A natural tapasin isoform lacking exon 3 modifies peptide loading complex function.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 23519916)

Published in Eur J Immunol on May 10, 2013

Authors

Nele Beutler1, Sebastian Hauka, Alexandra Niepel, Daniel Johannes Kowalewski, Julia Uhlmann, Esther Ghanem, Steffen Erkelenz, Constanze Wiek, Helmut Hanenberg, Heiner Schaal, Stefan Stevanović, Sebastian Springer, Frank Momburg, Hartmut Hengel, Anne Halenius

Author Affiliations

1: Institute for Virology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

Articles by these authors

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet (2010) 5.48

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genet (2006) 5.12

Host immune system gene targeting by a viral miRNA. Science (2007) 5.10

A 20-year perspective on the International Fanconi Anemia Registry (IFAR). Blood (2002) 4.59

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Nat Genet (2005) 4.13

Mutations of the SLX4 gene in Fanconi anemia. Nat Genet (2011) 3.60

Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet (2010) 3.57

Memory inflation: continuous accumulation of antiviral CD8+ T cells over time. J Immunol (2003) 3.02

Decoding human cytomegalovirus. Science (2012) 2.98

MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo. Nat Immunol (2002) 2.66

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol (2011) 2.51

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway. Nat Struct Mol Biol (2007) 2.47

The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc Natl Acad Sci U S A (2005) 2.47

Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts. Blood (2005) 2.40

Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E. J Gen Virol (2008) 2.35

Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57. Nat Immunol (2005) 2.09

Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci U S A (2007) 2.08

A novel human polyomavirus closely related to the african green monkey-derived lymphotropic polyomavirus. J Virol (2011) 2.03

Moderate degradation does not preclude microarray analysis of small amounts of RNA. Biotechniques (2003) 1.95

Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells. J Immunol (2002) 1.92

Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor homologs. J Virol (2002) 1.92

Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines. Proc Natl Acad Sci U S A (2002) 1.85

A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses. J Exp Med (2005) 1.68

Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia. Blood (2004) 1.67

Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype. Am J Hum Genet (2007) 1.67

Case definition for progressive multifocal leukoencephalopathy following treatment with monoclonal antibodies. J Neurol Neurosurg Psychiatry (2012) 1.66

Early clinical experiences with the new influenza A (H1N1/09). Dtsch Arztebl Int (2009) 1.65

NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145. J Exp Med (2005) 1.60

Hepatitis C virus mutation affects proteasomal epitope processing. J Clin Invest (2004) 1.58

Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells. Hum Gene Ther (2003) 1.58

Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses. J Virol (2004) 1.55

A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. Mol Ther (2005) 1.48

Delayed diagnosis and complications of Fanconi anaemia at advanced age--a paradigm. Br J Haematol (2006) 1.48

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. 1991. J Immunol (2006) 1.45

Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia. J Natl Cancer Inst (2003) 1.42

NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies. Blood (2010) 1.38

A novel approach to describe a U1 snRNA binding site. Nucleic Acids Res (2003) 1.35

A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression. J Virol (2004) 1.35

Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles. Retrovirology (2010) 1.32

A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network. J Med Genet (2006) 1.30

A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species. J Biol Chem (2013) 1.29

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms. RNA (2012) 1.28

Integrated functional genomics approach for the design of patient-individual antitumor vaccines. Cancer Res (2002) 1.28

The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. J Exp Med (2006) 1.27

Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance. Eur J Immunol (2005) 1.27

Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44. PLoS One (2007) 1.26

Rapid replacement of endemic measles virus genotypes. J Gen Virol (2002) 1.25

Conformational flexibility of the MHC class I alpha1-alpha2 domain in peptide bound and free states: a molecular dynamics simulation study. Biophys J (2004) 1.24

The strength of the HIV-1 3' splice sites affects Rev function. Retrovirology (2006) 1.24

Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer. Cancer Res (2007) 1.24

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. PLoS One (2008) 1.23

Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules. EMBO J (2009) 1.23

Pregenomic RNA is required for efficient incorporation of pol polyprotein into foamy virus capsids. J Virol (2002) 1.22

Towards patient-specific tumor antigen selection for vaccination. Immunol Rev (2002) 1.22

Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein. J Virol (2005) 1.21

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo. Blood (2009) 1.20

Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase. J Virol (2009) 1.20

Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation. J Gen Virol (2008) 1.19

A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. Eur J Immunol (2003) 1.19

Restriction of foamy viruses by primate Trim5alpha. J Virol (2008) 1.19

Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons. Nat Commun (2013) 1.18

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading. J Immunol (2002) 1.18

The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J Biol Chem (2007) 1.18

Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans. Blood (2011) 1.18

The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling. J Virol (2011) 1.17

IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion. J Clin Invest (2014) 1.17

Extended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognition. Nucleic Acids Res (2005) 1.17

A conserved, lipid-mediated sorting mechanism of yeast Ist2 and mammalian STIM proteins to the peripheral ER. Traffic (2009) 1.16

Construction of a fully retargeted herpes simplex virus 1 recombinant capable of entering cells solely via human epidermal growth factor receptor 2. J Virol (2008) 1.16

Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study. Biopolymers (2009) 1.16

Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases. Am J Pathol (2007) 1.15

Multifunctionalized polymer microcapsules: novel tools for biological and pharmacological applications. Small (2007) 1.15

Comparative in silico analyses and experimental validation of novel splice site and missense mutations in the genes MLH1 and MSH2. J Cancer Res Clin Oncol (2010) 1.14

Altered glycosylation of recombinant NKp30 hampers binding to heparan sulfate: a lesson for the use of recombinant immunoreceptors as an immunological tool. Glycobiology (2007) 1.12

Laboratory investigations are indispensable to monitor the progress of measles elimination--results of the German Measles Sentinel 1999-2003. J Clin Virol (2004) 1.11

Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin. PLoS Pathog (2011) 1.11

Diagnostics of pathogenic splicing mutations: does bioinformatics cover all bases? Front Biosci (2008) 1.09

HLA ligand profiles of primary renal cell carcinoma maintained in metastases. Cancer Immunol Immunother (2009) 1.08

Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry. Eur J Immunol (2008) 1.08

Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis. Cancer Res (2009) 1.07

Tapasin and other chaperones: models of the MHC class I loading complex. Biol Chem (2004) 1.07

Probing neutralizing-antibody responses against emerging measles viruses (MVs): immune selection of MV by H protein-specific antibodies? J Gen Virol (2005) 1.06

A common founder mutation in FANCA underlies the world's highest prevalence of Fanconi anemia in Gypsy families from Spain. Blood (2004) 1.05

Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis. J Clin Invest (2007) 1.05

The influence of semen-derived enhancer of virus infection on the efficiency of retroviral gene transfer. J Gene Med (2010) 1.05

Tapasin edits peptides on MHC class I molecules by accelerating peptide exchange. Eur J Immunol (2010) 1.04

Quantitative analysis of prion-protein degradation by constitutive and immuno-20S proteasomes indicates differences correlated with disease susceptibility. J Immunol (2004) 1.04

Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia. Haematologica (2007) 1.04

Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytes. J Biol Chem (2007) 1.03