The HSP70 and autophagy inhibitor pifithrin-μ enhances the antitumor effects of TRAIL on human pancreatic cancer.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMID 23371857)

Published in Mol Cancer Ther on January 31, 2013

Authors

Hiroyuki Monma1, Nanae Harashima, Touko Inao, Shinji Okano, Yoshitsugu Tajima, Mamoru Harada

Author Affiliations

1: Department of Immunology, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan.

Articles citing this

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells. Front Oncol (2015) 1.05

Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease. Cell Chem Biol (2016) 0.92

Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells. PLoS One (2013) 0.87

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ. Pain (2015) 0.83

Role of CYB5A in pancreatic cancer prognosis and autophagy modulation. J Natl Cancer Inst (2013) 0.82

The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells. PLoS One (2015) 0.81

Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother (2015) 0.80

Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death. PLoS One (2015) 0.78

Autophagy Modulation in Disease Therapy: Where Do We Stand? Curr Pathobiol Rep (2013) 0.78

Pifithrin-µ prevents cisplatin-induced chemobrain by preserving neuronal mitochondrial function. Cancer Res (2016) 0.76

Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. J Virol (2016) 0.76

Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy. Autophagy (2015) 0.76

Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation. Sci Rep (2016) 0.75

Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy. Front Mol Neurosci (2017) 0.75

Reversal of the Apoptotic Resistance of Non-Small-Cell Lung Carcinoma towards TRAIL by Natural Product Toosendanin. Sci Rep (2017) 0.75

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function. Oncotarget (2017) 0.75

4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues. PLoS One (2017) 0.75

Articles by these authors

Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors. Circ Res (2005) 1.64

Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. J Clin Invest (2008) 1.58

Surgical management for the prevention of pancreatic fistula following distal pancreatectomy. J Hepatobiliary Pancreat Surg (2005) 1.56

Mutations in hepatitis C virus genotype 1b and the sensitivity of interferon-ribavirin therapy after liver transplantation. J Hepatol (2010) 1.48

Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C. Gastroenterology (2010) 1.47

A novel technique to minimize deformation of the stomach in laparoscopic partial gastrectomy for intraluminal gastric GISTs. J Laparoendosc Adv Surg Tech A (2014) 1.45

Pancreas-hanging maneuver in laparoscopic pancreaticoduodenectomy: a new technique for the safe resection of the pancreas head. Surg Endosc (2009) 1.39

Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas. Cancer Res (2005) 1.29

Essential role of PDGFRalpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRalpha during angiogenesis. Circ Res (2004) 1.23

Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo. Cancer Immunol Immunother (2012) 1.10

Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats. J Immunol (2002) 1.05

A simple culture protocol to detect peptide-specific cytotoxic T lymphocyte precursors in the circulation. Cancer Immunol Immunother (2002) 1.01

Fibroblast growth factor-2 gene transfer can stimulate hepatocyte growth factor expression irrespective of hypoxia-mediated downregulation in ischemic limbs. Circ Res (2002) 1.01

Comparative analysis of Helicobacter DNAs and biliary pathology in patients with and without hepatobiliary cancer. Carcinogenesis (2002) 1.01

Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells. Clin Exp Metastasis (2012) 0.99

Peptide vaccination for patients with melanoma and other types of cancer based on pre-existing peptide-specific ctotoxic T-lymphocyte precursors in the periphery. J Immunother (2003) 0.98

Immunological evaluation of neoadjuvant peptide vaccination before radical prostatectomy for patients with localized prostate cancer. Prostate (2007) 0.98

Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-beta gene. J Immunol (2006) 0.98

Identification of SART3-derived peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes from prostate cancer patients with HLA-A3 supertype alleles. Cancer Immunol Immunother (2006) 0.97

Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells. Cancer Immunol Immunother (2011) 0.97

Two-surgeon technique using saline-linked electric cautery and ultrasonic surgical aspirator in living donor hepatectomy: its safety and efficacy. Am J Surg (2008) 0.96

Identification of peptide vaccine candidates for prostate cancer patients with HLA-A3 supertype alleles. Clin Cancer Res (2005) 0.96

Rib-lifting method for retraction of the low-lying costal arch in laparoscopic cholecystectomy of gallbladder torsion with kyphoscoliosis. Hepatogastroenterology (2009) 0.96

Living donor liver transplantation for hepatitis C virus cirrhosis with a huge portal vein aneurysm. Liver Transpl (2008) 0.95

Hepatolithiasis and intrahepatic cholangiocarcinoma: carcinogenesis based on molecular mechanisms. J Hepatobiliary Pancreat Surg (2005) 0.94

Immunological evaluation of individualized peptide vaccination with a low dose of estramustine for HLA-A24+ HRPC patients. Prostate (2005) 0.94

Limited pancreatectomy for metastatic pancreatic tumors from renal cell carcinoma. Hepatogastroenterology (2010) 0.94

Evolution of living donor liver transplantation over 10 years: experience of a single center. Surg Today (2008) 0.94

Expression of S100 protein family members in normal skin and sweat gland tumors. J Dermatol Sci (2013) 0.93

Genetic alterations in gallbladder carcinoma. Surg Today (2005) 0.93

Compressive stenosis of the inferior vena cava due to localized ascites after living-donor liver transplantation. J Hepatobiliary Pancreat Surg (2008) 0.93

Vaccination with predesignated or evidence-based peptides for patients with recurrent gynecologic cancers. J Immunother (2003) 0.92

Role of hypermethylation on carcinogenesis in the pancreas. Surg Today (2004) 0.92

Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. Mol Ther (2013) 0.92

Gastric rupture with necrosis following acute gastric dilatation: report of a case. Surg Today (2012) 0.92

Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice. Hepatology (2014) 0.92

Significance of the serum level of soluble E-cadherin in patients with HCC. Hepatogastroenterology (2008) 0.91

Potential immunogenicity of adult T cell leukemia cells in vivo. Int J Cancer (2005) 0.91

Helicobacter pylori accelerates the biliary epithelial cell proliferation activity in hepatolithiasis. Hepatogastroenterology (2002) 0.91

Immunological risks of adult T-cell leukemia at primary HTLV-I infection. Trends Microbiol (2004) 0.91

Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation. J Gastroenterol (2009) 0.90

Chemopreventative effect of a cyclooxygenase-2-specific inhibitor (etodolac) on chemically induced biliary carcinogenesis in hamsters. Carcinogenesis (2004) 0.90

Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I:C), on human breast cancer. Breast Cancer Res Treat (2011) 0.90

Overexpression of interleukin-15 in vivo enhances antitumor activity against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response. Int J Cancer (2002) 0.90

Prostatic acid phosphatase as a target molecule in specific immunotherapy for patients with nonprostate adenocarcinoma. J Immunother (2005) 0.90

A case of mucin producing liver metastases with intrabiliary extension. World J Gastroenterol (2006) 0.89

Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy. J Gastroenterol (2014) 0.89

Oxidative stress and tumor progression in colorectal cancer. Hepatogastroenterology (2009) 0.89

Cytokeratin 20 (CK20) and apomucin 1 (MUC1) expression in ampullary carcinoma: Correlation with tumor progression and prognosis. Diagn Pathol (2010) 0.88

The critical role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen. Transplantation (2004) 0.88

ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. Oncol Rep (2005) 0.87

Resectable carcinoma developing in the remnant pancreas 3 years after pylorus-preserving pancreaticoduodenectomy for invasive ductal carcinoma of the pancreas. Pancreas (2008) 0.87

Identification of new prostate stem cell antigen-derived peptides immunogenic in HLA-A2(+) patients with hormone-refractory prostate cancer. Cancer Immunol Immunother (2003) 0.87

Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma. Am J Surg (2006) 0.87

Bile-reflux into the pancreatic ducts is associated with the development of intraductal papillary carcinoma in hamsters. J Surg Res (2006) 0.87

Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells. PLoS One (2013) 0.87

Adult T-cell leukemia: future prophylaxis and immunotherapy. Expert Rev Anticancer Ther (2004) 0.86

Tape-guided living donor left hepatectomy. Am J Surg (2007) 0.86

Repression of tax expression is associated both with resistance of human T-cell leukemia virus type 1-infected T cells to killing by tax-specific cytotoxic T lymphocytes and with impaired tumorigenicity in a rat model. J Virol (2004) 0.86

Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus. J Immunol (2010) 0.86

IL-12 gene therapy is an effective therapeutic strategy for hepatocellular carcinoma in immunosuppressed mice. J Immunol (2004) 0.86

Development of immunostimulatory virotherapy using non-transmissible Sendai virus-activated dendritic cells. Biochem Biophys Res Commun (2007) 0.86

Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma. Cancer Immunol Immunother (2009) 0.86

Protein-bound polysaccharide-K (PSK) induces apoptosis via p38 mitogen-activated protein kinase pathway in promyelomonocytic leukemia HL-60 cells. Anticancer Res (2012) 0.86

Gastric wall-covering method prevents pancreatic fistula after distal pancreatectomy. Hepatogastroenterology (2009) 0.85

Intratumoral neoadjuvant immunotherapy using IL-12 and dendritic cells is an effective strategy to control recurrence of murine hepatocellular carcinoma in immunosuppressed mice. J Immunol (2010) 0.85

Common fragile genes and digestive tract cancers. Surg Today (2006) 0.85

Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages. Cancer Sci (2009) 0.85

Non-transmissible Sendai virus encoding granulocyte macrophage colony-stimulating factor is a novel and potent vector system for producing autologous tumor vaccines. Cancer Sci (2008) 0.85

Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8. Lab Invest (2013) 0.85

Glycine reduces hepatic warm ischaemia-reperfusion injury by suppressing inflammatory reactions in rats. Liver Int (2007) 0.85

Identification of Programmed Death Ligand 1-derived Peptides Capable of Inducing Cancer-reactive Cytotoxic T Lymphocytes From HLA-A24+ Patients With Renal Cell Carcinoma. J Immunother (2015) 0.85

Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation. Ann Transplant (2007) 0.85

Laparoscopic stomach-partitioning gastrojejunostomy with reduced-port techniques for unresectable distal gastric cancer. J Laparoendosc Adv Surg Tech A (2014) 0.84

Solitary recurrence of hilar cholangiocarcinoma in a mediastinal lymph node two years after curative resection. World J Gastroenterol (2007) 0.84

Characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors. Cancer Sci (2014) 0.84

Radical surgery for advanced pure squamous cell carcinoma of the gallbladder: report of a case. Hepatogastroenterology (2012) 0.84

The effect of denervation on liver regeneration in partially hepatectomized rats. J Surg Res (2007) 0.84

Tumor immunity against adult T-cell leukemia. Cancer Sci (2005) 0.84

HER2/neu-derived peptides recognized by both cellular and humoral immune systems in HLA-A2+ cancer patients. Int J Oncol (2004) 0.84

A secure taping technique for a liver hanging maneuver using a surgical probe. Surg Today (2008) 0.83

Loss of heterozygosity of chromosome 16q in gallbladder carcinoma. J Surg Res (2002) 0.83

Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages. Cancer Sci (2008) 0.83

New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype alleles. J Immunother (2007) 0.83

Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil derivative (TS-1) for advanced gastric or colorectal carcinoma patients. Cancer Sci (2007) 0.83

Secure hemostasis in transhiatal esophagectomy for esophageal cancer with gauze packing. World J Surg Oncol (2012) 0.83

Newly-developed Sendai virus vector for retinal gene transfer: reduction of innate immune response via deletion of all envelope-related genes. J Gene Med (2008) 0.83

Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis. Clin Immunol (2007) 0.83

The impact of the intra-abdominal space on liver regeneration after a partial hepatectomy in rats. J Surg Res (2010) 0.82

A prostate stem cell antigen-derived peptide immunogenic in HLA-A24- prostate cancer patients. Prostate (2004) 0.82