Lithium treatment moderate-dose use study (LiTMUS) for bipolar disorder: a randomized comparative effectiveness trial of optimized personalized treatment with and without lithium.

PubWeight™: 2.80‹?› | Rank: Top 1%

🔗 View Article (PMID 23288387)

Published in Am J Psychiatry on January 01, 2013

Authors

Andrew A Nierenberg1, Edward S Friedman, Charles L Bowden, Louisa G Sylvia, Michael E Thase, Terence Ketter, Michael J Ostacher, Andrew C Leon, Noreen Reilly-Harrington, Dan V Iosifescu, Michael Pencina, Joanne B Severe, Joseph R Calabrese

Author Affiliations

1: Massachusetts General Hospital, Boston, USA. anierenberg@partners.org

Associated clinical trials:

Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder (LiTMUS) | NCT00667745

Articles citing this

In whom does lithium work? Am J Psychiatry (2013) 1.07

Applications of time-series analysis to mood fluctuations in bipolar disorder to promote treatment innovation: a case series. Transl Psychiatry (2016) 0.82

Lithium efficacy in bipolar depression with flexible dosing: A six-week, open-label, proof-of-concept study. Exp Ther Med (2014) 0.78

The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry (2016) 0.78

Practical clinical trials in psychopharmacology: a systematic review. J Clin Psychopharmacol (2015) 0.77

An exploratory study of responses to low-dose lithium in African Americans and Hispanics. J Affect Disord (2015) 0.76

A simple question answered: adding moderate-dosage lithium does not help patients with bipolar disorder. Am J Psychiatry (2013) 0.75

Illness progression as a function of independent and accumulating poor prognosis factors in outpatients with bipolar disorder in the United States. Prim Care Companion CNS Disord (2014) 0.75

Diagnosis and treatment of patients with bipolar disorder: A review for advanced practice nurses. J Am Assoc Nurse Pract (2015) 0.75

Response to Carlson letter. Am J Psychiatry (2013) 0.75

Who will benefit from antidepressants in the acute treatment of bipolar depression? A reanalysis of the STEP-BD study by Sachs et al. 2007, using Q-learning. Int J Bipolar Disord (2015) 0.75

Testing for clinical inertia in medication treatment of bipolar disorder. J Affect Disord (2016) 0.75

A novel application of the Intent to Attend assessment to reduce bias due to missing data in a randomized controlled clinical trial. Clin Trials (2014) 0.75

Does the "Silver Bullet" Lose its Shine Over the Time? Assessment of Loss of Lithium Response in a Preliminary Sample of Bipolar Disorder Outpatients. Clin Pract Epidemiol Ment Health (2016) 0.75

Articles by these authors

The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry (2003) 13.60

Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry (2006) 12.41

The NimStim set of facial expressions: judgments from untrained research participants. Psychiatry Res (2009) 11.53

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet (2008) 10.49

Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med (2007) 8.07

The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry (2002) 6.99

Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design. Control Clin Trials (2004) 6.64

A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34

Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. N Engl J Med (2006) 6.00

Medication augmentation after the failure of SSRIs for depression. N Engl J Med (2006) 5.16

Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study. Psychiatr Clin North Am (2003) 5.05

Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry (2013) 4.84

Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry (2005) 4.81

Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet (2003) 4.79

A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia. Schizophr Bull (2005) 4.66

Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biol Psychiatry (2006) 4.37

Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990-98. Addiction (2003) 4.25

Screening for bipolar disorder in the community. J Clin Psychiatry (2003) 4.24

Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry (2002) 4.08

Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. Am J Psychiatry (2009) 3.96

Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report. Am J Psychiatry (2006) 3.90

The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD. Am J Psychiatry (2008) 3.82

Report by the ACNP Task Force on response and remission in major depressive disorder. Neuropsychopharmacology (2006) 3.80

Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study). J Clin Psychopharmacol (2006) 3.77

L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatry (2012) 3.73

Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet (2010) 3.72

Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry (2006) 3.66

The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a second multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol (2008) 3.65

Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry (2003) 3.60

A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Arch Gen Psychiatry (2003) 3.59

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009. Bipolar Disord (2009) 3.56

Suicide among New York City police officers, 1977-1996. Am J Psychiatry (2002) 3.51

Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry (2004) 3.43

Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program. Arch Gen Psychiatry (2007) 3.38

3-year follow-up of the NIMH MTA study. J Am Acad Child Adolesc Psychiatry (2007) 3.33

C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Arch Intern Med (2005) 3.31

Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Arch Gen Psychiatry (2005) 3.23

Why do clinical trials fail? The problem of measurement error in clinical trials: time to test new paradigms? J Clin Psychopharmacol (2007) 2.99

A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report. Am J Psychiatry (2006) 2.90

Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report. Am J Psychiatry (2007) 2.84

The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer. Am J Psychiatry (2014) 2.82

Improving clinical trials: American Society of Clinical Psychopharmacology recommendations. Arch Gen Psychiatry (2002) 2.70

Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy. Am J Psychiatry (2006) 2.69

A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry (2003) 2.69

Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol Psychiatry (2012) 2.69

Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety. Am J Psychiatry (2002) 2.59

Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proc Natl Acad Sci U S A (2003) 2.56

Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection. Arch Intern Med (2010) 2.55

Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshop. Schizophr Bull (2006) 2.53

C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. Circ Cardiovasc Qual Outcomes (2008) 2.50

Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial. Am J Psychiatry (2007) 2.43

Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study. Arch Gen Psychiatry (2005) 2.32

A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report. Am J Psychiatry (2006) 2.21

Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine. Am J Psychiatry (2006) 2.19

Subthreshold hypomanic symptoms in progression from unipolar major depression to bipolar disorder. Am J Psychiatry (2010) 2.18

A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorder. J Clin Psychiatry (2006) 2.17

Mixed features in patients with a major depressive episode: the BRIDGE-II-MIX study. J Clin Psychiatry (2015) 2.15

Prevalence and correlates of tobacco use in bipolar disorder: data from the first 2000 participants in the Systematic Treatment Enhancement Program. Gen Hosp Psychiatry (2005) 2.13

Randomized, placebo-controlled trial of fluoxetine for acute treatment of minor depressive disorder. Am J Psychiatry (2004) 2.11

Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode: the BRIDGE study. Arch Gen Psychiatry (2011) 2.10

Validity of the mood disorder questionnaire: a general population study. Am J Psychiatry (2003) 2.10

Troponin criteria for myocardial infarction after percutaneous coronary intervention. Arch Intern Med (2012) 2.09

Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry (2004) 2.04

Which treatment for whom for ADHD? Moderators of treatment response in the MTA. J Consult Clin Psychol (2003) 2.02

Prevalence and prognostic significance of preprocedural cardiac troponin elevation among patients with stable coronary artery disease undergoing percutaneous coronary intervention: results from the evaluation of drug eluting stents and ischemic events registry. Circulation (2008) 2.01

Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy. Arch Gen Psychiatry (2002) 2.01

Income distribution and risk of fatal drug overdose in New York City neighborhoods. Drug Alcohol Depend (2003) 2.01

Rationale and design of the dual antiplatelet therapy study, a prospective, multicenter, randomized, double-blind trial to assess the effectiveness and safety of 12 versus 30 months of dual antiplatelet therapy in subjects undergoing percutaneous coronary intervention with either drug-eluting stent or bare metal stent placement for the treatment of coronary artery lesions. Am Heart J (2010) 2.00

Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study. Arch Gen Psychiatry (2005) 1.99

Fluoxetine increases suicide ideation less than placebo during treatment of adults with minor depressive disorder. J Psychiatr Res (2013) 1.99

Delinquent behavior and emerging substance use in the MTA at 36 months: prevalence, course, and treatment effects. J Am Acad Child Adolesc Psychiatry (2007) 1.98

The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry (2013) 1.97

Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry (2009) 1.96

A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder. Am J Psychiatry (2007) 1.93

Comprehensive analysis of remission (COMPARE) with venlafaxine versus SSRIs. Biol Psychiatry (2007) 1.93

The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders. Bipolar Disord (2009) 1.91

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord (2009) 1.90

A cross-sectional study of the prevalence of cognitive and physical symptoms during long-term antidepressant treatment. J Clin Psychiatry (2006) 1.90

Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD. Am J Psychiatry (2007) 1.88

Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nucl Med Biol (2007) 1.87