PubRank

Ulf R Rapp

Author PubWeight™ 69.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J Carcinog 2004 3.02
2 Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol 2005 2.41
3 Ras oncogenes and their downstream targets. Biochim Biophys Acta 2007 2.00
4 X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nat Cell Biol 2008 1.55
5 MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. J Biol Chem 2004 1.48
6 Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc Natl Acad Sci U S A 2004 1.43
7 Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer. Cancer Cell 2007 1.35
8 Raf kinases: oncogenesis and drug discovery. Int J Cancer 2006 1.25
9 Regulation of glycolysis by Raf protein serine/threonine kinases. Adv Enzyme Regul 2002 1.15
10 Immunogenicity of constitutively active V599EBRaf. Cancer Res 2004 1.12
11 Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci 2005 1.10
12 Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma. J Invest Dermatol 2008 1.09
13 Negative regulation of mitochondrial VDAC channels by C-Raf kinase. BMC Cell Biol 2002 1.04
14 Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism. Anticancer Res 2008 1.02
15 Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins. J Biol Chem 2008 1.02
16 Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure. BMC Cancer 2004 1.01
17 Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding. J Biol Chem 2006 1.01
18 Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts. J Biol Chem 2002 1.00
19 Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells. Int J Cancer 2012 0.99
20 BAG-1 haplo-insufficiency impairs lung tumorigenesis. BMC Cancer 2004 0.99
21 Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase. J Biol Chem 2011 0.97
22 Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch. Cancer Res 2003 0.97
23 B-Raf specific antibody responses in melanoma patients. BMC Cancer 2004 0.96
24 B-Raf/Rap1 signaling, but not c-Raf-1/Ras, induces the histidine decarboxylase promoter in Helicobacter pylori infection. FASEB J 2002 0.95
25 Raf and the road to cell survival: a tale of bad spells, ring bearers and detours. Biochem Pharmacol 2003 0.95
26 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol Cell Biol 2010 0.95
27 Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer. PLoS One 2009 0.95
28 Validation of a liquid chromatography assay for the quantification of the Raf kinase inhibitor BAY 43-9006 in small volumes of mouse serum. J Chromatogr B Analyt Technol Biomed Life Sci 2004 0.94
29 Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling. Oncogene 2002 0.94
30 Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene. Int J Oncol 2007 0.93
31 Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation. FEBS Lett 2005 0.93
32 B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding. J Biol Chem 2007 0.92
33 KSR--a regulator and scaffold protein of the MAPK pathway. Sci STKE 2002 0.92
34 Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice. BMC Cancer 2005 0.92
35 Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites. J Biol Chem 2003 0.91
36 A-RAF kinase functions in ARF6 regulated endocytic membrane traffic. PLoS One 2009 0.91
37 RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development. PLoS One 2010 0.91
38 The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways. Int J Cancer 2007 0.90
39 Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf. Cancer Res 2002 0.89
40 Isoform-specific interaction of C-RAF with mitochondria. J Biol Chem 2008 0.89
41 Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates. J Biol Chem 2007 0.88
42 Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum. PLoS One 2013 0.88
43 Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype. J Biol Chem 2002 0.87
44 Ras signaling: PP2A puts Ksr and Raf in the right place. Curr Biol 2003 0.86
45 Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites. J Biol Chem 2008 0.86
46 Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice. Oncogene 2004 0.86
47 Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. J Biol Chem 2009 0.86
48 Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines. BMC Microbiol 2011 0.85
49 Tumor induction by activated JNK occurs through deregulation of cellular growth. Cancer Lett 2004 0.85
50 Mitogen-activated 3p kinase is active in the nucleus. Exp Cell Res 2004 0.84
51 Cortical migration defects in mice expressing A-RAF from the B-RAF locus. Mol Cell Biol 2006 0.84
52 Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling. Cell Signal 2007 0.83
53 Vivotif--a 'magic shield' for protection against typhoid fever and delivery of heterologous antigens. Chemotherapy 2007 0.82
54 BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling. J Biol Chem 2011 0.82
55 Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression. PLoS One 2010 0.81
56 Use of the alpha-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain. Int J Med Microbiol 2004 0.81
57 Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages. Immunol Cell Biol 2011 0.80
58 Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways. Biochem J 2002 0.80
59 Improvement of the live vaccine strain Salmonella enterica serovar Typhi Ty21a for antigen delivery via the hemolysin secretion system of Escherichia coli. Int J Med Microbiol 2008 0.80
60 E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice. Neoplasia 2012 0.79
61 Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem 2012 0.79
62 Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part. Biochim Biophys Acta 2010 0.78
63 Conditional expression of oncogenic C-RAF in mouse pulmonary epithelial cells reveals differential tumorigenesis and induction of autophagy leading to tumor regression. Neoplasia 2011 0.78
64 MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma. Mol Cancer Res 2012 0.78
65 Can BAD pores be good? New insights from examining BAD as a target of RAF kinases. Adv Enzyme Regul 2009 0.77
66 Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanoma. J Carcinog 2005 0.76
67 Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice. PLoS One 2011 0.75
68 The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF. J Biol Chem 2012 0.75
69 Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. J Biol Chem 2013 0.75
70 C-Raf controlled pathways in the protection of tumor cells from apoptosis. Int J Cancer 2003 0.75
71 Correction: Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation. Cancer Res 2022 0.75
72 B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade. Biol Chem 2005 0.75
73 Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control. Biochim Biophys Acta 2002 0.75