Published in PLoS One on December 17, 2012
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Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres. Nucleic Acids Res (2015) 0.82
Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. J Pathol Clin Res (2015) 0.75
Unbiased phosphoproteomic method identifies the initial effects of a methacrylic acid copolymer on macrophages. Proc Natl Acad Sci U S A (2015) 0.75
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5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer (2003) 11.78
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (2011) 10.26
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res (1995) 6.24
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73
Altered telomeres in tumors with ATRX and DAXX mutations. Science (2011) 4.60
MyoD is required for myogenic stem cell function in adult skeletal muscle. Genes Dev (1996) 4.59
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. Cell (2010) 4.34
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev (2010) 4.00
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget (2012) 3.88
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A (2003) 3.52
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Genome Res (2010) 3.46
Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nat Genet (2000) 3.24
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Proc Natl Acad Sci U S A (1998) 3.14
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome). Cell (1995) 3.09
Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. J Virol (1995) 3.06
Critical role for Daxx in regulating Mdm2. Nat Cell Biol (2006) 2.96
Toll receptors, CD14, and macrophage activation and deactivation by LPS. Microbes Infect (2002) 2.90
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur J Cancer (1998) 2.29
Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. Proc Natl Acad Sci U S A (1999) 2.24
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A (1998) 2.20
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18
Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol (2012) 2.17
Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin. J Biol Chem (2003) 2.15
Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes Dev (1998) 2.12
Mutations in the chromatin-associated protein ATRX. Hum Mutat (2008) 2.12
Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation. Curr Biol (1999) 2.08
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. Mol Cell Biol (2006) 2.04
A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. J Biol Chem (2004) 1.98
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A (2007) 1.84
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Nat Struct Mol Biol (2011) 1.79
Loss of ATRX leads to chromosome cohesion and congression defects. J Cell Biol (2008) 1.79
Strand pairing by Rad54 and Rad51 is enhanced by chromatin. Genes Dev (2002) 1.74
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest (2005) 1.74
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9. Hum Mol Genet (2011) 1.67
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet (2006) 1.64
Nuclear structure in normal and Bloom syndrome cells. Proc Natl Acad Sci U S A (2000) 1.60
Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association. Hum Mol Genet (2000) 1.59
Interaction of human recombination proteins Rad51 and Rad54. Nucleic Acids Res (1997) 1.54
Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors. J Gen Virol (1997) 1.53
Alpha thalassaemia-mental retardation, X linked. Orphanet J Rare Dis (2006) 1.51
Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. Hum Mol Genet (1998) 1.42
HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions. J Cell Biol (2008) 1.27
Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains. Mamm Genome (1998) 1.13
Development of a size-restricted pIX-deleted helper virus for amplification of helper-dependent adenovirus vectors. Gene Ther (2004) 1.11
Patient mutations alter ATRX targeting to PML nuclear bodies. Eur J Hum Genet (2007) 1.05
Concern Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis. J Cell Sci (2011) 1.03
Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J Neurosci (2008) 0.96
Cancer therapy utilizing an adenoviral vector expressing only E1A. Cancer Gene Ther (2002) 0.93
Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet (2011) 0.92
Loss of ATRX in chondrocytes has minimal effects on skeletal development. PLoS One (2009) 0.90
Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome. Hum Mol Genet (2008) 0.90
dXNP/DATRX increases apoptosis via the JNK and dFOXO pathway in Drosophila neurons. Biochem Biophys Res Commun (2009) 0.83
Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide. Res Vet Sci (2008) 0.83
Construction and characterization of adenovirus vectors. Cold Spring Harb Protoc (2009) 0.82
dXNP, a Drosophila homolog of XNP/ATRX, induces apoptosis via Jun-N-terminal kinase activation. FEBS Lett (2007) 0.82
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature (2008) 9.01
Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J Cell Biol (2006) 3.22
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. Mol Cell Biol (2006) 2.04
A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. J Biol Chem (2004) 1.98
Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest (2005) 1.74
Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. J Virol (2004) 1.70
T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6. Pediatr Blood Cancer (2010) 1.67
Pax7 is critical for the normal function of satellite cells in adult skeletal muscle. Proc Natl Acad Sci U S A (2013) 1.66
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet (2009) 1.47
Preparation of helper-dependent adenoviral vectors. Methods Mol Med (2002) 1.40
Snapshots: chromatin control of viral infection. Virology (2013) 1.39
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Mol Biol Cell (2009) 1.28
Separating fact from fiction: assessing the potential of modified adenovirus vectors for use in human gene therapy. Curr Gene Ther (2002) 1.22
Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions. J Lipid Res (2010) 1.21
Use of adenovirus protein IX (pIX) to display large polypeptides on the virion--generation of fluorescent virus through the incorporation of pIX-GFP. Mol Ther (2004) 1.21
A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells. Stem Cells (2010) 1.15
Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice. Hum Mol Genet (2002) 1.13
Chromatin structure of adenovirus DNA throughout infection. Nucleic Acids Res (2011) 1.11
Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. PLoS One (2012) 1.08
Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity. PLoS One (2013) 1.06
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1. J Lipid Res (2003) 1.06
Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months. Biol Psychiatry (2011) 1.05
Patient mutations alter ATRX targeting to PML nuclear bodies. Eur J Hum Genet (2007) 1.05
Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies. FASEB J (2005) 1.05
PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. J Proteome Res (2012) 1.02
Persistence of transgene expression influences CD8+ T-cell expansion and maintenance following immunization with recombinant adenovirus. J Virol (2009) 1.02
Further clinical delineation of the Börjeson-Forssman-Lehmann syndrome in patients with PHF6 mutations. Am J Med Genet A (2009) 1.01
Increasing D4Z4 repeat copy number compromises C2C12 myoblast differentiation. FEBS Lett (2003) 0.98
SCO-ping out the mechanisms underlying the etiology of hydrocephalus. Physiology (Bethesda) (2009) 0.97
DNA genome size affects the stability of the adenovirus virion. J Virol (2008) 0.96
A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. J Biol Chem (2004) 0.95
Regulation of neurite outgrowth in N1E-115 cells through PDZ-mediated recruitment of diacylglycerol kinase zeta. Mol Cell Biol (2005) 0.95
Assembly of helper-dependent adenovirus DNA into chromatin promotes efficient gene expression. J Virol (2011) 0.94
Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain. Dev Cell (2012) 0.94
The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. Mol Biol Cell (2009) 0.94
Cancer therapy utilizing an adenoviral vector expressing only E1A. Cancer Gene Ther (2002) 0.93
Activation of adenoviral gene expression by protein IX is not required for efficient virus replication. J Virol (2004) 0.93
Compromised genomic integrity impedes muscle growth after Atrx inactivation. J Clin Invest (2012) 0.92
Use of a murine secreted alkaline phosphatase as a non-immunogenic reporter gene in mice. J Gene Med (2005) 0.92
Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression. J Am Soc Nephrol (2013) 0.91
Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome. Hum Mol Genet (2008) 0.90
Host cell detection of noncoding stuffer DNA contained in helper-dependent adenovirus vectors leads to epigenetic repression of transgene expression. J Virol (2009) 0.89
Retargeting of adenovirus vectors through genetic fusion of a single-chain or single-domain antibody to capsid protein IX. J Virol (2010) 0.88
Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components. Eur J Cell Biol (2011) 0.87
The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells. Mol Endocrinol (2006) 0.87
The RNA-binding protein HuR binds to acetylcholinesterase transcripts and regulates their expression in differentiating skeletal muscle cells. J Biol Chem (2005) 0.86
Use of an improved quantitative polymerase chain reaction assay to determine differences in human rhinovirus viral loads in different populations. Diagn Microbiol Infect Dis (2012) 0.86
Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons. Mol Cell Neurosci (2010) 0.84
Helper-dependent adenoviral vectors containing modified fiber for improved transduction of developing and mature muscle cells. Hum Gene Ther (2004) 0.84
Adenovirus virion stability and the viral genome: size matters. Mol Ther (2009) 0.84
ISWI chromatin remodeling in ovarian somatic and germ cells: revenge of the NURFs. Trends Endocrinol Metab (2007) 0.83
The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy. J Neurosci (2007) 0.83
Characterization of novel isoforms and evaluation of SNF2L/SMARCA1 as a candidate gene for X-linked mental retardation in 12 families linked to Xq25-26. BMC Med Genet (2008) 0.82
Construction and characterization of adenovirus vectors. Cold Spring Harb Protoc (2009) 0.82
Development of a gene therapy strategy for the restoration of survival motor neuron protein expression: implications for spinal muscular atrophy therapy. Hum Gene Ther (2003) 0.82
Diacylglycerol kinase ζ regulates RhoA activation via a kinase-independent scaffolding mechanism. Mol Biol Cell (2012) 0.81
Börjeson-Forssman-Lehmann Syndrome due to a novel plant homeodomain zinc finger mutation in the PHF6 gene. J Child Neurol (2009) 0.81
Secretion of triacylglycerol-poor VLDL particles from McA-RH7777 cells expressing human hepatic lipase. J Lipid Res (2010) 0.79
Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal. Hum Mol Genet (2012) 0.79
Matters of life and death: the role of chromatin remodeling proteins in retinal neuron survival. J Ocul Biol Dis Infor (2012) 0.79
Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan. J Biol Chem (2004) 0.78
Use of Cre/loxP recombination to swap cell binding motifs on the adenoviral capsid protein IX. Virology (2011) 0.78
The imitation switch ATPase Snf2l is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells. Biol Reprod (2013) 0.78
Supraphysiological expression of survival motor neuron protein from an adenovirus vector does not adversely affect cell function. Biochem Cell Biol (2013) 0.78
The role of chromatin in adenoviral vector function. Viruses (2013) 0.78
Rational design of murine secreted alkaline phosphatase for enhanced performance as a reporter gene in mouse gene therapy preclinical studies. Hum Gene Ther (2011) 0.77
Disparate regulation of LPS-induced MAPK signaling and IL-12p40 expression between different myeloid cell types with and without HIV infection. Viral Immunol (2010) 0.77
Oncolytic adenovirus: getting there is half the battle. Mol Ther (2003) 0.75