Published in Neurobiol Dis on January 08, 2013
Brain Injury Therapy of Exercise and Enriched Environment (BITEEE) | NCT03256643
Treating Persistent Post-concussion Symptoms With Exercise | NCT03895450
Reactive gliosis and the multicellular response to CNS damage and disease. Neuron (2014) 2.08
Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. J Neuropathol Exp Neurol (2014) 1.29
Microglia in the TBI brain: The good, the bad, and the dysregulated. Exp Neurol (2015) 1.10
Neuroprotective strategies for traumatic brain injury: improving clinical translation. Int J Mol Sci (2014) 1.04
Modulation of adult-born neurons in the inflamed hippocampus. Front Cell Neurosci (2013) 0.94
Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation? Neurotherapeutics (2015) 0.94
CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab (2014) 0.93
Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury. Br J Pharmacol (2015) 0.83
Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies. Front Neurol (2015) 0.82
Chronic Histopathological and Behavioral Outcomes of Experimental Traumatic Brain Injury in Adult Male Animals. J Neurotrauma (2015) 0.81
Strategies targeting endogenous neurogenic cell response to improve recovery following traumatic brain injury. Brain Res (2016) 0.77
Physical Exercise as a Diagnostic, Rehabilitation, and Preventive Tool: Influence on Neuroplasticity and Motor Recovery after Stroke. Neural Plast (2015) 0.76
Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia. Neurobiol Stress (2016) 0.76
Robust training attenuates TBI-induced deficits in reference and working memory on the radial 8-arm maze. Front Behav Neurosci (2013) 0.76
The Effects of Exercise on Cognitive Recovery after Acquired Brain Injury in Animal Models: A Systematic Review. Neural Plast (2015) 0.76
Voluntary Exercise Preconditioning Activates Multiple Antiapoptotic Mechanisms and Improves Neurological Recovery after Experimental Traumatic Brain Injury. J Neurotrauma (2015) 0.76
A CONCEPTUAL MODEL FOR PHYSICAL THERAPISTS TREATING ATHLETES WITH PROTRACTED RECOVERY FOLLOWING A CONCUSSION. Int J Sports Phys Ther (2017) 0.75
Delayed voluntary exercise does not enhance cognitive performance after hippocampal injury: an investigation of differentially distributed exercise protocols. J Exerc Rehabil (2016) 0.75
Exercise attenuates neurological deficits by stimulating a critical HSP70/NF-κB/IL-6/synapsin I axis in traumatic brain injury rats. J Neuroinflammation (2017) 0.75
Tetramethylpyrazine attenuates periorbital allodynia and neuroinflammation in a model of traumatic brain injury. J Inflamm (Lond) (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A (1999) 8.83
The anti-inflammatory effect of exercise. J Appl Physiol (1985) (2005) 6.87
The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev (2005) 4.64
Impaired recognition memory in rats after damage to the hippocampus. J Neurosci (2000) 4.07
Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J Neurosci (2007) 3.93
Inflammation after trauma: microglial activation and traumatic brain injury. Ann Neurol (2011) 3.42
Cellular and molecular mechanisms of neural repair after stroke: making waves. Ann Neurol (2006) 2.83
Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics (2010) 2.52
Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol Sci (2010) 2.40
Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience (2004) 2.15
Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. Brain Behav Immun (2012) 2.14
Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord. J Appl Physiol (1985) (2006) 2.14
Efficacy of rehabilitative experience declines with time after focal ischemic brain injury. J Neurosci (2004) 2.06
Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies. Prog Brain Res (2007) 1.97
Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine. J Neurosci (2001) 1.66
Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. Brain Behav Immun (2011) 1.64
Progressive atrophy and neuron death for one year following brain trauma in the rat. J Neurotrauma (1997) 1.64
Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods. J Neurosci Res (2001) 1.62
Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J Neurosci (1996) 1.61
Use-dependent growth of pyramidal neurons after neocortical damage. J Neurosci (1994) 1.60
Dynamic changes in local cerebral glucose utilization following cerebral conclusion in rats: evidence of a hyper- and subsequent hypometabolic state. Brain Res (1991) 1.60
Recovery recapitulates ontogeny. Trends Neurosci (2000) 1.59
Cell death mechanisms and modulation in traumatic brain injury. Neurotherapeutics (2010) 1.54
Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Sci Int (2004) 1.48
Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain. Glia (2005) 1.42
Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent. J Neurotrauma (2007) 1.36
Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learn Mem (2011) 1.36
Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. J Neuroinflammation (2012) 1.31
Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. J Neurochem (2002) 1.30
Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B). Neuropsychopharmacology (2007) 1.29
Neuronal hyperexcitability and reduction of GABAA-receptor expression in the surround of cerebral photothrombosis. J Cereb Blood Flow Metab (1996) 1.29
The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise. Brain Res (2004) 1.27
Lesion-induced plasticity as a potential mechanism for recovery and rehabilitative training. Curr Opin Neurol (1998) 1.25
Quantitative structural changes in white and gray matter 1 year following traumatic brain injury in rats. Acta Neuropathol (2002) 1.23
Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp Neurol (1998) 1.23
Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma. J Cereb Blood Flow Metab (2011) 1.19
Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury. J Neurosci (2012) 1.16
Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury. J Neuroinflammation (2010) 1.15
Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period. Brain Res (1998) 1.15
Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem (2009) 1.15
Early training may exacerbate brain damage after focal brain ischemia in the rat. J Cereb Blood Flow Metab (1999) 1.13
Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic-ischemic brain injury. J Neurosci (2010) 1.13
Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system. Prog Neurobiol (1999) 1.13
Delayed and remote effects of focal cortical infarctions: secondary damage and reactive plasticity. Adv Neurol (1997) 1.05
Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury. J Neurotrauma (2012) 1.04
Metabolic changes following cortical contusion: relationships to edema and morphological changes. Acta Neurochir Suppl (Wien) (1994) 1.04
Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Brain Res (2012) 0.98
Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats. Am J Physiol (1997) 0.96
Effectiveness of physical therapy for improving gait and balance in individuals with traumatic brain injury: a systematic review. Brain Inj (2011) 0.95
Changes in cellular bioenergetic state following graded traumatic brain injury in rats: determination by phosphorus 31 magnetic resonance spectroscopy. J Neurotrauma (1988) 0.92
Exercise pre-conditioning reduces brain inflammation and protects against toxicity induced by traumatic brain injury: behavioral and neurochemical approach. Neurotox Res (2011) 0.90
Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma. J Biol Chem (1988) 0.90
Randomized controlled trials in adult traumatic brain injury. Brain Inj (2012) 0.88
Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury. J Neural Transm (Vienna) (2011) 0.88
Injury-induced physiological events that may modulate gene expression in neurons and glia. Rev Neurosci (1998) 0.87
Physical activity, exercise, and immune function. Brain Behav Immun (2005) 0.87
Complement C1qB and C4 mRNAs responses to lesioning in rat brain. Exp Neurol (1992) 0.87
Effects of cortical ischemia and postischemic environmental enrichment on hippocampal cell genesis and differentiation in the adult rat. J Cereb Blood Flow Metab (2002) 0.87
Microglial activation and traumatic brain injury. Ann Neurol (2011) 0.86
Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury. Neurobiol Dis (2012) 0.86
Blockade of basic fibroblast growth factor retards recovery from motor cortex injury in rats. Eur J Neurosci (1997) 0.85
Early overuse and disuse of the affected forelimb after moderately severe intraluminal suture occlusion of the middle cerebral artery in rats. Behav Brain Res (2001) 0.84
The effects of acute voluntary wheel running on recovery of function following medial frontal cortical contusions in rats. Restor Neurol Neurosci (2012) 0.81
Long-term changes of ionotropic glutamate and GABA receptors after unilateral permanent focal cerebral ischemia in the mouse brain. Neuroscience (1998) 0.81
The behavioral neurobiology of learning and memory: a conceptual reorientation. Brain Res Brain Res Rev (1994) 0.80
Fixed-ratio discrimination training as replacement therapy in Parkinson's disease: studies in a 6-hydroxydopamine-treated rat model. Brain Res (1998) 0.78
Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol Sci (2010) 2.40
Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. Brain Behav Immun (2012) 2.14
Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci U S A (2005) 2.10
Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Ann Neurol (2003) 2.06
Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med (2009) 1.95
Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev (2006) 1.86
Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain (2007) 1.56
Cell death mechanisms and modulation in traumatic brain injury. Neurotherapeutics (2010) 1.54
The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. EMBO J (2006) 1.54
Propofol limits microglial activation after experimental brain trauma through inhibition of nicotinamide adenine dinucleotide phosphate oxidase. Anesthesiology (2013) 1.49
Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Aging (2012) 1.41
Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma. J Cereb Blood Flow Metab (2008) 1.41
Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle (2005) 1.32
Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. J Neuroinflammation (2012) 1.31
Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. J Neuropathol Exp Neurol (2014) 1.29
Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia (2009) 1.28
BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem (2004) 1.25
Gene expression profile changes are commonly modulated across models and species after traumatic brain injury. J Neurotrauma (2003) 1.25
The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats. Neurobiol Dis (2004) 1.21
Role of cell cycle proteins in CNS injury. Neurochem Res (2007) 1.21
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. Mol Cell Neurosci (2003) 1.20
In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury. J Biol Chem (2004) 1.20
Environmental enrichment enhances neurogranin expression and hippocampal learning and memory but fails to rescue the impairments of neurogranin null mutant mice. J Neurosci (2006) 1.20
Gene expression profiling of experimental traumatic spinal cord injury as a function of distance from impact site and injury severity. Physiol Genomics (2005) 1.19
Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma. J Cereb Blood Flow Metab (2011) 1.19
Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab (2004) 1.16
Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem (2009) 1.15
Expression of two temporally distinct microglia-related gene clusters after spinal cord injury. Glia (2006) 1.14
Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol Cell Neurosci (2005) 1.14
Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and phosphatidylinositol 3-kinase activation. J Neurosci (2010) 1.13
Glial scar expression of CHL1, the close homolog of the adhesion molecule L1, limits recovery after spinal cord injury. J Neurosci (2007) 1.11
Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth. FASEB J (2004) 1.09
Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury. Brain (2007) 1.08
Multiple caspases are activated after traumatic brain injury: evidence for involvement in functional outcome. J Neurotrauma (2002) 1.07
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. J Neurochem (2012) 1.07
Cell cycle activation and CNS injury. Neurotox Res (2009) 1.06
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. Br J Pharmacol (2005) 1.05
Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders. Neurotherapeutics (2009) 1.05
MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. J Neurochem (2004) 1.04
A combined scoring method to assess behavioral recovery after mouse spinal cord injury. Neurosci Res (2010) 1.04
Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury. J Neurotrauma (2012) 1.04
Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol (2009) 1.04
Gut microbiota composition modifies fecal metabolic profiles in mice. J Proteome Res (2013) 1.03
Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion. J Neuroinflammation (2012) 1.02
Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus. Neurobiol Aging (2006) 1.02
CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury. Neurotherapeutics (2012) 1.02
Delayed inflammatory mRNA and protein expression after spinal cord injury. J Neuroinflammation (2011) 1.01
Fluid-percussion-induced traumatic brain injury model in rats. Nat Protoc (2010) 1.00
High-fat diet induces dynamic metabolic alterations in multiple biological matrices of rats. J Proteome Res (2013) 0.99
Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Brain Res (2012) 0.98
Neuropathological differences between rats and mice after spinal cord injury. J Magn Reson Imaging (2010) 0.98
Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury. J Neurotrauma (2011) 0.98
Cell cycle activation and spinal cord injury. Neurotherapeutics (2011) 0.97
Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current. Pharmacol Biochem Behav (2002) 0.97
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. Autophagy (2014) 0.96
Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies. NeuroRx (2004) 0.96
Multifunctional drug treatment in neurotrauma. Neurotherapeutics (2009) 0.96
Cyclin D1 gene ablation confers neuroprotection in traumatic brain injury. J Neurotrauma (2012) 0.96
TGF-β1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production. BMC Dev Biol (2014) 0.96
Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis in vitro and confers neuroprotection after spinal cord injury in vivo. PLoS One (2012) 0.95
Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury. J Neurotrauma (2013) 0.95
Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. Learn Mem (2013) 0.94
Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats. Neurochem Int (2009) 0.94
Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation? Neurotherapeutics (2015) 0.94
Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes. Pharmacol Toxicol (2002) 0.94
Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. J Neurosci Res (2002) 0.93