Anti-viral CD8 T cells and the cytokines that they love.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 3580945)

Published in Virology on January 05, 2013

Authors

Maureen A Cox1, Shannon M Kahan, Allan J Zajac

Author Affiliations

1: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Articles citing this

Single-cell mass cytometry for analysis of immune system functional states. Curr Opin Immunol (2013) 1.35

T cell exhaustion during persistent viral infections. Virology (2015) 1.00

Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol (2015) 0.89

Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection. Infect Immun (2014) 0.82

Quantitative and Qualitative Analysis of Bone Marrow CD8(+) T Cells from Different Bones Uncovers a Major Contribution of the Bone Marrow in the Vertebrae. Front Immunol (2016) 0.82

Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+ T cells during subsequent infection. J Virol (2014) 0.79

A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets. J Immunol (2016) 0.79

Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine (2015) 0.77

A direct and nonredundant role for thymic stromal lymphopoietin on antiviral CD8 T cell responses in the respiratory mucosa. J Immunol (2014) 0.76

IL-12 Signals through the TCR To Support CD8 Innate Immune Responses. J Immunol (2016) 0.76

IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. Infect Immun (2015) 0.75

Type I Interferon Elevates Co-Regulatory Receptor Expression on CMV- and EBV-Specific CD8 T Cells in Chronic Hepatitis C. Front Immunol (2015) 0.75

IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection. J Immunol (2016) 0.75

How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis. Front Immunol (2017) 0.75

Articles cited by this

(truncated to the top 100)

Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med (2006) 24.38

Functional role of type I and type II interferons in antiviral defense. Science (1994) 18.92

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol (2003) 15.51

Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity (2007) 12.98

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol (2000) 12.81

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol (2003) 11.48

T cell exhaustion. Nat Immunol (2011) 11.08

Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature (1995) 10.89

Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity (2007) 10.83

Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature (1994) 8.85

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity (2002) 8.19

Interleukin-10 determines viral clearance or persistence in vivo. Nat Med (2006) 8.01

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med (2005) 7.87

Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (2003) 7.75

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science (1990) 7.18

Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med (2002) 7.11

Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity (2007) 6.48

Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis (2009) 6.17

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature (2006) 5.90

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med (2002) 5.64

Interleukin-10 and related cytokines and receptors. Annu Rev Immunol (2004) 5.41

Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol (1997) 5.38

Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med (2006) 4.97

Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc Natl Acad Sci U S A (2004) 4.93

IL-21 is required to control chronic viral infection. Science (2009) 4.80

The biology of interleukin-2. Annu Rev Immunol (2008) 4.77

The IL-1 family: regulators of immunity. Nat Rev Immunol (2010) 4.65

Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature (2012) 4.64

Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A (2004) 4.56

A vital role for interleukin-21 in the control of a chronic viral infection. Science (2009) 4.55

The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One (2008) 4.52

Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity (2010) 4.52

Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity (2009) 4.42

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med (2009) 4.22

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J Virol (1995) 4.16

Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity (2010) 4.06

Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (2008) 4.04

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science (2009) 3.90

Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol (2005) 3.89

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature (2005) 3.81

Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. J Immunol (2006) 3.73

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence. Proc Natl Acad Sci U S A (2010) 3.68

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med (2003) 3.68

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity (2009) 3.66

Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity (2009) 3.66

IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell (2011) 3.61

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol (2001) 3.59

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood (2008) 3.52

Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity (2010) 3.49

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci U S A (2009) 3.39

Understanding the generation and function of memory T cell subsets. Curr Opin Immunol (2005) 3.22

Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen. J Exp Med (2003) 3.20

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood (2009) 3.14

CD8+ T cell contraction is controlled by early inflammation. Nat Immunol (2004) 3.13

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest (1994) 3.12

Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol (1999) 3.10

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection. J Exp Med (2007) 3.05

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol (2009) 3.05

Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J Exp Med (1999) 2.98

Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest (2009) 2.92

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89

Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity (2012) 2.87

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 2.83

Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L. J Immunol (2005) 2.80

An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity (2011) 2.77

Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol (2012) 2.70

Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation. Eur J Immunol (2005) 2.70

Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens. J Immunol (2001) 2.70

Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J Virol (2001) 2.69

Generation of CD8 T cell memory is regulated by IL-12. J Immunol (2007) 2.69

Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J Immunol (2006) 2.69

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc Natl Acad Sci U S A (2012) 2.64

A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy. Immunity (2009) 2.64

Ablation of CD8 and CD4 T cell responses by high viral loads. J Immunol (2003) 2.63

Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. J Immunol (2010) 2.63

Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help. J Immunol (2005) 2.61

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood (2009) 2.50

Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc Natl Acad Sci U S A (2007) 2.48

CD8(+) T cells: foot soldiers of the immune system. Immunity (2011) 2.45

Inflammatory cytokines as a third signal for T cell activation. Curr Opin Immunol (2010) 2.44

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol (2011) 2.44

IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J Immunol (2003) 2.42

High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A (2009) 2.42

Interleukin-33 - cytokine of dual function or novel alarmin? Trends Immunol (2009) 2.40

IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates. Blood (2002) 2.31

Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J Immunol (2004) 2.28

T-cell exhaustion: characteristics, causes and conversion. Immunology (2010) 2.24

Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation. J Immunol (2006) 2.23

IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J Exp Med (2008) 2.20

Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. Vaccine (2009) 2.15

Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science (2011) 2.15

HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control. J Immunol (2010) 2.10

The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses. Science (2012) 2.10

IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res (2003) 2.08

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc Natl Acad Sci U S A (2010) 2.05

CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses. Proc Natl Acad Sci U S A (2009) 2.01

Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells. Nat Immunol (2011) 1.98

The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells. J Immunol (2002) 1.98

Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity (2009) 1.94

Articles by these authors

A vital role for interleukin-21 in the control of a chronic viral infection. Science (2009) 4.55

Ablation of CD8 and CD4 T cell responses by high viral loads. J Immunol (2003) 2.63

Memory CD4 T cells emerge from effector T-cell progenitors. Nature (2008) 2.62

Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help. J Immunol (2005) 2.61

Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J Immunol (2004) 2.28

T-cell exhaustion: characteristics, causes and conversion. Immunology (2010) 2.24

CD4 T cell-dependent CD8 T cell maturation. J Immunol (2004) 2.04

Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory. Eur J Immunol (2006) 1.95

Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice. AIDS Res Hum Retroviruses (2003) 1.73

Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. J Immunol (2002) 1.44

IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol (2010) 1.28

Identification of immune and viral correlates of norovirus protective immunity through comparative study of intra-cluster norovirus strains. PLoS Pathog (2013) 1.22

Type I and type II interferons inhibit the translation of murine norovirus proteins. J Virol (2009) 1.18

Interleukin-21: a multifunctional regulator of immunity to infections. Microbes Infect (2010) 1.17

Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers. J Virol (2010) 1.15

T cell responses to viral infections: lessons from lymphocytic choriomeningitis virus. Immunol Res (2002) 1.09

Cytokines and the inception of CD8 T cell responses. Trends Immunol (2011) 1.07

Primary high-dose murine norovirus 1 infection fails to protect from secondary challenge with homologous virus. J Virol (2009) 1.06

Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses. J Virol (2005) 1.06

IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells. J Immunol (2013) 0.99

Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections. PLoS Pathog (2011) 0.94

Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatment. J Infect Dis (2006) 0.94

IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response. Diabetes (2011) 0.92

Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice. Arthritis Rheumatol (2014) 0.91

Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels. J Immunol (2010) 0.91

ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection. Proc Natl Acad Sci U S A (2013) 0.90

Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol (2013) 0.89

Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome. J Virol (2002) 0.88

Expression of the full-length form of gp2 of equine herpesvirus 1 (EHV-1) completely restores respiratory virulence to the attenuated EHV-1 strain KyA in CBA mice. J Virol (2005) 0.88

Shaping successful and unsuccessful CD8 T cell responses following infection. J Biomed Biotechnol (2010) 0.87

IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis. J Neuroimmunol (2013) 0.81

HIV-1(89.6) Gag expressed from a replication competent HSV-1 vector elicits persistent cellular immune responses in mice. Vaccine (2007) 0.79

In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin. Hum Gene Ther (2006) 0.79