Published in Am J Pathol on November 22, 2012
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Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma. PLoS One (2013) 1.05
CD147, CD44, and the epidermal growth factor receptor (EGFR) signaling pathway cooperate to regulate breast epithelial cell invasiveness. J Biol Chem (2013) 0.95
The role of EMMPRIN expression in ovarian epithelial carcinomas. Cell Cycle (2013) 0.87
How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity. Biosci Rep (2015) 0.87
CD147 and Prostate Cancer: A Systematic Review and Meta-Analysis. PLoS One (2016) 0.85
Emmprin and KSHV: new partners in viral cancer pathogenesis. Cancer Lett (2013) 0.78
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Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res (2008) 6.38
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The increasing complexity of the cancer stem cell paradigm. Science (2009) 5.45
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Targeting breast cancer stem cells. J Clin Oncol (2010) 2.53
Combined transcriptome and genome analysis of single micrometastatic cells. Nat Biotechnol (2002) 2.48
Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res (2005) 2.42
Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res (2001) 2.33
Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res (2007) 2.19
EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie (2005) 2.10
Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thromb Haemost (2005) 2.07
Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res (2011) 1.96
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Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histol Histopathol (2003) 1.78
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Tumorigenic potential of extracellular matrix metalloproteinase inducer. Am J Pathol (2001) 1.71
EMMPRIN-mediated MMP regulation in tumor and endothelial cells. Clin Exp Metastasis (2002) 1.64
Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Res (2004) 1.61
Regulation of multidrug resistance in cancer cells by hyaluronan. J Biol Chem (2003) 1.61
Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells. J Biol Chem (2005) 1.60
Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer (2002) 1.56
HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res (2007) 1.48
A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res (2006) 1.46
Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci U S A (2005) 1.44
Tumor cell-derived collagenase-stimulatory factor increases expression of interstitial collagenase, stromelysin, and 72-kDa gelatinase. Cancer Res (1993) 1.41
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
Monoclonal antibody preparation and purification of a tumor cell collagenase-stimulatory factor. Cancer Res (1989) 1.31
Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides. Clin Cancer Res (2009) 1.31
Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer Res (2009) 1.26
Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts. J Cell Physiol (2001) 1.25
Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas. Int J Cancer (2000) 1.25
Metabolic activation-related CD147-CD98 complex. Mol Cell Proteomics (2005) 1.18
Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression. Br J Cancer (2010) 1.16
A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis. Cancer Lett (2008) 1.16
EMMPRIN (extracellular matrix metalloproteinase inducer) is a novel marker of poor outcome in serous ovarian carcinoma. Clin Exp Metastasis (2003) 1.13
The multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cells. Eur J Cancer (2002) 1.11
RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Lett (2008) 1.10
Enhanced expression of a tumor-cell-derived collagenase-stimulatory factor in urothelial carcinoma: its usefulness as a tumor marker for bladder cancers. Int J Cancer (1993) 1.10
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The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. Mol Membr Biol (2006) 1.08
Involvement of CD147 in regulation of multidrug resistance to P-gp substrate drugs and in vitro invasion in breast cancer cells. Cancer Sci (2007) 1.05
Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem Biophys Res Commun (2008) 1.05
Targeting hyaluronan interactions in malignant gliomas and their drug-resistant multipotent progenitors. Clin Cancer Res (2008) 1.04
Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphoma. Leukemia (2011) 1.04
Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells. Am J Pathol (2003) 0.97
Regulation of invadopodia formation and activity by CD147. J Cell Sci (2012) 0.95
Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma. Clin Exp Metastasis (2003) 0.94
Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells. Chemotherapy (2008) 0.86
Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential. Anticancer Res (2006) 0.82
Molar tooth sign of the midbrain-hindbrain junction: occurrence in multiple distinct syndromes. Am J Med Genet A (2004) 3.75
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Neurofibromatosis type 1 revisited. Pediatrics (2009) 3.06
Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Med (2010) 2.24
Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thromb Haemost (2005) 2.07
Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2. J Biol Chem (2005) 1.81
Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. J Biol Chem (2002) 1.81
Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells. J Biol Chem (2003) 1.66
EMMPRIN-mediated MMP regulation in tumor and endothelial cells. Clin Exp Metastasis (2002) 1.64
Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Res (2004) 1.61
Regulation of multidrug resistance in cancer cells by hyaluronan. J Biol Chem (2003) 1.61
Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells. J Biol Chem (2005) 1.60
Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells. Semin Cancer Biol (2008) 1.52
Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance. Drug Resist Updat (2008) 1.49
Defining future directions in spinal cord tumor research: proceedings from the National Institutes of Health workshop. J Neurosurg Spine (2010) 1.45
Hyaluronan constitutively regulates activation of multiple receptor tyrosine kinases in epithelial and carcinoma cells. J Biol Chem (2006) 1.41
Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Circulation (2006) 1.40
Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides. Clin Cancer Res (2009) 1.31
Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. J Clin Invest (2006) 1.29
High-frequency ultrasonographic imaging of avian cardiovascular development. Dev Dyn (2007) 1.29
Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer Res (2009) 1.26
Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn (2006) 1.22
Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Development (2009) 1.18
Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Dev Biol (2007) 1.15
Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. J Biol Chem (2008) 1.13
Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment. Cancer Res (2013) 1.12
Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T-cell lymphomas. J Pathol (2004) 1.10
Congenital bone fractures in spinal muscular atrophy: functional role for SMN protein in bone remodeling. J Child Neurol (2007) 1.10
Hyaluronan in limb morphogenesis. Dev Biol (2007) 1.09
Abrogating drug resistance in malignant peripheral nerve sheath tumors by disrupting hyaluronan-CD44 interactions with small hyaluronan oligosaccharides. Cancer Res (2009) 1.06
Targeting hyaluronan interactions in malignant gliomas and their drug-resistant multipotent progenitors. Clin Cancer Res (2008) 1.04
Direct activation of emmprin and associated pathogenesis by an oncogenic herpesvirus. Cancer Res (2010) 1.03
Stem cells as vectors to deliver HSV/tk gene therapy for malignant gliomas. Curr Stem Cell Res Ther (2009) 0.98
Extracellular Hsp90 serves as a co-factor for NF-κB activation and cellular pathogenesis induced by an oncogenic herpesvirus. Am J Cancer Res (2011) 0.98
Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells. Am J Pathol (2003) 0.97
Regulation of invadopodia formation and activity by CD147. J Cell Sci (2012) 0.95
CD147, CD44, and the epidermal growth factor receptor (EGFR) signaling pathway cooperate to regulate breast epithelial cell invasiveness. J Biol Chem (2013) 0.95
Hyaluronan is not elevated in urine or serum in Hutchinson-Gilford Progeria Syndrome. Hum Genet (2003) 0.93
Absence of decussation of the superior cerebellar peduncles in patients with Joubert syndrome. Am J Med Genet A (2008) 0.91
Bone loss in survival motor neuron (Smn(-/-) SMN2) genetic mouse model of spinal muscular atrophy. J Pathol (2009) 0.91
Increased intracranial pressure in a case of pediatric multiple sclerosis. J Child Neurol (2008) 0.91
Cerebral and cerebellar motor activation abnormalities in a subject with Joubert syndrome: functional magnetic resonance imaging (MRI) study. J Child Neurol (2004) 0.90
KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transduction. Int J Cancer (2011) 0.89
Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization. J Biol Chem (2014) 0.89
Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection. J Virol (2012) 0.89
The face of Joubert syndrome: a study of dysmorphology and anthropometry. Am J Med Genet A (2007) 0.89
Oromotor and communication findings in joubert syndrome: further evidence of multisystem apraxia. J Child Neurol (2006) 0.89
Injury to the preterm brain and cerebral palsy: clinical aspects, molecular mechanisms, unanswered questions, and future research directions. J Child Neurol (2009) 0.88
Synthetic emmprin peptides inhibit tumor cell-fibroblast interaction-stimulated upregulation of MMP-2 and tumor cell invasion. Int J Oncol (2011) 0.87
Spinal muscular atrophy: classification, diagnosis, management, pathogenesis, and future research directions. J Child Neurol (2007) 0.86
Cancer may be a pathway to cell survival under persistent hypoxia and elevated ROS: a model for solid-cancer initiation and early development. Int J Cancer (2014) 0.85
Rett syndrome: pathogenesis, diagnosis, strategies, therapies, and future research directions. J Child Neurol (2005) 0.84
Kaposi sarcoma-associated herpesvirus (KSHV) induces a functional tumor-associated phenotype for oral fibroblasts. Cancer Lett (2011) 0.83
Acute disseminated encephalomyelitis following infectious mononucleosis. J Child Neurol (2007) 0.82
Emmprin in epithelioid sarcoma: expression in tumor cell membrane and stimulation of MMP-2 production in tumor-associated fibroblasts. Int J Cancer (2007) 0.82
Primary antiphospholipid syndrome presenting with a branch retinal artery occlusion in a 15-year-old boy. J Child Neurol (2002) 0.81
Tumors of the central nervous system: clinical aspects, molecular mechanisms, unanswered questions, and future research directions. J Child Neurol (2008) 0.81
The immune mechanisms of abscopal effect in radiation therapy. Curr Probl Cancer (2015) 0.81
Childhood ataxia: clinical features, pathogenesis, key unanswered questions, and future directions. J Child Neurol (2012) 0.81
Canonical WNT signaling enhances stem cell expression in the developing heart without a corresponding inhibition of cardiogenic differentiation. Stem Cells Dev (2011) 0.80
Batten disease: clinical aspects, molecular mechanisms, translational science, and future directions. J Child Neurol (2013) 0.79
High-yield bacterial expression and structural characterization of recombinant human insulin-like growth factor binding protein-2. Arch Biochem Biophys (2010) 0.79
Modulation of tumor tolerance in primary central nervous system malignancies. Clin Dev Immunol (2012) 0.79
Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts. Mech Ageing Dev (2006) 0.79
Case of desmoplastic infantile ganglioglioma secreting ceruloplasmin. J Child Neurol (2005) 0.78
Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas. J Child Neurol (2008) 0.78
Emmprin and KSHV: new partners in viral cancer pathogenesis. Cancer Lett (2013) 0.78
Prevention of Traumatic Brain Injury in Youth and Adolescents. J Child Neurol (2012) 0.77
Cerebrovascular disease in children: recent advances in diagnosis and management. J Child Neurol (2011) 0.77
Hyaluronan regulates ceruloplasmin production by gliomas and their treatment-resistant multipotent progenitors. J Child Neurol (2008) 0.77
Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts. BMC Cancer (2011) 0.77
Evidence-based versus reported epilepsy management practices. J Child Neurol (2008) 0.76
BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration. PLoS One (2013) 0.76
Correlation of emmprin expression in vascular endothelial cells with blood-brain-barrier function: a study using magnetic resonance imaging enhanced by Gd-DTPA and immunohistochemistry in brain tumors. Virchows Arch (2003) 0.76
Tourette syndrome: diagnosis, strategies, therapies, pathogenesis, and future research directions. J Child Neurol (2006) 0.76
Inhibition of heart formation by lithium is an indirect result of the disruption of tissue organization within the embryo. Dev Growth Differ (2011) 0.76
Ex vivo high-resolution magnetic resonance imaging of the brain in Joubert's syndrome. J Child Neurol (2002) 0.76
Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome. J Gerontol A Biol Sci Med Sci (2011) 0.76
Parenting stress and its relationship to the behavior of children with Joubert syndrome. J Child Neurol (2006) 0.75
Childhood cerebrovascular disease: current understanding and future directions. J Child Neurol (2011) 0.75
Muscular dystrophies: a way forward. J Child Neurol (2010) 0.75
Synthesis of a glycosylated peptide thioester by the Boc strategy and its application to segment condensation. Biosci Biotechnol Biochem (2006) 0.75
Neurobiology of disease in children: neurofibromatosis 1. J Child Neurol (2002) 0.75
Muscular dystrophy: new opportunities for diagnosis and treatment. J Child Neurol (2010) 0.75