Published in Front Pharmacol on February 11, 2013
Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors. Proc Natl Acad Sci U S A (2015) 2.12
GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease. J Cell Physiol (2015) 0.98
GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases. J Cell Physiol (2015) 0.96
OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies. J Cell Physiol (2015) 0.94
Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis. BMC Cancer (2013) 0.88
Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents? Mar Drugs (2015) 0.84
Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. PLoS One (2013) 0.82
Serum GRP78 as a Tumor Marker and Its Prognostic Significance in Non-Small Cell Lung Cancers: A Retrospective Study. Dis Markers (2015) 0.82
Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3. PLoS One (2015) 0.82
Enhanced antitumor effects of adenoviral-mediated siRNA against GRP78 gene on adenosine-induced apoptosis in human hepatoma HepG2 cells. Int J Mol Sci (2014) 0.78
Cell surface GRP78: A potential marker of good prognosis and response to chemotherapy in breast cancer. Oncol Lett (2015) 0.78
A novel combination treatment for breast cancer cells involving BAPTA-AM and proteasome inhibitor bortezomib. Oncol Lett (2016) 0.77
Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther (2016) 0.77
The unfolded protein response in glioblastomas: targetable or trouble? Future Sci OA (2015) 0.76
RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures. Nano Lett (2016) 0.76
Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress. Oncol Rep (2014) 0.75
Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein. J Biol Chem (2016) 0.75
Comparative proteomic analysis of paclitaxel resistance-related proteins in human breast cancer cell lines. Oncol Lett (2016) 0.75
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression. Neoplasia (2016) 0.75
Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers. Breast Cancer Res (2016) 0.75
PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis. Front Endocrinol (Lausanne) (2017) 0.75
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep (2017) 0.75
BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers. Oncotarget (2017) 0.75
HSPA5/Dna K may be a useful target for human disease therapies. DNA Cell Biol (2015) 0.75
ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer. Oncotarget (2016) 0.75
Plumbagin sensitizes breast cancer cells to tamoxifen-induced cell death through GRP78 inhibition and Bik upregulation. Sci Rep (2017) 0.75
Effects of 17-DMAG on diffuse large B-cell lymphoma cell apoptosis. Exp Ther Med (2017) 0.75
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell (2001) 11.21
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell (1993) 9.84
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol (2001) 8.03
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
Immunoglobulin heavy chain binding protein. Nature (1984) 5.64
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J Biol Chem (2000) 4.37
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol (2002) 4.11
The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer (2004) 3.86
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem (2004) 3.70
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature (2006) 3.65
The ER function BiP is a master regulator of ER function. Mt Sinai J Med (2004) 3.01
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell (2004) 2.99
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res (2007) 2.82
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. Breast Cancer Res Treat (2000) 2.20
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci U S A (2008) 2.07
Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders. Antioxid Redox Signal (2009) 1.98
GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res (2006) 1.96
Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. Cancer Biol Ther (2010) 1.85
Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study. Mol Ther (2005) 1.81
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum Pathol (2007) 1.74
Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer. Clin Cancer Res (2006) 1.73
(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. Cancer Res (2006) 1.60
BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis. Cancer Res (2006) 1.58
Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One (2009) 1.58
Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res (2008) 1.58
De-regulation of GRP stress protein expression in human breast cancer cell lines. Breast Cancer Res Treat (1999) 1.57
Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment. Cancer Res (2005) 1.55
A new tumor-specific variant of GRP78 as target for antibody-based therapy. Lab Invest (2008) 1.42
Activation and clinical significance of the unfolded protein response in breast cancer. Br J Cancer (2009) 1.28
Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors. Cancer Res (2010) 1.17
Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. Br J Haematol (2011) 1.02
GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy. Int J Cancer (2011) 1.01
The human IgM antibody SAM-6 induces tumor-specific apoptosis with oxidized low-density lipoprotein. Mol Cancer Ther (2007) 1.01
Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34. Genomics (1994) 0.99
A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. Melanoma Res (2012) 0.99
Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78. Int J Cancer (2010) 0.98
GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer. J Pathol (2010) 0.93
A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy. Bioorg Med Chem Lett (2008) 0.91
Altered gene expression in drug-resistant human breast cancer cells. Clin Cancer Res (1997) 0.91
A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death. PLoS One (2012) 0.90
Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin. Cancer Sci (2009) 0.89
Prunustatin A, a novel GRP78 molecular chaperone down-regulator isolated from Streptomyces violaceoniger. J Antibiot (Tokyo) (2005) 0.83
The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection. Prostate (2010) 1.10
Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis. BMC Cancer (2013) 0.88
Intracellular refolding assay. J Vis Exp (2012) 0.78
Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type iα of protein kinase a in vivo. Int J Mol Sci (2013) 0.75
Corrigendum: In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature (2015) 0.75