The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy.

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Published in Chemother Res Pract on December 20, 2012

Authors

Zahi Mitri1, Tina Constantine, Ruth O'Regan

Author Affiliations

1: Department of Internal Medicine, Emory University, Atlanta, GA 30322, USA.

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (1987) 49.88

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