Published in Anesthesiology on April 01, 2013
The power of unbiased genetic screens to discover novel anesthetic targets. Anesthesiology (2013) 1.07
In reply. Anesthesiology (2013) 0.75
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci (2008) 6.05
General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J (2002) 4.20
Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor. Br J Pharmacol (1997) 2.08
Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice. Anesthesiology (2012) 1.81
HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine. J Neurosci (2009) 1.66
Correlating the clinical actions and molecular mechanisms of general anesthetics. Curr Opin Anaesthesiol (2007) 1.40
Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology (2009) 1.31
Optogenetics. Shining new light on neural circuits. Science (2006) 1.28
Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology (2005) 1.22
New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci (2007) 1.11
Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I. PLoS One (2012) 1.02
Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg (2011) 0.99
Forebrain HCN1 channels contribute to hypnotic actions of ketamine. Anesthesiology (2013) 0.95
Mechanisms of actions of inhaled anesthetics. N Engl J Med (2003) 4.06
Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology (2009) 2.19
Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation. J Biol Chem (2004) 1.83
2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem (2003) 1.73
Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors. Anesth Analg (2002) 1.48
Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation. Mol Pharmacol (2008) 1.47
Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors. Anesthesiology (2005) 1.45
Correlating the clinical actions and molecular mechanisms of general anesthetics. Curr Opin Anaesthesiol (2007) 1.40
Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology (2009) 1.31
Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study. J Biol Chem (2005) 1.29
Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology (2010) 1.27
Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors. J Neurosci (2002) 1.26
Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels. J Med Chem (2006) 1.16
A paradigm shift from biophysical to neurobiological: the fading influence of Claude Bernard's ideas about general anesthesia. Anesthesiology (2013) 1.07
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem (2012) 1.07
High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors. Protein Sci (2010) 1.06
Protein kinase C modulates inactivation of Kv3.3 channels. J Biol Chem (2008) 1.06
Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor. Mol Pharmacol (2009) 1.05
p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. J Med Chem (2011) 1.04
An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors. Anesthesiology (2012) 1.03
Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of gamma-aminobutyric acid type A receptors. Anesthesiology (2008) 1.02
Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model. J Neurosci (2007) 1.01
Iatrogenic risk factors for Alzheimer's disease: surgery and anesthesia. J Alzheimers Dis (2010) 1.00
Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite. Anesth Analg (2011) 1.00
Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site. Anesthesiology (2016) 0.99
Mechanisms of general anesthesia: from molecules to mind. Best Pract Res Clin Anaesthesiol (2005) 0.97
Azo-propofols: photochromic potentiators of GABA(A) receptors. Angew Chem Int Ed Engl (2012) 0.95
p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem (2010) 0.93
Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating. Anesthesiology (2012) 0.90
State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor. Mol Pharmacol (2013) 0.89
Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition. Anesth Analg (2003) 0.86
Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors. J Biol Chem (2013) 0.85
Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state. Protein Sci (2013) 0.82
A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors. Anesthesiology (2016) 0.79
Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals. Anesth Analg (2012) 0.78
Of mice and nematodes. Anesthesiology (2006) 0.75
Alphaxalone Binds in Inner Transmembrane β+-α- Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors. Anesthesiology (2017) 0.75
Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits. Anesthesiology (2019) 0.75
Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology (2020) 0.75