Published in Mol Biol Cell on January 30, 2013
Specific Cx43 phosphorylation events regulate gap junction turnover in vivo. FEBS Lett (2014) 1.19
Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size. J Cell Sci (2013) 1.13
Connexins modulate autophagosome biogenesis. Nat Cell Biol (2014) 1.13
Managing the complexity of communication: regulation of gap junctions by post-translational modification. Front Pharmacol (2013) 1.00
Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. Pharmacol Ther (2015) 0.97
Cardiac to cancer: connecting connexins to clinical opportunity. FEBS Lett (2014) 0.96
Connexins: mechanisms regulating protein levels and intercellular communication. FEBS Lett (2014) 0.93
Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis. Mol Biol Cell (2013) 0.87
Gap junctions and cancer: communicating for 50 years. Nat Rev Cancer (2016) 0.83
TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication. J Cell Sci (2014) 0.83
EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368. FEBS Lett (2014) 0.83
Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision. BMC Cell Biol (2016) 0.80
Vitamin D3 regulates the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. PLoS One (2014) 0.80
Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization. Mol Biol Cell (2015) 0.79
Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E2 Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress. J Biol Chem (2015) 0.77
Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions. BMC Cell Biol (2016) 0.76
Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair. Semin Cell Dev Biol (2015) 0.76
Genetic Method for Labeling Electrically Coupled Cells: Application to Retina. Front Mol Neurosci (2016) 0.75
Secondary structural analysis of the carboxyl-terminal domain from different connexin isoforms. Biopolymers (2016) 0.75
The carboxyl tail of connexin32 regulates gap junction assembly in human prostate and pancreatic cancer cells. J Biol Chem (2014) 0.75
Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2. J Biol Chem (2016) 0.75
Myosin VI facilitates connexin 43 gap junction accretion. J Cell Sci (2017) 0.75
Cx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signaling. Cell Commun Signal (2014) 0.75
Adrenocortical Gap Junctions and Their Functions. Front Endocrinol (Lausanne) (2016) 0.75
Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics. Biochim Biophys Acta (2017) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Methods in mammalian autophagy research. Cell (2010) 20.08
Rab proteins as membrane organizers. Nat Rev Mol Cell Biol (2001) 19.95
Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem (2003) 13.66
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell (1992) 10.53
The mechanisms of vesicle budding and fusion. Cell (2004) 7.96
Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science (1995) 7.77
The multiple faces of caveolae. Nat Rev Mol Cell Biol (2007) 6.85
Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J Cell Biol (1989) 6.76
Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol (2010) 6.41
Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol (2011) 6.32
Characterization of a cis-Golgi matrix protein, GM130. J Cell Biol (1995) 6.22
Multicolor and electron microscopic imaging of connexin trafficking. Science (2002) 5.60
Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J Cell Biol (1994) 4.30
Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol (2007) 4.17
Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol (2004) 4.15
Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat Rev Mol Cell Biol (2009) 3.98
Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques. J Cell Biol (1991) 3.76
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol (2006) 3.55
Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell (2007) 3.52
Life cycle of connexins in health and disease. Biochem J (2006) 3.44
Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J Cell Biol (1990) 3.32
β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci (2011) 3.02
Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol (2009) 2.83
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell (2009) 2.77
Connexin43 phosphorylation: structural changes and biological effects. Biochem J (2009) 2.75
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci (2011) 2.51
Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. Nat Cell Biol (2011) 2.48
Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport. Mol Biol Cell (2005) 2.40
The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane. J Cell Biol (1996) 2.32
Gap junctions. Cold Spring Harb Perspect Biol (2009) 2.27
Heteromeric connexons in lens gap junction channels. Proc Natl Acad Sci U S A (1996) 2.22
Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells. Proc Natl Acad Sci U S A (2002) 2.21
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (2004) 2.19
Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Curr Biol (1998) 2.15
Intracellular trafficking of lysosomal membrane proteins. Bioessays (1996) 2.09
Apical trafficking in epithelial cells: signals, clusters and motors. J Cell Sci (2009) 2.08
Growth inhibition of transformed cells correlates with their junctional communication with normal cells. Cell (1986) 2.04
GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. Mol Cell Biol (2006) 1.85
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J Biol Chem (1998) 1.80
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J (2007) 1.74
Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC. J Cell Biol (2007) 1.70
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation. Biochim Biophys Acta (2005) 1.70
Characterization of a new primary human pancreatic tumor line. Cancer Invest (1986) 1.67
Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem (1996) 1.67
Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. J Biol Chem (2003) 1.66
The gap junction proteome and its relationship to disease. Trends Cell Biol (2009) 1.64
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Gap junction channels formed by coexpressed connexin40 and connexin43. Am J Physiol Heart Circ Physiol (2001) 1.58
Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci U S A (2005) 1.56
Colocalization analysis in fluorescence micrographs: verification of a more accurate calculation of pearson's correlation coefficient. Microsc Microanal (2010) 1.53
Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation. Mol Biol Cell (1999) 1.48
The clathrin adaptor AP-1A mediates basolateral polarity. Dev Cell (2012) 1.47
Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process. Mol Biol Cell (2006) 1.46
Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions. Proc Natl Acad Sci U S A (2009) 1.42
Ultrastructure and regulation of lateralized connexin43 in the failing heart. Circ Res (2010) 1.40
The origin of annular junctions: a mechanism of gap junction internalization. J Cell Sci (2001) 1.38
Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP. J Cell Biol (2001) 1.37
Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates. Autophagy (2009) 1.36
Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment. J Biol Chem (2004) 1.34
Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43. J Cell Sci (2004) 1.33
Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6. J Cell Biol (2008) 1.31
Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci (2005) 1.21
Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process. J Cell Sci (2006) 1.21
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic (2007) 1.20
Autophagy: a pathway that contributes to connexin degradation. J Cell Sci (2011) 1.17
PKB and megalin determine the survival or death of renal proximal tubule cells. Proc Natl Acad Sci U S A (2006) 1.16
Connexins: key mediators of endocrine function. Physiol Rev (2011) 1.16
Analysis of connexin intracellular transport and assembly. Methods (2000) 1.15
Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth. J Membr Biol (1991) 1.15
Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner. Mol Biol Cell (2012) 1.15
Eps15 interacts with ubiquitinated Cx43 and mediates its internalization. Exp Cell Res (2009) 1.15
Gap junctional channels are parts of multiprotein complexes. Biochim Biophys Acta (2011) 1.13
Suppression of human prostate cancer cell growth by forced expression of connexin genes. Dev Genet (1999) 1.12
Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles. Mol Biol Cell (2009) 1.11
Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery. FEBS Lett (2008) 1.11
Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation. J Cell Biochem (2001) 1.10
Connexin 43 in LA-25 cells with active v-src is phosphorylated on Y247, Y265, S262, S279/282, and S368 via multiple signaling pathways. Cell Commun Adhes (2008) 1.06
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101. J Cell Sci (2009) 1.04
Internalized gap junctions are degraded by autophagy. Autophagy (2012) 1.04
Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin. J Biol Chem (2002) 1.04
Clathrin-mediated endocytosis before fluorescent proteins. Nat Rev Mol Cell Biol (2006) 1.03
Endocytic processing of connexin43 gap junctions: a morphological study. Biochem J (2006) 1.03
A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover. J Cell Sci (2003) 1.02
Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells. Mol Cell Biol (2005) 1.00
Requirements for recruitment of a G protein-coupled receptor to clathrin-coated pits in budding yeast. Mol Biol Cell (2009) 0.94
Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal. Biochem J (2011) 0.94
Clathrin and Cx43 gap junction plaque endoexocytosis. Biochem Biophys Res Commun (2008) 0.91
Morphogenesis of "duct-like" structures in three-dimensional cultures of human cancerous pancreatic duct cells (Capan-1). In Vitro Cell Dev Biol Anim (1993) 0.90
E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells. J Biol Chem (2010) 0.86
Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells. Mol Biol Cell (2010) 0.86
The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants. Biochem J (2010) 0.84
Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. Mol Biol Cell (2006) 0.84
Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. PLoS One (2012) 0.83
Facilitation of gap-junctional communication and gap-junction formation in mammalian cells by inhibition of glycosylation. Eur J Cell Biol (1995) 0.80
Cadherin switching. J Cell Sci (2008) 3.70
Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol (2003) 3.67
Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. J Cell Sci (2005) 2.88
Cadherin-mediated cellular signaling. Curr Opin Cell Biol (2003) 1.80
Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol (2007) 1.78
MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Res (2008) 1.77
Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin. J Biol Chem (2003) 1.73
Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol (2008) 1.66
E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer. Cancer Res (2005) 1.62
Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res (2006) 1.61
N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem (2003) 1.60
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. Proc Natl Acad Sci U S A (2012) 1.44
NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motility. Mol Biol Cell (2007) 1.18
Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells. Mol Biol Cell (2006) 1.17
Sphingobium lactosutens sp. nov., isolated from a hexachlorocyclohexane dump site and Sphingobium abikonense sp. nov., isolated from oil-contaminated soil. Int J Syst Evol Microbiol (2009) 1.16
ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer (2008) 1.08
Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma. PLoS One (2012) 1.05
The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane. Exp Cell Res (2007) 1.04
Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin. J Biol Chem (2002) 1.04
Expression of E-cadherin, P-cadherin and N-cadherin in oral squamous cell carcinoma: correlation with the clinicopathologic features and patient outcome. J Craniomaxillofac Surg (2007) 1.03
R-cadherin influences cell motility via Rho family GTPases. J Biol Chem (2004) 1.01
Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II. Cardiovasc Res (2011) 0.99
TGF-beta induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways. Exp Cell Res (2008) 0.94
Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis. Cancer Res (2013) 0.92
Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies. Endocr Rev (2008) 0.92
E-cadherin/catenin complexes are formed cotranslationally in the endoplasmic reticulum/Golgi compartments. Cell Commun Adhes (2008) 0.91
Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2. Hybridoma (Larchmt) (2008) 0.89
N-cadherin-mediated cell motility requires cis dimers. Cell Commun Adhes (2005) 0.89
Regulation of Aerobic Glycolysis by microRNAs in Cancer. Mol Cell Pharmacol (2011) 0.89
Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II. J Biol Chem (2005) 0.88
Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton. Exp Cell Res (2011) 0.87
E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells. J Biol Chem (2010) 0.86
Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells. Mol Biol Cell (2010) 0.86
Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. Mol Biol Cell (2006) 0.84
Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades. Growth Factors (2007) 0.83
Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. PLoS One (2012) 0.83
Differential displacement of classical cadherins by VE-cadherin. Cell Commun Adhes (2002) 0.82
Effect of N-cadherin misexpression by the mammary epithelium in mice. J Cell Biochem (2005) 0.82
Modulating the strength of cadherin adhesion: evidence for a novel adhesion complex. J Cell Sci (2005) 0.80
Evidence that the V832M E-cadherin germ-line missense mutation does not influence the affinity of alpha -catenin for the cadherin/catenin complex. Cell Commun Adhes (2007) 0.79
Characterization of cadherin-24, a novel alternatively spliced type II cadherin. J Biol Chem (2003) 0.78
Expression artifact with retroviral vectors based on pBMN. Anal Biochem (2009) 0.75