PubRank

Alexander Dömling

Author PubWeight™ 47.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Transient protein states in designing inhibitors of the MDM2-p53 interaction. Structure 2013 1.63
2 Survivin is a therapeutic target in Merkel cell carcinoma. Sci Transl Med 2012 1.61
3 Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. PLoS One 2012 1.60
4 Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle 2010 1.52
5 The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. Angew Chem Int Ed Engl 2011 1.30
6 Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. Angew Chem Int Ed Engl 2010 1.29
7 1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity. Chem Biol Drug Des 2010 1.07
8 Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel. Chemistry 2010 1.06
9 Efficient and diverse synthesis of indole derivatives. J Org Chem 2009 1.04
10 Efficient assembly of iminodicarboxamides by a "truly" four-component reaction. Angew Chem Int Ed Engl 2012 1.03
11 Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists. J Comb Chem 2010 1.03
12 Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists. ChemMedChem 2011 1.01
13 Polycyclic indole alkaloid-type compounds by MCR. Chem Commun (Camb) 2009 1.01
14 The Gewald multicomponent reaction. Mol Divers 2010 0.97
15 Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J 2006 0.96
16 Tritylamine as an ammonia surrogate in the Ugi tetrazole synthesis. Org Lett 2013 0.96
17 Design and modular parallel synthesis of a MCR derived alpha-helix mimetic protein-protein interaction inhibitor scaffold. Bioorg Med Chem Lett 2006 0.95
18 Robust NMR screening for lead compounds using tryptophan-containing proteins. J Am Chem Soc 2009 0.95
19 MCR synthesis of praziquantel derivatives. Chem Biol Drug Des 2012 0.94
20 Cyanoacetamide multicomponent reaction (I): Parallel synthesis of cyanoacetamides. J Comb Chem 2009 0.93
21 Efficient C2 functionalisation of 2H-2-imidazolines. Org Biomol Chem 2007 0.93
22 Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present). Expert Opin Ther Pat 2013 0.91
23 Polycyclic compounds by Ugi-Pictet-Spengler sequence. J Org Chem 2010 0.90
24 Efficient synthesis of arrays of amino acid derived Ugi products with subsequent amidation. J Comb Chem 2009 0.90
25 Design of a versatile multicomponent reaction leading to 2-amino-5-ketoaryl pyrroles. Chem Biol Drug Des 2010 0.89
26 Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem Biol 2014 0.87
27 Cyanoacetamide MCR (III): three-component Gewald reactions revisited. J Comb Chem 2010 0.87
28 Desosamine in multicomponent reactions. Bioorg Med Chem Lett 2006 0.87
29 Massive parallel catalyst screening: toward asymmetric MCRs. Org Lett 2003 0.85
30 Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds. Org Lett 2012 0.85
31 Various cyclization scaffolds by a truly Ugi 4-CR. Org Biomol Chem 2013 0.84
32 One-pot synthesis of highly functionalized seleno amino acid derivatives. Chem Biol Drug Des 2009 0.84
33 One-pot multicomponent synthesis of two novel thiolactone scaffolds. Mol Divers 2010 0.83
34 Short and diverse route toward complex natural product-like macrocycles. Org Lett 2003 0.82
35 One-pot synthesis of 2-amino-indole-3-carboxamide and analogous. ACS Comb Sci 2010 0.82
36 A universal isocyanide for diverse heterocycle syntheses. Org Lett 2014 0.82
37 Identification of Hsp70 modulators through modeling of the substrate binding domain. Bioorg Med Chem Lett 2009 0.82
38 Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder. J Med Chem 2011 0.81
39 (-)-Bacillamide C: the convergent approach. Org Biomol Chem 2009 0.81
40 1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy. Chem Biol Drug Des 2010 0.80
41 Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot. Chemistry 2013 0.79
42 Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2. Bioorg Med Chem 2012 0.78
43 Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor. ACS Comb Sci 2014 0.78
44 Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy. Bioorg Med Chem Lett 2004 0.78
45 Highly substituted pyrrolidinones and pyridones by 4-CR/2-CR sequence. Org Lett 2004 0.76
46 Cyanoacetamides (IV): versatile one-pot route to 2-quinoline-3-carboxamides. ACS Comb Sci 2012 0.76
47 Modern Multicomponent Reactions for better Drug Syntheses** Org Chem Front 2014 0.76
48 2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists. Bioorg Med Chem Lett 2015 0.76
49 New MCRs: the first 4-component reaction leading to 2,4-disubstituted thiazoles. Mol Divers 2003 0.76
50 Hot, hotter, hottest. Cell Cycle 2009 0.75
51 Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions. Org Biomol Chem 2014 0.75
52 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 2017 0.75
53 Library-to-library synthesis of highly substituted α-aminomethyl tetrazoles via Ugi reaction. ACS Comb Sci 2017 0.75
54 Special issue on Mini-MCR issue and SCS-09--Second International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials. Editorial. Mol Divers 2011 0.75