Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease.

PubWeight™: 1.28‹?› | Rank: Top 10%

🔗 View Article (PMC 3485241)

Published in PLoS One on October 31, 2012

Authors

Yoshiki Murakami1, Hidenori Toyoda, Toshihito Tanahashi, Junko Tanaka, Takashi Kumada, Yusuke Yoshioka, Nobuyoshi Kosaka, Takahiro Ochiya, Y-h Taguchi

Author Affiliations

1: Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan. m2079633@med.osaka-cu.ac.jp

Articles citing this

MicroRNAs in liver disease. Nat Rev Gastroenterol Hepatol (2013) 2.04

Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery. Int J Biol Sci (2013) 1.26

Trash or Treasure: extracellular microRNAs and cell-to-cell communication. Front Genet (2013) 1.25

Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. Br J Cancer (2015) 1.07

Identification and validation of reference genes for qPCR detection of serum microRNAs in colorectal adenocarcinoma patients. PLoS One (2013) 1.00

Comparison of hepatocellular carcinoma miRNA expression profiling as evaluated by next generation sequencing and microarray. PLoS One (2014) 0.97

TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer. BMC Genomics (2014) 0.89

Incubation of whole blood at room temperature does not alter the plasma concentrations of microRNA-16 and -223. Drug Metab Dispos (2013) 0.88

Identification of endogenous controls for analyzing serum exosomal miRNA in patients with hepatitis B or hepatocellular carcinoma. Dis Markers (2015) 0.88

Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma. Sci Rep (2015) 0.86

Universal disease biomarker: can a fixed set of blood microRNAs diagnose multiple diseases? BMC Res Notes (2014) 0.85

Principal component analysis-based unsupervised feature extraction applied to in silico drug discovery for posttraumatic stress disorder-mediated heart disease. BMC Bioinformatics (2015) 0.85

Evaluation of gene expression classification studies: factors associated with classification performance. PLoS One (2014) 0.84

Complex interactions between microRNAs and hepatitis B/C viruses. World J Gastroenterol (2014) 0.83

Identification of aberrant gene expression associated with aberrant promoter methylation in primordial germ cells between E13 and E16 rat F3 generation vinclozolin lineage. BMC Bioinformatics (2015) 0.82

Identification of More Feasible MicroRNA-mRNA Interactions within Multiple Cancers Using Principal Component Analysis Based Unsupervised Feature Extraction. Int J Mol Sci (2016) 0.81

Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma. J Clin Med (2016) 0.81

Circulating RNA molecules as biomarkers in liver disease. Int J Mol Sci (2014) 0.80

Principal component analysis based unsupervised feature extraction applied to budding yeast temporally periodic gene expression. BioData Min (2016) 0.80

Extracellular Vesicles: A New Frontier in Biomarker Discovery for Non-Alcoholic Fatty Liver Disease. Int J Mol Sci (2016) 0.77

Circulating let-7 levels in plasma and extracellular vesicles correlate with hepatic fibrosis progression in chronic hepatitis C. Hepatology (2016) 0.77

Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades. Sci Rep (2016) 0.77

Biomarkers in DILI: One More Step Forward. Front Pharmacol (2016) 0.76

SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer. BMC Med Genomics (2016) 0.76

Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis. Respir Res (2016) 0.76

Extracellular vesicles in liver pathobiology: Small particles with big impact. Hepatology (2016) 0.76

Expression profile and clinical significance of miRNAs at different stages of chronic hepatitis B virus infection. Int J Clin Exp Med (2015) 0.76

Gene expression signature in endemic osteoarthritis by microarray analysis. Int J Mol Sci (2015) 0.75

MicroRNAs for the Prediction of Early Response to Sorafenib Treatment in Human Hepatocellular Carcinoma. Liver Cancer (2016) 0.75

Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-The Young Finns Study. Sci Rep (2016) 0.75

MicroRNA and hepatitis C virus--challenges in investigation and translation: a review of the literature. Diagn Microbiol Infect Dis (2014) 0.75

Principal Components Analysis Based Unsupervised Feature Extraction Applied to Gene Expression Analysis of Blood from Dengue Haemorrhagic Fever Patients. Sci Rep (2017) 0.75

miRNA Signature of Hepatocellular Carcinoma Vascularization: How the Controls Can Influence the Signature. Dig Dis Sci (2017) 0.75

Articles cited by this

The functions of animal microRNAs. Nature (2004) 64.85

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol (2007) 37.10

A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03

Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A (2008) 33.65

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res (2008) 20.59

Membrane vesicles as conveyors of immune responses. Nat Rev Immunol (2009) 14.72

An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology (1996) 12.47

Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology (1999) 11.76

Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem (2010) 8.09

Detection of microRNA expression in human peripheral blood microvesicles. PLoS One (2008) 8.04

Exosomes--vesicular carriers for intercellular communication. Curr Opin Cell Biol (2009) 6.96

Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci U S A (2010) 6.72

Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene (2006) 6.61

Exosomes: extracellular organelles important in intercellular communication. J Proteomics (2010) 6.47

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun (2011) 5.95

Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell (2010) 5.77

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci (2010) 5.17

Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology (2011) 4.06

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest (2012) 3.46

The Trojan exosome hypothesis. Proc Natl Acad Sci U S A (2003) 3.45

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest (2012) 3.14

Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology (2011) 2.90

Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin Chem (2009) 2.76

Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One (2011) 2.48

Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci U S A (2010) 2.34

Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther (2010) 2.28

Toward the blood-borne miRNome of human diseases. Nat Methods (2011) 2.14

An array-based analysis of microRNA expression comparing matched frozen and formalin-fixed paraffin-embedded human tissue samples. J Mol Diagn (2008) 1.82

The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One (2011) 1.81

Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection. Am J Gastroenterol (2011) 1.66

Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans. Lab Invest (2010) 1.61

Serum alanine aminotransferase in skeletal muscle diseases. Hepatology (2005) 1.54

Circulating microRNAs in hepatitis B virus-infected patients. J Viral Hepat (2011) 1.53

The role of microRNAs in human liver cancers. Semin Oncol (2011) 1.34

MicroRNAs and haematology: small molecules, big function. Br J Haematol (2007) 1.29

Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C. BMC Med Genomics (2010) 1.04

Articles by these authors

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet (2008) 9.39

Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem (2010) 8.09

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci (2010) 5.17

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci U S A (2005) 3.24

Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther (2009) 2.92

Control of DNA replication and chromosome ploidy by geminin and cyclin A. Mol Cell Biol (2002) 2.47

Transarterial chemotherapy alone versus transarterial chemoembolization for hepatocellular carcinoma: a randomized phase III trial. J Hepatol (2009) 2.31

microRNA as a new immune-regulatory agent in breast milk. Silence (2010) 2.20

Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther (2012) 2.15

Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology (2007) 2.14

Monitoring cellular movement in vivo with photoconvertible fluorescence protein "Kaede" transgenic mice. Proc Natl Acad Sci U S A (2008) 2.04

Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res Commun (2003) 2.00

Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma. J Gastroenterol Hepatol (2007) 1.97

The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One (2011) 1.81

FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma. Hepatology (2013) 1.81

miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol (2011) 1.78

MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol Ther (2011) 1.77

IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells (2008) 1.75

Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. J Gastroenterol Hepatol (2008) 1.68

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res (2004) 1.67

Secretory microRNAs as a versatile communication tool. Commun Integr Biol (2010) 1.64

Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem (2013) 1.62

Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C. Liver Int (2009) 1.62

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A (2012) 1.61

Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology (2006) 1.60

Generation of genetically modified rats from embryonic stem cells. Proc Natl Acad Sci U S A (2010) 1.59

Dicer is required for maintaining adult pancreas. PLoS One (2009) 1.59

One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics (2007) 1.56

MOZ is essential for maintenance of hematopoietic stem cells. Genes Dev (2006) 1.56

Prevalence and clinical characterization of patients with acute hepatitis B induced by lamivudine-resistant strains. J Gastroenterol Hepatol (2010) 1.56

Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development. Pathol Int (2010) 1.49

Therapeutic potential of RNA interference against cancer. Cancer Sci (2006) 1.49

Competitive interactions of cancer cells and normal cells via secretory microRNAs. J Biol Chem (2011) 1.48

Combined functional genome survey of therapeutic targets for hepatocellular carcinoma. Clin Cancer Res (2010) 1.47

Non-hypervascular hypointense nodules on Gd-EOB-DTPA-enhanced MRI as a predictor of outcomes for early-stage HCC. Hepatol Int (2014) 1.47

Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. J Biol Chem (2004) 1.46

Transient reappearance of serum hepatitis C virus RNA observed by real-time PCR during antiviral therapy with peginterferon and ribavirin in patients with HCV genotype 1b. J Clin Virol (2010) 1.39

The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics (2013) 1.39

Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet (2009) 1.38

RPN2 gene confers docetaxel resistance in breast cancer. Nat Med (2008) 1.38

LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells (2012) 1.36

MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma. Biomarkers (2009) 1.35

Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus oralis functions as a coadhesin for Porphyromonas gingivalis major fimbriae. Infect Immun (2004) 1.35

Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev (2012) 1.34

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep (2013) 1.28

Prognostic significance of simultaneous measurement of three tumor markers in patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol (2006) 1.27

Trash or Treasure: extracellular microRNAs and cell-to-cell communication. Front Genet (2013) 1.25

Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology (2003) 1.24

Clinical utility of highly sensitive Lens culinaris agglutinin-reactive alpha-fetoprotein in hepatocellular carcinoma patients with alpha-fetoprotein <20 ng/mL. Cancer Sci (2011) 1.24

Sofosbuvir plus ribavirin in Japanese patients with chronic genotype 2 HCV infection: an open-label, phase 3 trial. J Viral Hepat (2014) 1.23

miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. Hepatology (2013) 1.22

Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression. Mol Ther (2013) 1.19

Evolution of hypointense hepatocellular nodules observed only in the hepatobiliary phase of gadoxetate disodium-enhanced MRI. AJR Am J Roentgenol (2011) 1.18

Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer. Cancer Sci (2005) 1.16

Circulating vascular endothelial growth factor is independently and negatively associated with trait anxiety and depressive mood in healthy Japanese university students. Int J Psychophysiol (2011) 1.14

Establishment of rat embryonic stem cells and making of chimera rats. PLoS One (2008) 1.14

National prevention of hepatocellular carcinoma in Japan based on epidemiology of hepatitis C virus infection in the general population. Intervirology (2006) 1.13

B-mode ultrasound with algorithm based on statistical analysis of signals: evaluation of liver fibrosis in patients with chronic hepatitis C. AJR Am J Roentgenol (2009) 1.12

SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population. J Hum Genet (2007) 1.12

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations. J Clin Invest (2013) 1.12

Management of hepatocellular carcinoma: Report of Consensus Meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009). Hepatol Res (2010) 1.11

Staging hepatocellular carcinoma by a novel scoring system (BALAD score) based on serum markers. Clin Gastroenterol Hepatol (2006) 1.11

The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers. Proteomics (2014) 1.10

Impact of surveillance on survival of patients with initial hepatocellular carcinoma: a study from Japan. Clin Gastroenterol Hepatol (2006) 1.10

Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation. Cancer Res (2002) 1.09

Lower incidence of hepatocellular carcinoma in patients with transient virologic response to peginterferon and ribavirin combination therapy: is it really the effect of the therapy? J Hepatol (2012) 1.07

Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells. J Gastroenterol (2012) 1.07

Direct hepatic fate specification from mouse embryonic stem cells. Hepatology (2005) 1.07

Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect (2004) 1.06

Comparative marker analysis of extracellular vesicles in different human cancer types. J Extracell Vesicles (2013) 1.06

An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells. Mol Cancer (2011) 1.05

Stem cells for hepatic regeneration: the role of adipose tissue derived mesenchymal stem cells. Curr Stem Cell Res Ther (2010) 1.05

Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice. Physiol Genomics (2009) 1.05