Published in J Biol Inorg Chem on March 31, 2013
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem (1969) 15.62
Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer (2012) 5.15
Is the multidrug transporter a flippase? Trends Biochem Sci (1992) 2.68
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res (1997) 2.67
Fluorescent cellular indicators are extruded by the multidrug resistance protein. J Biol Chem (1993) 2.52
Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells. Mol Cancer Ther (2005) 1.89
Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications. Clin Pharmacol Ther (2009) 1.77
V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol (1999) 1.77
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance. Biochem Biophys Res Commun (1995) 1.68
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest (1998) 1.65
Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium(I) in cultured chick myocardial cells. Mitochondrial and plasma membrane potential dependence. Circulation (1990) 1.58
Overcoming implementation challenges of personalized cancer therapy. Nat Rev Clin Oncol (2012) 1.56
Mechanism for myocardial localization and rapid liver clearance of Tc-99m-N-MPO: a new perfusion radiotracer for heart imaging. J Nucl Cardiol (2009) 1.56
Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts. J Nucl Med (1990) 1.52
The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem Neurosci (2010) 1.46
Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. J Natl Cancer Inst (1999) 1.46
Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. J Biol Chem (1998) 1.42
Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era. Chem Rev (2010) 1.16
Is PET always an advantage versus planar and SPECT imaging? Eur J Nucl Med Mol Imaging (2008) 1.15
Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1. FEBS Lett (1997) 1.14
Mitochondrial defects in cis-diamminedichloroplatinum(II)-resistant human ovarian carcinoma cells. Cancer Res (1992) 1.10
Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer. Mol Cancer Ther (2006) 1.08
Detection of in vivo P-glycoprotein inhibition by PSC 833 using Tc-99m sestamibi. Clin Cancer Res (1997) 1.07
To use MIBI or not to use MIBI? That is the question when assessing tumour cells. Eur J Nucl Med Mol Imaging (2005) 1.06
Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin. Biochem Pharmacol (2000) 1.02
99mTc-N-DBODC5, a new myocardial perfusion imaging agent with rapid liver clearance: comparison with 99mTc-sestamibi and 99mTc-tetrofosmin in rats. J Nucl Med (2004) 1.00
Regulation of cellular glutathione modulates nuclear accumulation of daunorubicin in human MCF7 cells overexpressing multidrug resistance associated protein. Eur J Cancer (2000) 0.98
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials. J Med Chem (2010) 0.97
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors. ChemMedChem (2009) 0.97
Radiopharmaceuticals for assessment of multidrug resistance P-glycoprotein-mediated drug transport activity. Bioconjug Chem (2004) 0.94
Cell viability assays: introduction. Methods Mol Biol (2011) 0.94
Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression. J Med Chem (2009) 0.94
Evaluation of novel cationic (99m)Tc-nitrido complexes as radiopharmaceuticals for heart imaging: improving liver clearance with crown ether groups. Nucl Med Biol (2006) 0.93
Impact of bidentate chelators on lipophilicity, stability, and biodistribution characteristics of cationic 99mTc-nitrido complexes. Bioconjug Chem (2007) 0.93
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives. Bioorg Med Chem (2007) 0.91
Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenoses. J Nucl Cardiol (2006) 0.91
99mTc-MIBI in the evaluation of breast cancer biology. Eur J Nucl Med Mol Imaging (2004) 0.90
Tc-99m-N-MPO: novel cationic Tc-99m radiotracer for myocardial perfusion imaging. J Nucl Cardiol (2008) 0.89
Synthesis and biologic evaluation of monocationic asymmetric 99mTc-nitride heterocomplexes showing high heart uptake and improved imaging properties. J Nucl Med (2003) 0.88
Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Neuroimaging Clin N Am (2006) 0.88
Evaluation of novel cationic 99mTc(I)-tricarbonyl complexes as potential radiotracers for myocardial perfusion imaging. Nucl Med Biol (2006) 0.88
Subcellular distribution and metabolism studies of the potential myocardial imaging agent [99mTc(N)(DBODC)(PNP5)]+. J Nucl Med (2008) 0.87
Carbon-11 labeled tracers for in vivo imaging P-glycoprotein function: kinetics, advantages and disadvantages. Curr Top Med Chem (2010) 0.85
Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs. Curr Top Med Chem (2010) 0.85
N1,N12-bis(ethyl)spermine effect on growth of cis-diamminedichloroplatinum(II)-sensitive and -resistant human ovarian-carcinoma cell lines. Int J Cancer (1998) 0.84
Substrates, inhibitors and activators of P-glycoprotein: candidates for radiolabeling and imaging perspectives. Curr Top Med Chem (2010) 0.82
Direct binding of chloroquine to the multidrug resistance protein (MRP): possible role for MRP in chloroquine drug transport and resistance in tumor cells. Biochem Pharmacol (1998) 0.82
[99mTc]oxotechnetium(V) complexes amine-amide-dithiol chelates with dialkylaminoalkyl substituents as potential diagnostic probes for malignant melanoma. J Med Chem (2001) 0.82
Whole-body biodistribution and radiation dosimetry of the new cardiac tracer 99mTc-N-DBODC. J Nucl Med (2008) 0.81
Probing multidrug resistance P-glycoprotein transporter activity with SPECT radiopharmaceuticals. Curr Top Med Chem (2010) 0.81
Why are investors not interested in my radiotracer? The industrial and regulatory constraints in the development of radiopharmaceuticals. Nucl Med Biol (2012) 0.80
Uptake of cationic technetium complexes in cultured human carcinoma cells and human xenografts. Nucl Med Biol (1998) 0.79
A novel ternary ligand system useful for preparation of cationic (99m)Tc-diazenido complexes and (99m)Tc-labeling of small biomolecules. Bioconjug Chem (2006) 0.79
Involvement of glutathione in loss of technetium-99m-MIBI accumulation related to membrane MDR protein expression in tumor cells. J Nucl Med (1998) 0.79
Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy. Curr Top Med Chem (2010) 0.79
Technetium-99m-sestamibi uptake by human benign and malignant breast tumor cells: correlation with mdr gene expression. J Nucl Med (1996) 0.78
Characterization of P-glycoprotein transport and inhibition in vivo. Cancer Res (1998) 0.77
The breast cancer cell line MCF7 as a model of 99mTc-SestaMIBI, 99mTc-tetrofosmin and 99mTc-Medronate incorporation. Anticancer Res (1999) 0.77
The quinoline-based drug, N-[4-[1-hydroxy-2-(dibutylamino)ethyl] quinolin-8-yl]-4-azidosalicylamide, photoaffinity labels the multidrug resistance protein (MRP) at a biologically relevant site. Biochem Biophys Res Commun (1997) 0.76
Biological in vitro and in vivo studies of a series of new asymmetrical cationic [99mTc(N)(DTC-Ln)(PNP)]+ complex (DTC-Ln = alicyclic dithiocarbamate and PNP = diphosphinoamine). Bioconjug Chem (2010) 0.76
Metalloprobes for functional monitoring of tumour multidrug resistance by nuclear imaging. Dalton Trans (2011) 0.76
PET imaging of MRP1 function in the living brain: method development and future perspectives. Curr Top Med Chem (2010) 0.75
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91
S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells. Free Radic Biol Med (2006) 1.69
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer Res (2012) 1.62
The electroencephalographic fingerprint of sleep is genetically determined: a twin study. Ann Neurol (2008) 1.57
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase. Biochem Pharmacol (2009) 1.28
Copper in diseases and treatments, and copper-based anticancer strategies. Med Res Rev (2010) 1.27
Validity of the Italian version of the Pittsburgh Sleep Quality Index (PSQI). Neurol Sci (2012) 1.18
Sleep to find your way: the role of sleep in the consolidation of memory for navigation in humans. Hippocampus (2008) 1.14
Advances in copper complexes as anticancer agents. Chem Rev (2013) 1.12
Modulation of corticospinal excitability by paired associative stimulation: reproducibility of effects and intraindividual reliability. Clin Neurophysiol (2006) 1.04
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators. Bioorg Med Chem (2008) 1.03
Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways. Proc Natl Acad Sci U S A (2005) 1.01
Neurophysiological correlates of sleepiness: a combined TMS and EEG study. Neuroimage (2007) 1.01
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors. ChemMedChem (2009) 0.97
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials. J Med Chem (2010) 0.97
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. J Med Chem (2011) 0.94
Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression. J Med Chem (2009) 0.94
Cortical plasticity induced by transcranial magnetic stimulation during wakefulness affects electroencephalogram activity during sleep. PLoS One (2008) 0.93
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development (2012) 0.92
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives. Bioorg Med Chem (2007) 0.91
The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition. J Med Chem (2009) 0.91
Slow EEG rhythms and inter-hemispheric synchronization across sleep and wakefulness in the human hippocampus. Neuroimage (2011) 0.89
Lack of sleep affects the evaluation of emotional stimuli. Brain Res Bull (2010) 0.89
Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift. Free Radic Biol Med (2009) 0.88
Pyran derivatives. Part XXI. Antiproliferative and cytotoxic properties of novel N-substituted 4-aminocoumarins, their benzo-fused derivatives, and some related 2-aminochromones. Farmaco (2003) 0.88
4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity. J Med Chem (2004) 0.88
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells. Cell Calcium (2009) 0.87
Procedural learning and sleep hippocampal low frequencies in humans. Neuroimage (2008) 0.87
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein. J Med Chem (2010) 0.85
Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates. Nanoscale (2011) 0.85
Can an inert sleeping pill affect sleep? Effects on polysomnographic, behavioral and subjective measures. Psychopharmacology (Berl) (2005) 0.85
GABP complex regulates transcription of eIF6 (p27BBP), an essential trans-acting factor in ribosome biogenesis. FEBS Lett (2006) 0.84
Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand. J Med Chem (2006) 0.84
A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation. J Med Chem (2010) 0.84
Distinct translational control in CD4+ T cell subsets. PLoS Genet (2013) 0.84
Dorsolateral prefrontal transcranial magnetic stimulation in patients with major depression locally affects alpha power of REM sleep. Front Hum Neurosci (2013) 0.84
Selenium induces a multi-targeted cell death process in addition to ROS formation. J Cell Mol Med (2014) 0.84
Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer. ChemMedChem (2010) 0.84
Chemistry and biological activity of platinum amidine complexes. ChemMedChem (2011) 0.83
Cisplatinum and transplatinum complexes with benzyliminoether ligands; synthesis, characterization, structure-activity relationships, and in vitro and in vivo antitumor efficacy. J Med Chem (2007) 0.83
Sleep in the human hippocampus: a stereo-EEG study. PLoS One (2007) 0.83
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity. ChemMedChem (2011) 0.83
A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling. J Cell Mol Med (2012) 0.83
Heritability of intracortical inhibition and facilitation. J Neurosci (2009) 0.82
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells. Cell Calcium (2006) 0.82
In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands. J Inorg Biochem (2010) 0.82
Substrates, inhibitors and activators of P-glycoprotein: candidates for radiolabeling and imaging perspectives. Curr Top Med Chem (2010) 0.82
Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies. J Med Chem (2007) 0.81
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 (sigma1) and sigma-2 (sigma2) receptor ligands: a review. Cent Nerv Syst Agents Med Chem (2009) 0.81
Avidin-biotin system: a small library of cysteine biotinylated derivatives designed for the [99mTc(N)(PNP)]2+ metal fragment. Nucl Med Biol (2007) 0.81
Role of zinc trafficking in male fertility: from germ to sperm. Hum Reprod (2014) 0.81
The electroencephalographic substratum of the awakening. Behav Brain Res (2005) 0.81
Dopamine on D2-like receptors is involved in reward evaluation in water-deprived rats licking for NaCl and water. Pharmacol Biochem Behav (2010) 0.80
Revisiting [PtCl₂(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer. J Med Chem (2012) 0.80
Amygdala and hippocampus volumetry and diffusivity in relation to dreaming. Hum Brain Mapp (2010) 0.80
Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists. Bioorg Med Chem (2007) 0.80
Synthesis and biological activity of ester- and amide-functionalized imidazolium salts and related water-soluble coinage metal N-heterocyclic carbene complexes. Inorg Chem (2012) 0.80
Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems. PLoS One (2012) 0.80
In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand. J Med Chem (2008) 0.79
How we remember the stuff that dreams are made of: neurobiological approaches to the brain mechanisms of dream recall. Behav Brain Res (2011) 0.79
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity. ChemMedChem (2013) 0.79
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line. Mol Cancer (2013) 0.79
The relationship between the electrospray ionization behaviour and biological activity of some phosphino Cu(I) complexes. Rapid Commun Mass Spectrom (2010) 0.79
Monofunctional platinum(II) complexes with potent tumor cell growth inhibitory activity: the effect of a hydrogen-bond donor/acceptor N-heterocyclic ligand. ChemMedChem (2014) 0.79
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters. Bioorg Med Chem (2012) 0.79
Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies. Bioorg Med Chem (2002) 0.78
Photoreactivity of 5-fluorouracil under UVB light: photolysis and cytotoxicity studies. Chem Res Toxicol (2011) 0.78
Synthesis and characterization of azolate gold(I) phosphane complexes as thioredoxin reductase inhibiting antitumor agents. Dalton Trans (2012) 0.78
trans,cis,cis-bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a prodrug candidate for the treatment of oxaliplatin-refractory colorectal cancer. ChemMedChem (2014) 0.78
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels. J Med Chem (2012) 0.78
SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein. J Med Chem (2014) 0.77
Nitroimidazole and glucosamine conjugated heteroscorpionate ligands and related copper(II) complexes. Syntheses, biological activity and XAS studies. Dalton Trans (2011) 0.77
MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol (2011) 0.77
Clinical pharmacokinetic and metabolism of PET radiotracers for imaging P-glycoprotein in chemoresistant tumor of colorectal cancer. Curr Drug Metab (2011) 0.77
Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours. Dalton Trans (2009) 0.77
Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity. ChemMedChem (2010) 0.77
DNA binding ellipticine analogues: synthesis, biological evaluation, and structure-activity relationships. ChemMedChem (2009) 0.77
Folic acid-conjugated europium complexes as luminescent probes for selective targeting of cancer cells. J Med Chem (2015) 0.77
Hippocampal slow EEG frequencies during NREM sleep are involved in spatial memory consolidation in humans. Hippocampus (2014) 0.77
Synthesis, characterization and biological evaluation of [188Re(N)(cys ∼)(PNP)]+/0 mixed-ligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals. Nucl Med Biol (2010) 0.76
Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity. J Inorg Biochem (2009) 0.76
Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors. J Med Chem (2013) 0.76
Psoralenquinones as a novel class of proteasome inhibitors: design, synthesis and biological evaluation. ChemMedChem (2011) 0.76
Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression. J Cell Mol Med (2012) 0.76
Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications. Free Radic Biol Med (2011) 0.76