Published in Gastroenterology on January 24, 2013
New insights into the pathogenesis of pancreatitis. Curr Opin Gastroenterol (2013) 1.18
Risk factors for pancreatic cancer: underlying mechanisms and potential targets. Front Physiol (2014) 1.10
Endoplasmic reticulum stress is chronically activated in chronic pancreatitis. J Biol Chem (2014) 0.97
Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol (2014) 0.92
Inflammasomes in pancreatic physiology and disease. Am J Physiol Gastrointest Liver Physiol (2015) 0.85
Impaired autophagy triggers chronic pancreatitis: lessons from pancreas-specific atg5 knockout mice. Gastroenterology (2015) 0.84
Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop. J Biol Chem (2013) 0.80
The conspiracy of autophagy, stress and inflammation in acute pancreatitis. Curr Opin Gastroenterol (2014) 0.80
CXCR2 inhibition suppresses acute and chronic pancreatic inflammation. J Pathol (2015) 0.79
Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis. J Biol Chem (2016) 0.78
A small molecule inhibitor of NFκB blocks ER stress and the NLRP3 inflammasome and prevents progression of pancreatitis. J Gastroenterol (2016) 0.76
Framework for interpretation of trypsin-antitrypsin imbalance and genetic heterogeneity in pancreatitis. Saudi J Gastroenterol (2015) 0.75
Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar. Cell Mol Gastroenterol Hepatol (2016) 0.75
Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas (2016) 0.75
Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: an answer from nature. World J Gastroenterol (2014) 0.75
Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Do Animal Models of Acute Pancreatitis Reproduce Human Disease? Cell Mol Gastroenterol Hepatol (2017) 0.75
Pancreatic Disorders. Pediatr Clin North Am (2017) 0.75
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med (1997) 14.51
Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol (2009) 11.76
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet (1996) 7.94
Aberrant rel/nfkb genes and activity in human cancer. Oncogene (1999) 5.62
Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology (2001) 4.44
Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology (2007) 3.73
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest (2000) 3.47
Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin Gastroenterol Hepatol (2004) 2.82
The natural history of hereditary pancreatitis: a national series. Gut (2008) 2.33
Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol (1998) 2.18
Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage. Gastroenterology (2010) 2.00
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. Gut (2006) 1.97
Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol (1998) 1.89
Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Gastroenterology (2010) 1.86
NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology (2002) 1.84
Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis. Hum Mutat (2006) 1.80
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest (2003) 1.73
Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice. Gastroenterology (2012) 1.68
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet (2012) 1.63
Induction of chronic pancreatic disease by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts. Pancreas (1996) 1.59
Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism. Hum Mutat (2009) 1.56
Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. J Clin Invest (2007) 1.56
Why does pancreatic overstimulation cause pancreatitis? Annu Rev Physiol (2007) 1.56
Repetitive self-limited acute pancreatitis induces pancreatic fibrogenesis in the mouse. Dig Dis Sci (2000) 1.55
Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. Gastroenterology (2002) 1.54
Genetic aspects of pancreatitis. Annu Rev Med (2010) 1.51
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology (2006) 1.48
The role of NF-kappaB activation in the pathogenesis of acute pancreatitis. Gut (2007) 1.46
Chronic pancreatitis: genetics and pathogenesis. Annu Rev Genomics Hum Genet (2009) 1.46
Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride. Gastroenterology (1997) 1.43
Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology (2005) 1.38
Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis. Pancreas (2006) 1.34
Pathogenesis of chronic pancreatitis: an evidence-based review of past theories and recent developments. Am J Gastroenterol (2004) 1.32
Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis. Gut (2002) 1.29
Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology (2005) 1.29
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis. Gastroenterology (2011) 1.27
A mouse model of ethanol dependent pancreatic fibrosis. Gut (2005) 1.27
Mechanisms of alcoholic pancreatitis. J Gastroenterol Hepatol (2010) 1.26
Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol (2007) 1.25
Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis. Gut (2011) 1.25
Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis. Gut (2004) 1.25
CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells. Am J Physiol Cell Physiol (2001) 1.24
Biochemical models of hereditary pancreatitis. Endocrinol Metab Clin North Am (2006) 1.24
Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. J Clin Invest (2007) 1.24
Pancreatic duct obstruction in rabbits causes digestive zymogen and lysosomal enzyme colocalization. J Clin Invest (1989) 1.23
Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential. Clin Sci (Lond) (2009) 1.22
Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells. Gut (2009) 1.20
Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation. J Biol Chem (2009) 1.19
Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis. Gastroenterology (2008) 1.18
Natural history following the first attack of acute pancreatitis. Am J Gastroenterol (2012) 1.18
Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells. Virchows Arch A Pathol Anat Histopathol (1986) 1.17
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. Gut (2012) 1.13
Genetics of pancreatitis. Curr Opin Gastroenterol (2011) 1.11
Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB-deficient mice. Lab Invest (2003) 1.10
Transcription factors as activators of gene transcription: AP-1 and NF-kappa B. Monaldi Arch Chest Dis (1997) 1.08
Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death. J Biol Chem (2009) 1.07
Chronic pancreatitis, pseudotumors and other tumor-like lesions. Mod Pathol (2007) 1.06
Relationship between NF-kappaB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation. Biochem Biophys Res Commun (2001) 1.05
Comparison of histological features and inflammatory cell reaction in alcoholic, idiopathic and tropical chronic pancreatitis. Br J Surg (2003) 1.02
Molecular mechanisms of pancreatic injury. Curr Opin Gastroenterol (2011) 1.00
TGFbeta-induced fibrogenesis of the pancreas. Int J Gastrointest Cancer (2002) 0.99
Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut (2006) 0.98
Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutations. J Med Genet (2010) 0.98
Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis. Gastroenterology (2011) 0.97
Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules. Digestion (2002) 0.96
Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis. Front Physiol (2012) 0.93
Does chronic ethanol intake cause chronic pancreatitis?: evidence and mechanism. Pancreas (2008) 0.90
Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases. Exp Anim (2011) 0.90
Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas (2010) 0.88
Recurrent and relapsing pancreatitis. Curr Gastroenterol Rep (2011) 0.85
Trypsinogen activation in acute and chronic pancreatitis: is it a prerequisite? Gut (2011) 0.82
Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis. Pancreatology (2010) 0.78
Acute pancreatitis: bench to the bedside. Gastroenterology (2007) 2.78
Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70. Cancer Res (2007) 2.27
Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology (2010) 2.13
Development of a new mouse model of acute pancreatitis induced by administration of L-arginine. Am J Physiol Gastrointest Liver Physiol (2006) 2.05
Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma. Cancer Res (2007) 1.87
A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med (2012) 1.84
Why does pancreatic overstimulation cause pancreatitis? Annu Rev Physiol (2007) 1.56
Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. Gastroenterology (2009) 1.43
Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo. Surgery (2009) 1.43
Extremity soft tissue sarcoma care in the elderly: insights into the generalizability of NCI Cancer Trials. Ann Surg Oncol (2010) 1.43
Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity. Am J Physiol Gastrointest Liver Physiol (2002) 1.34
Pathogenic mechanisms of acute pancreatitis. Curr Opin Gastroenterol (2012) 1.29
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis. Gastroenterology (2011) 1.27
New insights into the pathogenesis of pancreatitis. Curr Opin Gastroenterol (2013) 1.18
Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion. Gut (2006) 1.13
Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation. Mol Cancer Ther (2013) 1.09
Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma. J Surg Res (2010) 1.07
Minnelide reduces tumor burden in preclinical models of osteosarcoma. Cancer Lett (2013) 1.07
Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol (2002) 1.06
Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats. Gastroenterology (2002) 1.05
miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death. Mol Cancer (2013) 1.04
Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1. J Biol Chem (2013) 1.04
Disparities in pancreas cancer care. Ann Surg Oncol (2013) 0.99
Autophagy in pancreatic cancer: an emerging mechanism of cell death. Autophagy (2010) 0.97
Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity. Am J Surg (2013) 0.97
Heat shock proteins in pancreatic diseases. J Gastroenterol Hepatol (2008) 0.97
Relevance of animal models of pancreatic cancer and pancreatitis to human disease. Gastroenterology (2013) 0.96
Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors. Am J Physiol Gastrointest Liver Physiol (2011) 0.95
In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury. Am J Physiol Lung Cell Mol Physiol (2002) 0.95
An improved method for extracting myeloperoxidase and determining its activity in the pancreas and lungs during pancreatitis. Pancreas (2008) 0.95
CD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to Minnelide. Clin Cancer Res (2014) 0.94
TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells. J Gastrointest Surg (2009) 0.93
Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini. Am J Physiol Gastrointest Liver Physiol (2010) 0.92
Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma. J Surg Res (2010) 0.92
Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation. J Cell Physiol (2008) 0.90
Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis. Am J Physiol Gastrointest Liver Physiol (2009) 0.87
Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of α-1 antitrypsin treatment. Transplantation (2011) 0.84
MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization. PLoS One (2012) 0.82
Trypsinogen activation in acute and chronic pancreatitis: is it a prerequisite? Gut (2011) 0.82
A new drug delivery method of bispecific ligand-directed toxins, which reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer. Pancreas (2010) 0.81
Total pancreatectomy with islet autotransplantation in patients with malignancy: are we there yet? Ann Surg (2013) 0.81
Pancreatitis and associated lung injury: when MIF miffs. Gastroenterology (2003) 0.79
Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide. Pancreas (2015) 0.76
Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas (2016) 0.75
Minutes of the Business Meeting of the American Pancreatic Association, Friday, October 28, 2016, Boston, Massachusetts. Pancreas (2017) 0.75
American Pancreatic Association: the Vay Liang and Frisca Go Award for lifetime achievement. Pancreas (2012) 0.75
Minutes of the Business Meeting of the American Pancreatic Association, Friday, November 7, 2014, Kohala Coast, Hawaii. Pancreas (2015) 0.75
Minutes of the Business Meeting of the American Pancreatic Association, Friday, November 6, 2015, San Diego, California. Pancreas (2016) 0.75
American Pancreatic Association and Japan Pancreas Society: Sisterhood Memorandum of Understanding. Pancreas (2017) 0.75
Minutes of the business meeting of the American Pancreatic Association, Friday, November 2, 2012, Miami, Florida. Pancreas (2013) 0.75
Inflammation and pain in pancreatic disorders: summary of the symposium sponsored by the American Pancreatic Association and the National Pancreas Foundation (Chicago, November 4-5, 2005). Pancreas (2006) 0.75
Genetics of pancreatic cyst-cancer progression: standing on the shoulders of giants. Curr Opin Gastroenterol (2017) 0.75
2012 International Association of Pancreatology presidential address: A time for change. Pancreas (2012) 0.75
Cannabis-Induced Acute Pancreatitis: A Systematic Review. Pancreas (2017) 0.75
American Pancreatic Association: 2015 Vay Liang and Frisca Go Award for Lifetime Achievement, APA Distinguished Service Award, and Other Awardees. Pancreas (2016) 0.75
The 47th Annual Meeting of the American Pancreatic Association: 2016 Vay Liang and Frisca Go Award for Lifetime Achievement, APA Distinguished Service Award, Highlights, and Other Awardees. Pancreas (2017) 0.75