Published in Hypertension on December 24, 2012
Angiotensin II-induced endothelial dysfunction is temporally linked with increases in interleukin-6 and vascular macrophage accumulation. Front Physiol (2014) 0.90
Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Am J Respir Cell Mol Biol (2013) 0.90
Heart failure with preserved ejection fraction: emerging drug strategies. J Cardiovasc Pharmacol (2013) 0.87
Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. J Clin Invest (2016) 0.85
Interleukin-10 protects against aging-induced endothelial dysfunction. Physiol Rep (2013) 0.83
Emerging translational approaches to target STAT3 signalling and its impact on vascular disease. Cardiovasc Res (2015) 0.83
Context-dependent effects of SOCS3 in angiotensin II-induced vascular dysfunction and hypertension in mice: mechanisms and role of bone marrow-derived cells. Am J Physiol Heart Circ Physiol (2016) 0.81
Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease. Oncotarget (2016) 0.81
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke. Circ Res (2017) 0.80
IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor. JAKSTAT (2016) 0.75
Genetic Interference With Endothelial Peroxisome Proliferator-Activated Receptor-γ Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7. Hypertension (2017) 0.75
Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33
Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation (2007) 11.95
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol (2006) 6.38
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature (1991) 5.16
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A (2007) 4.77
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A (2006) 4.10
Vascular inflammation and the renin-angiotensin system. Arterioscler Thromb Vasc Biol (2002) 3.04
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J (1998) 2.99
Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature (1995) 2.33
Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular disease. Stroke (2009) 2.28
Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation (2004) 2.04
Janus kinases: components of multiple signaling pathways. Oncogene (2000) 2.02
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene (2009) 1.97
Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element-binding protein. J Biol Chem (1998) 1.83
Protecting against vascular disease in brain. Am J Physiol Heart Circ Physiol (2011) 1.66
IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy. Arterioscler Thromb Vasc Biol (2007) 1.65
Role of oxidative stress in angiotensin-induced hypertension. Am J Physiol Regul Integr Comp Physiol (2003) 1.60
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol (1998) 1.57
Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. Arterioscler Thromb Vasc Biol (2006) 1.50
Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res (2008) 1.48
Endothelial function in resistance and conduit arteries and 5-year risk of cardiovascular disease. Circulation (2011) 1.40
Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction. Hypertension (2009) 1.38
Tyrphostins--potential antiproliferative agents and novel molecular tools. Biochem Pharmacol (1990) 1.31
The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension. Am J Physiol Heart Circ Physiol (2010) 1.24
Hypertension and longitudinal changes in cerebral blood flow: the SMART-MR study. Ann Neurol (2012) 1.21
Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ Physiol (2009) 1.21
Critical role for CuZn-superoxide dismutase in preventing angiotensin II-induced endothelial dysfunction. Hypertension (2005) 1.19
Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. J Biol Chem (1997) 1.19
Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX. J Cell Sci (2009) 1.18
Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension (2004) 1.15
Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice. Atherosclerosis (2006) 1.15
cSrc is a major cytosolic tyrosine kinase in vascular tissue. Can J Physiol Pharmacol (1999) 1.07
Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein. Free Radic Biol Med (2001) 1.03
The interleukin-6 pathway and atherosclerosis. Lancet (2012) 0.94
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase. Exp Cell Res (1998) 0.91
Angiotensin II utilizes Janus kinase 2 in hypertension, but not in the physiological control of blood pressure, during low-salt intake. Am J Physiol Regul Integr Comp Physiol (2011) 0.89
Gene-targeted mice reveal a critical role for inducible nitric oxide synthase in vascular dysfunction during diabetes. Stroke (2003) 0.87
Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats. Brain Res (2008) 0.87
Overexpression of CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction. Stroke (2004) 0.84
Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells. J Signal Transduct (2011) 0.83
Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia. Hypertension (2010) 0.80
Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells. Mol Cell Biochem (2000) 0.79
The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell (2009) 3.03
Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke (2012) 2.18
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab (2008) 2.17
Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood (2011) 2.02
Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. Cell Metab (2012) 1.99
Cerebral vascular dysfunction during hypercholesterolemia. Stroke (2007) 1.94
Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging. Hypertension (2006) 1.81
Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction. Hypertension (2008) 1.76
IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy. Arterioscler Thromb Vasc Biol (2007) 1.65
Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res (2002) 1.64
PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension (2004) 1.64
Gene transfer of extracellular superoxide dismutase improves endothelial function in rats with heart failure. Am J Physiol Heart Circ Physiol (2005) 1.55
Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension (2008) 1.55
Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res (2008) 1.48
Receptor activity-modifying protein-1 augments cerebrovascular responses to calcitonin gene-related peptide and inhibits angiotensin II-induced vascular dysfunction. Stroke (2010) 1.48
The role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Mol Med (2008) 1.46
Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. Hypertension (2003) 1.40
Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction. Hypertension (2009) 1.38
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke (2004) 1.37
MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (2006) 1.25
Effect of aging, MnSOD deficiency, and genetic background on endothelial function: evidence for MnSOD haploinsufficiency. Arterioscler Thromb Vasc Biol (2007) 1.23
Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ Physiol (2009) 1.21
Quantification of mRNA for endothelial NO synthase in mouse blood vessels by real-time polymerase chain reaction. Arterioscler Thromb Vasc Biol (2002) 1.21
Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase. Stroke (2006) 1.20
Critical role for CuZn-superoxide dismutase in preventing angiotensin II-induced endothelial dysfunction. Hypertension (2005) 1.19
Cerebral vascular effects of angiotensin II: new insights from genetic models. J Cereb Blood Flow Metab (2006) 1.19
Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Circ Res (2003) 1.18
Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes. Stroke (2005) 1.17
Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension (2004) 1.15
Vascular effects of the human extracellular superoxide dismutase R213G variant. Circulation (2005) 1.14
Endothelial dysfunction and blood pressure variability in selected inbred mouse strains. Arterioscler Thromb Vasc Biol (2002) 1.13
Gene expression profiling of potential PPARgamma target genes in mouse aorta. Physiol Genomics (2004) 1.12
Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arterioscler Thromb Vasc Biol (2002) 1.11
PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circ Res (2012) 1.11
Trans-forming endothelial nitric oxide synthase in hypertension: more than meets the eye. Hypertension (2011) 1.09
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood (2003) 1.09
Spontaneous stroke in a genetic model of hypertension in mice. Stroke (2005) 1.09
Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Stroke (2007) 1.07
Free radical biology of the cardiovascular system. Clin Sci (Lond) (2012) 1.07
20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase. Am J Physiol Heart Circ Physiol (2006) 1.05
Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. Arterioscler Thromb Vasc Biol (2009) 1.05
Gene transfer of extracellular superoxide dismutase protects against vascular dysfunction with aging. Am J Physiol Heart Circ Physiol (2006) 1.04
Angiotensin II produces superoxide-mediated impairment of endothelial function in cerebral arterioles. Stroke (2003) 1.03
Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase. Circ Res (2004) 1.02
Cerebral vascular dysfunction in methionine synthase-deficient mice. Circulation (2005) 1.01
Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature? J Biol Chem (2010) 1.00
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. Am J Physiol Heart Circ Physiol (2002) 1.00
Cerebral vascular dysfunction in TallyHo mice: a new model of Type II diabetes. Am J Physiol Heart Circ Physiol (2006) 1.00
Effects of NADH and NADPH on superoxide levels and cerebral vascular tone. Am J Physiol Heart Circ Physiol (2002) 0.99
Hyperhomocysteinemia: a million ways to lose control. Arterioscler Thromb Vasc Biol (2003) 0.98
Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain. J Appl Physiol (1985) (2012) 0.97
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol (2008) 0.97
Muscarinic (M) receptors in coronary circulation: gene-targeted mice define the role of M2 and M3 receptors in response to acetylcholine. Arterioscler Thromb Vasc Biol (2004) 0.97
Vasomotor responses in MnSOD-deficient mice. Am J Physiol Heart Circ Physiol (2004) 0.96
Vascular effects of a common gene variant of extracellular superoxide dismutase in heart failure. Am J Physiol Heart Circ Physiol (2006) 0.95
Interleukin-10 protects nitric oxide-dependent relaxation during diabetes: role of superoxide. Diabetes (2002) 0.95
Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. J Cereb Blood Flow Metab (2008) 0.95
Sex differences in protection against angiotensin II-induced endothelial dysfunction by manganese superoxide dismutase in the cerebral circulation. Hypertension (2010) 0.93
Hydrogen peroxide: watery fuel for change in vascular biology. Arterioscler Thromb Vasc Biol (2006) 0.92
Ceramide-induced impairment of endothelial function is prevented by CuZn superoxide dismutase overexpression. Arterioscler Thromb Vasc Biol (2004) 0.92
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circ Res (2009) 0.91
Effects of a common human gene variant of extracellular superoxide dismutase on endothelial function after endotoxin in mice. J Physiol (2007) 0.90
Neuronal expression and regulation of CGRP promoter activity following viral gene transfer into cultured trigeminal ganglia neurons. Brain Res (2004) 0.90
Impairment of dilator responses of cerebral arterioles during diabetes mellitus: role of inducible NO synthase. Stroke (2006) 0.89
Role of angiotensin II in endothelial dysfunction induced by lipopolysaccharide in mice. Am J Physiol Heart Circ Physiol (2007) 0.89
Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke (2013) 0.88
Effects of angiotensin II on the cerebral circulation: role of oxidative stress. Front Physiol (2013) 0.88
Modulation of dilator responses of cerebral arterioles by extracellular superoxide dismutase. Stroke (2006) 0.88
Gene-targeted mice reveal a critical role for inducible nitric oxide synthase in vascular dysfunction during diabetes. Stroke (2003) 0.87
Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol (2005) 0.87
Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension (2016) 0.87
Overexpression of CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction. Stroke (2004) 0.84
Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. J Hypertens (2014) 0.82
Vascular interleukin-10 protects against LPS-induced vasomotor dysfunction. Am J Physiol Heart Circ Physiol (2005) 0.82
Gene transfer of extracellular superoxide dismutase improves relaxation of aorta after treatment with endotoxin. Am J Physiol Heart Circ Physiol (2004) 0.82
Gene transfer of extracellular superoxide dismutase reduces cerebral vasospasm after subarachnoid hemorrhage. Stroke (2003) 0.82
Peroxisome proliferator-activated receptor-γ protects against vascular aging. Am J Physiol Regul Integr Comp Physiol (2012) 0.81
Role of hydrogen peroxide and the impact of glutathione peroxidase-1 in regulation of cerebral vascular tone. J Cereb Blood Flow Metab (2009) 0.81
Novel insights into M5 muscarinic acetylcholine receptor function by the use of gene targeting technology. Life Sci (2003) 0.81
Endothelial vasodilator production by uterine and systemic arteries. VIII. Estrogen and progesterone effects on cPLA2, COX-1, and PGIS protein expression. Biol Reprod (2002) 0.80
Endothelial vasodilator production by uterine and systemic arteries. IX. eNOS gradients in cycling and pregnant ewes. Am J Physiol Heart Circ Physiol (2002) 0.79
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin. Neurosurgery (2015) 0.77
Protecting the brain with eNOS: run for your life. Circ Res (2006) 0.77
Neuronal NO mediates cerebral vasodilator responses to K+ in hypertensive rats. Hypertension (2002) 0.76
Breathe, breathe in the air: the ins and outs of hypoxia take their toll. Hypertension (2012) 0.76
Leaky vessels: how the brain deals with pregnancy under pressure. J Appl Physiol (1985) (2010) 0.75
Response to letter regarding article, "Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging". Stroke (2013) 0.75