Published in Mol Microbiol on March 26, 2013
Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs. Cell Host Microbe (2015) 2.16
Inducible knockdown of Plasmodium gene expression using the glmS ribozyme. PLoS One (2013) 1.01
Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes. Eukaryot Cell (2013) 0.98
Conditional Degradation of Plasmodium Calcineurin Reveals Functions in Parasite Colonization of both Host and Vector. Cell Host Microbe (2015) 0.97
Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite. Biol Open (2013) 0.96
Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites. Cell Microbiol (2014) 0.93
The malarial serine protease SUB1 plays an essential role in parasite liver stage development. PLoS Pathog (2013) 0.91
Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cell Microbiol (2014) 0.91
A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite. Cell Host Microbe (2015) 0.90
Antiparasitic chemotherapy: from genomes to mechanisms. Annu Rev Pharmacol Toxicol (2013) 0.88
Novel thioredoxin-like proteins are components of a protein complex coating the cortical microtubules of Toxoplasma gondii. Eukaryot Cell (2013) 0.87
Versatile control of Plasmodium falciparum gene expression with an inducible protein-RNA interaction. Nat Commun (2014) 0.84
Paths to a malaria vaccine illuminated by parasite genomics. Trends Genet (2015) 0.84
Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle. Mol Microbiol (2015) 0.83
A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum. Sci Rep (2016) 0.82
Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion. J Cell Sci (2015) 0.82
Conditional U1 Gene Silencing in Toxoplasma gondii. PLoS One (2015) 0.81
Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum. PLoS One (2016) 0.81
From technology to biology: a malaria genetic toolbox for the functional dissection of essential genes. Mol Microbiol (2013) 0.79
Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress. Proc Natl Acad Sci U S A (2017) 0.79
A Telomeric Cluster of Antimony Resistance Genes on Chromosome 34 of Leishmania infantum. Antimicrob Agents Chemother (2016) 0.77
Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites. J Biol Chem (2016) 0.76
The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. Elife (2017) 0.76
Generation of rodent malaria parasites with a high mutation rate by destructing proofreading activity of DNA polymerase δ. DNA Res (2014) 0.76
Host cell remodeling by pathogens: the exomembrane system in Plasmodium-infected erythrocytes. FEMS Microbiol Rev (2016) 0.76
The HIV-1 transmission bottleneck. Retrovirology (2017) 0.75
Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation. Mol Microbiol (2016) 0.75
Generating conditional gene knockouts in Plasmodium - a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9. Sci Rep (2017) 0.75
Evidence that the Malaria Parasite Plasmodium falciparum Putative Rhoptry Protein 2 Localizes to the Golgi Apparatus throughout the Erythrocytic Cycle. PLoS One (2015) 0.75
Characterization of a putative Plasmodium falciparum SAC1 phosphoinositide-phosphatase homologue potentially required for survival during the asexual erythrocytic stages. Sci Rep (2017) 0.75
Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development. BMC Biol (2017) 0.75
Proteases as Antimalarial Targets: Strategies for Genetic, Chemical, and Therapeutic Validation. FEBS J (2017) 0.75
Human malaria parasites in continuous culture. Science (1976) 59.70
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (1996) 5.92
Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry. Nature (2002) 5.48
Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Nature (1997) 4.39
Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science (2002) 4.26
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A (1998) 3.88
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A (1995) 3.87
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res (2004) 3.63
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes. Cell (2007) 3.37
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (2010) 3.27
The genome of the simian and human malaria parasite Plasmodium knowlesi. Nature (2008) 3.02
An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat Methods (2007) 3.01
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol (2002) 2.70
Molecular identification of a malaria merozoite surface sheddase. PLoS Pathog (2005) 2.06
Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms. Nat Methods (2012) 2.00
Processing of the Plasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion. Mol Biochem Parasitol (1991) 1.92
Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa. Cell Host Microbe (2011) 1.91
Malarial proteases and host cell egress: an 'emerging' cascade. Cell Microbiol (2008) 1.86
Modulation of myosin A expression by a newly established tetracycline repressor-based inducible system in Toxoplasma gondii. Nucleic Acids Res (2001) 1.78
Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Res (2009) 1.71
A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J Biol Chem (2002) 1.71
Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chem Biol (2006) 1.65
Purification of Plasmodium falciparum merozoites for analysis of the processing of merozoite surface protein-1. Methods Cell Biol (1994) 1.63
A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development. Proc Natl Acad Sci U S A (2009) 1.62
Clonal conditional mutagenesis in malaria parasites. Cell Host Microbe (2009) 1.57
Regulation of Cre recombinase by ligand-induced complementation of inactive fragments. Nucleic Acids Res (2003) 1.57
Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators. Proc Natl Acad Sci U S A (2005) 1.49
Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag. Proc Natl Acad Sci U S A (2011) 1.46
A 50 kilodalton exoantigen specific to the merozoite release-reinvasion stage of Plasmodium falciparum. Mol Biochem Parasitol (1985) 1.35
Dimerizer-regulated gene expression. Curr Opin Biotechnol (2002) 1.32
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes. Proc Natl Acad Sci U S A (2012) 1.24
Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design. Infect Immun (2007) 1.23
A novel 'gene insertion/marker out' (GIMO) method for transgene expression and gene complementation in rodent malaria parasites. PLoS One (2011) 1.22
Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. Biochem Pharmacol (1994) 1.19
A tetracycline-repressible transactivator system to study essential genes in malaria parasites. Cell Host Microbe (2012) 1.16
Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 1.14
Role of Plasmodium berghei cGMP-dependent protein kinase in late liver stage development. J Biol Chem (2009) 1.13
Rapamycin: distribution, pharmacokinetics, and therapeutic range investigations. Ther Drug Monit (1995) 1.10
MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking. Mol Microbiol (2008) 1.07
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1. J Biol Chem (2003) 1.07
Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth. Mol Microbiol (2010) 1.07
Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. Proc Natl Acad Sci U S A (2012) 1.06
FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei. Nat Protoc (2011) 1.02
Genome engineering of Toxoplasma gondii using the site-specific recombinase Cre. Gene (1999) 1.01
A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities. Mol Biochem Parasitol (2005) 0.98
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte. J Biol Chem (2012) 0.98
Conditional transgenesis using Dimerizable Cre (DiCre). PLoS One (2007) 0.98
Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update. Clin Biochem (1998) 0.93
Clues to evolution of the SERA multigene family in 18 Plasmodium species. PLoS One (2011) 0.93
Gene deletion from Plasmodium falciparum using FLP and Cre recombinases: implications for applied site-specific recombination. Int J Parasitol (2010) 0.90
Functional expression of ribozymes in Apicomplexa: towards exogenous control of gene expression by inducible RNA-cleavage. Int J Parasitol (2007) 0.85
Tricks in Plasmodium's molecular repertoire--escaping 3'UTR excision-based conditional silencing of the chloroquine resistance transporter gene. Int J Parasitol (2012) 0.83
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science (2007) 4.89
High-throughput generation of selected reaction-monitoring assays for proteins and proteomes. Nat Methods (2009) 4.17
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes. Cell (2007) 3.37
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (2010) 3.27
Rapid control of protein level in the apicomplexan Toxoplasma gondii. Nat Methods (2007) 3.13
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites. J Biol Chem (2003) 2.84
High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion. Infect Immun (2002) 2.61
Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion. Mol Biol Cell (2005) 2.49
Crystal structure of the malaria vaccine candidate apical membrane antigen 1. Science (2005) 2.39
Molecular identification of a malaria merozoite surface sheddase. PLoS Pathog (2005) 2.06
Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms. Nat Methods (2012) 2.00
A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage. J Biol Chem (2003) 1.88
Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode. Science (2010) 1.86
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite. J Cell Biol (2006) 1.84
An inhibitory antibody blocks interactions between components of the malarial invasion machinery. PLoS Pathog (2009) 1.81
Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development. J Cell Sci (2003) 1.78
A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii. Curr Biol (2009) 1.77
A multifunctional serine protease primes the malaria parasite for red blood cell invasion. EMBO J (2009) 1.67
Regulation of Cre recombinase by ligand-induced complementation of inactive fragments. Nucleic Acids Res (2003) 1.57
Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites. Mol Biochem Parasitol (2005) 1.51
Toxoplasma as a novel system for motility. Curr Opin Cell Biol (2004) 1.48
Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1. J Biol Chem (2006) 1.47
The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases. Mol Microbiol (2005) 1.46
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens. Mol Microbiol (2005) 1.45
Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex. Mol Cell Proteomics (2004) 1.44
Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma. Trends Parasitol (2008) 1.44
Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. Biochem J (2002) 1.41
A new release on life: emerging concepts in proteolysis and parasite invasion. Mol Microbiol (2005) 1.38
Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages. J Biol Chem (2002) 1.37
Comprehensive quantitative analysis of central carbon and amino-acid metabolism in Saccharomyces cerevisiae under multiple conditions by targeted proteomics. Mol Syst Biol (2011) 1.35
Microneme protein 8--a new essential invasion factor in Toxoplasma gondii. J Cell Sci (2008) 1.35
Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion. Nat Commun (2013) 1.32
The diversity and evolution of thioredoxin reductase: new perspectives. Trends Parasitol (2002) 1.24
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes. Proc Natl Acad Sci U S A (2012) 1.24
Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis. PLoS Pathog (2009) 1.22
Atomic resolution insight into host cell recognition by Toxoplasma gondii. EMBO J (2007) 1.22
A novel dynamin-related protein has been recruited for apicoplast fission in Toxoplasma gondii. Curr Biol (2009) 1.20
TgSUB2 is a Toxoplasma gondii rhoptry organelle processing proteinase. Mol Microbiol (2003) 1.19
The role of malaria merozoite proteases in red blood cell invasion. Curr Opin Microbiol (2005) 1.17
Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. PLoS Pathog (2013) 1.16
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease. Infect Immun (2011) 1.15
Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum. Mol Microbiol (2006) 1.14
Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B. PLoS Pathog (2010) 1.12
Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background. PLoS Negl Trop Dis (2012) 1.11
Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis. Biochem J (2006) 1.11
Subtilisin-like proteases of the malaria parasite. Mol Microbiol (2004) 1.10
Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling. J Biol Chem (2002) 1.07
Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth. Mol Microbiol (2010) 1.07
Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites. J Biol Chem (2009) 1.07
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1. J Biol Chem (2003) 1.07
Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii. J Biol Chem (2004) 1.07
Comparative genomics of the Rab protein family in Apicomplexan parasites. Microbes Infect (2008) 1.06
The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system. J Biol Chem (2003) 1.06
Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights. J Biol Chem (2005) 1.05
An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes. PLoS Pathog (2013) 1.05
The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways. Mol Microbiol (2004) 1.04
Cytoskeleton assembly in Toxoplasma gondii cell division. Int Rev Cell Mol Biol (2012) 1.02
Cryoelectron tomography reveals periodic material at the inner side of subpellicular microtubules in apicomplexan parasites. J Exp Med (2007) 1.01
3-Aminooxy-1-aminopropane and derivatives have an antiproliferative effect on cultured Plasmodium falciparum by decreasing intracellular polyamine concentrations. Antimicrob Agents Chemother (2005) 1.00
Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog (2011) 0.99
A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes. Cell Microbiol (2013) 0.99
Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum. J Biol Chem (2003) 0.99
Intracellular transport of Toxoplasma gondii through the blood-brain barrier. J Neuroimmunol (2010) 0.98
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte. J Biol Chem (2012) 0.98
Conditional transgenesis using Dimerizable Cre (DiCre). PLoS One (2007) 0.98
Glutathione synthetase from Plasmodium falciparum. Biochem J (2002) 0.97
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies. PLoS Pathog (2011) 0.97
Glutathione transport: a new role for PfCRT in chloroquine resistance. Antioxid Redox Signal (2012) 0.97
Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition. EMBO Rep (2008) 0.94
Dissecting the role of glutathione biosynthesis in Plasmodium falciparum. Mol Microbiol (2011) 0.93
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity. Biochemistry (2003) 0.93
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target. Int J Parasitol (2012) 0.93
Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion. Malar J (2010) 0.93
Commentary to 'The postmodern assault on science' by Marcel Kuntz. EMBO Rep (2012) 0.92
Roles of proteases during invasion and egress by Plasmodium and Toxoplasma. Subcell Biochem (2008) 0.92
Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum. PLoS Pathog (2007) 0.92
Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies. Infect Immun (2009) 0.91
Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cell Microbiol (2014) 0.91