Published in Evid Based Complement Alternat Med on January 21, 2013
The formalin test: an evaluation of the method. Pain (1992) 7.29
The evolving role of natural products in drug discovery. Nat Rev Drug Discov (2005) 7.18
Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J Pathol (1971) 6.97
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain (1987) 6.37
The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain (1977) 5.45
Medicinal plants in therapy. Bull World Health Organ (1985) 5.24
The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother (1968) 4.75
Plants as source of drugs. Toxicon (2001) 3.66
Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics. J Pharmacol Exp Ther (1959) 3.50
Nonsteroidal antiinflammatory drugs--differences and similarities. N Engl J Med (1991) 3.05
Modified formalin test: characteristic biphasic pain response. Pain (1989) 3.00
A method for evaluating both non-narcotic and narcotic analgesics. Proc Soc Exp Biol Med (1958) 2.70
Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther (1977) 2.11
Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods (1985) 1.95
Peripheral mechanisms of opioid analgesia. Anesth Analg (1993) 1.81
Studies on the antinociceptive action of alpha-agonist drugs and their interactions with opioid mechanisms. Br J Pharmacol (1983) 1.81
Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors. J Ethnopharmacol (1996) 1.67
Naturally occurring antinociceptive substances from plants. Phytother Res (2000) 1.63
The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation. Eur J Pharmacol (1980) 1.48
Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse. Br J Pharmacol (1993) 1.39
Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat. Proc Soc Exp Biol Med (1973) 1.36
Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. Agents Actions (1991) 1.30
Blockade of bradykinin-induced nociception in the rat as a test for analgesic drugs with particular reference to morphine antagonists. J Pharm Pharmacol (1967) 1.29
The croton oil ear test revisited. Agents Actions (1986) 1.24
Peripheral antinociceptive effects of N-methyl morphine. Life Sci (1983) 1.21
Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Neuropeptides (1997) 1.18
Methodological refinements to the mouse paw formalin test. An animal model of tonic pain. J Pharmacol Methods (1988) 1.16
INHIBITION OF PHENYLQUINONE-INDUCED WRITHING BY NARCOTIC ANTAGONISTS. Nature (1964) 1.09
USE OF WRITHING TEST FOR EVALUATING ANALGESIC ACTIVITY OF NARCOTIC ANTAGONISTS. Proc Soc Exp Biol Med (1965) 0.98
Antinociceptive models displaying peripheral opioid activity. Int J Tissue React (1985) 0.98
Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui. J Nat Prod (1991) 0.97
Non-specificity of the mouse writhing test. Arch Int Pharmacodyn Ther (1967) 0.95
Kinins and peritoneal exudates induced by carrageenin and zymosan in rats. Br J Pharmacol (1990) 0.93
Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: a comparison to other classes of antinociceptive agent. Pain (1995) 0.93
In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg. (Euphorbiaceae). J Ethnopharmacol (2004) 0.92
Antinociceptive and antiinflammatory activities of grandisin extracted from Virola surinamensis. Phytother Res (2010) 0.92
Prevention of writhing and other effects of narcotics and narcotic antagonists in mice. J Pharmacol Exp Ther (1968) 0.90
Differential antinociceptive effects of morphine and methylmorphine in the formalin test. Pain (1992) 0.85
Effects of several anti-inflammatory drugs on the various parameters involved in the inflammatory response in rat carrageenin-induced pleurisy. Eur J Pharmacol (1983) 0.85
Comparative analgetic testing of various compounds in mice using writhing techniques. Arzneimittelforschung (1978) 0.82
Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus. Gen Pharmacol (1995) 0.81
The formalin test in mice: the influence of ambient temperature. Pain (1991) 0.79
Comparison of croton oil and cantharidin induced inflammations of the mouse ear and their modification by topically applied drugs. Arch Int Pharmacodyn Ther (1981) 0.78
Arachidonic acid (AA) and tetradecanoylphorbol acetate (TPA) exert systemic effects when applied topically in the mouse. Inflammation (1998) 0.78
Global phytochemistry: the Brazilian approach. Phytochemistry (2001) 0.77
Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma. Oral Oncol (2012) 0.97
Chemical Constituents of Essential Oil from Lippia sidoides Cham. (Verbenaceae) Leaves Cultivated in Hidrolândia, Goiás, Brazil. Int J Anal Chem (2012) 0.92
Impact of ultrasound-assisted extraction on quality and photostability of the Pothomorphe umbellata extracts. Ultrason Sonochem (2011) 0.87
Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil. Evid Based Complement Alternat Med (2012) 0.84
Repellent activity of plant-derived compounds against Amblyomma cajennense (Acari: Ixodidae) nymphs. Vet Parasitol (2009) 0.84
Investigation of Ehrlich ascites tumor cell death mechanisms induced by Synadenium umbellatum Pax. J Ethnopharmacol (2011) 0.82
Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid. J Nat Med (2011) 0.82
Phytochemical Analysis and Antimicrobial, Antinociceptive, and Anti-Inflammatory Activities of Two Chemotypes of Pimenta pseudocaryophyllus (Myrtaceae). Evid Based Complement Alternat Med (2012) 0.81
Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients. Lasers Surg Med (2015) 0.80
The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.79
Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta. Evid Based Complement Alternat Med (2012) 0.79
Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus. J Ethnopharmacol (2012) 0.79
Bioconversion of quercetin and rutin and the cytotoxicity activities of the transformed products. Food Chem Toxicol (2012) 0.78
Antidepressive-Like Property of Dichloromethane Fraction of Pimenta pseudocaryophyllus and Relevance of Monoamine Metabolic Enzymes. Evid Based Complement Alternat Med (2013) 0.77
Hypotensive effect of Aspidosperma subincanum Mart. in rats and its mechanism of vasorelaxation in isolated arteries. J Ethnopharmacol (2012) 0.77
The clinicopathological significance of the expression of Granzyme B in oral squamous cell carcinoma. Oral Oncol (2010) 0.77
The compound cis-(dichloro)tetrammineruthenium(III) chloride induces caspase-mediated apoptosis in K562 cells. Toxicol In Vitro (2010) 0.77
Multicompartimental nanoparticles for co-encapsulation and multimodal drug delivery to tumor cells and neovasculature. Pharm Res (2013) 0.76
Anti-inflammatory effect of (E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol. J Pharm Pharmacol (2012) 0.76
Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax. J Ethnopharmacol (2008) 0.76
Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol. Food Funct (2014) 0.76
Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark. J Nat Med (2011) 0.75
Preliminary studies of gastroprotective effect of Celtis iguanaea (Jacq.) Sargent leaves (Ulmaceae). Nat Prod Res (2012) 0.75
Anti-inflammatory effect of Spiranthera odoratissima A. St.-Hil. leaves involves reduction of TNF-α. Nat Prod Res (2012) 0.75
4-Nerolidylcatechol and its synthetic analogues: antioxidant activity and toxicity evaluation. Eur J Med Chem (2012) 0.75
Central pharmacological activity of a new piperazine derivative: 4-(1-phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester. Life Sci (2012) 0.75