Published in Transl Psychiatry on January 22, 2013
A Chart Review to Evaluate the Safety and Efficacy of MeRT on Subjects With ASD | NCT02758496
Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort. PLoS One (2014) 1.20
Specialized metabolites from the microbiome in health and disease. Cell Metab (2014) 1.12
Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines. Transl Psychiatry (2014) 1.11
Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol (2014) 1.04
Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. PLoS One (2014) 1.03
Autism: metabolism, mitochondria, and the microbiome. Glob Adv Health Med (2013) 0.93
Biomarkers in autism. Front Psychiatry (2014) 0.92
Treatments for biomedical abnormalities associated with autism spectrum disorder. Front Pediatr (2014) 0.91
Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders. Microb Ecol Health Dis (2015) 0.91
Studying autism in rodent models: reconciling endophenotypes with comorbidities. Front Hum Neurosci (2013) 0.90
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. Microb Ecol Health Dis (2015) 0.89
Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microb Ecol Health Dis (2015) 0.89
Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model. Mol Autism (2015) 0.87
Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic acid, alters development and behavior in adolescent rats in a sexually dimorphic manner. PLoS One (2014) 0.86
Environment, dysbiosis, immunity and sex-specific susceptibility: a translational hypothesis for regressive autism pathogenesis. Nutr Neurosci (2014) 0.84
Potential therapeutic use of the ketogenic diet in autism spectrum disorders. Front Pediatr (2014) 0.83
Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: relation to gastrointestinal manifestations. Behav Brain Funct (2015) 0.82
Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes. Clin Med Insights Pediatr (2016) 0.82
Metabolomics as a tool for discovery of biomarkers of autism spectrum disorder in the blood plasma of children. PLoS One (2014) 0.81
Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome. Sci Rep (2016) 0.78
Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radic Biol Med (2016) 0.78
An n=1 case report of a child with autism improving on antibiotics and a father's quest to understand what it may mean. Microb Ecol Health Dis (2015) 0.78
Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB J (2016) 0.78
MIRA: mutual information-based reporter algorithm for metabolic networks. Bioinformatics (2014) 0.77
The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder. J Clin Med (2017) 0.76
Dietary glycemic index modulates the behavioral and biochemical abnormalities associated with autism spectrum disorder. Mol Psychiatry (2015) 0.76
Glutathione as a Redox Biomarker in Mitochondrial Disease-Implications for Therapy. J Clin Med (2017) 0.75
The Microbiome and Sustainable Healthcare. Healthcare (Basel) (2015) 0.75
Alterations in the carnitine cycle in a mouse model of Rett syndrome. Sci Rep (2017) 0.75
Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism. Exp Ther Med (2016) 0.75
Potency of pre-post treatment of coenzyme Q10 and melatonin supplement in ameliorating the impaired fatty acid profile in rodent model of autism. Food Nutr Res (2016) 0.75
GUT in FOCUS Symposium NOBEL FORUM, Karolinska Institutet, February 2nd 2015. Microb Ecol Health Dis (2015) 0.75
Nutritional and Metabolic Biomarkers in Autism Spectrum Disorders: An Exploratory Study. Integr Med (Encinitas) (2015) 0.75
Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches. Front Mol Neurosci (2017) 0.75
The potential role of nitrous oxide in the etiology of autism spectrum disorder. Transl Psychiatry (2016) 0.75
Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines. Transl Psychiatry (2016) 0.75
Bioenergetic variation is related to autism symptomatology. Metab Brain Dis (2017) 0.75
Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis. Bioessays (2017) 0.75
L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res (2017) 0.75
Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers. Metab Brain Dis (2017) 0.75
Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry (2011) 6.98
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem (2003) 4.79
Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis (2002) 2.80
Biochemical assays of respiratory chain complex activity. Methods Cell Biol (2007) 2.56
Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe (2010) 2.51
Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol (2000) 2.50
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet (2006) 2.44
The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes. Acta Neuropathol (2010) 2.42
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry (2011) 2.28
The in-depth evaluation of suspected mitochondrial disease. Mol Genet Metab (2008) 2.13
Mitochondrial dysfunction in autism. JAMA (2010) 2.04
Oxidative stress in autism. Pathophysiology (2006) 1.95
A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry (2011) 1.85
A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism. Proc Natl Acad Sci U S A (2012) 1.85
The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies. J Inherit Metab Dis (2004) 1.75
Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One (2011) 1.74
Mitochondrial disease in autism spectrum disorder patients: a cohort analysis. PLoS One (2008) 1.68
Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res (2006) 1.59
A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection. J Nutr Biochem (1999) 1.58
Mitochondrial disease criteria: diagnostic applications in children. Neurology (2006) 1.58
Could one of the most widely prescribed antibiotics amoxicillin/clavulanate "augmentin" be a risk factor for autism? Med Hypotheses (2005) 1.51
Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes. Biochim Biophys Acta (2010) 1.50
Carnitine, valproate, and toxicity. J Child Neurol (1991) 1.49
Quantitative PCR analysis of mitochondrial DNA content in patients with mitochondrial disease. Ann N Y Acad Sci (2004) 1.48
Clinical spectrum and diagnosis of mitochondrial disorders. Am J Med Genet (2001) 1.47
Simultaneous detection and quantification of mitochondrial DNA deletion(s), depletion, and over-replication in patients with mitochondrial disease. J Mol Diagn (2005) 1.43
Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr (2008) 1.42
Autism associated with the mitochondrial DNA G8363A transfer RNA(Lys) mutation. J Child Neurol (2000) 1.41
Is autism an autoimmune disease? Autoimmun Rev (2004) 1.37
Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microb Ecol Health Dis (2012) 1.35
Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder. Behav Brain Res (2010) 1.33
Mitochondrial dysfunction in mut methylmalonic acidemia. FASEB J (2008) 1.31
The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders. Biomarkers (2009) 1.31
Biochemistry, physiology and biotechnology of sulfate-reducing bacteria. Adv Appl Microbiol (2009) 1.26
Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders. Pediatr Res (2011) 1.24
Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology (2008) 1.23
Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins. Biochem J (2006) 1.23
Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10. J Clin Immunol (2004) 1.21
Pathogenic mitochondrial DNA mutations in protein-coding genes. Muscle Nerve (2007) 1.17
Autism and environmental genomics. Neurotoxicology (2006) 1.15
A review of autism and the immune response. Clin Dev Immunol (2004) 1.15
Recent developments in the investigation of inherited metabolic disorders using cultured human cells. Mol Genet Metab (1999) 1.13
Role of common gene variations in the molecular pathogenesis of short-chain acyl-CoA dehydrogenase deficiency. Pediatr Res (2001) 1.13
Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann Clin Psychiatry (2009) 1.12
Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine. J Nutr (1999) 1.10
Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism. Behav Brain Res (2008) 1.06
Novel plasma phospholipid biomarkers of autism: mitochondrial dysfunction as a putative causative mechanism. Prostaglandins Leukot Essent Fatty Acids (2009) 1.06
Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain. Dev Neurosci (2011) 1.06
Propionic acidemia: identification of twenty-four novel mutations in Europe and North America. Mol Genet Metab (2003) 1.03
Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. J Neurochem (2010) 1.03
A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders. Med Sci Monit (2011) 1.00
Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder. Dig Dis Sci (2012) 1.00
Infantile zinc deficiency: association with autism spectrum disorders. Sci Rep (2011) 1.00
The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. J Neuroinflammation (2012) 0.98
Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders. J Neurochem (2010) 0.98
Characterization of alpha-keto acid transport across blood-brain barrier in rats. Am J Physiol (1983) 0.96
Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase. Med Hypotheses (2004) 0.96
Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway. Brain Res Mol Brain Res (2005) 0.95
Unexpectedly high prevalence of the mild form of propionic acidemia in Japan: presence of a common mutation and possible clinical implications. Hum Genet (2002) 0.93
Inhibition of the mitochondrial respiratory chain complex activities in rat cerebral cortex by methylmalonic acid. Neurochem Int (2002) 0.92
Marginal zinc deficiency exacerbates experimental colitis induced by dextran sulfate sodium in rats. J Nutr (2011) 0.92
Intracellular acidification reduced gap junction coupling between immature rat neocortical pyramidal neurones. J Physiol (1996) 0.89
L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation. Clin Exp Immunol (2009) 0.88
Impact of the mitochondrial genetic background in complex III deficiency. PLoS One (2010) 0.88
Propionic acid stimulates superoxide generation in human neutrophils. Cell Biol Int (1998) 0.87
The role of zinc and metallothionein in the dextran sulfate sodium-induced colitis mouse model. Dig Dis Sci (2007) 0.87
Interaction of carnitine and propionate with pyruvate oxidation by hepatocytes from clofibrate-treated rats: importance of coenzyme A availability. J Nutr (1992) 0.86
Differential inhibitory effects of methylmalonic acid on respiratory chain complex activities in rat tissues. Int J Dev Neurosci (2006) 0.86
Trace elements and vitamins at diagnosis in pediatric-onset inflammatory bowel disease. Clin Pediatr (Phila) (2011) 0.85
Autism spectrum disorder in a child with propionic acidemia. JIMD Rep (2012) 0.83
Zinc and micronutrient combinations to combat gastrointestinal inflammation. Curr Opin Clin Nutr Metab Care (2009) 0.83
Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia. J Neurochem (2007) 0.82
Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism. Biomark Insights (2011) 0.82
Antioxidative potential of a combined therapy of anti TNFα and Zn acetate in experimental colitis. World J Gastroenterol (2011) 0.82
Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood-brain barrier. J Neurochem (2007) 0.81
Effect of oral antibiotics on intestinal production of propionic acid. Arch Dis Child (2000) 0.80
Formation of propionate after short-term ethanol treatment and its interaction with the carnitine pool in rat. Alcohol (1999) 0.77
Molecular analysis of mitochondrial DNA point mutations by polymerase chain reaction. Methods Mol Biol (2006) 0.77
Calcineurin inhibition by polaprezinc in rats with experimentally-induced colitis. Life Sci (2011) 0.76
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet (2001) 2.93
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr (1999) 2.71
Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem (2000) 2.60
Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr (2001) 1.79
Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Physiol Genomics (2005) 1.43
Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry (2012) 1.35
Homocysteine metabolism in children with Down syndrome: in vitro modulation. Am J Hum Genet (2001) 1.34
Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect. Am J Med Genet (2001) 1.04
Redox metabolism abnormalities in autistic children associated with mitochondrial disease. Transl Psychiatry (2013) 1.00
Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study. Transl Psychiatry (2013) 0.93
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency. J Inherit Metab Dis (2008) 0.80
Penicillin amidase from E. coli. Enzyme heterogeneity and stability. Ann N Y Acad Sci (1987) 0.77
Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines. Transl Psychiatry (2015) 0.76
Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro. Reprod Toxicol (2001) 0.76