Drug targets and predictive biomarkers in the management of metastatic melanoma.

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Published in Pharmgenomics Pers Med on September 28, 2012

Authors

Jaykumar Thumar1, Eva Giesen, Harriet M Kluger

Author Affiliations

1: Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.

Associated clinical trials:

A Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma | NCT01227889

GSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma | NCT01245062

A Study of GSK2118436 in BRAF Mutant Metastatic Melanoma to the Brain (Break MB) | NCT01266967

MEK162 and RAF265 in Adult Patients With Advanced Solid Tumors Harboring RAS or BRAFV600E Mutations | NCT01352273

Phase Ib Study of PI3(Phosphoinositol 3)-Kinase Inhibitor Copanlisib With MEK (Mitogen-activated Protein Kinase) Inhibitor Refametinib (BAY86-9766) in Patients With Advanced Cancer | NCT01392521

Tissue and Blood Biomarkers From Patients With Stage III or Stage IV Melanoma Treated With Ipilimumab With or Without Sargramostim | NCT01489423

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