PubRank

Guoqiang Dong

Author PubWeight™ 19.98‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. J Biol Chem 2007 1.25
2 New azoles with potent antifungal activity: design, synthesis and molecular docking. Eur J Med Chem 2009 1.07
3 Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding. Antimicrob Agents Chemother 2009 0.96
4 Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction. J Med Chem 2012 0.93
5 High-throughput screening for inhibitors of the e3 ubiquitin ligase APC. Methods Enzymol 2005 0.92
6 Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design. J Comput Aided Mol Des 2009 0.88
7 State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors. Chem Soc Rev 2015 0.84
8 Design and synthesis of cyclopropylamide analogues of combretastatin-A4 as novel microtubule-stabilizing agents. J Med Chem 2013 0.83
9 Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors. Eur J Med Chem 2010 0.83
10 Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement. Eur J Med Chem 2013 0.83
11 A homogeneous FRET assay system for multiubiquitin chain assembly and disassembly. Methods Enzymol 2005 0.80
12 Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53-MDM2 protein-protein interaction. Eur J Med Chem 2011 0.78
13 Structure-activity relationship and antitumor activity of thio-benzodiazepines as p53-MDM2 protein-protein interaction inhibitors. Eur J Med Chem 2012 0.78
14 A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors. J Med Chem 2013 0.78
15 Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors. Eur J Med Chem 2011 0.77
16 Novel conformationally restricted triazole derivatives with potent antifungal activity. Eur J Med Chem 2010 0.77
17 Evolutionary trace analysis of CYP51 family: implication for site-directed mutagenesis and novel antifungal drug design. J Mol Model 2009 0.77
18 From antidiabetic to antifungal: discovery of highly potent triazole-thiazolidinedione hybrids as novel antifungal agents. ChemMedChem 2014 0.76
19 Discovery of novel human acrosin inhibitors by virtual screening. J Comput Aided Mol Des 2011 0.76
20 Phosphate ester derivatives of homocamptothecin: synthesis, solution stabilities and antitumor activities. Bioorg Med Chem 2010 0.76
21 Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents. Eur J Med Chem 2012 0.76
22 Improved model of lanosterol 14alpha-demethylase by ligand-supported homology modeling: validation by virtual screening and azole optimization. ChemMedChem 2010 0.75
23 Synthesis and biological evaluation of 7-alkenyl homocamptothecins as potent topoisomerase I inhibitors. Chem Biodivers 2012 0.75
24 The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine. Chem Commun (Camb) 2015 0.75
25 Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket. J Med Chem 2020 0.75
26 Correction: State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors. Chem Soc Rev 2015 0.75
27 Synthesis of 9-(heteroarylmethylidene)amino derivatives of homocamptothecin with biological activities. Chem Biodivers 2011 0.75
28 Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective Michael-Michael cascade. Org Lett 2014 0.75
29 Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. Eur J Med Chem 2012 0.75
30 Improving the Potency of Cancer Immunotherapy by Dual Targeting IDO1 and DNA. ChemMedChem 2017 0.75
31 Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase I inhibitors. Arch Pharm (Weinheim) 2011 0.75
32 Synthesis and biological assays of 9-(acylamino) homocamptothecins as DNA topoisomerase I inhibitors. Chem Biodivers 2013 0.75
33 ERK1/2 and Akt pathway activated during (3R,6R)-bassiatin(1)-induced apoptosis in MCF-7 cells. Cell Biol Int 2012 0.75
34 Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes. Org Biomol Chem 2016 0.75
35 Asymmetric synthesis of chiral dihydrothiopyrans via an organocatalytic enantioselective formal thio [3 + 3] cycloaddition reaction with binucleophilic bisketone thioethers. Org Lett 2013 0.75
36 Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors. J Enzyme Inhib Med Chem 2011 0.75
37 Facile construction of structurally diverse thiazolidinedione-derived compounds via divergent stereoselective cascade organocatalysis and their biological exploratory studies. ACS Comb Sci 2013 0.75
38 Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. Bioorg Med Chem Lett 2010 0.75