Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 4011555)

Published in Clin Exp Pharmacol Physiol on August 01, 2013

Authors

Robert M Carey1, Shetal H Padia

Author Affiliations

1: Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA. rmc4c@virginia.edu

Articles cited by this

International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev (2000) 6.30

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A (2006) 4.10

Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med (1972) 2.99

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest (2005) 2.59

The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats. J Clin Invest (1996) 2.46

Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest (1999) 2.09

The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest (1997) 2.05

AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab (2011) 2.03

Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation. Endocr Rev (2003) 1.97

Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney. Am J Physiol (1999) 1.79

The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem (1997) 1.78

Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension (1997) 1.77

AT2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats. Hypertens Res (2012) 1.60

Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor. Proc Natl Acad Sci U S A (1999) 1.60

Evidence that intrarenal dopamine acts as a paracrine substance at the renal tubule. Am J Physiol (1989) 1.55

AT2 receptors: functional relevance in cardiovascular disease. Pharmacol Ther (2008) 1.46

Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane. Proc Natl Acad Sci U S A (1998) 1.45

Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age. Hypertension (2005) 1.42

Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. Am J Physiol Heart Circ Physiol (2001) 1.41

The surprising kidney-fluid mechanism for pressure control--its infinite gain! Hypertension (1990) 1.40

Angiotensin AT2 receptors: cardiovascular hope or hype? Br J Pharmacol (2003) 1.34

Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. Hypertension (2003) 1.33

Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries. Circulation (2004) 1.31

Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Hypertension (2005) 1.30

Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond) (2011) 1.29

Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am J Physiol Renal Physiol (2005) 1.25

Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats. Hypertension (2007) 1.22

Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism. Hypertension (2006) 1.20

Theodore Cooper Lecture: Renal dopamine system: paracrine regulator of sodium homeostasis and blood pressure. Hypertension (2001) 1.19

Renin-angiotensin system modulates renal bradykinin production. Am J Physiol (1996) 1.18

In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Am J Physiol (1999) 1.13

Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension. Hypertension (2011) 1.12

Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension (2004) 1.12

Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. Am J Physiol Regul Integr Comp Physiol (2011) 1.12

AT2 receptor agonists: hypertension and beyond. Curr Opin Nephrol Hypertens (2012) 1.09

Renal angiotensin II AT2 receptors promote natriuresis in streptozotocin-induced diabetic rats. Am J Physiol Renal Physiol (2005) 1.06

Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats. Hypertension (2006) 1.04

Bradykinin B2 receptor modulates renal prostaglandin E2 and nitric oxide. Hypertension (1997) 1.04

Role of renal hemodynamics and arterial pressure in aldosterone "escape". Hypertension (1984) 1.03

Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation. Hypertension (2004) 1.01

Angiotensin II stimulates thick ascending limb NO production via AT(2) receptors and Akt1-dependent nitric-oxide synthase 3 (NOS3) activation. J Biol Chem (2010) 1.01

Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats. Hypertension (2006) 1.00

Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension (2012) 1.00

Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. Hypertension (2012) 0.97

Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology (2011) 0.95

Mechanisms of dopamine D(1) and angiotensin type 2 receptor interaction in natriuresis. Hypertension (2011) 0.93

Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats. J Hypertens (2012) 0.93

Mechanisms of escape from sodium retention during angiotensin II hypertension. Am J Physiol (1984) 0.89

Role of pressure natriuresis in long-term control of renal electrolyte excretion. Hypertension (1993) 0.87

Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats. Am J Physiol Renal Physiol (2010) 0.87

Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats. Hypertension (2012) 0.83

Selective dopamine-1 receptor stimulation produces natriuresis by a direct tubular action. J Hypertens Suppl (1986) 0.82

Sodium retention and hypertension after kidney transplantation in rats. Hypertension (1993) 0.81

Selective peripheral dopamine-1 receptor stimulation. Differential responses to sodium loading and depletion in humans. Hypertension (1990) 0.79

Source of kidney determines blood pressure in young renal transplanted rats. Am J Physiol (1993) 0.79

Diuresis and natriuresis during continuous dopamine-1 receptor stimulation. Hypertension (1988) 0.78

Hypertension in rats induced by renal grafts from renovascular hypertensive donors. Hypertension (1990) 0.77