Published in Toxins (Basel) on December 28, 2012
Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence. Cell Mol Life Sci (2013) 1.15
Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cell Mol Gastroenterol Hepatol (2016) 0.93
The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis. BMC Genomics (2014) 0.87
Biochemical characterization of the SPATE members EspPα and EspI. Toxins (Basel) (2014) 0.76
Structural and functional characterization of cleavage and inactivation of human serine protease inhibitors by the bacterial SPATE protease EspPα from enterohemorrhagic E. coli. PLoS One (2014) 0.75
Signal sequences. The limits of variation. J Mol Biol (1985) 21.24
Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans. J Clin Microbiol (1999) 6.66
Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Nature (1987) 5.88
Type V protein secretion pathway: the autotransporter story. Microbiol Mol Biol Rev (2004) 5.80
Molecular analysis of the plasmid-encoded hemolysin of Escherichia coli O157:H7 strain EDL 933. Infect Immun (1995) 5.34
The great escape: structure and function of the autotransporter proteins. Trends Microbiol (1998) 4.72
Virulence functions of autotransporter proteins. Infect Immun (2001) 4.07
EspP, a novel extracellular serine protease of enterohaemorrhagic Escherichia coli O157:H7 cleaves human coagulation factor V. Mol Microbiol (1997) 3.75
Structure of the translocator domain of a bacterial autotransporter. EMBO J (2004) 3.14
Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917. J Bacteriol (2004) 2.80
Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli. Infect Immun (1999) 2.78
Identification of sat, an autotransporter toxin produced by uropathogenic Escherichia coli. Mol Microbiol (2000) 2.53
Pet, an autotransporter enterotoxin from enteroaggregative Escherichia coli. Infect Immun (1998) 2.49
Functional comparison of serine protease autotransporters of enterobacteriaceae. Infect Immun (2002) 2.44
Mechanism of action of the group A streptococcal C5a inactivator. Proc Natl Acad Sci U S A (1985) 2.38
Characterization of EspC, a 110-kilodalton protein secreted by enteropathogenic Escherichia coli which is homologous to members of the immunoglobulin A protease-like family of secreted proteins. J Bacteriol (1996) 2.36
Isolation and characterization of a gene involved in hemagglutination by an avian pathogenic Escherichia coli strain. Infect Immun (1994) 2.33
SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion. Mol Microbiol (1995) 2.27
RTX toxin structure and function: a story of numerous anomalies and few analogies in toxin biology. Curr Top Microbiol Immunol (2001) 2.23
Non-O157:H7 pathogenic Shiga toxin-producing Escherichia coli: phenotypic and genetic profiling of virulence traits and evidence for clonality. J Infect Dis (1999) 2.04
espC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin. Infect Immun (2001) 2.03
Virulence factors of Escherichia coli O157 and other Shiga toxin-producing E. coli. J Appl Microbiol (2000) 2.00
The large plasmids of Shiga-toxin-producing Escherichia coli (STEC) are highly variable genetic elements. Microbiology (1999) 1.97
Detection and characterization of verocytotoxin-producing Escherichia coli by automated 5' nuclease PCR assay. J Clin Microbiol (2003) 1.84
Identification and characterization of a novel genomic island integrated at selC in locus of enterocyte effacement-negative, Shiga toxin-producing Escherichia coli. Infect Immun (2001) 1.82
Influence of the 60-megadalton plasmid on adherence of Escherichia coli O157:H7 and genetic derivatives. Infect Immun (1990) 1.80
Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane. Proc Natl Acad Sci U S A (2009) 1.79
Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli. J Biol Chem (2005) 1.76
The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins. Biochem Biophys Res Commun (1978) 1.75
The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol Med (2012) 1.75
Secretion by numbers: Protein traffic in prokaryotes. Mol Microbiol (2006) 1.75
A conserved region within the Bordetella pertussis autotransporter BrkA is necessary for folding of its passenger domain. Mol Microbiol (2003) 1.74
Role of Escherichia coli O157:H7 virulence factors in colonization at the bovine terminal rectal mucosa. Infect Immun (2006) 1.72
Furin-induced cleavage and activation of Shiga toxin. J Biol Chem (1995) 1.71
Characterization of an exported protease from Shiga toxin-producing Escherichia coli. Mol Microbiol (1997) 1.69
Cytoskeletal effects induced by pet, the serine protease enterotoxin of enteroaggregative Escherichia coli. Infect Immun (1999) 1.65
From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis. Nat Rev Microbiol (2012) 1.62
Infection by Shiga toxin-producing Escherichia coli: an overview. Mol Biotechnol (2004) 1.60
Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1. J Exp Med (1998) 1.60
Autotransporter structure reveals intra-barrel cleavage followed by conformational changes. Nat Struct Mol Biol (2007) 1.60
Characterization of an RTX toxin from enterohemorrhagic Escherichia coli O157:H7. Infect Immun (1996) 1.59
An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter. Proc Natl Acad Sci U S A (2004) 1.59
High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation? Autoimmun Rev (2002) 1.58
Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells. Infect Immun (2002) 1.56
The Pic protease of enteroaggregative Escherichia coli promotes intestinal colonization and growth in the presence of mucin. Infect Immun (2009) 1.55
The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation. Infect Immun (2000) 1.55
Temperature- and medium-dependent secretion of proteins by Shiga toxin-producing Escherichia coli. Infect Immun (1996) 1.55
In vitro inactivation of bacterial endotoxin by human lipoproteins and apolipoproteins. Infect Immun (1992) 1.52
In vitro effects of a high-molecular-weight heat-labile enterotoxin from enteroaggregative Escherichia coli. Infect Immun (1998) 1.51
Virulence gene profiling of enterohemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli strains: a basis for molecular risk assessment of typical and atypical EPEC strains. BMC Microbiol (2011) 1.47
Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism. EMBO J (2007) 1.46
Identification and molecular characterization of EatA, an autotransporter protein of enterotoxigenic Escherichia coli. Infect Immun (2004) 1.45
Short report: high prevalence of serine protease autotransporter cytotoxins among strains of enteroaggregative Escherichia coli. Am J Trop Med Hyg (2009) 1.43
Autotransporter-encoding sequences are phylogenetically distributed among Escherichia coli clinical isolates and reference strains. Appl Environ Microbiol (2007) 1.43
Transfer region of pO113 from enterohemorrhagic Escherichia coli: similarity with R64 and identification of a novel plasmid-encoded autotransporter, EpeA. Infect Immun (2003) 1.42
Discovery of an archetypal protein transport system in bacterial outer membranes. Nat Struct Mol Biol (2012) 1.41
Micro-array for the identification of Shiga toxin-producing Escherichia coli (STEC) seropathotypes associated with Hemorrhagic Colitis and Hemolytic Uremic Syndrome in humans. Int J Food Microbiol (2010) 1.41
Prevention of endotoxin-induced monokine release by human low- and high-density lipoproteins and by apolipoprotein A-I. Infect Immun (1993) 1.39
Prevalence and characterization of non-O157 shiga toxin-producing Escherichia coli isolates from commercial ground beef in the United States. Appl Environ Microbiol (2011) 1.38
A long-term study on the prevalence of shiga toxin-producing Escherichia coli (STEC) on four German cattle farms. Epidemiol Infect (2002) 1.36
Autotransporter genes pic and tsh are associated with Escherichia coli strains that cause acute pyelonephritis and are expressed during urinary tract infection. Infect Immun (2004) 1.36
Effect of Pseudomonas aeruginosa elastase and alkaline protease on serum complement and isolated components C1q and C3. Clin Immunol Immunopathol (1992) 1.33
Sequential and spatially restricted interactions of assembly factors with an autotransporter beta domain. Proc Natl Acad Sci U S A (2011) 1.32
Activation of Shiga toxin type 2d (Stx2d) by elastase involves cleavage of the C-terminal two amino acids of the A2 peptide in the context of the appropriate B pentamer. Mol Microbiol (2002) 1.29
Extracellular gelatinase of Enterococcus faecalis destroys a defense system in insect hemolymph and human serum. Infect Immun (2007) 1.28
Roles of periplasmic chaperone proteins in the biogenesis of serine protease autotransporters of Enterobacteriaceae. J Bacteriol (2009) 1.28
Prevalence and genetic profiling of virulence determinants of non-O157 Shiga toxin-producing Escherichia coli isolated from cattle, beef, and humans, Calcutta, India. Emerg Infect Dis (2002) 1.27
Incorporation of a polypeptide segment into the beta-domain pore during the assembly of a bacterial autotransporter. Mol Microbiol (2007) 1.25
Type V secretion: mechanism(s) of autotransport through the bacterial outer membrane. Philos Trans R Soc Lond B Biol Sci (2012) 1.25
The autotransporter secretion system. Res Microbiol (2004) 1.24
In vitro proteolytic processing and activation of the recombinant precursor of El Tor cytolysin/hemolysin (pro-HlyA) of Vibrio cholerae by soluble hemagglutinin/protease of V. cholerae, trypsin, and other proteases. Infect Immun (1996) 1.22
Shiga toxin, cytolethal distending toxin, and hemolysin repertoires in clinical Escherichia coli O91 isolates. J Clin Microbiol (2009) 1.20
Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment. Proc Natl Acad Sci U S A (2010) 1.19
Hydrophobic residues of the autotransporter EspP linker domain are important for outer membrane translocation of its passenger. J Biol Chem (2004) 1.17
Common themes and variations in serine protease autotransporters. Trends Microbiol (2008) 1.17
Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. PLoS Pathog (2009) 1.16
An unusual signal peptide extension inhibits the binding of bacterial presecretory proteins to the signal recognition particle, trigger factor, and the SecYEG complex. J Biol Chem (2006) 1.15
PicU, a second serine protease autotransporter of uropathogenic Escherichia coli. FEMS Microbiol Lett (2004) 1.14
The serine protease motif of EspC from enteropathogenic Escherichia coli produces epithelial damage by a mechanism different from that of Pet toxin from enteroaggregative E. coli. Infect Immun (2004) 1.13
Subtypes of the plasmid-encoded serine protease EspP in Shiga toxin-producing Escherichia coli: distribution, secretion, and proteolytic activity. Appl Environ Microbiol (2007) 1.13
Active-site gating regulates substrate selectivity in a chymotrypsin-like serine protease the structure of haemophilus influenzae immunoglobulin A1 protease. J Mol Biol (2009) 1.12
Prevalence and characterization of verotoxin-producing Escherichia coli (VTEC) in cattle from an Ontario abattoir. Can J Vet Res (2008) 1.11
Genome-wide transposon mutagenesis reveals a role for pO157 genes in biofilm development in Escherichia coli O157:H7 EDL933. Infect Immun (2010) 1.10
The immunogenic SigA enterotoxin of Shigella flexneri 2a binds to HEp-2 cells and induces fodrin redistribution in intoxicated epithelial cells. PLoS One (2009) 1.09
Functional analysis of the Tsh autotransporter from an avian pathogenic Escherichia coli strain. Infect Immun (2004) 1.09
Detection of Shiga toxin-producing Escherichia coli serotypes O26:H11, O103:H2, O111:H8, O145:H28, and O157:H7 in raw-milk cheeses by using multiplex real-time PCR. Appl Environ Microbiol (2011) 1.07
Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins. J Biol Chem (2011) 1.07
A novel intein-like autoproteolytic mechanism in autotransporter proteins. J Mol Biol (2010) 1.07
Autotransporters of Escherichia coli: a sequence-based characterization. Microbiology (2010) 1.06
Hemolysin from Shiga toxin-negative Escherichia coli O26 strains injures microvascular endothelium. Microbes Infect (2006) 1.06
Molecular analysis of shiga toxin-producing Escherichia coli strains isolated from hemolytic-uremic syndrome patients and dairy samples in France. Appl Environ Microbiol (2008) 1.04
The secreted autotransporter toxin, Sat, functions as a virulence factor in Afa/Dr diffusely adhering Escherichia coli by promoting lesions in tight junction of polarized epithelial cells. Cell Microbiol (2006) 1.04
Increased opsonization of a prtH-defective mutant of Porphyromonas gingivalis W83 is caused by reduced degradation of complement-derived opsonins. J Immunol (1995) 1.03
EspP, a serine protease of enterohemorrhagic Escherichia coli, impairs complement activation by cleaving complement factors C3/C3b and C5. Infect Immun (2010) 1.02
Serine protease autotransporters of enterobacteriaceae (SPATEs): biogenesis and function. Toxins (Basel) (2010) 1.02
Structure and function relationship of the autotransport and proteolytic activity of EspP from Shiga toxin-producing Escherichia coli. PLoS One (2009) 1.01
Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytes. Microbes Infect (2006) 1.00
Bacterial macroscopic rope-like fibers with cytopathic and adhesive properties. J Biol Chem (2010) 1.00
Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin. Mol Microbiol (2009) 1.00
Metabolic and genetic profiling of clinical O157 and non-O157 Shiga-toxin-producing Escherichia coli. Res Microbiol (2007) 1.00
Shiga toxin activates complement and binds factor H: evidence for an active role of complement in hemolytic uremic syndrome. J Immunol (2009) 1.29
Shiga toxin, cytolethal distending toxin, and hemolysin repertoires in clinical Escherichia coli O91 isolates. J Clin Microbiol (2009) 1.20
Hemolysin from Shiga toxin-negative Escherichia coli O26 strains injures microvascular endothelium. Microbes Infect (2006) 1.06
EspP, a serine protease of enterohemorrhagic Escherichia coli, impairs complement activation by cleaving complement factors C3/C3b and C5. Infect Immun (2010) 1.02
New sensitive high-performance liquid chromatography-tandem mass spectrometry method for the detection of horse and pork in halal beef. J Agric Food Chem (2013) 0.94
Meat authentication: a new HPLC-MS/MS based method for the fast and sensitive detection of horse and pork in highly processed food. J Agric Food Chem (2014) 0.84
Shiga toxin 2 reduces complement inhibitor CD59 expression on human renal tubular epithelial and glomerular endothelial cells. Infect Immun (2013) 0.78
Impact of dietary factors and food processing on food allergy. Mol Nutr Food Res (2012) 0.78
Characterization of mustard 2S albumin allergens by bottom-up, middle-down, and top-down proteomics: a consensus set of isoforms of Sin a 1. J Proteome Res (2015) 0.75