Published in Diabetes Care on April 01, 2013
High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial. Diabetologia (2015) 1.54
Incidence of remission in adults with type 2 diabetes: the diabetes & aging study. Diabetes Care (2014) 0.95
AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins. Traffic (2014) 0.90
The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Fam Pract (2016) 0.79
Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma. Exp Eye Res (2016) 0.78
Gestational diabetes mellitus and retinal microvasculature. BMC Ophthalmol (2017) 0.76
Effects of analogue insulin in multiple daily injection therapy of type 2 diabetes on postprandial glucose control and cardiac function compared to human insulin: a randomized controlled long-term study. Cardiovasc Diabetol (2016) 0.76
Matrix Metalloproteinase-9 -1562C/T Gene Polymorphism Is Associated with Diabetic Nephropathy. Biomed Res Int (2016) 0.75
Protamine zinc insulin combined with sodium selenite improves glycometabolism in the diabetic KKAy mice. Sci Rep (2016) 0.75
A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment. Dis Model Mech (2017) 0.75
Childhood type 2 diabetes: Risks and complications. Exp Ther Med (2016) 0.75
Exercise Ameliorates Endocrine Pancreas Damage Induced by Chronic Cola Drinking in Rats. PLoS One (2016) 0.75
Effects of intermittent fasting on health markers in those with type 2 diabetes: A pilot study. World J Diabetes (2017) 0.75
Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes. Indian J Endocrinol Metab (2017) 0.75
Lifestyle precision medicine: the next generation in type 2 diabetes prevention? BMC Med (2017) 0.75
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med (2004) 18.86
Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med (2004) 17.91
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes (2003) 16.62
Economic costs of diabetes in the U.S. In 2007. Diabetes Care (2008) 15.73
Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA (2008) 13.69
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med (2006) 10.97
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet (2008) 10.87
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell (1998) 8.10
Long-term weight loss maintenance. Am J Clin Nutr (2005) 7.42
Mechanisms for insulin resistance: common threads and missing links. Cell (2012) 6.85
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab (2002) 6.79
Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest (1996) 6.50
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes (2005) 5.22
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes (2002) 5.21
Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet (2009) 4.96
Lipid-induced insulin resistance: unravelling the mechanism. Lancet (2010) 4.88
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A (1998) 4.72
Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care (2007) 4.42
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes (1995) 4.33
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A (1994) 4.01
Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care (2010) 3.98
The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg (2006) 3.97
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia (2011) 3.97
Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab (2008) 3.96
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest (2000) 3.79
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A (2007) 3.76
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J Clin Invest (2006) 3.75
Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. J Clin Endocrinol Metab (2004) 2.92
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia (2010) 2.91
Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia (2006) 2.88
Surgical treatment of obesity and its effect on diabetes: 10-y follow-up. Am J Clin Nutr (1992) 2.62
Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care (2007) 2.61
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem (1998) 2.59
Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology (2007) 2.50
Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr (2003) 2.44
The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study. Diabetes (2006) 2.40
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A (2011) 2.39
Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut (2011) 2.38
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes (2009) 2.36
UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabet Med (1998) 2.20
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest (2006) 2.09
Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes (2004) 2.08
NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology (2006) 2.06
Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects. Diabetologia (2006) 1.97
Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men. Diabetes Care (2007) 1.90
Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery. Diabetes (2006) 1.89
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr (2012) 1.80
Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes (2004) 1.76
Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care (2004) 1.75
Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Diabetes (2006) 1.72
Metabolic and behavioral compensatory responses to exercise interventions: barriers to weight loss. Obesity (Silver Spring) (2007) 1.58
Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children. Diabetes Care (2007) 1.58
Mode of onset of type 2 diabetes from normal or impaired glucose tolerance. Diabetes (2004) 1.53
Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence. Diabetologia (1995) 1.52
Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia (2008) 1.50
Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology (2009) 1.49
Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care (2007) 1.45
Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans (2008) 1.45
Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study. Diabetes (2012) 1.44
Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes. Diabetes Care (2009) 1.41
Primary defects in beta-cell function further exacerbated by worsening of insulin resistance mark the development of impaired glucose tolerance in obese adolescents. Diabetes Care (2008) 1.35
Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc Natl Acad Sci U S A (2011) 1.32
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology (2012) 1.27
Preoperative weight loss with a very-low-energy diet: quantitation of changes in liver and abdominal fat by serial imaging. Am J Clin Nutr (2006) 1.26
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state. Pflugers Arch (2005) 1.24
Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Diabetes (2005) 1.24
Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18. Diabetes (2012) 1.19
Direct assessment of muscle glycogen storage after mixed meals in normal and type 2 diabetic subjects. Am J Physiol Endocrinol Metab (2002) 1.18
Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes (2009) 1.17
Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content. Diabetes (2008) 1.13
Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatology (2005) 1.12
Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes. Am J Physiol Endocrinol Metab (2006) 1.10
Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment. Diabet Med (1988) 1.08
Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care (2011) 1.07
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes. Proc Natl Acad Sci U S A (2012) 1.05
Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. Diabetes (2006) 1.02
Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol (2007) 1.01
Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes (2012) 0.99
Pancreatic steatosis and its relationship to β-cell dysfunction in humans: racial and ethnic variations. Diabetes Care (2012) 0.97
Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents. Int J Obes (Lond) (2009) 0.94
Population response to information on reversibility of Type 2 diabetes. Diabet Med (2013) 0.94
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLoS Med (2008) 0.91
Insulin resistance and type 2 diabetes. Diabetes (2012) 0.90
Reduced intrahepatic fat content is associated with increased whole-body lipid oxidation in patients with type 1 diabetes. Diabetologia (2005) 0.90
Beta-cell function in severely obese type 2 diabetic patients: long-term effects of bariatric surgery. Diabetes Care (2007) 0.89
Dietary management of maturity-onset diabetes. Br Med J (1980) 0.88
Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration. Diabetologia (2012) 0.86
Influence of the World War II food shortage on the incidence of diabetes mellitus in Japan. Diabetes (1958) 0.86
Effects of exercise on VLDL-triglyceride oxidation and turnover. Am J Physiol Endocrinol Metab (2011) 0.85
Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy. NMR Biomed (2010) 0.82
Comparison of insulin secretion and in vivo insulin action in nonobese and moderately obese individuals with non-insulin-dependent diabetes mellitus. Diabetes (1982) 0.82
Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates. Clin Sci (Lond) (2011) 0.80
Postprandial insulin secretion after gastric bypass surgery: the role of glucagon-like peptide 1. Diabetes (2011) 0.80
Measurement of total energy expenditure in grossly obese women: comparison of the bicarbonate-urea method with whole-body calorimetry and free-living doubly labelled water. Int J Obes Relat Metab Disord (2003) 0.77
Fasting and decreased B cell sensitivity: important role for fatty acid-induced inhibition of PDH activity. Am J Physiol (1996) 0.77