Published in BMC Biochem on December 05, 2012
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 8.30
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab (2005) 7.15
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem (2005) 6.27
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science (1991) 4.53
Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2. Neuron (2006) 4.10
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem (1995) 3.46
Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature (1998) 3.31
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J Exp Med (2006) 2.69
The Ca-calmodulin-dependent protein kinase cascade. Trends Biochem Sci (1999) 2.69
Ca(2+)/CaM-dependent kinases: from activation to function. Annu Rev Pharmacol Toxicol (2001) 2.60
STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem (2002) 2.28
Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. J Biol Chem (1998) 2.10
Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron (2008) 1.94
A novel target recognition revealed by calmodulin in complex with Ca2+-calmodulin-dependent kinase kinase. Nat Struct Biol (1999) 1.92
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87
Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast. J Biol Chem (2005) 1.64
Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr Purif (2003) 1.62
Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice. J Neurosci (2000) 1.55
GTP plus water mimic ATP in the active site of protein kinase CK2. Nat Struct Biol (1999) 1.45
Phosvitin kinase from brain: activation by ions and subcellular distribution. Biochem J (1964) 1.44
Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J Neurosci (2009) 1.43
Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. Nat Genet (2000) 1.41
Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase. J Biol Chem (1995) 1.30
Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. J Biol Chem (1997) 1.26
A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep (2002) 1.22
An expression system of rat calmodulin using T7 phage promoter in Escherichia coli. Protein Expr Purif (1998) 1.13
Requirements for calcium and calmodulin in the calmodulin kinase activation cascade. J Biol Chem (1996) 1.12
The Year in Basic Science: calmodulin kinase cascades. Mol Endocrinol (2008) 1.09
Differential regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms. Biochemistry (2001) 1.00
Activation of SAD kinase by Ca2+/calmodulin-dependent protein kinase kinase. Biochemistry (2008) 0.99
Mechanism of the generation of autonomous activity of Ca2+/calmodulin-dependent protein kinase IV. J Biol Chem (2004) 0.94
Effect of metal ions on the activity of casein kinase II from Xenopus laevis. FEBS Lett (1993) 0.92
Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. J Biol Chem (2000) 0.89
Protein kinase C delta accepts GTP for autophosphorylation. Biochem Biophys Res Commun (1995) 0.89
Regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase. J Biol Chem (2000) 0.86
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. Biochem J (2000) 0.82
CaMKII uses GTP as a phosphate donor for both substrate and autophosphorylation. Biochem Biophys Res Commun (2009) 0.80
Identification of a novel CaMKK substrate. Biochem Biophys Res Commun (2011) 0.78
Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron (2008) 3.14
STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem (2002) 2.28
Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. Blood (2008) 1.73
Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J Neurosci (2004) 1.57
Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan Marrow Donor Program. Blood (2002) 1.55
ACTN1 mutations cause congenital macrothrombocytopenia. Am J Hum Genet (2013) 1.49
CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34. J Leukoc Biol (2013) 1.47
Analysis of CaM-kinase signaling in cells. Cell Calcium (2011) 1.30
Long-term efficacy of hematopoietic stem cell transplantation on brain involvement in patients with mucopolysaccharidosis type II: a nationwide survey in Japan. Mol Genet Metab (2012) 1.30
Risk-stratified therapy and the intensive use of cytarabine improves the outcome in childhood acute myeloid leukemia: the AML99 trial from the Japanese Childhood AML Cooperative Study Group. J Clin Oncol (2009) 1.26
A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep (2002) 1.22
FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma. Br J Haematol (2009) 1.12
Breast cancer cells expressing stem cell markers CD44+ CD24 lo are eliminated by Numb-1 peptide-activated T cells. Cancer Immunol Immunother (2008) 1.10
Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins. Bioconjug Chem (2007) 1.09
Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases. J Biol Chem (2005) 1.09
Improved treatment results of children with B-cell non-Hodgkin lymphoma: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group B-NHL03 study. Pediatr Blood Cancer (2014) 1.07
Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development (2011) 1.04
Prospective study of a pirarubicin, intermediate-dose cytarabine, and etoposide regimen in children with Down syndrome and acute myeloid leukemia: the Japanese Childhood AML Cooperative Study Group. J Clin Oncol (2007) 1.03
Epstein-Barr virus-associated B-cell lymphoma in a patient with DNA ligase IV (LIG4) syndrome. Am J Med Genet A (2007) 1.02
A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609. J Biol Chem (2003) 1.01
Epidemiology and treatment outcome of invasive fungal infections in patients with hematological malignancies. Int J Hematol (2012) 0.99
Activation of SAD kinase by Ca2+/calmodulin-dependent protein kinase kinase. Biochemistry (2008) 0.99
Immunogenicity of an inflammation-associated product, tyrosine nitrated self-proteins. Autoimmun Rev (2004) 0.99
Clinical impact of HLA-DR15, a minor population of paroxysmal nocturnal haemoglobinuria-type cells, and an aplastic anaemia-associated autoantibody in children with acquired aplastic anaemia. Br J Haematol (2008) 0.98
Biologic activity of RANTES in apheresis PLT concentrates and its involvement in nonhemolytic transfusion reactions. Transfusion (2003) 0.97
PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery. J Am Chem Soc (2005) 0.96
Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing. J Am Chem Soc (2004) 0.96
Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan. Blood (2008) 0.95
Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia. Haematologica (2013) 0.95
Mechanism of the generation of autonomous activity of Ca2+/calmodulin-dependent protein kinase IV. J Biol Chem (2004) 0.94
IL-21-dependent B cell death driven by prostaglandin E2, a product secreted from follicular dendritic cells. J Immunol (2011) 0.93
Haematopoietic stem cell transplantation for relapsed or refractory anaplastic large cell lymphoma: a study of children and adolescents in Japan. Br J Haematol (2014) 0.93
Identification of intracellular target proteins of the calcium-signaling protein S100A12. Eur J Biochem (2004) 0.92
Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein. Biochem Biophys Res Commun (2002) 0.92
Wiskott-Aldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemia. Pediatr Blood Cancer (2012) 0.92
Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. J Biol Chem (2008) 0.91
Predicting response to immunosuppressive therapy in childhood aplastic anemia. Haematologica (2011) 0.90
Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line. Nucleic Acids Res (2006) 0.90
Treatment of neurodegenerative CNS disease in Langerhans cell histiocytosis with a combination of intravenous immunoglobulin and chemotherapy. Pediatr Blood Cancer (2008) 0.89
Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2. FEBS Lett (2006) 0.89
The role of tumor lysis in reversible posterior leukoencephalopathy syndrome. Pediatr Radiol (2005) 0.89
Establishment of lymphotoxin beta receptor signaling-dependent cell lines with follicular dendritic cell phenotypes from mouse lymph nodes. J Immunol (2006) 0.88
Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Biochemistry (2009) 0.88
S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex. J Biol Chem (2003) 0.88
Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. FEBS Lett (2003) 0.87
A missense mutation in Rev7 disrupts formation of Polζ, impairing mouse development and repair of genotoxic agent-induced DNA lesions. J Biol Chem (2013) 0.87
PEGylated gene nanocarriers based on block catiomers bearing ethylenediamine repeating units directed to remarkable enhancement of photochemical transfection. J Control Release (2006) 0.87
Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Biochem J (2003) 0.87
S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation. J Biol Chem (2012) 0.87
36-kDa microfibril-associated glycoprotein (MAGP-36) is an elastin-binding protein increased in chick aortae during development and growth. Exp Cell Res (2005) 0.87
Acute promyelocytic leukemia after living donor partial orthotopic liver transplantation in two Japanese girls. Leuk Lymphoma (2005) 0.87
Characterization of Ca2+/calmodulin-dependent protein kinase I as a myosin II regulatory light chain kinase in vitro and in vivo. Biochem J (2002) 0.86
S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. FEBS Lett (2010) 0.86
The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression. Diabetes (2004) 0.85
Prospective study of a therapeutic regimen with all-trans retinoic acid and anthracyclines in combination of cytarabine in children with acute promyelocytic leukaemia: the Japanese childhood acute myeloid leukaemia cooperative study. Br J Haematol (2011) 0.85
Hematopoietic stem cell transplantation in patients with severe congenital neutropenia: an analysis of 18 Japanese cases. Pediatr Transplant (2010) 0.84
Identification and characterization of PRG-1 as a neuronal calmodulin-binding protein. Biochem J (2010) 0.84
A prospective, randomized study comparing cefozopran with piperacillin-tazobactam plus ceftazidime as empirical therapy for febrile neutropenia in children with hematological disorders. Pediatr Blood Cancer (2008) 0.84
Rabbit antithymocyte globulin and cyclosporine as first-line therapy for children with acquired aplastic anemia. Blood (2013) 0.83
Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype: a study by the Japanese Childhood AML Cooperative Study Group. Int J Hematol (2010) 0.83
Development of poly(ethylene glycol) conjugated lactoferrin for oral administration. Bioconjug Chem (2008) 0.83
Near-infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate). Nanoscale (2011) 0.82
Differential gene expression of 36-kDa microfibril-associated glycoprotein (MAGP-36/MFAP4) in rat organs. Cell Tissue Res (2008) 0.82
Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res (2006) 0.82
Stem cell transplantation in primary immunodeficiency disease patients. Pediatr Int (2007) 0.82
Regulatory mechanism of Dictyostelium myosin light chain kinase A. J Biol Chem (2003) 0.82
Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein). J Biol Chem (2013) 0.82
Risk factor analysis of non-Hodgkin lymphoma-associated haemophagocytic syndromes: a multicentre study. Br J Haematol (2014) 0.82
Congenital dermatofibrosarcoma protuberans in a newborn infant with a massive back tumor: favorable effects of oral imatinib on the control of residual tumor growth. J Pediatr Hematol Oncol (2011) 0.82
RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group. Int J Hematol (2012) 0.81
Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells. J Control Release (2004) 0.81
Expression of 36-kDa microfibril-associated glycoprotein (MAGP-36) in human keratinocytes and its localization in skin. J Dermatol Sci (2002) 0.81
Cerebellar ataxia in pediatric patients with Langerhans cell histiocytosis. J Pediatr Hematol Oncol (2004) 0.81
Neurodegenerative central nervous system disease as late sequelae of Langerhans cell histiocytosis. Report from the Japan LCH Study Group. Haematologica (2008) 0.81
Incidence and risk factors of early bacterial infections after unrelated cord blood transplantation. Biol Blood Marrow Transplant (2009) 0.81
Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation. FEBS Lett (2004) 0.81
Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases. Sci Signal (2011) 0.81
Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases and their involvement in hippocampal dendritic formation. Neurosci Lett (2007) 0.80
Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library. J Biosci Bioeng (2006) 0.80
Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning. J Clin Immunol (2015) 0.80
Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line. J Biosci Bioeng (2009) 0.80
Immunogenicity of autologous IgG bearing the inflammation-associated marker 3-nitrotyrosine. Immunol Lett (2005) 0.80