Published in Obesity (Silver Spring) on June 13, 2013
Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes (2014) 3.21
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J Clin Invest (2015) 1.56
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity. Nat Commun (2016) 1.40
Increased brown adipose tissue oxidative capacity in cold-acclimated humans. J Clin Endocrinol Metab (2014) 1.27
Brown fat in humans: consensus points and experimental guidelines. Cell Metab (2014) 1.23
Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men. J Physiol (2014) 1.04
Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning. J Clin Invest (2016) 0.97
Molecular imaging of brown adipose tissue in health and disease. Eur J Nucl Med Mol Imaging (2014) 0.92
Reduced UCP-1 content in in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity. PLoS One (2014) 0.86
Targeting adipose tissue in the treatment of obesity-associated diabetes. Nat Rev Drug Discov (2016) 0.83
Adipose tissue oxygenation: Effects on metabolic function. Adipocyte (2013) 0.82
Central control of body temperature. F1000Res (2016) 0.81
The Therapeutic Potential of Brown Adipocytes in Humans. Front Endocrinol (Lausanne) (2015) 0.81
Mitochondria in White, Brown, and Beige Adipocytes. Stem Cells Int (2016) 0.80
Brown adipose tissue and the cold war against obesity. Diabetes (2014) 0.79
Imaging of Brown Adipose Tissue: State of the Art. Radiology (2016) 0.78
A high-fat diet impairs cooling-evoked brown adipose tissue activation via a vagal afferent mechanism. Am J Physiol Endocrinol Metab (2016) 0.78
Brown Adipose Tissue Is Linked to a Distinct Thermoregulatory Response to Mild Cold in People. Front Physiol (2016) 0.78
Adrenergic regulation of cellular plasticity in brown, beige/brite and white adipose tissues. Adipocyte (2016) 0.78
Transcriptional control and hormonal response of thermogenic fat. J Endocrinol (2015) 0.77
Brown adipose tissue function is accompanied by cerebral activation in lean but not in obese humans. J Cereb Blood Flow Metab (2014) 0.77
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis. J Clin Invest (2016) 0.76
Human brown adipose tissue [(15)O]O2 PET imaging in the presence and absence of cold stimulus. Eur J Nucl Med Mol Imaging (2016) 0.76
Bariatric surgery and type 2 diabetes: are there weight loss-independent therapeutic effects of upper gastrointestinal bypass? J Intern Med (2016) 0.75
The Relationship Between Brown Adipose Tissue Content in Supraclavicular Fat Depots and Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus and Prediabetes. Diabetes Technol Ther (2017) 0.75
Renaissance of brown adipose tissue research: integrating the old and new. Int J Obes Suppl (2015) 0.75
Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle aged men. Diabetes Obes Metab (2017) 0.75
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Functional brown adipose tissue in healthy adults. N Engl J Med (2009) 16.22
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet (2009) 7.24
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology (2009) 3.67
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A (2004) 3.45
Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab (2011) 3.40
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure. Circulation (2006) 3.12
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness. Clin Cancer Res (2009) 3.01
Evidence for two types of brown adipose tissue in humans. Nat Med (2013) 2.97
Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries. Twin Res (2003) 2.96
Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study. PLoS One (2007) 2.38
Epidemiology and course of anorexia nervosa in the community. Am J Psychiatry (2007) 2.36
FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurol (2011) 2.36
Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease. Ann Neurol (2008) 2.24
Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation. Diabetes Care (2011) 2.20
Maternal smoking during pregnancy and regional brain volumes in preterm infants. J Pediatr (2009) 2.19
Liver fat in the metabolic syndrome. J Clin Endocrinol Metab (2007) 2.17
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes (2007) 2.08
Intention to lose weight, weight changes, and 18-y mortality in overweight individuals without co-morbidities. PLoS Med (2005) 2.02
Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab (2006) 1.98
Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. PLoS Med (2008) 1.94
Imaging perfusion and hypoxia with PET to predict radiotherapy response in head-and-neck cancer. Int J Radiat Oncol Biol Phys (2004) 1.93
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol (2011) 1.89
Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Circulation (2008) 1.82
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr (2012) 1.80
Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes (2003) 1.71
Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease. J Gastroenterol Hepatol (2012) 1.67
Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs. Gastroenterology (2006) 1.66
Physical inactivity and obesity: a vicious circle. Obesity (Silver Spring) (2008) 1.65
Effects of age, diet, and type 2 diabetes on the development and FDG uptake of atherosclerotic plaques. JACC Cardiovasc Imaging (2011) 1.63
Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Obes Res (2003) 1.63
Exercise training improves biventricular oxidative metabolism and left ventricular efficiency in patients with dilated cardiomyopathy. J Am Coll Cardiol (2003) 1.62
Dietary fat content modifies liver fat in overweight nondiabetic subjects. J Clin Endocrinol Metab (2005) 1.62
Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas. J Nucl Med (2010) 1.61
Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development (2003) 1.59
Genetic influences on growth traits of BMI: a longitudinal study of adult twins. Obesity (Silver Spring) (2008) 1.56
Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults. Vasc Med (2003) 1.56
Lowering of LDL cholesterol rather than moderate weight loss improves endothelium-dependent vasodilatation in obese women with previous gestational diabetes. Diabetes Care (2003) 1.56
Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. J Clin Invest (2004) 1.53
Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. J Clin Endocrinol Metab (2002) 1.53
A nationwide survey of mortality in acromegaly. J Clin Endocrinol Metab (2005) 1.51
Myocardial and skeletal muscle glucose uptake during exercise in humans. J Physiol (2002) 1.50
Cognitive and neuropsychological outcomes at 5 years of age in preterm children born in the 2000s. Dev Med Child Neurol (2010) 1.49
Brain white matter expansion in human obesity and the recovering effect of dieting. J Clin Endocrinol Metab (2007) 1.46
Weight loss and weight maintenance, ambulatory blood pressure and cardiac autonomic tone in obese persons with the metabolic syndrome. J Hypertens (2003) 1.45
Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers. Diabetologia (2016) 1.45
Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography. Diabetes (2006) 1.37
Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) positron emission tomography as a tool to localize an insulinoma or beta-cell hyperplasia in adult patients. J Clin Endocrinol Metab (2007) 1.34
Dorsal striatum and its limbic connectivity mediate abnormal anticipatory reward processing in obesity. PLoS One (2012) 1.33
Is emotional contagion special? An fMRI study on neural systems for affective and cognitive empathy. Neuroimage (2008) 1.32
Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertility. EMBO J (2006) 1.32
Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication. Arch Neurol (2008) 1.31
Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. Obes Res (2002) 1.31
Modification effects of physical activity and protein intake on heritability of body size and composition. Am J Clin Nutr (2009) 1.30
Prospective analysis of accuracy of positron emission tomography, computed tomography, and endoscopic ultrasonography in staging of adenocarcinoma of the esophagus and the esophagogastric junction. Ann Surg Oncol (2003) 1.28
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc Natl Acad Sci U S A (2008) 1.27
Foxe3 haploinsufficiency in mice: a model for Peters' anomaly. Invest Ophthalmol Vis Sci (2002) 1.26
Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study. Eur J Endocrinol (2008) 1.26
Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Hum Mol Genet (2005) 1.25
Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. PLoS Genet (2010) 1.24
Effect of orlistat on weight regain and cardiovascular risk factors following a very-low-energy diet in abdominally obese patients: a 3-year randomized, placebo-controlled study. Diabetes Care (2007) 1.24
Body dissatisfaction and drive for thinness in young adult twins. Int J Eat Disord (2005) 1.23
Differential effects of rosiglitazone and metformin on adipose tissue distribution and glucose uptake in type 2 diabetic subjects. Diabetes (2003) 1.23
The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis. PLoS One (2009) 1.21
Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J Clin Endocrinol Metab (2004) 1.21