Published in Genes Dev on November 15, 2012
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A mutation in a splicing factor that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing. BMC Res Notes (2014) 0.78
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Active disruption of an RNA-protein interaction by a DExH/D RNA helicase. Science (2001) 3.05
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A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol (2008) 2.12
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Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Mol Cell (2006) 1.89
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Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics (2000) 1.51
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Structure and function of an RNase H domain at the heart of the spliceosome. EMBO J (2008) 1.49
The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome. EMBO Rep (2002) 1.47
Structural elucidation of a PRP8 core domain from the heart of the spliceosome. Nat Struct Mol Biol (2008) 1.45
Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA (2006) 1.43
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Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps. RNA (2009) 1.35
Structural basis for the function of DEAH helicases. EMBO Rep (2010) 1.34
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The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes Dev (2012) 1.17
Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning. Genes Dev (2012) 1.13
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Identification of RNA helicase target sites by UV cross-linking and analysis of cDNA. Methods Enzymol (2012) 0.89
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Exon ligation is proofread by the DExD/H-box ATPase Prp22p. Nat Struct Mol Biol (2006) 2.75
A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol (2008) 2.12
The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase. Mol Cell (2006) 2.09
RNA catalyses nuclear pre-mRNA splicing. Nature (2013) 1.86
Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs. Am J Hum Genet (2009) 1.73
The splicing factor Prp43p, a DEAH box ATPase, functions in ribosome biogenesis. Mol Cell Biol (2006) 1.70
U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing. Genes Dev (2007) 1.56
Multiple functions for the invariant AGC triad of U6 snRNA. RNA (2004) 1.48
Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps. RNA (2009) 1.35
Spliceosome discards intermediates via the DEAH box ATPase Prp43p. Proc Natl Acad Sci U S A (2010) 1.26
The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing. Mol Cell (2010) 1.23
Staying on message: ensuring fidelity in pre-mRNA splicing. Trends Biochem Sci (2012) 1.13
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat Struct Mol Biol (2013) 0.98
The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome. RNA (2014) 0.89
Splicing fidelity: DEAD/H-box ATPases as molecular clocks. RNA Biol (2013) 0.87
Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast. Genes Dev (2013) 0.87
Meiosis-induced alterations in transcript architecture and noncoding RNA expression in S. cerevisiae. RNA (2012) 0.86
DEAD on. Nat Struct Mol Biol (2006) 0.80
Long-distance splicing. Proc Natl Acad Sci U S A (2008) 0.77
Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis. J Org Chem (2014) 0.75
Hanging on to the branch. Nat Struct Biol (2002) 0.75
Structure of DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA. RNA (2017) 0.75