Published in PLoS One on December 07, 2012
Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer (2016) 1.40
Ketone bodies as signaling metabolites. Trends Endocrinol Metab (2013) 1.37
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology (2014) 1.19
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metab (2015) 1.11
Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes (2014) 1.03
Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta (2014) 1.03
Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21. Aging Cell (2014) 1.00
Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans? Osteoporos Int (2013) 0.87
Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor. Nutr Metab (Lond) (2013) 0.84
Adipose Tissue Residing Progenitors (Adipocyte Lineage Progenitors and Adipose Derived Stem Cells (ADSC). Curr Mol Biol Rep (2015) 0.83
Nutritionally-induced catch-up growth. Nutrients (2015) 0.83
Scallop protein with endogenous high taurine and glycine content prevents high-fat, high-sucrose-induced obesity and improves plasma lipid profile in male C57BL/6J mice. Amino Acids (2014) 0.82
Personalized metabolomics for predicting glucose tolerance changes in sedentary women after high-intensity interval training. Sci Rep (2014) 0.82
Compromised responses to dietary methionine restriction in adipose tissue but not liver of ob/ob mice. Obesity (Silver Spring) (2015) 0.82
Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. PLoS One (2013) 0.81
The first international mini-symposium on methionine restriction and lifespan. Front Genet (2014) 0.80
The impact of dietary methionine restriction on biomarkers of metabolic health. Prog Mol Biol Transl Sci (2014) 0.80
Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes (2015) 0.79
FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but not its Effects on Hepatic Lipid Metabolism. Diabetes (2017) 0.78
Metabolic responses to dietary leucine restriction involve remodeling of adipose tissue and enhanced hepatic insulin signaling. Biofactors (2015) 0.78
Dietary methionine restriction in mice elicits an adaptive cardiovascular response to hyperhomocysteinemia. Sci Rep (2015) 0.78
Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction. J Bioenerg Biomembr (2015) 0.77
Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice. Metabolism (2014) 0.76
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator. J Biol Chem (2016) 0.76
Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan? Ageing Res Rev (2016) 0.76
Animal Models for the Study of the Relationships between Diet and Obesity: A Focus on Dietary Protein and Estrogen Deficiency. Front Nutr (2017) 0.75
Methionine restriction alters bone morphology and affects osteoblast differentiation. Bone Rep (2016) 0.75
Effects of different diets on intestinal microbiota and nonalcoholic fatty liver disease development. World J Gastroenterol (2016) 0.75
A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem (1957) 173.99
Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 11.77
FGF-21 as a novel metabolic regulator. J Clin Invest (2005) 10.69
Obesity and insulin resistance. J Clin Invest (2000) 10.47
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med (2001) 6.09
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes (2008) 5.62
Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta (2000) 4.19
The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes (2004) 4.09
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell (2005) 4.02
Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes (2010) 3.30
Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J Biol Chem (2002) 3.24
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell (2012) 3.07
Low methionine ingestion by rats extends life span. J Nutr (1993) 3.05
Animal models of steatosis. Semin Liver Dis (2001) 2.88
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab (2008) 2.76
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes (2005) 2.72
Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord (2000) 2.59
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci U S A (2004) 2.48
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology (2007) 2.43
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc Natl Acad Sci U S A (2012) 2.38
Nutritional control of aging. Exp Gerontol (2003) 2.35
The role of collagen in bone strength. Osteoporos Int (2005) 2.19
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science (2006) 2.02
Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. J Gerontol A Biol Sci Med Sci (2009) 2.02
Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem (2008) 1.94
Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J Biol Chem (2006) 1.63
Insulin and leptin as adiposity signals. Recent Prog Horm Res (2004) 1.60
Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. Trends Endocrinol Metab (2011) 1.53
Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction. Aging Cell (2006) 1.53
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochem J (2012) 1.49
Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. Am J Physiol Regul Integr Comp Physiol (2010) 1.31
Role of beta-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction. Am J Physiol Regul Integr Comp Physiol (2010) 1.21
Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. J Clin Endocrinol Metab (2011) 1.18
Mouse Phenome Database (MPD). Nucleic Acids Res (2011) 1.14
Methionine restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue. J Lipid Res (2007) 1.13
Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats. Metabolism (2010) 1.13
Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. PLoS One (2011) 1.13
Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res (2010) 1.12
The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function. Brain Res Bull (2008) 1.09
Body fat content can be predicted in vivo in mice using a modified dual-energy X-ray absorptiometry technique. J Nutr (2001) 1.08
Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice. Hepatology (2010) 1.03
Adiponectin and adiponectin receptors in obesity-linked insulin resistance. Novartis Found Symp (2007) 1.00
Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. Scand J Gastroenterol (2010) 0.98
TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. Diabetes (2012) 0.94
Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. Scand J Gastroenterol (2009) 0.93
Inactivation of the Rcan2 gene in mice ameliorates the age- and diet-induced obesity by causing a reduction in food intake. PLoS One (2011) 0.85
No bones about it: insulin modulates skeletal remodeling. Cell (2010) 0.84
[The mechanisms by which PPARgamma and adiponectin regulate glucose and lipid metabolism]. Nihon Yakurigaku Zasshi (2003) 0.82
Anti-diabetic effect of pyroglutamic acid in type 2 diabetic Goto-Kakizaki rats and KK-Ay mice. Br J Nutr (2011) 0.81
Additive action of 11beta-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats. Int J Obes (Lond) (2009) 0.79
Nutritional control of aging. Exp Gerontol (2003) 2.35
Helicobacter pylori infection and the risk of development of esophageal adenocarcinoma. J Infect Dis (2005) 2.28
Epstein-Barr virus and multiple sclerosis: evidence of association from a prospective study with long-term follow-up. Arch Neurol (2006) 2.00
CagA status of Helicobacter pylori infection and p53 gene mutations in gastric adenocarcinoma. Carcinogenesis (2002) 1.72
Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia. Nutrition (2010) 1.53
Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction. Aging Cell (2006) 1.53
Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. Am J Physiol Regul Integr Comp Physiol (2010) 1.31
Role of beta-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction. Am J Physiol Regul Integr Comp Physiol (2010) 1.21
Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. J Clin Endocrinol Metab (2011) 1.18
Helicobacter pylori infection and development of pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2008) 1.14
Insulin-like growth factor I (IGF-I), IGF-binding proteins, and breast cancer. Cancer Epidemiol Biomarkers Prev (2002) 1.14
Methionine restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue. J Lipid Res (2007) 1.13
Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats. Metabolism (2010) 1.13
Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res (2010) 1.12
Tissue glutathione and cysteine levels in methionine-restricted rats. Nutrition (2004) 1.04
Serum ghrelin levels and risk of subsequent adenocarcinoma of the esophagus. Am J Gastroenterol (2007) 1.04
Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle. J Nutrigenet Nutrigenomics (2012) 1.04
Effects of monopolar radiofrequency treatment over soft-tissue fillers in an animal model. Lasers Surg Med (2005) 1.01
Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma. J Invest Dermatol (2009) 1.01
Utility of insulin-like growth factor-1 as a biomarker in epidemiologic studies. Clin Chem (2002) 0.97
Circulating angiopoietins-1 and -2, angiopoietin receptor Tie-2 and vascular endothelial growth factor-A as biomarkers of acute myocardial infarction: a prospective nested case-control study. BMC Cardiovasc Disord (2011) 0.95
Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents. Exp Gerontol (2012) 0.95
Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice. Metabolism (2013) 0.91
Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice. Prostate (2014) 0.87
Does the association between serum endostatin, an endogenous anti-angiogenic protein, and acute myocardial infarction differ by race? Vasc Med (2006) 0.81
No association between serum levels of tumor necrosis factor-alpha (TNF-alpha) or the soluble receptors sTNFR1 and sTNFR2 and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2003) 0.81
Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance. Metabolism (2012) 0.81
In ovo carcinogenicity assay (IOCA): evaluation of mannitol, caprolactam and nitrosoproline. Arch Toxicol (2002) 0.80
C-reactive protein, Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus and risk for myocardial infarction. Ann Epidemiol (2003) 0.78
Highly purified 1000-cSt silicone oil for treatment of human immunodeficiency virus-associated facial lipoatrophy: an open pilot trial. Dermatol Surg (2004) 0.78
Transplants from balding and hairy androgenetic alopecia scalp regrow hair comparably well on immunodeficient mice. J Am Acad Dermatol (2003) 0.77
A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but increase intrinsic strength in growing male rats. J Nutr (2014) 0.76
Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. Eur J Cancer Prev (2007) 0.75
Infections and "unrelated" diseases. Hawaii Med J (2006) 0.75