Published in Int J Mol Med on January 11, 2013
Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment. Ann N Y Acad Sci (2014) 1.01
Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway. J Biol Chem (2015) 0.78
Voluntary Exercise Can Ameliorate Insulin Resistance by Reducing iNOS-Mediated S-Nitrosylation of Akt in the Liver in Obese Rats. PLoS One (2015) 0.75
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol (2001) 10.85
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature (1994) 6.50
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci (2001) 6.11
The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE (2001) 6.09
The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med (2005) 5.95
Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci (2004) 4.40
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol (2002) 3.77
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell (2002) 3.53
PKB binding proteins. Getting in on the Akt. Cell (2002) 3.34
Insulin signaling in health and disease. Science (2003) 2.93
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A (2006) 2.89
NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation. Arch Biochem Biophys (1995) 2.70
Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells. Proc Natl Acad Sci U S A (2006) 2.58
The biochemistry and physiology of S-nitrosothiols. Annu Rev Pharmacol Toxicol (2002) 2.23
Protein kinase B/Akt at a glance. J Cell Sci (2005) 2.18
Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol (1997) 2.02
S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem (2005) 1.96
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes (2005) 1.91
AKT crystal structure and AKT-specific inhibitors. Oncogene (2005) 1.67
Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners. Endocrinology (2005) 1.64
Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition. PLoS One (2010) 1.62
Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. J Biol Chem (2003) 1.49
Crystal structure of an inactive Akt2 kinase domain. Structure (2003) 1.48
Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation. Life Sci (2005) 1.39
Nitrosative stress and pathogenesis of insulin resistance. Antioxid Redox Signal (2007) 1.38
Detection and proteomic identification of S-nitrosylated proteins in endothelial cells. Arch Biochem Biophys (2004) 1.36
Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients. J Endocrinol (2004) 1.31
Inverse regulation of protein turnover and amino acid transport in skeletal muscle of hypercatabolic patients. J Clin Endocrinol Metab (2002) 1.29
Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. J Biol Chem (1997) 1.29
Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle. Am J Physiol Endocrinol Metab (2004) 1.18
Proteomic analysis of S-nitrosylated proteins in mesangial cells. Mol Cell Proteomics (2003) 1.16
Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab (2006) 1.13
The PKB/FOXO switch in aging and cancer. Biochim Biophys Acta (2011) 1.12
Insulin: a wonder drug in the critically ill? Crit Care (2002) 1.08
Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates. J Biomol NMR (2004) 1.06
Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue. Int J Mol Med (2004) 1.04
Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4. Mol Cell Biochem (2000) 1.04
Interdomain conformational changes in Akt activation revealed by chemical cross-linking and tandem mass spectrometry. Mol Cell Proteomics (2006) 1.01
Nitrosative stress in the ER: a new role for S-nitrosylation in neurodegenerative diseases. ACS Chem Biol (2006) 1.01
Regulation and specificity of S-nitrosylation and denitrosylation. ACS Chem Biol (2006) 1.01
Nitric oxide production is intensely and persistently increased in tissue by thermal injury. Biochem J (1994) 0.98
Site-specific detection of S-nitrosylated PKB alpha/Akt1 from rat soleus muscle using CapLC-Q-TOF(micro) mass spectrometry. J Mass Spectrom (2005) 0.88
Another role for the celebrity: Akt and insulin resistance. Circ Res (2005) 0.88
Glucose control by insulin for critically ill surgical patients. J Trauma (2004) 0.88
Cell signaling. A new way to burn fat. Science (2006) 0.81
A new approach for sequencing human IRS1 phosphotyrosine-containing peptides using CapLC-Q-TOF(micro). J Mass Spectrom (2005) 0.80
Roles of nitric oxide and prostaglandins in pathogenesis of delayed colonic transit after burn injury in rats. Am J Physiol Regul Integr Comp Physiol (2005) 0.80
Common virulence factors for bacterial pathogenicity in plants and animals. Science (1995) 11.22
Objective estimates of the probability of death from burn injuries. N Engl J Med (1998) 5.56
Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Proc Natl Acad Sci U S A (1999) 5.10
Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors. Proc Natl Acad Sci U S A (1997) 3.88
Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat Neurosci (1998) 3.71
Plants and animals share functionally common bacterial virulence factors. Proc Natl Acad Sci U S A (2000) 3.21
Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Prog (1991) 3.21
Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis (1990) 3.20
Imaging amyloid deposition in Lewy body diseases. Neurology (2008) 3.09
Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet (2000) 2.95
Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration. FASEB J (1989) 2.89
Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry (1994) 2.70
A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiatry (1996) 2.22
When magic bullets ricochet. J Nucl Med (1990) 2.01
Technetium-99m-human polyclonal IgG radiolabeled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats. J Nucl Med (1990) 1.92
A quantitative model of invasive Pseudomonas infection in burn injury. J Burn Care Rehabil (1994) 1.91
The dose uptake ratio as an index of glucose metabolism: useful parameter or oversimplification? J Nucl Med (1994) 1.80
High microvascular blood volume is associated with high glucose uptake and tumor angiogenesis in human gliomas. Clin Cancer Res (2000) 1.80
Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats. Gastroenterology (1993) 1.76
111In-labeled nonspecific immunoglobulin scanning in the detection of focal infection. N Engl J Med (1989) 1.76
Burn depth estimation by use of indocyanine green fluorescence: initial human trial. J Burn Care Rehabil (1996) 1.66
A 10-year experience with toxic epidermal necrolysis. J Burn Care Rehabil (2000) 1.66
Effects of short-term treatment of hyperlipidemia on coronary vasodilator function and myocardial perfusion in regions having substantial impairment of baseline dilator reverse. Circulation (1998) 1.64
A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women. Prenat Diagn (2008) 1.63
Management of burn wounds with prompt excision and immediate closure. J Intensive Care Med (1994) 1.60
Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomography. J Pediatr (2001) 1.58
The metabolic basis of the increase of the increase in energy expenditure in severely burned patients. JPEN J Parenter Enteral Nutr (1999) 1.56
Increased gut permeability early after burns correlates with the extent of burn injury. Crit Care Med (1992) 1.53
Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation. J Cell Biol (1992) 1.53
The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation. Biol Psychiatry (1997) 1.52
Retrovirus infection: effect of time and target cell number. J Virol (1995) 1.51
Simplified measurement of deoxyglucose utilization rate. J Nucl Med (1996) 1.48
Maximal parenteral glucose oxidation in hypermetabolic young children: a stable isotope study. JPEN J Parenter Enteral Nutr (1998) 1.45
Localization of radiolabeled chemotactic peptide at focal sites of Escherichia coli infection in rabbits: evidence for a receptor-specific mechanism. J Nucl Med (1997) 1.42
Arterial blood pressure immediately after thermal injury: the role of anesthesia. J Burn Care Rehabil (1994) 1.39
Quantification of inflammation in the wrist with gadolinium-enhanced MR imaging and PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology (1995) 1.35
Prompt eschar excision: a treatment system contributing to reduced burn mortality. A statistical evaluation of burn care at the Massachusetts General Hospital (1974-1984). Ann Surg (1986) 1.32
The acutely burned hand: management and outcome based on a ten-year experience with 1047 acute hand burns. J Trauma (1995) 1.32
Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function. Biomaterials (1996) 1.31
Functional MR in the evaluation of dementia: correlation of abnormal dynamic cerebral blood volume measurements with changes in cerebral metabolism on positron emission tomography with fludeoxyglucose F 18. AJNR Am J Neuroradiol (1995) 1.31
Prefrontal regions supporting spontaneous and directed application of verbal learning strategies: evidence from PET. Brain (2001) 1.30
Nucleation and growth of ice crystals inside cultured hepatocytes during freezing in the presence of dimethyl sulfoxide. Biophys J (1993) 1.29
Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. J Biol Chem (1997) 1.29
A fulminant hepatic failure model in the rat: involvement of interleukin-1beta and tumor necrosis factor-alpha. Dig Dis Sci (2001) 1.28
Activation of anterior paralimbic structures during guilt-related script-driven imagery. Biol Psychiatry (2000) 1.27
Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet. Proc Natl Acad Sci U S A (2000) 1.27
Long-term outcome of children surviving massive burns. JAMA (2000) 1.20
Hepatic tissue engineering. Development of critical technologies. Ann N Y Acad Sci (1992) 1.20
A positron emission tomographic study of simple phobic symptom provocation. Arch Gen Psychiatry (1995) 1.20
Anger in healthy men: a PET study using script-driven imagery. Biol Psychiatry (1999) 1.19
Strategies for success in academic surgery. Surgery (1995) 1.17
Accumulation of immunoglobulin G at focal sites of inflammation. Eur J Nucl Med (1992) 1.17
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res (2001) 1.15
Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results. Cell Transplant (2000) 1.14
Probing striatal function in obsessive-compulsive disorder: a PET study of implicit sequence learning. J Neuropsychiatry Clin Neurosci (1997) 1.12
Oxygen is a factor determining in vitro tissue assembly: Effects on attachment and spreading of hepatocytes. Biotechnol Bioeng (1994) 1.12
Acute hand burns in children: management and long-term outcome based on a 10-year experience with 698 injured hands. Ann Surg (1999) 1.11
Antibody-targeted photolysis of bacteria in vivo. Biotechnology (N Y) (1994) 1.11
Functional imaging of memory retrieval in deficit vs nondeficit schizophrenia. Arch Gen Psychiatry (1999) 1.10
Intrahepatic amino acid and glucose metabolism in a D-galactosamine-induced rat liver failure model. Hepatology (2001) 1.10
Cellular distribution of endotoxin after injection of chemically purified lipopolysaccharide differs from that after injection of live bacteria. J Infect Dis (1994) 1.09
Thermal injury induces very early production of interleukin-1 alpha in the rat by mechanisms other than endotoxemia. Surgery (1994) 1.09
Oxygen uptake rates in cultured rat hepatocytes. Biotechnol Bioeng (1992) 1.08
Nonequilibrium freezing of one-cell mouse embryos. Membrane integrity and developmental potential. Biophys J (1993) 1.08
Transplantation of embryonic porcine mesencephalic tissue in patients with PD. Neurology (2000) 1.07
Cocaine induced secretion of ACTH, beta-endorphin, and corticosterone. Peptides (1988) 1.07
Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging. AJR Am J Roentgenol (1998) 1.05
Skin substitutes in burns. Burns (1999) 1.05
Biodistribution and dosimetry of technetium-99m-hydrazino nicotinamide IgG: comparison with indium-111-DTPA-IgG. J Nucl Med (1996) 1.04
A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels. Cancer Res (1992) 1.04
A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes. Biotechnol Prog (1992) 1.03
Effect of "co-ligand" on the biodistribution of 99mTc-labeled hydrazino nicotinic acid derivatized chemotactic peptides. Nucl Med Biol (1995) 1.02
Imaging human atherosclerosis with 99mTc-labeled low density lipoproteins. Arteriosclerosis (1988) 1.02
Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans. Crit Care Med (1992) 1.02
Dynamics of photoinduced cell plasma membrane injury. Biophys J (1995) 1.01
Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells. J Infect Dis (1998) 1.01
Dynamics of cell membrane permeability changes at supraphysiological temperatures. Biophys J (1995) 1.01
Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal. Am J Physiol Endocrinol Metab (2001) 1.00
Robot-aided functional imaging: application to a motor learning study. Hum Brain Mapp (1998) 0.99
Carrier-mediated transport of enkephalins and N-Tyr-MIF-1 across blood-brain barrier. Am J Physiol (1986) 0.99
Single photon emission computed tomography perfusion differences in mild cognitive impairment. J Neurol Neurosurg Psychiatry (2006) 0.99
Selective adhesion of hepatocytes on patterned surfaces. Ann N Y Acad Sci (1994) 0.99
Differences in dermal analogs influence subsequent pigmentation, epidermal differentiation, basement membrane, and rete ridge formation of transplanted composite skin grafts. Transplantation (1997) 0.98
Nitric oxide production is intensely and persistently increased in tissue by thermal injury. Biochem J (1994) 0.98
Death in the burn unit: sterile multiple organ failure. Burns (1998) 0.98
Artificial skin. Annu Rev Med (2000) 0.98
Effectiveness of poloxamer 188 in arresting calcein leakage from thermally damaged isolated skeletal muscle cells. Ann N Y Acad Sci (1994) 0.97
Radionuclide imaging of sequential torsions of the appendix testis. J Nucl Med (1987) 0.97
Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for obsessive compulsive disorder. Biol Psychiatry (2001) 0.97
Emergency management of major hydrofluoric acid exposures. Burns (1995) 0.96
Assessment of artificial liver support technology. Cell Transplant (1992) 0.95
Dynamic T1-weighted magnetic resonance imaging and positron emission tomography in patients with lung cancer: correlating vascular physiology with glucose metabolism. Clin Cancer Res (1998) 0.95
Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography. Proc Natl Acad Sci U S A (2006) 0.95
Nosocomial infections in pediatric patients with burns. Am J Infect Control (1997) 0.95
Technetium-99m-labeled hydrazino nicotinamide derivatized chemotactic peptide analogs for imaging focal sites of bacterial infection. J Nucl Med (1993) 0.95
Comparison of thallium redistribution with rest "reinjection" imaging for the detection of viable myocardium. Am J Cardiol (1990) 0.95
Selective inhibition of N-formylpeptide-induced neutrophil activation by carbamate-modified peptide analogues. Biochemistry (1996) 0.94
Flavobacterial sepsis in massively burned pediatric patients. Clin Infect Dis (1993) 0.93