Published in Microb Biotechnol on February 25, 2013
Engineering unnatural variants of plantazolicin through codon reprogramming. ACS Chem Biol (2013) 0.98
Bioengineering Lantibiotics for Therapeutic Success. Front Microbiol (2015) 0.86
In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products. ACS Chem Biol (2016) 0.77
Lanthipeptides: chemical synthesis versus in vivo biosynthesis as tools for pharmaceutical production. Microb Cell Fact (2016) 0.76
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis (2009) 22.98
Searching for peptide ligands with an epitope library. Science (1990) 10.75
Peptides on phage: a vast library of peptides for identifying ligands. Proc Natl Acad Sci U S A (1990) 6.34
Bacteriocins: developing innate immunity for food. Nat Rev Microbiol (2005) 5.77
Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature (1988) 4.41
Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J Biol Chem (2000) 3.65
Lipid II as a target for antibiotics. Nat Rev Drug Discov (2006) 3.01
Lantibiotics: mode of action, biosynthesis and bioengineering. Curr Pharm Biotechnol (2009) 2.56
The mode of action of the lantibiotic lacticin 3147--a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II. Mol Microbiol (2006) 2.53
Bacterial lantibiotics: strategies to improve therapeutic potential. Curr Protein Pept Sci (2005) 2.21
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19
Bacteriocin-based strategies for food biopreservation. Int J Food Microbiol (2007) 2.14
Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95
Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5. Antimicrob Agents Chemother (2005) 1.79
Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. Appl Environ Microbiol (2009) 1.68
The generation of nisin variants with enhanced activity against specific gram-positive pathogens. Mol Microbiol (2008) 1.62
Protein engineering of lantibiotics. Antonie Van Leeuwenhoek (1996) 1.54
Enterococcal cytolysin: a novel two component peptide system that serves as a bacterial defense against eukaryotic and prokaryotic cells. Curr Protein Pept Sci (2005) 1.54
Enhancement of the chemical and antimicrobial properties of subtilin by site-directed mutagenesis. J Biol Chem (1992) 1.48
Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation. Appl Environ Microbiol (2007) 1.46
Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design. Mol Microbiol (2006) 1.45
Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering. Appl Environ Microbiol (1995) 1.45
In vivo conversion of L-serine to D-alanine in a ribosomally synthesized polypeptide. J Biol Chem (1994) 1.40
Site-directed mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants. Appl Microbiol Biotechnol (2004) 1.40
Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics. Microbiology (2001) 1.34
Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations. Antimicrob Agents Chemother (2005) 1.30
Discovery of medically significant lantibiotics. Curr Drug Discov Technol (2009) 1.29
Two-peptide lantibiotics: a medical perspective. Mini Rev Med Chem (2007) 1.26
Dissecting structural and functional diversity of the lantibiotic mersacidin. Chem Biol (2009) 1.25
NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity. J Biol Chem (2003) 1.25
Identification of a novel two-peptide lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125. FEMS Microbiol Lett (2007) 1.21
Posttranslational conversion of L-serines to D-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147. Proc Natl Acad Sci U S A (2005) 1.20
Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin. Appl Environ Microbiol (2003) 1.20
A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species. J Antimicrob Chemother (2009) 1.20
Streptococcus rattus strain BHT produces both a class I two-component lantibiotic and a class II bacteriocin. FEMS Microbiol Lett (2005) 1.19
The dawning of a 'Golden era' in lantibiotic bioengineering. Mol Microbiol (2010) 1.18
Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13. PLoS One (2009) 1.14
Studies with bioengineered Nisin peptides highlight the broad-spectrum potency of Nisin V. Microb Biotechnol (2010) 1.14
Structure-activity study of the lantibiotic mutacin II from Streptococcus mutans T8 by a gene replacement strategy. Appl Environ Microbiol (1998) 1.10
Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system. Mol Microbiol (2009) 1.09
Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob Agents Chemother (2010) 1.08
Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin. FEBS Lett (1996) 1.08
Bioengineered nisin A derivatives with enhanced activity against both Gram positive and Gram negative pathogens. PLoS One (2012) 1.08
The structure of the antimicrobial peptide Ac-RRWWRF-NH2 bound to micelles and its interactions with phospholipid bilayers. J Pept Res (2003) 1.07
Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning. Mol Microbiol (2009) 1.05
Influence of charge differences in the C-terminal part of nisin on antimicrobial activity and signaling capacity. Eur J Biochem (1997) 0.99
Engineering a disulfide bond and free thiols in the lantibiotic nisin Z. Eur J Biochem (2000) 0.95
Identification of genes encoding two-component lantibiotic production in Staphylococcus aureus C55 and other phage group II S. aureus strains and demonstration of an association with the exfoliative toxin B gene. Infect Immun (1999) 0.95
Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry. J Am Chem Soc (2011) 0.94
Comparison of the activities of the lantibiotics nisin and lacticin 3147 against clinically significant mycobacteria. Int J Antimicrob Agents (2010) 0.93
Bioengineered nisin derivatives with enhanced activity in complex matrices. Microb Biotechnol (2012) 0.90
A system for the random mutagenesis of the two-peptide lantibiotic lacticin 3147: analysis of mutants producing reduced antibacterial activities. J Mol Microbiol Biotechnol (2007) 0.88
Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147. Microb Biotechnol (2009) 0.86
Relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55 based on structure, genetics and biological activity. BMC Microbiol (2007) 0.84
Homologues and bioengineered derivatives of LtnJ vary in ability to form D-alanine in the lantibiotic lacticin 3147. J Bacteriol (2011) 0.83
Gut microbiota composition correlates with diet and health in the elderly. Nature (2012) 6.94
Bacteriocins: developing innate immunity for food. Nat Rev Microbiol (2005) 5.77
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A (2010) 5.02
Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS One (2009) 4.93
Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions. Nucleic Acids Res (2010) 4.17
The interaction between bacteria and bile. FEMS Microbiol Rev (2005) 3.86
Surviving the acid test: responses of gram-positive bacteria to low pH. Microbiol Mol Biol Rev (2003) 3.54
Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence. FEMS Microbiol Rev (2002) 3.40
Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proc Natl Acad Sci U S A (2007) 3.32
Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev (2010) 3.30
Bacteriocins - a viable alternative to antibiotics? Nat Rev Microbiol (2012) 2.76
Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci U S A (2008) 2.53
The mode of action of the lantibiotic lacticin 3147--a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II. Mol Microbiol (2006) 2.53
Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity. Gut (2012) 2.24
Bacterial lantibiotics: strategies to improve therapeutic potential. Curr Protein Pept Sci (2005) 2.21
Bile salt hydrolase activity in probiotics. Appl Environ Microbiol (2006) 2.19
Genome sequence of Lactobacillus helveticus, an organism distinguished by selective gene loss and insertion sequence element expansion. J Bacteriol (2007) 2.15
Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon. Proc Natl Acad Sci U S A (2010) 2.11
The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Lett (2004) 1.93
Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. Infect Immun (2005) 1.90
Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc Natl Acad Sci U S A (2010) 1.89
Tools for functional postgenomic analysis of listeria monocytogenes. Appl Environ Microbiol (2008) 1.78
A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes. Mol Microbiol (2005) 1.74
High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob Agents Chemother (2012) 1.69
Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. Appl Environ Microbiol (2009) 1.68
The generation of nisin variants with enhanced activity against specific gram-positive pathogens. Mol Microbiol (2008) 1.62
Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity. Biochemistry (2004) 1.61
Bacteriophages φMR299-2 and φNH-4 can eliminate Pseudomonas aeruginosa in the murine lung and on cystic fibrosis lung airway cells. MBio (2012) 1.59
Bacteriocin production: a probiotic trait? Appl Environ Microbiol (2011) 1.57
Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ. Therap Adv Gastroenterol (2013) 1.56
Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro. Appl Environ Microbiol (2007) 1.54
Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes. PLoS Pathog (2008) 1.53
The gut microbiota and its relationship to diet and obesity: new insights. Gut Microbes (2012) 1.52
Novel luciferase reporter system for in vitro and organ-specific monitoring of differential gene expression in Listeria monocytogenes. Appl Environ Microbiol (2006) 1.50
Bacteriophage and their lysins for elimination of infectious bacteria. FEMS Microbiol Rev (2009) 1.48
Programming infant gut microbiota: influence of dietary and environmental factors. Curr Opin Biotechnol (2010) 1.48
Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. PLoS Pathog (2011) 1.46
Bile stress response in Listeria monocytogenes LO28: adaptation, cross-protection, and identification of genetic loci involved in bile resistance. Appl Environ Microbiol (2002) 1.46
Multiple deletions of the osmolyte transporters BetL, Gbu, and OpuC of Listeria monocytogenes affect virulence and growth at high osmolarity. Appl Environ Microbiol (2002) 1.46
Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design. Mol Microbiol (2006) 1.45
Streptolysin S-like virulence factors: the continuing sagA. Nat Rev Microbiol (2011) 1.42
The LisRK signal transduction system determines the sensitivity of Listeria monocytogenes to nisin and cephalosporins. Antimicrob Agents Chemother (2002) 1.41
A five-strain probiotic combination reduces pathogen shedding and alleviates disease signs in pigs challenged with Salmonella enterica Serovar Typhimurium. Appl Environ Microbiol (2007) 1.38
Marine bioactives as functional food ingredients: potential to reduce the incidence of chronic diseases. Mar Drugs (2011) 1.36
Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota. J Clin Microbiol (2011) 1.34
Bacteriophage-resistance systems in dairy starter strains: molecular analysis to application. Antonie Van Leeuwenhoek (2002) 1.34
Disruption of putative regulatory loci in Listeria monocytogenes demonstrates a significant role for Fur and PerR in virulence. Infect Immun (2004) 1.34
The CtsR regulator of Listeria monocytogenes contains a variant glycine repeat region that affects piezotolerance, stress resistance, motility and virulence. Mol Microbiol (2003) 1.33
Antimicrobial activity of lacticin 3,147 against clinical Clostridium difficile strains. J Med Microbiol (2007) 1.33
Isolation and analysis of bacteria with antimicrobial activities from the marine sponge Haliclona simulans collected from Irish waters. Mar Biotechnol (NY) (2008) 1.30
Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations. Antimicrob Agents Chemother (2005) 1.30
The interaction between Listeria monocytogenes and the host gastrointestinal tract. Microbiology (2009) 1.29
Discovery of medically significant lantibiotics. Curr Drug Discov Technol (2009) 1.29
AgrD-dependent quorum sensing affects biofilm formation, invasion, virulence and global gene expression profiles in Listeria monocytogenes. Mol Microbiol (2009) 1.29
M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis. FEMS Immunol Med Microbiol (2007) 1.27
A postgenomic appraisal of osmotolerance in Listeria monocytogenes. Appl Environ Microbiol (2003) 1.26
Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance. Environ Microbiol (2009) 1.26
Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci. Appl Environ Microbiol (2008) 1.26
Two-peptide lantibiotics: a medical perspective. Mini Rev Med Chem (2007) 1.26
Comparative genomics of lactic acid bacteria reveals a niche-specific gene set. BMC Microbiol (2009) 1.24
Molecular and physiological analysis of the role of osmolyte transporters BetL, Gbu, and OpuC in growth of Listeria monocytogenes at low temperatures. Appl Environ Microbiol (2004) 1.24
Role for HtrA in stress induction and virulence potential in Listeria monocytogenes. Appl Environ Microbiol (2005) 1.24