| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.
|
Bioorg Med Chem
|
2005
|
1.93
|
|
2
|
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
|
Mol Pharmacol
|
2010
|
1.86
|
|
3
|
Pregnenolone can protect the brain from cannabis intoxication.
|
Science
|
2014
|
1.85
|
|
4
|
A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.
|
J Biol Chem
|
2010
|
1.59
|
|
5
|
An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.
|
J Med Chem
|
2003
|
1.43
|
|
6
|
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor.
|
Mol Pharmacol
|
2002
|
1.28
|
|
7
|
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
|
Mol Pharmacol
|
2012
|
1.26
|
|
8
|
Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation.
|
J Biol Chem
|
2004
|
1.26
|
|
9
|
(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.
|
Mol Pharmacol
|
2005
|
1.24
|
|
10
|
Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.
|
Mol Pharmacol
|
2007
|
1.24
|
|
11
|
Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.
|
Chem Biol
|
2008
|
1.22
|
|
12
|
Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.
|
J Biol Chem
|
2007
|
1.13
|
|
13
|
Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system.
|
Life Sci
|
2005
|
1.11
|
|
14
|
Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling.
|
BMC Cell Biol
|
2012
|
1.10
|
|
15
|
Adamantyl cannabinoids: a novel class of cannabinergic ligands.
|
J Med Chem
|
2005
|
1.09
|
|
16
|
3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor.
|
Bioorg Med Chem
|
2003
|
1.06
|
|
17
|
Endocannabinoid tone versus constitutive activity of cannabinoid receptors.
|
Br J Pharmacol
|
2011
|
1.05
|
|
18
|
Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template.
|
Mol Pharmacol
|
2005
|
1.01
|
|
19
|
Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.
|
Biochemistry
|
2011
|
1.00
|
|
20
|
Residues accessible in the binding-site crevice of transmembrane helix 6 of the CB2 cannabinoid receptor.
|
Biochemistry
|
2008
|
0.97
|
|
21
|
Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.
|
J Med Chem
|
2002
|
0.97
|
|
22
|
Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling.
|
J Biol Chem
|
2013
|
0.91
|
|
23
|
A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition.
|
Biochem Pharmacol
|
2002
|
0.89
|
|
24
|
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
|
Biochemistry
|
2013
|
0.88
|
|
25
|
Conformational memories with variable bond angles.
|
J Comput Chem
|
2008
|
0.87
|
|
26
|
Opioid receptors: toward separation of analgesic from undesirable effects.
|
Trends Biochem Sci
|
2013
|
0.84
|
|
27
|
GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect.
|
J Biol Chem
|
2008
|
0.84
|
|
28
|
Inhibition of striatal dopamine release by CB1 receptor activation requires nonsynaptic communication involving GABA, H2O2, and KATP channels.
|
Neurochem Int
|
2007
|
0.84
|
|
29
|
Crucial positively charged residues for ligand activation of the GPR35 receptor.
|
J Biol Chem
|
2013
|
0.82
|
|
30
|
Endogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulations.
|
Chem Phys Lipids
|
2013
|
0.81
|
|
31
|
Molecular dynamics simulations of the endocannabinoid N-arachidonoylethanolamine (anandamide) in a phospholipid bilayer: probing structure and dynamics.
|
J Med Chem
|
2005
|
0.81
|
|
32
|
Chromenopyrazoles: non-psychoactive and selective CB₁ cannabinoid agonists with peripheral antinociceptive properties.
|
ChemMedChem
|
2012
|
0.81
|
|
33
|
Parameterization of Org27569: an allosteric modulator of the cannabinoid CB1 G protein-coupled receptor.
|
J Comput Chem
|
2011
|
0.80
|
|
34
|
Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer.
|
J Comput Aided Mol Des
|
2006
|
0.80
|
|
35
|
Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55.
|
Chem Phys Lipids
|
2010
|
0.79
|
|
36
|
Inhibition of milk ingestion and growth after administration of a neutral cannabinoid CB1 receptor antagonist on the first postnatal day in the mouse.
|
Pediatr Res
|
2007
|
0.79
|
|
37
|
Cannabinoid CB(1) receptor ligand binding and function examined through mutagenesis studies of F200 and S383.
|
Eur J Pharmacol
|
2010
|
0.79
|
|
38
|
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
|
J Pharmacol Exp Ther
|
2013
|
0.78
|
|
39
|
Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations.
|
Proteins
|
2013
|
0.78
|
|
40
|
The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).
|
J Med Chem
|
2013
|
0.77
|
|
41
|
CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.
|
J Med Chem
|
2014
|
0.76
|
|
42
|
Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.
|
Bioorg Med Chem
|
2010
|
0.76
|
|
43
|
Probing the carboxyester side chain in controlled deactivation (-)-δ(8)-tetrahydrocannabinols.
|
J Med Chem
|
2014
|
0.76
|
|
44
|
Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinity.
|
Eur J Med Chem
|
2008
|
0.75
|