Synthesis and characterization of hybrid hyaluronic acid-gelatin hydrogels.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMC 3643200)

Published in Biomacromolecules on March 28, 2013

Authors

Gulden Camci-Unal1, Davide Cuttica, Nasim Annabi, Danilo Demarchi, Ali Khademhosseini

Author Affiliations

1: Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA.

Articles citing this

25th anniversary article: Rational design and applications of hydrogels in regenerative medicine. Adv Mater (2014) 1.52

A fibrin/hyaluronic acid hydrogel for the delivery of mesenchymal stem cells and potential for articular cartilage repair. J Biol Eng (2014) 1.44

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Lab Chip (2014) 1.34

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials (2015) 1.15

Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels. Biofabrication (2014) 1.02

Gradient static-strain stimulation in a microfluidic chip for 3D cellular alignment. Lab Chip (2014) 0.90

Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells. Acta Biomater (2013) 0.90

Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. Biomaterials (2016) 0.85

Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Adv Healthc Mater (2014) 0.84

Hyaluronic acid enhances the mechanical properties of tissue-engineered cartilage constructs. PLoS One (2014) 0.82

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation. J Mol Cell Cardiol (2016) 0.78

Facile One-step Micropatterning Using Photodegradable Methacrylated Gelatin Hydrogels for Improved Cardiomyocyte Organization and Alignment. Adv Funct Mater (2015) 0.77

Opportunities for multicomponent hybrid hydrogels in biomedical applications. Biomacromolecules (2014) 0.77

High-throughput approaches for screening and analysis of cell behaviors. Biomaterials (2017) 0.75

Engineered 3D Cardiac Fibrotic Tissue to Study Fibrotic Remodeling. Adv Healthc Mater (2017) 0.75

Articles cited by this

Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00

Geometric control of cell life and death. Science (1997) 18.13

Role of cell shape in growth control. Nature (1978) 12.46

Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56

Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials (2003) 7.15

Hydrogels in regenerative medicine. Adv Mater (2009) 3.80

Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials (2010) 3.72

Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules (2005) 3.44

Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.19

Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. Biomaterials (2001) 3.12

Mechanical properties of hydrogels and their experimental determination. Biomaterials (1996) 2.96

Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release (2005) 2.32

Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties. Biomaterials (2006) 2.10

Rational design of hydrogels for tissue engineering: impact of physical factors on cell behavior. Biomaterials (2006) 1.74

Photocrosslinking of gelatin macromers to synthesize porous hydrogels that promote valvular interstitial cell function. Tissue Eng Part A (2009) 1.67

Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels. Adv Funct Mater (2012) 1.63

Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells. Biomaterials (2005) 1.51

In vitro characterization of chitosan-gelatin scaffolds for tissue engineering. Biomaterials (2005) 1.43

Designing scaffolds for valvular interstitial cells: cell adhesion and function on naturally derived materials. J Biomed Mater Res A (2004) 1.43

Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc Res (1999) 1.43

Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly(ethylene glycol)-based hydrogels as a scaffold for cartilage repair. Tissue Eng (2004) 1.43

The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels. Biomaterials (2010) 1.40

Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Biomaterials (2006) 1.40

An improved protocol for primary culture of cardiomyocyte from neonatal mice. In Vitro Cell Dev Biol Anim (2008) 1.31

Adipose tissue engineering based on human preadipocytes combined with gelatin microspheres containing basic fibroblast growth factor. Biomaterials (2003) 1.26

Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione. Bioconjug Chem (2005) 1.23

The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation. Biomaterials (2010) 1.21

BIOMIMETIC GRADIENT HYDROGELS FOR TISSUE ENGINEERING. Can J Chem Eng (2010) 1.17

Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions. Biochim Biophys Acta (2010) 1.10

Correlations between structure, material properties and bioproperties in self-assembled beta-hairpin peptide hydrogels. Faraday Discuss (2008) 1.10

Enzyme-catalyzed gel formation of gelatin and chitosan: potential for in situ applications. Biomaterials (2003) 1.09

Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin. Int J Oncol (2009) 1.05

Photopatterned collagen-hyaluronic acid interpenetrating polymer network hydrogels. Acta Biomater (2009) 1.05

Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture. Biomaterials (2009) 1.01

Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche. Biomaterials (2011) 1.01

Reduced thrombus formation by hyaluronic acid coating of endovascular devices. Arterioscler Thromb Vasc Biol (2000) 0.98

The role of stiffness of gelatin-hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell. Biomaterials (2010) 0.96

Hydrogel surfaces to promote attachment and spreading of endothelial progenitor cells. J Tissue Eng Regen Med (2012) 0.91

Decoupled control of stiffness and permeability with a cell-encapsulating poly(ethylene glycol) dimethacrylate hydrogel. Biomaterials (2010) 0.91

The characteristics of spontaneously forming physically cross-linked hydrogels composed of two water-soluble phospholipid polymers for oral drug delivery carrier I: hydrogel dissolution and insulin release under neutral pH condition. Eur J Pharm Sci (2004) 0.90

Surface-modified hyaluronic acid hydrogels to capture endothelial progenitor cells. Soft Matter (2010) 0.90

Attachment of hyaluronic acid to polypropylene, polystyrene, and polytetrafluoroethylene. Biomaterials (2000) 0.89

Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line. Int J Cancer (1999) 0.88

Interdigitated array of Pt electrodes for electrical stimulation and engineering of aligned muscle tissue. Lab Chip (2012) 0.88

Production of arrays of cardiac and skeletal muscle myofibers by micropatterning techniques on a soft substrate. Biomed Microdevices (2009) 0.87

Hyaluronic acid hydrogel as Nogo-66 receptor antibody delivery system for the repairing of injured rat brain: in vitro. J Control Release (2005) 0.86

Morphologic recognition of complex carbohydrates in embryonic cardiac extracellular matrix. J Histochem Cytochem (1979) 0.85

Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-polyethylene glycol diacrylate hybrid hydrogels. Acta Biomater (2010) 0.85

Functionally modified gelatin microspheres impregnated collagen scaffold as novel wound dressing to attenuate the proteases and bacterial growth. Eur J Pharm Sci (2008) 0.85

A biomimetic hydrogel based on methacrylated dextran-graft-lysine and gelatin for 3D smooth muscle cell culture. Biomaterials (2009) 0.84

Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials. Biomaterials (2000) 0.84

Macromolecules of the extracellular compartment of embryonic and mature hearts. Circ Res (1976) 0.81

Development of hydrogels and biomimetic regulators as tissue engineering scaffolds. Membranes (Basel) (2012) 0.79

Articles by these authors

Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res (2004) 4.56

Hydrogels in regenerative medicine. Adv Mater (2009) 3.80

Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials (2010) 3.72

Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs. Proc Natl Acad Sci U S A (2008) 3.17

Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc Natl Acad Sci U S A (2009) 2.56

Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells. Lab Chip (2007) 2.30

Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators. ACS Nano (2013) 2.23

A cell-laden microfluidic hydrogel. Lab Chip (2007) 2.15

Micromolding of shape-controlled, harvestable cell-laden hydrogels. Biomaterials (2006) 2.12

A microwell array system for stem cell culture. Biomaterials (2007) 2.10

Directed 3D cell alignment and elongation in microengineered hydrogels. Biomaterials (2010) 1.94

Modular Tissue Engineering: Engineering Biological Tissues from the Bottom Up. Soft Matter (2009) 1.93

Nano/Microfluidics for diagnosis of infectious diseases in developing countries. Adv Drug Deliv Rev (2009) 1.87

A simple soft lithographic route to fabrication of poly(ethylene glycol) microstructures for protein and cell patterning. Biomaterials (2004) 1.84

Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir (2004) 1.76

Integrating microfluidics and lensless imaging for point-of-care testing. Biosens Bioelectron (2009) 1.74

Microfluidics for drug discovery and development: from target selection to product lifecycle management. Drug Discov Today (2007) 1.71

Microfabricated biomaterials for engineering 3D tissues. Adv Mater (2012) 1.65

Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels. Adv Funct Mater (2012) 1.63

Controlling the porosity and microarchitecture of hydrogels for tissue engineering. Tissue Eng Part B Rev (2010) 1.61

Cell and protein compatibility of parylene-C surfaces. Langmuir (2007) 1.58

Stop-flow lithography to generate cell-laden microgel particles. Lab Chip (2008) 1.57

Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures. Biomaterials (2006) 1.54

25th anniversary article: Rational design and applications of hydrogels in regenerative medicine. Adv Mater (2014) 1.52

Engineering microscale topographies to control the cell-substrate interface. Biomaterials (2012) 1.51

Controlled-size embryoid body formation in concave microwell arrays. Biomaterials (2010) 1.49

Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets. Tissue Eng Part C Methods (2010) 1.46

Carbon nanotube reinforced hybrid microgels as scaffold materials for cell encapsulation. ACS Nano (2011) 1.46

Microfluidic system for studying the interaction of nanoparticles and microparticles with cells. Anal Chem (2005) 1.45

Synthesis and characterization of tunable poly(ethylene glycol): gelatin methacrylate composite hydrogels. Tissue Eng Part A (2011) 1.44

Mechanically robust and bioadhesive collagen and photocrosslinkable hyaluronic acid semi-interpenetrating networks. Tissue Eng Part A (2009) 1.43

Fiber-based tissue engineering: Progress, challenges, and opportunities. Biotechnol Adv (2012) 1.42

Biomimetic tissues on a chip for drug discovery. Drug Discov Today (2011) 1.41

Digitally tunable physicochemical coding of material composition and topography in continuous microfibres. Nat Mater (2011) 1.38

Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro. Stem Cells (2005) 1.38

Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components. Biomaterials (2005) 1.38

Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography. Biomaterials (2012) 1.34

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Lab Chip (2014) 1.34

Directed endothelial cell morphogenesis in micropatterned gelatin methacrylate hydrogels. Biomaterials (2012) 1.33

Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering. Lab Chip (2011) 1.30

Sequential assembly of cell-laden hydrogel constructs to engineer vascular-like microchannels. Biotechnol Bioeng (2011) 1.28

Microscale electroporation: challenges and perspectives for clinical applications. Integr Biol (Camb) (2009) 1.28

Vascularized bone tissue engineering: approaches for potential improvement. Tissue Eng Part B Rev (2012) 1.24

Rapid generation of spatially and temporally controllable long-range concentration gradients in a microfluidic device. Lab Chip (2008) 1.24

A cell-based biosensor for real-time detection of cardiotoxicity using lensfree imaging. Lab Chip (2011) 1.22

Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration. Biomaterials (2006) 1.21

Integration column: microwell arrays for mammalian cell culture. Integr Biol (Camb) (2009) 1.21

Generation of static and dynamic patterned co-cultures using microfabricated parylene-C stencils. Lab Chip (2007) 1.21

Reusable, reversibly sealable parylene membranes for cell and protein patterning. J Biomed Mater Res A (2008) 1.21

The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules. Biomaterials (2012) 1.21

Stimuli-responsive microwells for formation and retrieval of cell aggregates. Lab Chip (2010) 1.20

Bioinspired materials for controlling stem cell fate. Acc Chem Res (2010) 1.19

Patterned differentiation of individual embryoid bodies in spatially organized 3D hybrid microgels. Adv Mater (2010) 1.18

Micro-masonry: construction of 3D structures by microscale self-assembly. Adv Mater (2010) 1.17

Electrospun scaffolds for tissue engineering of vascular grafts. Acta Biomater (2013) 1.17

BIOMIMETIC GRADIENT HYDROGELS FOR TISSUE ENGINEERING. Can J Chem Eng (2010) 1.17

Nanocomposite hydrogels for biomedical applications. Biotechnol Bioeng (2013) 1.15

Organs-on-a-chip: a new tool for drug discovery. Expert Opin Drug Discov (2014) 1.15

Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing. Lab Chip (2006) 1.14

Biocompatibility of engineered nanoparticles for drug delivery. J Control Release (2012) 1.14

Building vascular networks. Sci Transl Med (2012) 1.14

Gradient biomaterials for soft-to-hard interface tissue engineering. Acta Biomater (2011) 1.13

Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold. J Control Release (2006) 1.12

3D biofabrication strategies for tissue engineering and regenerative medicine. Annu Rev Biomed Eng (2014) 1.12

Carbon-based nanomaterials: multifunctional materials for biomedical engineering. ACS Nano (2013) 1.11

Controlling the porosity of fibrous scaffolds by modulating the fiber diameter and packing density. J Biomed Mater Res A (2011) 1.11

Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering. Biofabrication (2010) 1.11

Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells. Lab Chip (2012) 1.11

Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels. Acta Biomater (2011) 1.10

Electrochemical desorption of self-assembled monolayers for engineering cellular tissues. Biomaterials (2009) 1.10

Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions. Biochim Biophys Acta (2010) 1.10

Microcirculation within grooved substrates regulates cell positioning and cell docking inside microfluidic channels. Lab Chip (2008) 1.10

Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells. Adv Mater (2013) 1.10

Magnetically responsive polymeric microparticles for oral delivery of protein drugs. Pharm Res (2006) 1.09

A controlled-release strategy for the generation of cross-linked hydrogel microstructures. J Am Chem Soc (2006) 1.08

Characterization of chemisorbed hyaluronic acid directly immobilized on solid substrates. J Biomed Mater Res B Appl Biomater (2005) 1.07

Microfluidic chip-based fabrication of PLGA microfiber scaffolds for tissue engineering. Langmuir (2008) 1.07

Hybrid PGS-PCL microfibrous scaffolds with improved mechanical and biological properties. J Tissue Eng Regen Med (2011) 1.07

Highly Elastic Micropatterned Hydrogel for Engineering Functional Cardiac Tissue. Adv Funct Mater (2013) 1.04

Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair. ACS Nano (2014) 1.03

Engineered contractile skeletal muscle tissue on a microgrooved methacrylated gelatin substrate. Tissue Eng Part A (2012) 1.03

Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications. Biomaterials (2011) 1.03

Directed assembly of cell-laden hydrogels for engineering functional tissues. Organogenesis (2011) 1.03

DNA-directed self-assembly of shape-controlled hydrogels. Nat Commun (2013) 1.02

Rapid generation of biologically relevant hydrogels containing long-range chemical gradients. Adv Funct Mater (2010) 1.02

Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels. Biofabrication (2014) 1.02

Convection-driven generation of long-range material gradients. Biomaterials (2009) 1.01

Interface-directed self-assembly of cell-laden microgels. Small (2010) 1.00

Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel. Biomaterials (2013) 1.00

Controlling the fibroblastic differentiation of mesenchymal stem cells via the combination of fibrous scaffolds and connective tissue growth factor. Tissue Eng Part A (2011) 0.99

Cell confinement in patterned nanoliter droplets in a microwell array by wiping. J Biomed Mater Res A (2010) 0.99

Microporous cell-laden hydrogels for engineered tissue constructs. Biotechnol Bioeng (2010) 0.99