.49
The Radical SAM Superfamily. Crit Rev Biochem Mol Biol (2008) 4.05
The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe (2007) 3.11
Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science (2004) 2.65
A radically different mechanism for S-adenosylmethionine-dependent methyltransferases. Science (2011) 2.55
Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. J Virol (2007) 2.40
Radical SAM-dependent carbon insertion into the nitrogenase M-cluster. Science (2012) 2.28
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism. Proc Natl Acad Sci U S A (2006) 2.16
An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme. J Am Chem Soc (2002) 2.16
Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme. J Am Chem Soc (2002) 1.99
Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes. EMBO J (2003) 1.98
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat Chem Biol (2008) 1.96
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature (2010) 1.85
Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest (2011) 1.80
Structural insights into radical generation by the radical SAM superfamily. Chem Rev (2011) 1.77
The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Proc Natl Acad Sci U S A (2005) 1.72
Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme. Proc Natl Acad Sci U S A (2008) 1.71
MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA. J Biol Chem (2004) 1.69
Structural basis for methyl transfer by a radical SAM enzyme. Science (2011) 1.61
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA. J Am Chem Soc (2010) 1.60
Structure and mechanism of the glycyl radical enzyme pyruvate formate-lyase. Nat Struct Biol (1999) 1.57
Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol (2009) 1.56
ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications. J Am Chem Soc (2009) 1.54
Biochemical characterization of the HydE and HydG iron-only hydrogenase maturation enzymes from Thermatoga maritima. FEBS Lett (2005) 1.53
[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine. Angew Chem Int Ed Engl (2010) 1.51
Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. J Biol Chem (2010) 1.47
In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S] clusters. Biochemistry (2008) 1.46
Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG). Nature (2010) 1.44
The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A. Nat Chem Biol (2012) 1.39
Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide. Biochemistry (2004) 1.35
Control of radical chemistry in the AdoMet radical enzymes. Curr Opin Chem Biol (2009) 1.34
Pyrroloquinoline quinone biogenesis: demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme. Biochemistry (2009) 1.34
X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima. J Biol Chem (2008) 1.33
[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide. J Am Chem Soc (2010) 1.33
Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily. Biochemistry (2009) 1.33
Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold. Proc Natl Acad Sci U S A (2010) 1.26
Insights into [FeFe]-hydrogenase structure, mechanism, and maturation. Structure (2011) 1.24
The antiviral protein viperin is a radical SAM enzyme. FEBS Lett (2010) 1.19
Emerging paradigms for complex iron-sulfur cofactor assembly and insertion. Annu Rev Biochem (2012) 1.19
Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis. Acta Crystallogr D Biol Crystallogr (2007) 1.17
Identification of a methylase required for 2-methylhopanoid production and implications for the interpretation of sedimentary hopanes. Proc Natl Acad Sci U S A (2010) 1.17
Binding energy in the one-electron reductive cleavage of S-adenosylmethionine in lysine 2,3-aminomutase, a radical SAM enzyme. Biochemistry (2007) 1.14
A consensus mechanism for Radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters. Biochemistry (2010) 1.13
Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins. Proc Natl Acad Sci U S A (2009) 1.12
Cell-free H-cluster synthesis and [FeFe] hydrogenase activation: all five CO and CN⁻ ligands derive from tyrosine. PLoS One (2011) 1.12
Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor. J Bacteriol (2009) 1.10
Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct. J Am Chem Soc (2009) 1.10
Post-translational modification of ribosomal proteins: structural and functional characterization of RimO from Thermotoga maritima, a radical S-adenosylmethionine methylthiotransferase. J Biol Chem (2009) 1.09
Radical-mediated enzymatic carbon chain fragmentation-recombination. Nat Chem Biol (2011) 1.09
Biosynthesis of complex iron-sulfur enzymes. Curr Opin Chem Biol (2011) 1.09
Activation of HydA(DeltaEFG) requires a preformed [4Fe-4S] cluster. Biochemistry (2009) 1.09
Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation. J Am Chem Soc (2011) 1.07
Structural diversity in the AdoMet radical enzyme superfamily. Biochim Biophys Acta (2012) 1.06
Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes? FEBS J (2010) 1.06
Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme. Biochem Biophys Res Commun (2009) 1.05
Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme. Nucleic Acids Res (2012) 0.99
A glycyl free radical as the precursor in the synthesis of carbon monoxide and cyanide by the [FeFe]-hydrogenase maturase HydG. FEBS Lett (2010) 0.99
Biotin synthase: insights into radical-mediated carbon-sulfur bond formation. Biochim Biophys Acta (2012) 0.98
Pyruvate formate-lyase, evidence for an open conformation favored in the presence of its activating enzyme. J Biol Chem (2010) 0.92
Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: a [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme. J Biol Chem (2011) 0.90
Crystal structures and repair studies reveal the identity and the base-pairing properties of the UV-induced spore photoproduct DNA lesion. Chemistry (2011) 0.90
9-Mercaptodethiobiotin is generated as a ligand to the [2Fe-2S]+ cluster during the reaction catalyzed by biotin synthase from Escherichia coli. J Am Chem Soc (2012) 0.89
Characterization of yatakemycin gene cluster revealing a radical S-adenosylmethionine dependent methyltransferase and highlighting spirocyclopropane biosynthesis. J Am Chem Soc (2012) 0.88
S K-edge XAS and DFT calculations on SAM dependent pyruvate formate-lyase activating enzyme: nature of interaction between the Fe4S4 cluster and SAM and its role in reactivity. J Am Chem Soc (2011) 0.87
Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis. Nucleic Acids Res (2010) 0.86
The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin. PLoS One (2012) 0.85
Regioselectivity in the homolytic cleavage of S-adenosylmethionine. Biochemistry (2010) 0.85
Reduction of the [2Fe-2S] cluster accompanies formation of the intermediate 9-mercaptodethiobiotin in Escherichia coli biotin synthase. Biochemistry (2011) 0.85
Radical SAM activation of the B12-independent glycerol dehydratase results in formation of 5'-deoxy-5'-(methylthio)adenosine and not 5'-deoxyadenosine. Biochemistry (2011) 0.84
Radical AdoMet enzymes in complex metal cluster biosynthesis. Biochim Biophys Acta (2012) 0.81
Biochemistry: A radically different enzyme. Nature (2010) 0.80
Viperin: a radical response to viral infection. Biomol Concepts (2012) 0.78
Thioether crosslinkages created by a radical SAM enzyme. Chembiochem (2012) 0.76
An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme. J Am Chem Soc (2002) 2.16
Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme. J Am Chem Soc (2002) 1.99
Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme. Proc Natl Acad Sci U S A (2008) 1.71
[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine. Angew Chem Int Ed Engl (2010) 1.51
Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily. Inorg Chem (2005) 1.49
Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate. J Am Chem Soc (2002) 1.49
Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG). Nature (2010) 1.44
Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: a Mössbauer spectroscopic study. J Am Chem Soc (2002) 1.41
Control of radical chemistry in the AdoMet radical enzymes. Curr Opin Chem Biol (2009) 1.34
[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide. J Am Chem Soc (2010) 1.33
HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis. FEBS Lett (2008) 1.27
Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold. Proc Natl Acad Sci U S A (2010) 1.26
Insights into [FeFe]-hydrogenase structure, mechanism, and maturation. Structure (2011) 1.24
The antiviral protein viperin is a radical SAM enzyme. FEBS Lett (2010) 1.19
Characterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamily. J Biol Chem (2006) 1.19
Emerging paradigms for complex iron-sulfur cofactor assembly and insertion. Annu Rev Biochem (2012) 1.19
Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction. BMC Microbiol (2012) 1.16
Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct. J Am Chem Soc (2009) 1.10
Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor. J Bacteriol (2009) 1.10
Biosynthesis of complex iron-sulfur enzymes. Curr Opin Chem Biol (2011) 1.09
Activation of HydA(DeltaEFG) requires a preformed [4Fe-4S] cluster. Biochemistry (2009) 1.09
In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation. J Biol Inorg Chem (2007) 1.07
Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation. Arch Biochem Biophys (2005) 0.98
Complete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyase. J Biol Inorg Chem (2010) 0.98
Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG. Biochemistry (2013) 0.97
[FeFe]-hydrogenase maturation. Biochemistry (2014) 0.96
Inactivation of E. coli pyruvate formate-lyase: role of AdhE and small molecules. Arch Biochem Biophys (2007) 0.95
Structural studies of the interaction of S-adenosylmethionine with the [4Fe-4S] clusters in biotin synthase and pyruvate formate-lyase activating enzyme. Protein Sci (2003) 0.94
Pyruvate formate-lyase, evidence for an open conformation favored in the presence of its activating enzyme. J Biol Chem (2010) 0.92
Hydrogenase cluster biosynthesis: organometallic chemistry nature's way. Dalton Trans (2009) 0.90
[FeFe]-hydrogenase oxygen inactivation is initiated at the H cluster 2Fe subcluster. J Am Chem Soc (2015) 0.89
Glycyl radical activating enzymes: structure, mechanism, and substrate interactions. Arch Biochem Biophys (2014) 0.88
S K-edge XAS and DFT calculations on SAM dependent pyruvate formate-lyase activating enzyme: nature of interaction between the Fe4S4 cluster and SAM and its role in reactivity. J Am Chem Soc (2011) 0.87
Frontiers in enzymatic C-H-bond activation. Curr Opin Chem Biol (2009) 0.86
EPR and FTIR analysis of the mechanism of H2 activation by [FeFe]-hydrogenase HydA1 from Chlamydomonas reinhardtii. J Am Chem Soc (2013) 0.86
[FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis. Biochemistry (2015) 0.86
Chemoselective deprotection of triethylsilyl ethers. Nucleosides Nucleotides Nucleic Acids (2009) 0.85
Reversible H atom abstraction catalyzed by the radical S-adenosylmethionine enzyme HydG. J Am Chem Soc (2014) 0.84
The iron-sulfur cluster of pyruvate formate-lyase activating enzyme in whole cells: cluster interconversion and a valence-localized [4Fe-4S]2+ state. Biochemistry (2009) 0.84
Assembling iron-sulfur clusters in the cytosol. Nat Chem Biol (2007) 0.82
Pyruvate formate-lyase and its activation by pyruvate formate-lyase activating enzyme. J Biol Chem (2013) 0.81
Radical AdoMet enzymes in complex metal cluster biosynthesis. Biochim Biophys Acta (2012) 0.81
Iron-sulfur cluster coordination in the [FeFe]-hydrogenase H cluster biosynthetic factor HydF. FEBS Lett (2012) 0.81
Radical SAM enzymes in methylation and methylthiolation. Metallomics (2012) 0.80
Biochemistry: A radically different enzyme. Nature (2010) 0.80
Flavodoxin cofactor binding induces structural changes that are required for protein-protein interactions with NADP(+) oxidoreductase and pyruvate formate-lyase activating enzyme. Biochim Biophys Acta (2013) 0.78
Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase. J Biol Inorg Chem (2014) 0.76
An efficient deprotection of N-trimethylsilylethoxymethyl (SEM) groups from dinucleosides and dinucleotides. Nucleosides Nucleotides Nucleic Acids (2010) 0.75
Special issue on iron-sulfur proteins: Structure, function, biogenesis and diseases. Biochim Biophys Acta (2015) 0.75
Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme. J Am Chem Soc (2017) 0.75
Bioinorganic chemistry. Curr Opin Chem Biol (2003) 0.75